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Fusion gene ID: 14384 |
FusionGeneSummary for GAS2L3_KRT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GAS2L3_KRT2 | Fusion gene ID: 14384 | Hgene | Tgene | Gene symbol | GAS2L3 | KRT2 | Gene ID | 283431 | 3849 |
| Gene name | growth arrest specific 2 like 3 | keratin 2 | |
| Synonyms | G2L3 | CK-2e|K2e|KRT2A|KRT2E|KRTE | |
| Cytomap | 12q23.1 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GAS2-like protein 3growth arrest-specific protein 2-like 3 | keratin, type II cytoskeletal 2 epidermalcytokeratin-2eepithelial keratin-2ekeratin 2, type IIkeratin-2 epidermiskeratin-2etype-II keratin Kb2 | |
| Modification date | 20180529 | 20180522 | |
| UniProtAcc | Q86XJ1 | P35908 | |
| Ensembl transtripts involved in fusion gene | ENST00000266754, ENST00000547754, ENST00000547739, ENST00000539410, ENST00000537247, | ENST00000309680, | |
| Fusion gene scores | * DoF score | 5 X 2 X 3=30 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GAS2L3 [Title/Abstract] AND KRT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GAS2L3 | GO:0000226 | microtubule cytoskeleton organization | 21561867 |
| Hgene | GAS2L3 | GO:0030036 | actin cytoskeleton organization | 21561867 |
| Tgene | KRT2 | GO:0018149 | peptide cross-linking | 7543090 |
| Tgene | KRT2 | GO:0031424 | keratinization | 12598329 |
| Tgene | KRT2 | GO:0032980 | keratinocyte activation | 12598329 |
| Tgene | KRT2 | GO:0043616 | keratinocyte proliferation | 12598329 |
| Tgene | KRT2 | GO:0051546 | keratinocyte migration | 15737202 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A2J4-01A | GAS2L3 | chr12 | 100995531 | + | KRT2 | chr12 | 53044337 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000266754 | ENST00000309680 | GAS2L3 | chr12 | 100995531 | + | KRT2 | chr12 | 53044337 | - |
| In-frame | ENST00000547754 | ENST00000309680 | GAS2L3 | chr12 | 100995531 | + | KRT2 | chr12 | 53044337 | - |
| intron-3CDS | ENST00000547739 | ENST00000309680 | GAS2L3 | chr12 | 100995531 | + | KRT2 | chr12 | 53044337 | - |
| In-frame | ENST00000539410 | ENST00000309680 | GAS2L3 | chr12 | 100995531 | + | KRT2 | chr12 | 53044337 | - |
| 5UTR-3CDS | ENST00000537247 | ENST00000309680 | GAS2L3 | chr12 | 100995531 | + | KRT2 | chr12 | 53044337 | - |
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FusionProtFeatures for GAS2L3_KRT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GAS2L3 | KRT2 |
