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Fusion gene ID: 14385 |
FusionGeneSummary for GAS2L3_MED13L |
Fusion gene summary |
Fusion gene information | Fusion gene name: GAS2L3_MED13L | Fusion gene ID: 14385 | Hgene | Tgene | Gene symbol | GAS2L3 | MED13L | Gene ID | 283431 | 23389 |
Gene name | growth arrest specific 2 like 3 | mediator complex subunit 13 like | |
Synonyms | G2L3 | MRFACD|PROSIT240|THRAP2|TRAP240L | |
Cytomap | 12q23.1 | 12q24.21 | |
Type of gene | protein-coding | protein-coding | |
Description | GAS2-like protein 3growth arrest-specific protein 2-like 3 | mediator of RNA polymerase II transcription subunit 13-likethyroid hormone receptor-associated protein 2thyroid hormone receptor-associated protein complex 240 kDa component-like | |
Modification date | 20180529 | 20180523 | |
UniProtAcc | Q86XJ1 | Q71F56 | |
Ensembl transtripts involved in fusion gene | ENST00000266754, ENST00000547754, ENST00000547739, ENST00000539410, ENST00000537247, | ENST00000281928, ENST00000551197, | |
Fusion gene scores | * DoF score | 5 X 2 X 3=30 | 5 X 5 X 3=75 |
# samples | 5 | 6 | |
** MAII score | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GAS2L3 [Title/Abstract] AND MED13L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GAS2L3 | GO:0000226 | microtubule cytoskeleton organization | 21561867 |
Hgene | GAS2L3 | GO:0030036 | actin cytoskeleton organization | 21561867 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FD-A6TB-01A | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000266754 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
5CDS-intron | ENST00000266754 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
In-frame | ENST00000547754 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
5CDS-intron | ENST00000547754 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
intron-3CDS | ENST00000547739 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
intron-intron | ENST00000547739 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
In-frame | ENST00000539410 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
5CDS-intron | ENST00000539410 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
5UTR-3CDS | ENST00000537247 | ENST00000281928 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
5UTR-intron | ENST00000537247 | ENST00000551197 | GAS2L3 | chr12 | 100995531 | + | MED13L | chr12 | 116404048 | - |
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FusionProtFeatures for GAS2L3_MED13L |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GAS2L3 | MED13L |
Cytoskeletal linker protein. May promote and stabilizethe formation of the actin and microtubule network.{ECO:0000269|PubMed:21561867}. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. This subunit may specifically regulatetranscription of targets of the Wnt signaling pathway and SHHsignaling pathway. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000266754 | + | 4 | 9 | 208_281 | 101 | 695 | Domain | GAR |
Hgene | >GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000266754 | + | 4 | 9 | 48_168 | 101 | 695 | Domain | Calponin-homology (CH) |
Hgene | >GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000539410 | + | 4 | 9 | 208_281 | 101 | 695 | Domain | GAR |
Hgene | >GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000539410 | + | 4 | 9 | 48_168 | 101 | 695 | Domain | Calponin-homology (CH) |
Hgene | >GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000547754 | + | 5 | 10 | 208_281 | 101 | 695 | Domain | GAR |
Hgene | >GAS2L3 | chr12:100995531 | chr12:116404048 | ENST00000547754 | + | 5 | 10 | 48_168 | 101 | 695 | Domain | Calponin-homology (CH) |
Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | - | 27 | 31 | 1566_1610 | 2075 | 2211 | Compositional bias | Note=Ser-rich |
Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | - | 27 | 31 | 1225_1229 | 2075 | 2211 | Motif | Note=LXXLL motif 2 |
Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | - | 27 | 31 | 669_673 | 2075 | 2211 | Motif | Note=LXXLL motif 1 |
