FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14387

FusionGeneSummary for GAS2L3_PRDM1

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS2L3_PRDM1
Fusion gene ID: 14387
HgeneTgene
Gene symbol

GAS2L3

PRDM1

Gene ID

283431

639

Gene namegrowth arrest specific 2 like 3PR/SET domain 1
SynonymsG2L3BLIMP1|PRDI-BF1
Cytomap

12q23.1

6q21

Type of geneprotein-codingprotein-coding
DescriptionGAS2-like protein 3growth arrest-specific protein 2-like 3PR domain zinc finger protein 1B-lymphocyte-induced maturation protein 1BLIMP-1PR domain 1PR domain containing 1, with ZNF domainPRDI-binding factor-1beta-interferon gene positive-regulatory domain I binding factor
Modification date2018052920180527
UniProtAcc

Q86XJ1

O75626

Ensembl transtripts involved in fusion geneENST00000266754, ENST00000547754, 
ENST00000547739, ENST00000539410, 
ENST00000537247, 
ENST00000369091, 
ENST00000369096, ENST00000369089, 
Fusion gene scores* DoF score5 X 2 X 3=303 X 2 X 2=12
# samples 53
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GAS2L3 [Title/Abstract] AND PRDM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAS2L3

GO:0000226

microtubule cytoskeleton organization

21561867

HgeneGAS2L3

GO:0030036

actin cytoskeleton organization

21561867

TgenePRDM1

GO:0000122

negative regulation of transcription by RNA polymerase II

1851123


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3U5-01AGAS2L3chr12

101012365

+PRDM1chr6

106552700

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000266754ENST00000369091GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000266754ENST00000369096GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000266754ENST00000369089GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000547754ENST00000369091GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000547754ENST00000369096GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000547754ENST00000369089GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
intron-3CDSENST00000547739ENST00000369091GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
intron-3CDSENST00000547739ENST00000369096GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
intron-3CDSENST00000547739ENST00000369089GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000539410ENST00000369091GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000539410ENST00000369096GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000539410ENST00000369089GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000537247ENST00000369091GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000537247ENST00000369096GAS2L3chr12

101012365

+PRDM1chr6

106552700

+
Frame-shiftENST00000537247ENST00000369089GAS2L3chr12

101012365

+PRDM1chr6

106552700

+

Top

FusionProtFeatures for GAS2L3_PRDM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS2L3

Q86XJ1

PRDM1

O75626

Cytoskeletal linker protein. May promote and stabilizethe formation of the actin and microtubule network.{ECO:0000269|PubMed:21561867}. Transcription factor that mediates a transcriptionalprogram in various innate and adaptive immune tissue-residentlymphocyte T cell types such as tissue-resident memory T (Trm),natural killer (trNK) and natural killer T (NKT) cells andnegatively regulates gene expression of proteins that promote theegress of tissue-resident T-cell populations from non-lymphoidorgans. Plays a role in the development, retention and long-termestablishment of adaptive and innate tissue-resident lymphocyte Tcell types in non-lymphoid organs, such as the skin and gut, butalso in other nonbarrier tissues like liver and kidney, andtherefore may provide immediate immunological protection againstreactivating infections or viral reinfection (By similarity).Binds specifically to the PRDI element in the promoter of thebeta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associateswith the transcriptional repressor ZNF683 to chromatin at genepromoter regions (By similarity). {ECO:0000250|UniProtKB:Q60636,ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GAS2L3_PRDM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GAS2L3_PRDM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GAS2L3ELAVL1, CCDC8, ABCE1, DCTN1, CAPZA2, MYH9, PPP1CB, MYO19, TRIM25PRDM1TLE1, TLE2, HDAC2, EHMT2, PRMT5, PRMT7, KDM1A, HDAC1, ELAVL1, PIAS1, ATXN1, HSP90AA1, MS4A1, SENP1, IRF1, IRF2, HIST2H3A, HIST1H1A, PRDM1, ZBTB32, IKZF3, GTF2I, HSPA5, HSPA9, HSPD1, DPYSL3, BMX, SRC, RRAS, UBE4A, DLG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GAS2L3_PRDM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GAS2L3_PRDM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRDM1C0003873Rheumatoid Arthritis3CTD_human
TgenePRDM1C0009324Ulcerative Colitis1CTD_human
TgenePRDM1C0024141Lupus Erythematosus, Systemic1CTD_human
TgenePRDM1C1527336Sjogren's Syndrome1CTD_human