| Cytoskeletal linker protein. May promote and stabilizethe formation of the actin and microtubule network.{ECO:0000269|PubMed:21561867}. | Probably contributes to terminal cornification(PubMed:1380918). Associated with keratinocyte activation,proliferation and keratinization (PubMed:12598329). Plays a rolein the establishment of the epidermal barrier on plantar skin (Bysimilarity). {ECO:0000250|UniProtKB:Q3TTY5,ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 214_232 | 195 | 640 | Region | Note=Linker 1 |
| Tgene | >KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 233_324 | 195 | 640 | Region | Note=Coil 1B |
| Tgene | >KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 325_348 | 195 | 640 | Region | Note=Linker 12 |
| Tgene | >KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 349_487 | 195 | 640 | Region | Note=Coil 2 |
| Tgene | >KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 488_639 | 195 | 640 | Region | Note=Tail |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GAS2L3 | chr12:100995531 | chr12:53044337 | ENST00000266754 | + | 4 | 9 | 208_281 | 101 | 695 | Domain | GAR |
| Hgene | >GAS2L3 | chr12:100995531 | chr12:53044337 | ENST00000266754 | + | 4 | 9 | 48_168 | 101 | 695 | Domain | Calponin-homology (CH) |
| Hgene | >GAS2L3 | chr12:100995531 | chr12:53044337 | ENST00000539410 | + | 4 | 9 | 208_281 | 101 | 695 | Domain | GAR |
| Hgene | >GAS2L3 | chr12:100995531 | chr12:53044337 | ENST00000539410 | + | 4 | 9 | 48_168 | 101 | 695 | Domain | Calponin-homology (CH) |
| Hgene | >GAS2L3 | chr12:100995531 | chr12:53044337 | ENST00000547754 | + | 5 | 10 | 208_281 | 101 | 695 | Domain | GAR |
| Hgene | >GAS2L3 | chr12:100995531 | chr12:53044337 | ENST00000547754 | + | 5 | 10 | 48_168 | 101 | 695 | Domain | Calponin-homology (CH) |
| Tgene | KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 178_491 | 195 | 640 | Domain | IF rod |
| Tgene | KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 178_213 | 195 | 640 | Region | Note=Coil 1A |
| Tgene | KRT2 | chr12:100995531 | chr12:53044337 | ENST00000309680 | - | 0 | 9 | 1_177 | 195 | 640 | Region | Note=Head |
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FusionGeneSequence for GAS2L3_KRT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_546aa MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINK RTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSK EEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKE DLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGR QSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSV >In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_546aa MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINK RTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSK EEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKE DLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGR QSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSV >In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_546aa MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQN MVKTCNSEESGVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINK RTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSK EEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKE DLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGR QSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_1638nt ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC ATGGTGAAAACATGCAACTCTGAAGAATCAGGGGTGCGGTTCTTGGAGCAGCAGAACCAGGTGTTACAGACCAAATGGGAGCTGCTACAA CAAATGAATGTTGGCACCCGCCCCATCAACCTGGAGCCCATCTTCCAGGGGTATATCGACAGCCTCAAGAGATATCTGGATGGGCTCACT GCAGAAAGAACATCACAGAATTCAGAGCTGAATAACATGCAGGATCTTGTGGAGGATTATAAGAAGAAGTATGAGGATGAAATCAATAAG CGCACAGCTGCTGAGAATGATTTTGTGACGCTTAAAAAGGACGTGGACAATGCCTACATGATAAAGGTGGAGTTGCAGTCCAAGGTGGAC CTGCTGAACCAGGAAATTGAGTTTCTGAAAGTTCTCTATGATGCGGAGATATCCCAGATACATCAGAGTGTCACTGACACCAACGTCATC CTCTCCATGGACAACAGCCGCAACCTGGACTTGGATAGCATCATCGCCGAGGTCAAGGCCCAGTATGAGGAGATCGCCCAGAGGAGCAAG GAAGAAGCGGAGGCCCTGTACCACAGCAAGTATGAGGAGCTCCAGGTGACTGTCGGGAGACATGGAGACAGCCTGAAAGAGATCAAGATA GAGATCAGCGAGCTGAACCGCGTGATCCAGAGGCTGCAGGGGGAGATCGCACATGTGAAGAAGCAGTGTAAGAATGTGCAAGATGCCATC GCAGATGCCGAGCAGCGTGGGGAGCATGCCCTCAAGGATGCCAGGAACAAGTTGAATGACCTGGAGGAGGCCCTGCAGCAGGCCAAGGAG GACTTGGCGCGGCTGCTGCGTGACTACCAGGAGCTGATGAACGTGAAGCTGGCCCTAGATGTGGAGATCGCCACCTACCGCAAACTGCTG GAGGGCGAGGAGTGCAGGATGTCTGGAGACCTCAGCAGCAATGTGACTGTGTCTGTGACAAGCAGCACCATTTCATCAAATGTGGCATCC AAGGCTGCCTTTGGAGGTTCTGGAGGTAGAGGGTCCAGTTCCGGAGGAGGATACAGCTCTGGAAGCAGCAGTTATGGCTCTGGAGGCCGA CAGTCTGGCTCCAGAGGCGGTAGTGGAGGAGGAGGTTCTATCTCTGGAGGAGGATATGGCTCTGGCGGTGGTTCTGGAGGAAGATACGGA TCTGGTGGTGGCTCTAAGGGAGGGTCCATCTCTGGAGGAGGATATGGCTCTGGAGGTGGAAAACACAGCTCTGGAGGTGGCTCTAGAGGA GGCTCCAGCTCTGGAGGAGGATATGGCTCTGGAGGTGGGGGTTCTAGCTCTGTAAAGGGTAGCTCAGGTGAAGCTTTTGGTTCCAGCGTG >In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_1638nt ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC ATGGTGAAAACATGCAACTCTGAAGAATCAGGGGTGCGGTTCTTGGAGCAGCAGAACCAGGTGTTACAGACCAAATGGGAGCTGCTACAA CAAATGAATGTTGGCACCCGCCCCATCAACCTGGAGCCCATCTTCCAGGGGTATATCGACAGCCTCAAGAGATATCTGGATGGGCTCACT GCAGAAAGAACATCACAGAATTCAGAGCTGAATAACATGCAGGATCTTGTGGAGGATTATAAGAAGAAGTATGAGGATGAAATCAATAAG CGCACAGCTGCTGAGAATGATTTTGTGACGCTTAAAAAGGACGTGGACAATGCCTACATGATAAAGGTGGAGTTGCAGTCCAAGGTGGAC CTGCTGAACCAGGAAATTGAGTTTCTGAAAGTTCTCTATGATGCGGAGATATCCCAGATACATCAGAGTGTCACTGACACCAACGTCATC CTCTCCATGGACAACAGCCGCAACCTGGACTTGGATAGCATCATCGCCGAGGTCAAGGCCCAGTATGAGGAGATCGCCCAGAGGAGCAAG GAAGAAGCGGAGGCCCTGTACCACAGCAAGTATGAGGAGCTCCAGGTGACTGTCGGGAGACATGGAGACAGCCTGAAAGAGATCAAGATA GAGATCAGCGAGCTGAACCGCGTGATCCAGAGGCTGCAGGGGGAGATCGCACATGTGAAGAAGCAGTGTAAGAATGTGCAAGATGCCATC