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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14344

FusionGeneSummary for GANAB_GANAB

check button Fusion gene summary
Fusion gene informationFusion gene name: GANAB_GANAB
Fusion gene ID: 14344
HgeneTgene
Gene symbol

GANAB

GANAB

Gene ID

23193

23193

Gene nameglucosidase II alpha subunitglucosidase II alpha subunit
SynonymsG2AN|GIIA|GLUII|PKD3G2AN|GIIA|GLUII|PKD3
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionneutral alpha-glucosidase ABalpha-glucosidase 2neutral alpha-glucosidase ABalpha-glucosidase 2
Modification date2018052220180522
UniProtAcc

Q14697

Q14697

Ensembl transtripts involved in fusion geneENST00000346178, ENST00000356638, 
ENST00000534779, ENST00000540933, 
ENST00000534422, 		ENST00000346178, 
ENST00000356638, ENST00000534779, 
ENST00000540933, ENST00000534422, 
Fusion gene scores* DoF score6 X 8 X 5=2408 X 10 X 1=80
# samples 911
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/80*10)=0.459431618637297
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GANAB [Title/Abstract] AND GANAB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF987702GANABchr11

62393248

+GANABchr11

62396350

-
ChiTaRS3.1BE710656GANABchr11

62392861

+GANABchr11

62393141

-
ChiTaRS3.1AA557976GANABchr11

62392736

-GANABchr11

62392841

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000346178ENST00000346178GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000346178ENST00000356638GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000346178ENST00000534779GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000346178ENST00000540933GANABchr11

62393248

+GANABchr11

62396350

-
intron-intronENST00000346178ENST00000534422GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000356638ENST00000346178GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000356638ENST00000356638GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000356638ENST00000534779GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000356638ENST00000540933GANABchr11

62393248

+GANABchr11

62396350

-
intron-intronENST00000356638ENST00000534422GANABchr11

62393248

+GANABchr11

62396350

-
In-frameENST00000534779ENST00000346178GANABchr11

62393248

+GANABchr11

62396350

-
In-frameENST00000534779ENST00000356638GANABchr11

62393248

+GANABchr11

62396350

-
In-frameENST00000534779ENST00000534779GANABchr11

62393248

+GANABchr11

62396350

-
In-frameENST00000534779ENST00000540933GANABchr11

62393248

+GANABchr11

62396350

-
5CDS-intronENST00000534779ENST00000534422GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000540933ENST00000346178GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000540933ENST00000356638GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000540933ENST00000534779GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000540933ENST00000540933GANABchr11

62393248

+GANABchr11

62396350

-
intron-intronENST00000540933ENST00000534422GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000534422ENST00000346178GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000534422ENST00000356638GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000534422ENST00000534779GANABchr11

62393248

+GANABchr11

62396350

-
intron-3CDSENST00000534422ENST00000540933GANABchr11

62393248

+GANABchr11

62396350

-
intron-intronENST00000534422ENST00000534422GANABchr11

62393248

+GANABchr11

62396350

-
intron-3UTRENST00000346178ENST00000346178GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000346178ENST00000356638GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000346178ENST00000534779GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000346178ENST00000540933GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000346178ENST00000534422GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000356638ENST00000346178GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000356638ENST00000356638GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000356638ENST00000534779GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000356638ENST00000540933GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000356638ENST00000534422GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000534779ENST00000346178GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000534779ENST00000356638GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000534779ENST00000534779GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000534779ENST00000540933GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000534779ENST00000534422GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000540933ENST00000346178GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000540933ENST00000356638GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000540933ENST00000534779GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000540933ENST00000540933GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000540933ENST00000534422GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000534422ENST00000346178GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000534422ENST00000356638GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000534422ENST00000534779GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000534422ENST00000540933GANABchr11

62392861

+GANABchr11

62393141

-
intron-intronENST00000534422ENST00000534422GANABchr11

62392861

+GANABchr11

62393141

-
intron-3UTRENST00000346178ENST00000346178GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000346178ENST00000356638GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000346178ENST00000534779GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000346178ENST00000540933GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000346178ENST00000534422GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000356638ENST00000346178GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000356638ENST00000356638GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000356638ENST00000534779GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000356638ENST00000540933GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000356638ENST00000534422GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000534779ENST00000346178GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000534779ENST00000356638GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000534779ENST00000534779GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000534779ENST00000540933GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000534779ENST00000534422GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000540933ENST00000346178GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000540933ENST00000356638GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000540933ENST00000534779GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000540933ENST00000540933GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000540933ENST00000534422GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000534422ENST00000346178GANABchr11

62392736

-GANABchr11

62392841

+
intron-3UTRENST00000534422ENST00000356638GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000534422ENST00000534779GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000534422ENST00000540933GANABchr11

62392736

-GANABchr11

62392841

+
intron-intronENST00000534422ENST00000534422GANABchr11

62392736

-GANABchr11

62392841

+

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FusionProtFeatures for GANAB_GANAB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GANAB

Q14697

GANAB

Q14697

Catalytic subunit of glucosidase II that cleavessequentially the 2 innermost alpha-1,3-linked glucose residuesfrom the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor ofimmature glycoproteins (PubMed:10929008). Required forPKD1/Polycystin-1 and PKD2/Polycystin-2 maturation andlocalization to the cell surface and cilia (PubMed:27259053).{ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. Catalytic subunit of glucosidase II that cleavessequentially the 2 innermost alpha-1,3-linked glucose residuesfrom the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor ofimmature glycoproteins (PubMed:10929008). Required forPKD1/Polycystin-1 and PKD2/Polycystin-2 maturation andlocalization to the cell surface and cilia (PubMed:27259053).{ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GANAB_GANAB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GANAB_GANAB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GANAB_GANAB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGANABQ14697DB00491MiglitolNeutral alpha-glucosidase ABsmall moleculeapproved
TgeneGANABQ14697DB00491MiglitolNeutral alpha-glucosidase ABsmall moleculeapproved

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RelatedDiseases for GANAB_GANAB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGANABC3887964POLYCYSTIC KIDNEY DISEASE 3, AUTOSOMAL DOMINANT1UNIPROT
TgeneGANABC3887964POLYCYSTIC KIDNEY DISEASE 3, AUTOSOMAL DOMINANT1UNIPROT