Tgene | MED13L | chr12:100995531 | chr12:116404048 | ENST00000281928 | - | 27 | 31 | 1380_1401 | 2075 | 2211 | Region | Note=Leucine-zipper |
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FusionGeneSequence for GAS2L3_MED13L |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_237aa MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP >In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_237aa MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP >In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_237aa MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_711nt ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC ATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCC CTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGC CCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCA CACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCC >In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_711nt ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC ATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCC CTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGC CCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCA CACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCC >In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_711nt ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC ATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCC CTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGC CCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCA CACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_3534nt CAGGCGGCGGCGGCAGCGGCGGCGGTTGGTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGAC CCTCCTGCGCCTGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAG TCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCAC TTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGA TAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCG TCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCC CCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACA GACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTT GGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCTCAC TCAGTTGTACAATGCCATCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGTCCA AGGAACCTGCTACACTCTGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGGCAC ATGTCAATTCTGCAGTGTTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAGCCA GTGCGGTGGTGTGTGTAGCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTGTCC TTTTGCACAAGAGTCTGTGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGTATG GCCTGTGGGTTACCTGAACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGTCTC CCTAGTGTTCCCATCCAGATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATTTTG TTTATTTATTTTAATTTGTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCAATT CAGATCCACCATAGGATTCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAAAAG TAATATATTCAAAACCACCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTCATG AAGGATAACATTTTTATACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAACGGA AATATATTTTCTAGTGAATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAAGTG TTTGCTCATGAAATCAGTTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATTAAA TTAGTACTTGAAGTTGAGCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGACTC CTCATTCCTGGCCCAGAGGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTACTGG CCTCCCGGGAGCCACTGTGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGACTTC CATGTCCTGGTTATTAACAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTAAAA CATTATATTAAAAAAAAAGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCAGTT GAAGGGGGGGTTGACTTTCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGACTT TAAAAATATTGCAGTGCTATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAACTT GTATAAAATTATCTTGGTGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATTCAT CAGAACTTTGAATTTTTTTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAAAAA AAACACAAAAAATAAAAAACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAGTTT TTTAAGTTAAGAAAAGCTGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATGTAC TTCTGTGTGAAAAAGTCTGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTACAAG CCCTGGATTTGCTACAGAGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCATGGT TTGAACAAAAAAAGGGGAAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATGTAA AAGCTGTACATTTCTGGGAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGCAAA CAATTTGAAAGAATACAAAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGATAA AAAGAAACAATAATAAAAGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTTAGA >In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_3627nt GTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGACCCTCCTGCGCCTGATCAGAACACTGAGG CTCAGAGAAGTTAACTACTCCAAAGTCATATAGCCAGTATTTTCTGGAGCTGTAATTCAAATCAGATGTGTTCAATACCTTCTACTACCC CATTGCTGTCTTTATGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCT AAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGC CACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACT TGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGA GCGTCTTCTTTCTAGAGAAGCACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCT TCCCCAGTGGTTTTGGTCATCGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGC ACAGACAGACGAACTTCTGCCTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGT TTTGGAGCAGTACAACGCTCTGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCT CACTCAGTTGTACAATGCCATCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGT CCAAGGAACCTGCTACACTCTGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGG CACATGTCAATTCTGCAGTGTTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAG CCAGTGCGGTGGTGTGTGTAGCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTG TCCTTTTGCACAAGAGTCTGTGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGT ATGGCCTGTGGGTTACCTGAACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGT CTCCCTAGTGTTCCCATCCAGATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATT TTGTTTATTTATTTTAATTTGTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCA ATTCAGATCCACCATAGGATTCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAA AAGTAATATATTCAAAACCACCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTC ATGAAGGATAACATTTTTATACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAAC GGAAATATATTTTCTAGTGAATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAA GTGTTTGCTCATGAAATCAGTTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATT AAATTAGTACTTGAAGTTGAGCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGA CTCCTCATTCCTGGCCCAGAGGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTAC TGGCCTCCCGGGAGCCACTGTGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGAC TTCCATGTCCTGGTTATTAACAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTA AAACATTATATTAAAAAAAAAGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCA GTTGAAGGGGGGGTTGACTTTCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGA CTTTAAAAATATTGCAGTGCTATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAA CTTGTATAAAATTATCTTGGTGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATT CATCAGAACTTTGAATTTTTTTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAA AAAAAACACAAAAAATAAAAAACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAG TTTTTTAAGTTAAGAAAAGCTGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATG TACTTCTGTGTGAAAAAGTCTGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTAC AAGCCCTGGATTTGCTACAGAGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCAT GGTTTGAACAAAAAAAGGGGAAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATG TAAAAGCTGTACATTTCTGGGAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGC AAACAATTTGAAAGAATACAAAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGA TAAAAAGAAACAATAATAAAAGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTT >In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_MED13L_ENST00000281928_chr12_116404048_-_3787nt ATGTGGAACTCCATTTTAATAGGAGCAGCTTCTTTGCTGCATTTTTAAAAAATGGTCTTGGAAGCTTCTTACTTCCGAGAAGTGGATCTT TGTTGCGGACAAAGGATTATTTATGCTAAAGGAAAATGTATTCCCCACTGAATTAGCTCGTGGGAAGCATAACAAGCTCATTAGGAATGC TCACTTGTACTTTGGCCTTTTGCTGTGGTGGAGAGAAGGGAAAATGACATCAAAAAGGACATTCTGTTGTCTTTTGCCTTCCTGCAAAGA AAATGTGTTATAATATTAGGCTTTTCAGTATGGTTTAGCTCAGGTTCAACTTTGGTACTAGAAGAAATGTTCCTGAAAGGAAAGTGAAAA GAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGA CTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAG AAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTAT GTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGAGCCAGGGTGAGCGTCTTCTTTCTAGAGAAG CACCAGAGGAGCTAAAGCAGCAGCCCCTGGCCCTTGGGTATTTTGTATCAACTGCCAAAGCTGAGAATCTTCCCCAGTGGTTTTGGTCAT CGTGTCCCCAGGCTCAAAACCAGTGCCCTCTCTTCTTAAAGGCTTCGCTGCATCACCACATTTCAGTAGCACAGACAGACGAACTTCTGC CTGCCAGGAATTCTCAGCGGGTTCCACACCCTCTTGACTCCAAAACCACGTCGGATGTTTTAAGGTTTGTTTTGGAGCAGTACAACGCTC TGTCCTGGCTCACGTGCAATCCGGCCACCCAGGACCGTACTTCCTGCCTTCCCGTCCACTTTGTGGTGCTCACTCAGTTGTACAATGCCA TCATGAATATACTTTAATTGGAAAAGCACTTGTTCTCTCTGGCTCAGTTCCTTCTCCCTGCAACCTCAGTCCAAGGAACCTGCTACACTC TGCAAATAACCCACATCCTTTTCTTCAGACCACTCTCCACAGTCCTGCACTGTGATTCCTTCTCAGCAGGCACATGTCAATTCTGCAGTG TTCATTACCAGAGTGACTCCTTGACACTTCTCTCATGGACCTGGAAACTTCCATAAGTGGTGACTTTCAGCCAGTGCGGTGGTGTGTGTA GCCCCAACCACTGGTCCCCAGGAAGTGGTGGTGGTTGATGGCTTTTCAGCGGGAAACAGAAGAGACAGTGTCCTTTTGCACAAGAGTCTG TGTTTTCAGCCTCTGTATACAATTGAGGGCAGTCTAGCCCTTTGGATGAAATCCTCTTAGTTACTGGTGTATGGCCTGTGGGTTACCTGA ACTCCATAATCTGGGACTTTTTAAAAATAAGAACCAGCTCAAGTACATGGTTTCATACTGGGGTTTCTGTCTCCCTAGTGTTCCCATCCA GATTAGCATGAGTGCTTTGGTTGACTTCAAACCTGTGTGTCAATGCAGAAGGTCTGGAGACAGCTTCATTTTGTTTATTTATTTTAATTT GTTTTGTCATATGGTTTTTGTGACTTTATTTTTTTAATTCACAAGGACCAGGTACAGTAGCTGAAACCCAATTCAGATCCACCATAGGAT TCTTTGACTACATACCTCTGTCCTAGAAGCCGGAAAAGGAGTAAAAACACATTGGGGAGATCATGCCTAAAAGTAATATATTCAAAACCA CCCAGCAGTAGGTTTTGTTAACAACAAACTGGATTTTAAAAGTTCTGCCATGTTAAGTGGCCAGCATTTCATGAAGGATAACATTTTTAT ACAGAAGGCAGTCAAGCTCAACTCAGAGCCATGGAGGCAAGTACCTTAATTAGTTTTATATAGTCACAACGGAAATATATTTTCTAGTGA ATTCTTATTGGAAGCCAGGTCTCTCCTCTCATTAGATCAAAAGGGACTTATGTACATACAACAATTGAAAGTGTTTGCTCATGAAATCAG TTATAAATATGGTGAATTTTTTCTGGACCATAGGAATATTATTTCAAAGAAATATTACAACTTAACCATTAAATTAGTACTTGAAGTTGA GCCTTTGTGGTGGGACTTTTTAAAAAAATGCCTTTTTAAAGCATTAATGGCTAATTGAAGTATTTTATGACTCCTCATTCCTGGCCCAGA GGGTTGTCTTTGAAACCCTGTTTCTAACCCTTGTGTTGTGTGTTTCTGTCTGAGGACAGTGGGTGTGTACTGGCCTCCCGGGAGCCACTG TGACCAGGCCTTTGAGCTCTTGTCATCTGTGGAGAGAATCATGCAAATTTTAAAAGTTCTTCCAAGAGACTTCCATGTCCTGGTTATTAA CAAAAAAGGAAAAATGTAATAATTGATATGATTTTGTAAAAGTATTTTTCTTGAAATAATCTAAAGTTTAAAACATTATATTAAAAAAAA AGTTGTGTGGTGGGAATGTGAAAGCAGAGAAATAACTTGTAAATGGATAATTTTGTTCTCTGTACCACCAGTTGAAGGGGGGGTTGACTT TCGCAATGTATAGGATAAAAAATCTGATATATCAAACCATTTGTATCTAATGTGTACAGTGTAAAATTGACTTTAAAAATATTGCAGTGC TATTTTTTCTTAATCAGAAAGGAAAATTCTCAAGGCCTTTTGAAGAGCATAAGAAGATGAAGATTGTAAACTTGTATAAAATTATCTTGG TGAGAAGACAAATTGTAAAGTAGATATTTGTAATCTTTTACCACTTTGGGGTTGCTTTTTTCCCGGAATTCATCAGAACTTTGAATTTTT TTTTTAAATGGGCTGTTTTTAATGCAGGGGCTTTTCTTCCCTAGAAACCCAATTCTAAGCAGAAAAAGAAAAAAAACACAAAAAATAAAA AACCCCTACAAAAAAACTTTAAAAAAAATGGCAGCAAAGGGTAGTTTTCATCTGGTGTCTTTTATTTAAGTTTTTTAAGTTAAGAAAAGC TGGTGACATATTTATACGTTTTTGTGCAAAAATAAATGAATGGCAATAGATTTTAAAAAATCTTATTATGTACTTCTGTGTGAAAAAGTC TGTATAATATTTCCCTTAAATATGCATTATTTTACTTGTGAGTTTTTTACTGAATTAATCTGAAATGTACAAGCCCTGGATTTGCTACAG AGTGAGAAGTTATTTTATTTTTTTTTATTTTTAATTTTGGAAATTCTGCAGAAATCAGAACTCTTACCATGGTTTGAACAAAAAAAGGGG AAATGGGGAGGGGAAAAGGGTGGGATTGTCCAGCATGCTTGTATGTATATTTCAGAACCTTTTTTAAATGTAAAAGCTGTACATTTCTGG GAAGTTCTGAATTTCTTTTGTTTCCTTTTTTCCTTCAAGCATTTTGCAGTGAGCTTCTTTTATATATAGCAAACAATTTGAAAGAATACA AAAATATGTGAAGTTCATTTAAAAAAATAACTACAGTATAGCGCTGGTACAGTACACTAAAAGACTTTGATAAAAAGAAACAATAATAAA AGGCCTCCATTTTAAATGTCATTCATATATACCTTGTGGATGAGAGCTATATACTTTTACACACTTTTTTAGAGGAATAAATTATTGAAT |
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FusionGenePPI for GAS2L3_MED13L |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GAS2L3 | ELAVL1, CCDC8, ABCE1, DCTN1, CAPZA2, MYH9, PPP1CB, MYO19, TRIM25 | MED13L | MED10, MED9, MED29, MED19, MED28, MED26, FBXW7, MED1, CDK8, CDK19, MED7, CCNC, HIF1A, MED12, MED16, MED27, MED6, MED4, MED23, SORT1, SYNCRIP, SGTB, MED21, MED18, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAS2L3_MED13L |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAS2L3_MED13L |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MED13L | C1837341 | Transposition of the Great Arteries, Dextro-Looped 1 | 1 | CTD_human;UNIPROT |
Tgene | MED13L | C3714756 | Intellectual Disability | 1 | CTD_human |