GCAGATGCCGAGCAGCGTGGGGAGCATGCCCTCAAGGATGCCAGGAACAAGTTGAATGACCTGGAGGAGGCCCTGCAGCAGGCCAAGGAG GACTTGGCGCGGCTGCTGCGTGACTACCAGGAGCTGATGAACGTGAAGCTGGCCCTAGATGTGGAGATCGCCACCTACCGCAAACTGCTG GAGGGCGAGGAGTGCAGGATGTCTGGAGACCTCAGCAGCAATGTGACTGTGTCTGTGACAAGCAGCACCATTTCATCAAATGTGGCATCC AAGGCTGCCTTTGGAGGTTCTGGAGGTAGAGGGTCCAGTTCCGGAGGAGGATACAGCTCTGGAAGCAGCAGTTATGGCTCTGGAGGCCGA CAGTCTGGCTCCAGAGGCGGTAGTGGAGGAGGAGGTTCTATCTCTGGAGGAGGATATGGCTCTGGCGGTGGTTCTGGAGGAAGATACGGA TCTGGTGGTGGCTCTAAGGGAGGGTCCATCTCTGGAGGAGGATATGGCTCTGGAGGTGGAAAACACAGCTCTGGAGGTGGCTCTAGAGGA GGCTCCAGCTCTGGAGGAGGATATGGCTCTGGAGGTGGGGGTTCTAGCTCTGTAAAGGGTAGCTCAGGTGAAGCTTTTGGTTCCAGCGTG >In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_1638nt ATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCT AATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGT TTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAAC ATGGTGAAAACATGCAACTCTGAAGAATCAGGGGTGCGGTTCTTGGAGCAGCAGAACCAGGTGTTACAGACCAAATGGGAGCTGCTACAA CAAATGAATGTTGGCACCCGCCCCATCAACCTGGAGCCCATCTTCCAGGGGTATATCGACAGCCTCAAGAGATATCTGGATGGGCTCACT GCAGAAAGAACATCACAGAATTCAGAGCTGAATAACATGCAGGATCTTGTGGAGGATTATAAGAAGAAGTATGAGGATGAAATCAATAAG CGCACAGCTGCTGAGAATGATTTTGTGACGCTTAAAAAGGACGTGGACAATGCCTACATGATAAAGGTGGAGTTGCAGTCCAAGGTGGAC CTGCTGAACCAGGAAATTGAGTTTCTGAAAGTTCTCTATGATGCGGAGATATCCCAGATACATCAGAGTGTCACTGACACCAACGTCATC CTCTCCATGGACAACAGCCGCAACCTGGACTTGGATAGCATCATCGCCGAGGTCAAGGCCCAGTATGAGGAGATCGCCCAGAGGAGCAAG GAAGAAGCGGAGGCCCTGTACCACAGCAAGTATGAGGAGCTCCAGGTGACTGTCGGGAGACATGGAGACAGCCTGAAAGAGATCAAGATA GAGATCAGCGAGCTGAACCGCGTGATCCAGAGGCTGCAGGGGGAGATCGCACATGTGAAGAAGCAGTGTAAGAATGTGCAAGATGCCATC GCAGATGCCGAGCAGCGTGGGGAGCATGCCCTCAAGGATGCCAGGAACAAGTTGAATGACCTGGAGGAGGCCCTGCAGCAGGCCAAGGAG GACTTGGCGCGGCTGCTGCGTGACTACCAGGAGCTGATGAACGTGAAGCTGGCCCTAGATGTGGAGATCGCCACCTACCGCAAACTGCTG GAGGGCGAGGAGTGCAGGATGTCTGGAGACCTCAGCAGCAATGTGACTGTGTCTGTGACAAGCAGCACCATTTCATCAAATGTGGCATCC AAGGCTGCCTTTGGAGGTTCTGGAGGTAGAGGGTCCAGTTCCGGAGGAGGATACAGCTCTGGAAGCAGCAGTTATGGCTCTGGAGGCCGA CAGTCTGGCTCCAGAGGCGGTAGTGGAGGAGGAGGTTCTATCTCTGGAGGAGGATATGGCTCTGGCGGTGGTTCTGGAGGAAGATACGGA TCTGGTGGTGGCTCTAAGGGAGGGTCCATCTCTGGAGGAGGATATGGCTCTGGAGGTGGAAAACACAGCTCTGGAGGTGGCTCTAGAGGA GGCTCCAGCTCTGGAGGAGGATATGGCTCTGGAGGTGGGGGTTCTAGCTCTGTAAAGGGTAGCTCAGGTGAAGCTTTTGGTTCCAGCGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GAS2L3_ENST00000266754_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_2232nt CAGGCGGCGGCGGCAGCGGCGGCGGTTGGTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGAC CCTCCTGCGCCTGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAG TCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCAC TTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGA TAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGGTGCGGTTCTTGGA GCAGCAGAACCAGGTGTTACAGACCAAATGGGAGCTGCTACAACAAATGAATGTTGGCACCCGCCCCATCAACCTGGAGCCCATCTTCCA GGGGTATATCGACAGCCTCAAGAGATATCTGGATGGGCTCACTGCAGAAAGAACATCACAGAATTCAGAGCTGAATAACATGCAGGATCT TGTGGAGGATTATAAGAAGAAGTATGAGGATGAAATCAATAAGCGCACAGCTGCTGAGAATGATTTTGTGACGCTTAAAAAGGACGTGGA CAATGCCTACATGATAAAGGTGGAGTTGCAGTCCAAGGTGGACCTGCTGAACCAGGAAATTGAGTTTCTGAAAGTTCTCTATGATGCGGA GATATCCCAGATACATCAGAGTGTCACTGACACCAACGTCATCCTCTCCATGGACAACAGCCGCAACCTGGACTTGGATAGCATCATCGC CGAGGTCAAGGCCCAGTATGAGGAGATCGCCCAGAGGAGCAAGGAAGAAGCGGAGGCCCTGTACCACAGCAAGTATGAGGAGCTCCAGGT GACTGTCGGGAGACATGGAGACAGCCTGAAAGAGATCAAGATAGAGATCAGCGAGCTGAACCGCGTGATCCAGAGGCTGCAGGGGGAGAT CGCACATGTGAAGAAGCAGTGTAAGAATGTGCAAGATGCCATCGCAGATGCCGAGCAGCGTGGGGAGCATGCCCTCAAGGATGCCAGGAA CAAGTTGAATGACCTGGAGGAGGCCCTGCAGCAGGCCAAGGAGGACTTGGCGCGGCTGCTGCGTGACTACCAGGAGCTGATGAACGTGAA GCTGGCCCTAGATGTGGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTGCAGGATGTCTGGAGACCTCAGCAGCAATGTGAC TGTGTCTGTGACAAGCAGCACCATTTCATCAAATGTGGCATCCAAGGCTGCCTTTGGAGGTTCTGGAGGTAGAGGGTCCAGTTCCGGAGG AGGATACAGCTCTGGAAGCAGCAGTTATGGCTCTGGAGGCCGACAGTCTGGCTCCAGAGGCGGTAGTGGAGGAGGAGGTTCTATCTCTGG AGGAGGATATGGCTCTGGCGGTGGTTCTGGAGGAAGATACGGATCTGGTGGTGGCTCTAAGGGAGGGTCCATCTCTGGAGGAGGATATGG CTCTGGAGGTGGAAAACACAGCTCTGGAGGTGGCTCTAGAGGAGGCTCCAGCTCTGGAGGAGGATATGGCTCTGGAGGTGGGGGTTCTAG CTCTGTAAAGGGTAGCTCAGGTGAAGCTTTTGGTTCCAGCGTGACCTTCTCTTTTAGATAAAGATGAGCCCCCACCACCACCGACTCTCC CAACCCAGACTCTCCCACTCCAGAATGTAGAAGCCTGTCTCTGTACCTCTAACTGGCAGCAAGTTAAATTTTTGTCATTTATCTCTGATG GCACTTTGAGGGAAAAGAATGTCCACATACAGTTTTTGAAAGATCTTCTCTCCAAACCAGTTAGTTAGAGCCAGTGACGCCTCTGTGTTC TGGGGCGGAATCTGTGCTGTCTAGGTTTGTGCTTCTAGCCATGCCCATTCCCGCCCCCACCATGCCTCTTTGCATTGCCCATTTTCCAGA TGTGTATTCTGTTGAGGACCCAGGCCCATCCAGGGATTTCATCTCTAAGCCTGGCAGTGCTGGGGGGAAATGTGTTTCTGTGTATATAGC >In-frame_GAS2L3_ENST00000547754_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_2325nt GTCAGGGGCGTGTTGGCCCCGCACAGATTGAGCCGAGTTGTCGCCCCGCTGGGAGAAGTGACCCTCCTGCGCCTGATCAGAACACTGAGG CTCAGAGAAGTTAACTACTCCAAAGTCATATAGCCAGTATTTTCTGGAGCTGTAATTCAAATCAGATGTGTTCAATACCTTCTACTACCC CATTGCTGTCTTTATGAAAAGAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCT AAGTCCTCGGAGTCCTCTGACTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGC CACTTTGTTGCCCATGCAAGAAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACT TGATAATGGAGTACTATTATGTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGGTGCGGTTCTT GGAGCAGCAGAACCAGGTGTTACAGACCAAATGGGAGCTGCTACAACAAATGAATGTTGGCACCCGCCCCATCAACCTGGAGCCCATCTT CCAGGGGTATATCGACAGCCTCAAGAGATATCTGGATGGGCTCACTGCAGAAAGAACATCACAGAATTCAGAGCTGAATAACATGCAGGA TCTTGTGGAGGATTATAAGAAGAAGTATGAGGATGAAATCAATAAGCGCACAGCTGCTGAGAATGATTTTGTGACGCTTAAAAAGGACGT