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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14399

FusionGeneSummary for GAS5_PABPC1L

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS5_PABPC1L
Fusion gene ID: 14399
HgeneTgene
Gene symbol

GAS5

PABPC1L

Gene ID

60674

80336

Gene namegrowth arrest specific 5poly(A) binding protein cytoplasmic 1 like
SynonymsNCRNA00030|SNHG2C20orf119|EPAB|PABPC1L1|dJ1069P2.3
Cytomap

1q25.1

20q13.12

Type of genencRNAprotein-coding
Descriptiongrowth arrest specific 5 (non-protein coding)growth arrest specific transcript 5small nucleolar RNA host gene (non-protein coding) 2polyadenylate-binding protein 1-likeembryonic poly(A) binding protein
Modification date2018051920180523
UniProtAcc

Q4VXU2

Ensembl transtripts involved in fusion geneENST00000363840, ENST00000365524, 
ENST00000364822, ENST00000363859, 
ENST00000385578, ENST00000363146, 
ENST00000364084, 
ENST00000217074, 
ENST00000255136, ENST00000537323, 
ENST00000217073, ENST00000490798, 
ENST00000372824, ENST00000372819, 
ENST00000217075, 
Fusion gene scores* DoF score13 X 13 X 2=3385 X 5 X 4=100
# samples 145
** MAII scorelog2(14/338*10)=-1.27159641933722
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAS5 [Title/Abstract] AND PABPC1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB268518GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000363840ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363840ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
5CDS-intronENST00000365524ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364822ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363859ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000385578ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000363146ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000217074GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000255136GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000537323GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000217073GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000490798GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000372824GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000372819GAS5chr1

173833509

-PABPC1Lchr20

43589050

-
intron-intronENST00000364084ENST00000217075GAS5chr1

173833509

-PABPC1Lchr20

43589050

-

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FusionProtFeatures for GAS5_PABPC1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS5

PABPC1L

Q4VXU2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GAS5_PABPC1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GAS5_PABPC1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GAS5_PABPC1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GAS5_PABPC1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS5C0151744Myocardial Ischemia1CTD_human