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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 14345

FusionGeneSummary for GANAB_SLC22A8

check button Fusion gene summary
Fusion gene informationFusion gene name: GANAB_SLC22A8
Fusion gene ID: 14345
HgeneTgene
Gene symbol

GANAB

SLC22A8

Gene ID

23193

9376

Gene nameglucosidase II alpha subunitsolute carrier family 22 member 8
SynonymsG2AN|GIIA|GLUII|PKD3OAT3
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionneutral alpha-glucosidase ABalpha-glucosidase 2solute carrier family 22 member 8hOAT3organic anion transporter 3solute carrier family 22 (organic anion transporter), member 8
Modification date2018052220180522
UniProtAcc

Q14697

Q8TCC7

Ensembl transtripts involved in fusion geneENST00000346178, ENST00000356638, 
ENST00000534779, ENST00000540933, 
ENST00000534422, 
ENST00000336232, 
ENST00000545207, ENST00000535878, 
ENST00000311438, ENST00000430500, 
ENST00000542795, 
Fusion gene scores* DoF score6 X 8 X 5=2404 X 5 X 3=60
# samples 94
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GANAB [Title/Abstract] AND SLC22A8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-EY-A54A-01AGANABchr11

62396241

-SLC22A8chr11

62768295

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000346178ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000346178ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000356638ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000356638ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000534779ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000534779ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
In-frameENST00000540933ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
In-frameENST00000540933ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-3CDSENST00000534422ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-3CDSENST00000534422ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-

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FusionProtFeatures for GANAB_SLC22A8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GANAB

Q14697

SLC22A8

Q8TCC7

Catalytic subunit of glucosidase II that cleavessequentially the 2 innermost alpha-1,3-linked glucose residuesfrom the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor ofimmature glycoproteins (PubMed:10929008). Required forPKD1/Polycystin-1 and PKD2/Polycystin-2 maturation andlocalization to the cell surface and cilia (PubMed:27259053).{ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. Plays an important role in the excretion/detoxificationof endogenous and exogenous organic anions, especially from thebrain and kidney. Involved in the transport basolateral ofsteviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate(2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin(OTA). {ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:15644426,ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:16455804}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GANAB_SLC22A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GANAB_ENST00000540933_chr11_62396241_-_SLC22A8_ENST00000336232_chr11_62768295_-_1061aa
MTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVS
QGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPY
RLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLL
LGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLA
SKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPS
VFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLG
LVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMS
GTWCATPTNXRRWPSLSSWQVYXLEGSCLETCLTGLAAGPSXPAATCCWQPAAPVQPSAPPSPSTWSSASCVALASQALPXAPSSXMWNG
CLPGCGPSCRQHSGTATPLASSFCPAWPTPSPSGVGCSXLCPFPSSSSSYHPGGHQSPYAGWSCLESPRRPXRYSGGWLSSMARRKREKG
SAWRSSNSTCRRRSPWPRPSTPQVTCSGYPCCAAXPSVFPWPGLLPVLPTIVWLWVWKNLESTSTSSRSSLVGSMSQPSSSPSSPXATWA
GIPLRPLPCSWQEGPSWLSPLCPWTCRPXGQYWLCLGRDAYPAPSAASSSTQVNYTPQSSGKQVWAXVTCGPAWEAWCPRWXKSRVRYSP

