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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14398

FusionGeneSummary for GAS5_ORMDL1

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS5_ORMDL1
Fusion gene ID: 14398
HgeneTgene
Gene symbol

GAS5

ORMDL1

Gene ID

60674

94101

Gene namegrowth arrest specific 5ORMDL sphingolipid biosynthesis regulator 1
SynonymsNCRNA00030|SNHG2-
Cytomap

1q25.1

2q32.2

Type of genencRNAprotein-coding
Descriptiongrowth arrest specific 5 (non-protein coding)growth arrest specific transcript 5small nucleolar RNA host gene (non-protein coding) 2ORM1-like protein 1adoplin-1
Modification date2018051920180523
UniProtAcc

Q9P0S3

Ensembl transtripts involved in fusion geneENST00000363840, ENST00000365524, 
ENST00000364822, ENST00000363859, 
ENST00000385578, ENST00000363146, 
ENST00000364084, 
ENST00000392350, 
ENST00000325795, ENST00000496543, 
ENST00000392349, ENST00000409519, 
Fusion gene scores* DoF score13 X 13 X 2=3382 X 2 X 1=4
# samples 142
** MAII scorelog2(14/338*10)=-1.27159641933722
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: GAS5 [Title/Abstract] AND ORMDL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA439985GAS5chr1

173833971

-ORMDL1chr2

190649061

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000363840ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363840ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363840ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000363840ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363840ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000365524ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000365524ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000365524ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000365524ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000365524ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000364822ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000364822ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000364822ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000364822ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000364822ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000363859ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363859ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363859ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000363859ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363859ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000385578ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000385578ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000385578ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000385578ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000385578ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000363146ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363146ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363146ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000363146ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000363146ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000364084ENST00000392350GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000364084ENST00000325795GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000364084ENST00000496543GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-5UTRENST00000364084ENST00000392349GAS5chr1

173833971

-ORMDL1chr2

190649061

-
intron-intronENST00000364084ENST00000409519GAS5chr1

173833971

-ORMDL1chr2

190649061

-

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FusionProtFeatures for GAS5_ORMDL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS5

ORMDL1

Q9P0S3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Negative regulator of sphingolipid synthesis.{ECO:0000269|PubMed:20182505}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GAS5_ORMDL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GAS5_ORMDL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GAS5_ORMDL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GAS5_ORMDL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS5C0151744Myocardial Ischemia1CTD_human