GGACAATGCCTACATGATAAAGGTGGAGTTGCAGTCCAAGGTGGACCTGCTGAACCAGGAAATTGAGTTTCTGAAAGTTCTCTATGATGC GGAGATATCCCAGATACATCAGAGTGTCACTGACACCAACGTCATCCTCTCCATGGACAACAGCCGCAACCTGGACTTGGATAGCATCAT CGCCGAGGTCAAGGCCCAGTATGAGGAGATCGCCCAGAGGAGCAAGGAAGAAGCGGAGGCCCTGTACCACAGCAAGTATGAGGAGCTCCA GGTGACTGTCGGGAGACATGGAGACAGCCTGAAAGAGATCAAGATAGAGATCAGCGAGCTGAACCGCGTGATCCAGAGGCTGCAGGGGGA GATCGCACATGTGAAGAAGCAGTGTAAGAATGTGCAAGATGCCATCGCAGATGCCGAGCAGCGTGGGGAGCATGCCCTCAAGGATGCCAG GAACAAGTTGAATGACCTGGAGGAGGCCCTGCAGCAGGCCAAGGAGGACTTGGCGCGGCTGCTGCGTGACTACCAGGAGCTGATGAACGT GAAGCTGGCCCTAGATGTGGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTGCAGGATGTCTGGAGACCTCAGCAGCAATGT GACTGTGTCTGTGACAAGCAGCACCATTTCATCAAATGTGGCATCCAAGGCTGCCTTTGGAGGTTCTGGAGGTAGAGGGTCCAGTTCCGG AGGAGGATACAGCTCTGGAAGCAGCAGTTATGGCTCTGGAGGCCGACAGTCTGGCTCCAGAGGCGGTAGTGGAGGAGGAGGTTCTATCTC TGGAGGAGGATATGGCTCTGGCGGTGGTTCTGGAGGAAGATACGGATCTGGTGGTGGCTCTAAGGGAGGGTCCATCTCTGGAGGAGGATA TGGCTCTGGAGGTGGAAAACACAGCTCTGGAGGTGGCTCTAGAGGAGGCTCCAGCTCTGGAGGAGGATATGGCTCTGGAGGTGGGGGTTC TAGCTCTGTAAAGGGTAGCTCAGGTGAAGCTTTTGGTTCCAGCGTGACCTTCTCTTTTAGATAAAGATGAGCCCCCACCACCACCGACTC TCCCAACCCAGACTCTCCCACTCCAGAATGTAGAAGCCTGTCTCTGTACCTCTAACTGGCAGCAAGTTAAATTTTTGTCATTTATCTCTG ATGGCACTTTGAGGGAAAAGAATGTCCACATACAGTTTTTGAAAGATCTTCTCTCCAAACCAGTTAGTTAGAGCCAGTGACGCCTCTGTG TTCTGGGGCGGAATCTGTGCTGTCTAGGTTTGTGCTTCTAGCCATGCCCATTCCCGCCCCCACCATGCCTCTTTGCATTGCCCATTTTCC AGATGTGTATTCTGTTGAGGACCCAGGCCCATCCAGGGATTTCATCTCTAAGCCTGGCAGTGCTGGGGGGAAATGTGTTTCTGTGTATAT >In-frame_GAS2L3_ENST00000539410_chr12_100995531_+_KRT2_ENST00000309680_chr12_53044337_-_2485nt ATGTGGAACTCCATTTTAATAGGAGCAGCTTCTTTGCTGCATTTTTAAAAAATGGTCTTGGAAGCTTCTTACTTCCGAGAAGTGGATCTT TGTTGCGGACAAAGGATTATTTATGCTAAAGGAAAATGTATTCCCCACTGAATTAGCTCGTGGGAAGCATAACAAGCTCATTAGGAATGC TCACTTGTACTTTGGCCTTTTGCTGTGGTGGAGAGAAGGGAAAATGACATCAAAAAGGACATTCTGTTGTCTTTTGCCTTCCTGCAAAGA AAATGTGTTATAATATTAGGCTTTTCAGTATGGTTTAGCTCAGGTTCAACTTTGGTACTAGAAGAAATGTTCCTGAAAGGAAAGTGAAAA GAAATTTCATTTCAATATAGGTGACTATGCAGCCTGCAATTCAAGTATGGTTTGGAGAAGATCTGCCTCTAAGTCCTCGGAGTCCTCTGA CTCCCAGACACGGACCAGGATTGGCTAATGTTTGTCAGTACGATGAGTGGATAGCTGTGAGGCATGAAGCCACTTTGTTGCCCATGCAAG AAGATCTGTCAATCTGGTTATCTGGTTTATTAGGTATTAAAGTTAAGGCAGAAAAATTATTGGAAGAACTTGATAATGGAGTACTATTAT GTCAACTGATTGATGTTCTTCAAAACATGGTGAAAACATGCAACTCTGAAGAATCAGGGGTGCGGTTCTTGGAGCAGCAGAACCAGGTGT TACAGACCAAATGGGAGCTGCTACAACAAATGAATGTTGGCACCCGCCCCATCAACCTGGAGCCCATCTTCCAGGGGTATATCGACAGCC TCAAGAGATATCTGGATGGGCTCACTGCAGAAAGAACATCACAGAATTCAGAGCTGAATAACATGCAGGATCTTGTGGAGGATTATAAGA AGAAGTATGAGGATGAAATCAATAAGCGCACAGCTGCTGAGAATGATTTTGTGACGCTTAAAAAGGACGTGGACAATGCCTACATGATAA AGGTGGAGTTGCAGTCCAAGGTGGACCTGCTGAACCAGGAAATTGAGTTTCTGAAAGTTCTCTATGATGCGGAGATATCCCAGATACATC