>In-frame_GANAB_ENST00000540933_chr11_62396241_-_SLC22A8_ENST00000545207_chr11_62768295_-_1061aa
MTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVS
QGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPY
RLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLL
LGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLA
SKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPS
VFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLG
LVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMS
GTWCATPTNXRRWPSLSSWQVYXLEGSCLETCLTGLAAGPSXPAATCCWQPAAPVQPSAPPSPSTWSSASCVALASQALPXAPSSXMWNG
CLPGCGPSCRQHSGTATPLASSFCPAWPTPSPSGVGCSXLCPFPSSSSSYHPGGHQSPYAGWSCLESPRRPXRYSGGWLSSMARRKREKG
SAWRSSNSTCRRRSPWPRPSTPQVTCSGYPCCAAXPSVFPWPGLLPVLPTIVWLWVWKNLESTSTSSRSSLVGSMSQPSSSPSSPXATWA
GIPLRPLPCSWQEGPSWLSPLCPWTCRPXGQYWLCLGRDAYPAPSAASSSTQVNYTPQSSGKQVWAXVTCGPAWEAWCPRWXKSRVRYSP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GANAB_ENST00000540933_chr11_62396241_-_SLC22A8_ENST00000336232_chr11_62768295_-_3185nt
ATGACTCGGTTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTGGCTGATCCACCAATAGCCCGG
CTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTAACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCACGGCCATTCCGC
CTTGACCTACTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCATCAGAGGGCCCCTAGGGTCTCG
CAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAGACTCAGGGGAAG
GCAGAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGCCCCATGTCTGTGGGTTTGGAC
TTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGTGGGGAGCCATAT
CGCCTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCTGTGCTCCTGGCACACAACCCT
CATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACCCTGTTTGGGAAG
ATGATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGCATCATTGACGTCTTCCTGCTG
CTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCTAGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCCCTCGGCTACCAC
CAGAGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAACCTGCCCTGTGATGTCATCTGG
CTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTTGAGCGCTTGGCT
TCTAAGAGGCGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCACGAGGAGCTGCGGAACCTGGGG
CTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGCTGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACTAATCCCACGATG
AGGGCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGGAATGACATGAACGAACCATCT
GTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAACATCTATGGCCTT
TATGTGCACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTGGCCAGGGCCTTCTTCGCTGGC
TCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGTCTCAGCTTGGGG
CTGGTGGGACTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTTGTGCGCTGGTACCAGATGGGT
GCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCACAATGATATAATC
CGAGATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGGGAAGGCATTCCTGTCATGAGT
GGGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGCTCGTGCTTGGAG
ACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAGCCTTCAGCCCCA
CCTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGAATGTGGAATGGG
TGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCCTGGCCTACGCCA
TCCCCCAGTGGCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAGAGTCCATACGCT
GGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAGAGGGAGAAAGGC
TCAGCTTGGAGGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGTTCCGGATACCCA
TGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTGTGGAAGAATTTG
GAGTCAACCTCTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAAGCTACCTGGGCC
GGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGCAGACCGTGAGGA
CAGTATTGGCTGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACCCCACAGTCATCA
GGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTGAGGTACAGCCCT
TCATCCCCAATATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATCAGCCCTTGCCAG
AGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCCAGAGGATCCCTC

>In-frame_GANAB_ENST00000540933_chr11_62396241_-_SLC22A8_ENST00000545207_chr11_62768295_-_3185nt
ATGACTCGGTTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTGGCTGATCCACCAATAGCCCGG
CTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTAACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCACGGCCATTCCGC
CTTGACCTACTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCATCAGAGGGCCCCTAGGGTCTCG
CAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAGACTCAGGGGAAG
GCAGAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGCCCCATGTCTGTGGGTTTGGAC
TTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGTGGGGAGCCATAT
CGCCTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCTGTGCTCCTGGCACACAACCCT
CATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACCCTGTTTGGGAAG
ATGATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGCATCATTGACGTCTTCCTGCTG
CTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCTAGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCCCTCGGCTACCAC
CAGAGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAACCTGCCCTGTGATGTCATCTGG
CTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTTGAGCGCTTGGCT
TCTAAGAGGCGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCACGAGGAGCTGCGGAACCTGGGG
CTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGCTGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACTAATCCCACGATG
AGGGCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGGAATGACATGAACGAACCATCT
GTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAACATCTATGGCCTT
TATGTGCACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTGGCCAGGGCCTTCTTCGCTGGC
TCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGTCTCAGCTTGGGG
CTGGTGGGACTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTTGTGCGCTGGTACCAGATGGGT
GCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCACAATGATATAATC
CGAGATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGGGAAGGCATTCCTGTCATGAGT
GGGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGCTCGTGCTTGGAG
ACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAGCCTTCAGCCCCA
CCTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGAATGTGGAATGGG
TGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCCTGGCCTACGCCA
TCCCCCAGTGGCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAGAGTCCATACGCT
GGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAGAGGGAGAAAGGC
TCAGCTTGGAGGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGTTCCGGATACCCA
TGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTGTGGAAGAATTTG
GAGTCAACCTCTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAAGCTACCTGGGCC
GGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGCAGACCGTGAGGA
CAGTATTGGCTGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACCCCACAGTCATCA
GGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTGAGGTACAGCCCT
TCATCCCCAATATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATCAGCCCTTGCCAG
AGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCCAGAGGATCCCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_GANAB_ENST00000540933_chr11_62396241_-_SLC22A8_ENST00000336232_chr11_62768295_-_3790nt
TCTGCACAAGATGGCGGCGGTAGCGGCAGTGGCGGCGCGTAGGAGGCGGTCTTGGGCGTCTTTGGTACTGGCTTTTTTAGGGGTCTGCCT
GGGGATTACCCTTGCTGTGGATAGAAGCAACTTTAAGACCTGTGAAGAGAGTTCTTTCTGCAAGTGTTGCTGGTGCTAGAGCTTCAGGGG
CTTCAAAAGAACATGACTCGGTTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTGGCTGATCCA
CCAATAGCCCGGCTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTAACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCA
CGGCCATTCCGCCTTGACCTACTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCATCAGAGGGCC
CCTAGGGTCTCGCAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAG
ACTCAGGGGAAGGCAGAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGCCCCATGTCT
GTGGGTTTGGACTTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGT
GGGGAGCCATATCGCCTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCTGTGCTCCTG
GCACACAACCCTCATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACC
CTGTTTGGGAAGATGATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGCATCATTGAC
GTCTTCCTGCTGCTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCTAGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCC
CTCGGCTACCACCAGAGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAACCTGCCCTGT
GATGTCATCTGGCTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTT
GAGCGCTTGGCTTCTAAGAGGCGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCACGAGGAGCTG
CGGAACCTGGGGCTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGCTGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACT
AATCCCACGATGAGGGCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGGAATGACATG
AACGAACCATCTGTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAAC
ATCTATGGCCTTTATGTGCACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTGGCCAGGGCC
TTCTTCGCTGGCTCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGT
CTCAGCTTGGGGCTGGTGGGACTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTTGTGCGCTGG
TACCAGATGGGTGCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCAC
AATGATATAATCCGAGATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGGGAAGGCATT
CCTGTCATGAGTGGGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGC
TCGTGCTTGGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAG
CCTTCAGCCCCACCTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGA
ATGTGGAATGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCC
TGGCCTACGCCATCCCCCAGTGGCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAG
AGTCCATACGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAG
AGGGAGAAAGGCTCAGCTTGGAGGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGT
TCCGGATACCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTG
TGGAAGAATTTGGAGTCAACCTCTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAA
GCTACCTGGGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGC
AGACCGTGAGGACAGTATTGGCTGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACC
CCACAGTCATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTG
AGGTACAGCCCTTCATCCCCAATATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATC
AGCCCTTGCCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCC
AGAGGATCCCTCTACAGCCTCACGGACCAGGCCTGGGCTCCAGCTGAGGACAACGGAACCCCCTTTCCCTGCCCTCCAGAGACTGATCCT
AGCCAGGCACCTTAGGAGTATAGGGAGGCCCCATATAGGTCCATCCTCCTAGGATGAAGCCTTCTGAGAGCTTGGTGAAGGTGTCTCCAT
CACCACCACCAGAGCCTCCTGCCCAGCCCTGGCCAGTTCAAAGGTTCAGCCATCCCTGCCCTTGTTCTCCCTGCAACCCAGGCCCTGCCA
TTCTTCTGTCTAGCCCTTCCCCACTGGCCACCTTCCCCCACTGTCCCGGTCCTCTTCCCCTGAGGTCCCCTGATATCCCCTGGCTCAGTC
CTAACAAGACTGAGTCTTAACAAGATGAGAAGTCCTCCCCTTCTTGCCTCCCACACTTTTCTTTGATGGGAGGTTTCAATAAACAGCGAT

