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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 14385

FusionGeneSummary for GAS2L3_MED13L

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS2L3_MED13L
Fusion gene ID: 14385
HgeneTgene
Gene symbol

GAS2L3

MED13L

Gene ID

283431

23389

Gene namegrowth arrest specific 2 like 3mediator complex subunit 13 like
SynonymsG2L3MRFACD|PROSIT240|THRAP2|TRAP240L
Cytomap

12q23.1

12q24.21

Type of geneprotein-codingprotein-coding
DescriptionGAS2-like protein 3growth arrest-specific protein 2-like 3mediator of RNA polymerase II transcription subunit 13-likethyroid hormone receptor-associated protein 2thyroid hormone receptor-associated protein complex 240 kDa component-like
Modification date2018052920180523
UniProtAcc

Q86XJ1

Q71F56

Ensembl transtripts involved in fusion geneENST00000266754, ENST00000547754, 
ENST00000547739, ENST00000539410, 
ENST00000537247, 
ENST00000281928, 
ENST00000551197, 
Fusion gene scores* DoF score5 X 2 X 3=305 X 5 X 3=75
# samples 56
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAS2L3 [Title/Abstract] AND MED13L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAS2L3

GO:0000226

microtubule cytoskeleton organization

21561867

HgeneGAS2L3

GO:0030036

actin cytoskeleton organization

21561867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A6TB-01AGAS2L3chr12

100995531

+MED13Lchr12

116404048

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000266754ENST00000281928GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
5CDS-intronENST00000266754ENST00000551197GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
In-frameENST00000547754ENST00000281928GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
5CDS-intronENST00000547754ENST00000551197GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
intron-3CDSENST00000547739ENST00000281928GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
intron-intronENST00000547739ENST00000551197GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
In-frameENST00000539410ENST00000281928GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
5CDS-intronENST00000539410ENST00000551197GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
5UTR-3CDSENST00000537247ENST00000281928GAS2L3chr12

100995531

+MED13Lchr12

116404048

-
5UTR-intronENST00000537247ENST00000551197GAS2L3chr12

100995531

+MED13Lchr12

116404048

-

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FusionProtFeatures for GAS2L3_MED13L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS2L3

Q86XJ1

MED13L

Q71F56

Cytoskeletal linker protein. May promote and stabilizethe formation of the actin and microtubule network.{ECO:0000269|PubMed:21561867}. Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. This subunit may specifically regulatetranscription of targets of the Wnt signaling pathway and SHHsignaling pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAS2L3chr12:100995531chr12:116404048ENST00000266754+49208_281101695DomainGAR
HgeneGAS2L3chr12:100995531chr12:116404048ENST00000266754+4948_168101695DomainCalponin-homology (CH)
HgeneGAS2L3chr12:100995531chr12:116404048ENST00000539410+49208_281101695DomainGAR
HgeneGAS2L3chr12:100995531chr12:116404048ENST00000539410+4948_168101695DomainCalponin-homology (CH)
HgeneGAS2L3chr12:100995531chr12:116404048ENST00000547754+510208_281101695DomainGAR
HgeneGAS2L3chr12:100995531chr12:116404048ENST00000547754+51048_168101695DomainCalponin-homology (CH)
TgeneMED13Lchr12:100995531chr12:116404048ENST00000281928-27311566_161020752211Compositional biasNote=Ser-rich
TgeneMED13Lchr12:100995531chr12:116404048ENST00000281928-27311225_122920752211MotifNote=LXXLL motif 2
TgeneMED13Lchr12:100995531chr12:116404048ENST00000281928-2731669_67320752211MotifNote=LXXLL motif 1
TgeneMED13Lchr12:100995531chr12:116404048ENST00000281928-27311380_140120752211RegionNote=Leucine-zipper


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FusionGeneSequence for GAS2L3_MED13L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_237aa
MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN
MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP

>In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_237aa
MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN
MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP

>In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_237aa
MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN
MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_711nt
ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT
AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT
TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC
ATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCC
CTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGC
CCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCA
CACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCC

>In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_711nt
ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT
AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT
TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC
ATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCC
CTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGC
CCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCA
CACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCC

>In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_711nt
ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT
AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT
TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC
ATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCC
CTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGC
CCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCA
CACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_3534nt
CAGGCGGCGGCGGCAGCGGCGGCGGTTGGTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGAC
CCTCCTGCGCCTGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAG
TCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCAC
TTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGA
TAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCG
TCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCC
CCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACA
GACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTT
GGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCTCAC
TCAGTTGTACAATGCCATCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGTCCA
AGGAACCTGCTACACTCTGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGGCAC
ATGTCAATTCTGCAGTGTTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAGCCA
GTGCGGTGGTGTGTGTAGCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTGTCC
TTTTGCACAAGAGTCTGTGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGTATG
GCCTGTGGGTTACCTGAACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGTCTC
CCTAGTGTTCCCATCCAGATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATTTTG
TTTATTTATTTTAATTTGTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCAATT
CAGATCCACCATAGGATTCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAAAAG
TAATATATTCAAAACCACCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTCATG
AAGGATAACATTTTTATACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAACGGA
AATATATTTTCTAGTGAATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAAGTG
TTTGCTCATGAAATCAGTTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATTAAA
TTAGTACTTGAAGTTGAGCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGACTC
CTCATTCCTGGCCCAGAGGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTACTGG
CCTCCCGGGAGCCACTGTGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGACTTC
CATGTCCTGGTTATTAACAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTAAAA
CATTATATTAAAAAAAAAGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCAGTT
GAAGGGGGGGTTGACTTTCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGACTT
TAAAAATATTGCAGTGCTATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAACTT
GTATAAAATTATCTTGGTGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATTCAT
CAGAACTTTGAATTTTTTTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAAAAA
AAACACAAAAAATAAAAAACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAGTTT
TTTAAGTTAAGAAAAGCTGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATGTAC
TTCTGTGTGAAAAAGTCTGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTACAAG
CCCTGGATTTGCTACAGAGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCATGGT
TTGAACAAAAAAAGGGGAAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATGTAA
AAGCTGTACATTTCTGGGAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGCAAA
CAATTTGAAAGAATACAAAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGATAA
AAAGAAACAATAATAAAAGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTTAGA

>In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_3627nt
GTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGACCCTCCTGCGCCTGATCAGAACACTGAGG
CTCAGAGAAGTTAACTACTCCAAAGTCATATAGCCAGTATTTTCTGGAGCTGTAATTCAAATCAGATGTGTTCAATACCTTCTACTACCC
CATTGCTGTCTTTATGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCT
AAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGC
CACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACT
TGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGA
GCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCT
TCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGC
ACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGT
TTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCT
CACTCAGTTGTACAATGCCATCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGT
CCAAGGAACCTGCTACACTCTGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGG
CACATGTCAATTCTGCAGTGTTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAG
CCAGTGCGGTGGTGTGTGTAGCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTG
TCCTTTTGCACAAGAGTCTGTGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGT
ATGGCCTGTGGGTTACCTGAACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGT
CTCCCTAGTGTTCCCATCCAGATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATT
TTGTTTATTTATTTTAATTTGTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCA
ATTCAGATCCACCATAGGATTCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAA
AAGTAATATATTCAAAACCACCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTC
ATGAAGGATAACATTTTTATACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAAC
GGAAATATATTTTCTAGTGAATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAA
GTGTTTGCTCATGAAATCAGTTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATT
AAATTAGTACTTGAAGTTGAGCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGA
CTCCTCATTCCTGGCCCAGAGGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTAC
TGGCCTCCCGGGAGCCACTGTGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGAC
TTCCATGTCCTGGTTATTAACAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTA
AAACATTATATTAAAAAAAAAGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCA
GTTGAAGGGGGGGTTGACTTTCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGA
CTTTAAAAATATTGCAGTGCTATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAA
CTTGTATAAAATTATCTTGGTGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATT
CATCAGAACTTTGAATTTTTTTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAA
AAAAAACACAAAAAATAAAAAACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAG
TTTTTTAAGTTAAGAAAAGCTGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATG
TACTTCTGTGTGAAAAAGTCTGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTAC
AAGCCCTGGATTTGCTACAGAGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCAT
GGTTTGAACAAAAAAAGGGGAAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATG
TAAAAGCTGTACATTTCTGGGAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGC
AAACAATTTGAAAGAATACAAAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGA
TAAAAAGAAACAATAATAAAAGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTT

>In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_3787nt
ATGTGGAACTCCATTTTAATAGGAGCAGCTTCTTTGCTGCATTTTTAAAAAATGGTCTTGGAAGCTTCTTACTTCCGAGAAGTGGATCTT
TGTTGCGGACAAAGGATTATTTATGCTAAAGGAAAATGTATTCCCCACTGAATTAGCTCGTGGGAAGCATAACAAGCTCATTAGGAATGC
TCACTTGTACTTTGGCCTTTTGCTGTGGTGGAGAGAAGGGAAAATGACATCAAAAAGGACATTCTGTTGTCTTTTGCCTTCCTGCAAAGA
AAATGTGTTATAATATTAGGCTTTTCAGTATGGTTTAGCTCAGGTTCAACTTTGGTACTAGAAGAAATGTTCCTGAAAGGAAAGTGAAAA
GAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGA
CTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAG
AAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTAT
GTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAG
CACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCAT
CGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGC
CTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTC
TGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCTCACTCAGTTGTACAATGCCA
TCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGTCCAAGGAACCTGCTACACTC
TGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGGCACATGTCAATTCTGCAGTG
TTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAGCCAGTGCGGTGGTGTGTGTA
GCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTGTCCTTTTGCACAAGAGTCTG
TGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGTATGGCCTGTGGGTTACCTGA
ACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGTCTCCCTAGTGTTCCCATCCA
GATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATTTTGTTTATTTATTTTAATTT
GTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCAATTCAGATCCACCATAGGAT
TCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAAAAGTAATATATTCAAAACCA
CCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTCATGAAGGATAACATTTTTAT
ACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAACGGAAATATATTTTCTAGTGA
ATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAAGTGTTTGCTCATGAAATCAG
TTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATTAAATTAGTACTTGAAGTTGA
GCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGACTCCTCATTCCTGGCCCAGA
GGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTACTGGCCTCCCGGGAGCCACTG
TGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGACTTCCATGTCCTGGTTATTAA
CAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTAAAACATTATATTAAAAAAAA
AGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCAGTTGAAGGGGGGGTTGACTT
TCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGACTTTAAAAATATTGCAGTGC
TATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAACTTGTATAAAATTATCTTGG
TGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATTCATCAGAACTTTGAATTTTT
TTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAAAAAAAACACAAAAAATAAAA
AACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAGTTTTTTAAGTTAAGAAAAGC
TGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATGTACTTCTGTGTGAAAAAGTC
TGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTACAAGCCCTGGATTTGCTACAG
AGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCATGGTTTGAACAAAAAAAGGGG
AAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATGTAAAAGCTGTACATTTCTGG
GAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGCAAACAATTTGAAAGAATACA
AAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGATAAAAAGAAACAATAATAAA
AGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTTAGAGGAATAAATTATTGAAT


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FusionGenePPI for GAS2L3_MED13L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GAS2L3ELAVL1, CCDC8, ABCE1, DCTN1, CAPZA2, MYH9, PPP1CB, MYO19, TRIM25MED13LMED10, MED9, MED29, MED19, MED28, MED26, FBXW7, MED1, CDK8, CDK19, MED7, CCNC, HIF1A, MED12, MED16, MED27, MED6, MED4, MED23, SORT1, SYNCRIP, SGTB, MED21, MED18, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GAS2L3_MED13L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GAS2L3_MED13L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMED13LC1837341Transposition of the Great Arteries, Dextro-Looped 11CTD_human;UNIPROT
TgeneMED13LC3714756Intellectual Disability1CTD_human