AGAGTGTCACTGACACCAACGTCATCCTCTCCATGGACAACAGCCGCAACCTGGACTTGGATAGCATCATCGCCGAGGTCAAGGCCCAGT ATGAGGAGATCGCCCAGAGGAGCAAGGAAGAAGCGGAGGCCCTGTACCACAGCAAGTATGAGGAGCTCCAGGTGACTGTCGGGAGACATG GAGACAGCCTGAAAGAGATCAAGATAGAGATCAGCGAGCTGAACCGCGTGATCCAGAGGCTGCAGGGGGAGATCGCACATGTGAAGAAGC AGTGTAAGAATGTGCAAGATGCCATCGCAGATGCCGAGCAGCGTGGGGAGCATGCCCTCAAGGATGCCAGGAACAAGTTGAATGACCTGG AGGAGGCCCTGCAGCAGGCCAAGGAGGACTTGGCGCGGCTGCTGCGTGACTACCAGGAGCTGATGAACGTGAAGCTGGCCCTAGATGTGG AGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTGCAGGATGTCTGGAGACCTCAGCAGCAATGTGACTGTGTCTGTGACAAGCA GCACCATTTCATCAAATGTGGCATCCAAGGCTGCCTTTGGAGGTTCTGGAGGTAGAGGGTCCAGTTCCGGAGGAGGATACAGCTCTGGAA GCAGCAGTTATGGCTCTGGAGGCCGACAGTCTGGCTCCAGAGGCGGTAGTGGAGGAGGAGGTTCTATCTCTGGAGGAGGATATGGCTCTG GCGGTGGTTCTGGAGGAAGATACGGATCTGGTGGTGGCTCTAAGGGAGGGTCCATCTCTGGAGGAGGATATGGCTCTGGAGGTGGAAAAC ACAGCTCTGGAGGTGGCTCTAGAGGAGGCTCCAGCTCTGGAGGAGGATATGGCTCTGGAGGTGGGGGTTCTAGCTCTGTAAAGGGTAGCT CAGGTGAAGCTTTTGGTTCCAGCGTGACCTTCTCTTTTAGATAAAGATGAGCCCCCACCACCACCGACTCTCCCAACCCAGACTCTCCCA CTCCAGAATGTAGAAGCCTGTCTCTGTACCTCTAACTGGCAGCAAGTTAAATTTTTGTCATTTATCTCTGATGGCACTTTGAGGGAAAAG AATGTCCACATACAGTTTTTGAAAGATCTTCTCTCCAAACCAGTTAGTTAGAGCCAGTGACGCCTCTGTGTTCTGGGGCGGAATCTGTGC TGTCTAGGTTTGTGCTTCTAGCCATGCCCATTCCCGCCCCCACCATGCCTCTTTGCATTGCCCATTTTCCAGATGTGTATTCTGTTGAGG ACCCAGGCCCATCCAGGGATTTCATCTCTAAGCCTGGCAGTGCTGGGGGGAAATGTGTTTCTGTGTATATAGCTCCTCTTGTCCACTCTG |
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FusionGenePPI for GAS2L3_KRT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GAS2L3 | ELAVL1, CCDC8, ABCE1, DCTN1, CAPZA2, MYH9, PPP1CB, MYO19, TRIM25 | KRT2 | KAT2A, POU5F1, HDGF, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, INPPL1, CBL, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, KRT1, KRT10, MAGOH, EIF4A3, FN1, VCAM1, IQCB1, PAN2, ADRB2, LGR4, KRT13, KRT19, KRT31, KRT38, KRT40, MDM2, EED, RPS6KB2, HNRNPA1, KRT5, KRT77, PRSS1, SFN, EWSR1, YEATS4, CRY1, MCM2, MCM5, RC3H1, TRAF6, EGFR, MTM1, CYLD, LASP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GAS2L3_KRT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | KRT2 | P35908 | DB11157 | Anthralin | Keratin, type II cytoskeletal 2 epidermal | small molecule | approved |
| Tgene | KRT2 | P35908 | DB01593 | Zinc | Keratin, type II cytoskeletal 2 epidermal | small molecule | approved|investigational |
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RelatedDiseases for GAS2L3_KRT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KRT2 | C0432306 | Ichthyosis Bullosa of Siemens | 12 | CTD_human;ORPHANET;UNIPROT |
| Tgene | KRT2 | C0011616 | Contact Dermatitis | 1 | CTD_human |
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