>In-frame_GANAB_ENST00000540933_chr11_62396241_-_SLC22A8_ENST00000545207_chr11_62768295_-_3531nt
TCTGCACAAGATGGCGGCGGTAGCGGCAGTGGCGGCGCGTAGGAGGCGGTCTTGGGCGTCTTTGGTACTGGCTTTTTTAGGGGTCTGCCT
GGGGATTACCCTTGCTGTGGATAGAAGCAACTTTAAGACCTGTGAAGAGAGTTCTTTCTGCAAGTGTTGCTGGTGCTAGAGCTTCAGGGG
CTTCAAAAGAACATGACTCGGTTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTGGCTGATCCA
CCAATAGCCCGGCTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTAACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCA
CGGCCATTCCGCCTTGACCTACTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCATCAGAGGGCC
CCTAGGGTCTCGCAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAG
ACTCAGGGGAAGGCAGAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGCCCCATGTCT
GTGGGTTTGGACTTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGT
GGGGAGCCATATCGCCTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCTGTGCTCCTG
GCACACAACCCTCATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACC
CTGTTTGGGAAGATGATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGCATCATTGAC
GTCTTCCTGCTGCTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCTAGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCC
CTCGGCTACCACCAGAGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAACCTGCCCTGT
GATGTCATCTGGCTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTT
GAGCGCTTGGCTTCTAAGAGGCGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCACGAGGAGCTG
CGGAACCTGGGGCTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGCTGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACT
AATCCCACGATGAGGGCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGGAATGACATG
AACGAACCATCTGTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAAC
ATCTATGGCCTTTATGTGCACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTGGCCAGGGCC
TTCTTCGCTGGCTCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGT
CTCAGCTTGGGGCTGGTGGGACTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTTGTGCGCTGG
TACCAGATGGGTGCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCAC
AATGATATAATCCGAGATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGGGAAGGCATT
CCTGTCATGAGTGGGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGC
TCGTGCTTGGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAG
CCTTCAGCCCCACCTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGA
ATGTGGAATGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCC
TGGCCTACGCCATCCCCCAGTGGCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAG
AGTCCATACGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAG
AGGGAGAAAGGCTCAGCTTGGAGGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGT
TCCGGATACCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTG
TGGAAGAATTTGGAGTCAACCTCTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAA
GCTACCTGGGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGC
AGACCGTGAGGACAGTATTGGCTGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACC
CCACAGTCATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTG
AGGTACAGCCCTTCATCCCCAATATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATC
AGCCCTTGCCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCC
AGAGGATCCCTCTACAGCCTCACGGACCAGGCCTGGGCTCCAGCTGAGGACAACGGAACCCCCTTTCCCTGCCCTCCAGAGACTGATCCT
AGCCAGGCACCTTAGGAGTATAGGGAGGCCCCATATAGGTCCATCCTCCTAGGATGAAGCCTTCTGAGAGCTTGGTGAAGGTGTCTCCAT


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FusionGenePPI for GANAB_SLC22A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GANABPRRC2A, ELF3, TRAF6, PTPRC, CLN3, GBAS, PRKAG2, UBA5, TERF1, TERF2, H2AFX, MYC, HDAC5, PSMA3, SIRT7, ISG15, CDK2, FBXO6, PRKCSH, CALR, CANX, HSP90B1, P4HB, ATF2, METTL23, CLN5, MAPK7, HDAC6, ATP4A, CREB3L4, CCNH, MAPK8, RAP1A, ARMCX3, BUB1B, CUTC, DEK, FARSB, ATP6V1B2, CSDE1, NARS, PDE3A, SAMHD1, TRIM47, XRCC5, XRCC6, GARS, HYOU1, IRF2BP2, JUP, MSH6, PLOD2, PTPN12, SUPT5H, SWAP70, TNS3, TRMT1, ASB7, ASB11, HUWE1, CUL7, OBSL1, FOXRED2, MOGS, MRPL9, UQCRC2, NTRK1, TCTN3, CNTRL, RPGRIP1L, TCTN1, LGALS3BP, TUBG1, NIPSNAP1, PRMT7, CCDC88A, MCM2, SENP3, NANOG, POU5F1, U2AF2, DERL1, PTPRN, ACP5, DUSP21, UBAC1, TAB1, HSPA8, CCT2, CCT3, ZNF703, TCP1, RUFY3, CCT5, CCT6A, CCT4, PTPRE, PTPRO, COX15, DNM1L, SDHA, SOAT1, SOD1, EDEM3, BRCA1SLC22A8NEDD4L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GANAB_SLC22A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGANABQ14697DB00491MiglitolNeutral alpha-glucosidase ABsmall moleculeapproved
TgeneSLC22A8Q8TCC7DB00493CefotaximeSolute carrier family 22 member 8small moleculeapproved
TgeneSLC22A8Q8TCC7DB01212CeftriaxoneSolute carrier family 22 member 8small moleculeapproved
TgeneSLC22A8Q8TCC7DB01032ProbenecidSolute carrier family 22 member 8small moleculeapproved|investigational
TgeneSLC22A8Q8TCC7DB01053BenzylpenicillinSolute carrier family 22 member 8small moleculeapproved|vet_approved

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RelatedDiseases for GANAB_SLC22A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGANABC3887964POLYCYSTIC KIDNEY DISEASE 3, AUTOSOMAL DOMINANT1UNIPROT
TgeneSLC22A8C0015695Fatty Liver1CTD_human
TgeneSLC22A8C0021400Influenza1CTD_human
TgeneSLC22A8C0023890Liver Cirrhosis1CTD_human
TgeneSLC22A8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC22A8C4277682Chemical and Drug Induced Liver Injury1CTD_human