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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14295

FusionGeneSummary for GALNT11_TRABD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNT11_TRABD2A
Fusion gene ID: 14295
HgeneTgene
Gene symbol

GALNT11

TRABD2A

Gene ID

63917

129293

Gene namepolypeptide N-acetylgalactosaminyltransferase 11TraB domain containing 2A
SynonymsGALNAC-T11|GALNACT11C2orf89|TIKI1
Cytomap

7q36.1|7q36.1

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionpolypeptide N-acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)polypeptide GalNAc transferase 11pp-GaNTase 11pmetalloprotease TIKI1TRAB domain-containing protein 2AUPF0632 protein C2orf89
Modification date2018052320180329
UniProtAcc

Q8NCW6

Q86V40

Ensembl transtripts involved in fusion geneENST00000482812, ENST00000430044, 
ENST00000452146, ENST00000434507, 
ENST00000415421, ENST00000320311, 
ENST00000422997, 		ENST00000335459, 
ENST00000409520, ENST00000409133, 
ENST00000479944, 
Fusion gene scores* DoF score11 X 5 X 8=4402 X 2 X 1=4
# samples 122
** MAII scorelog2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: GALNT11 [Title/Abstract] AND TRABD2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGALNT11

GO:0018243

protein O-linked glycosylation via threonine

24226769

TgeneTRABD2A

GO:0006508

proteolysis

22726442

TgeneTRABD2A

GO:0030178

negative regulation of Wnt signaling pathway

22726442


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DC366721GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482812ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
3UTR-3CDSENST00000482812ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
3UTR-3CDSENST00000482812ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
3UTR-intronENST00000482812ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
5UTR-3CDSENST00000430044ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
5UTR-3CDSENST00000430044ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
5UTR-3CDSENST00000430044ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
5UTR-intronENST00000430044ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
Frame-shiftENST00000452146ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
Frame-shiftENST00000452146ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
Frame-shiftENST00000452146ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
5CDS-intronENST00000452146ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000434507ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000434507ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000434507ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-intronENST00000434507ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000415421ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000415421ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000415421ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-intronENST00000415421ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000320311ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000320311ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000320311ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-intronENST00000320311ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000422997ENST00000335459GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000422997ENST00000409520GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-3CDSENST00000422997ENST00000409133GALNT11chr7

151722969

+TRABD2Achr2

85097910

-
intron-intronENST00000422997ENST00000479944GALNT11chr7

151722969

+TRABD2Achr2

85097910

-

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FusionProtFeatures for GALNT11_TRABD2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALNT11

Q8NCW6

TRABD2A

Q86V40

Polypeptide N-acetylgalactosaminyltransferase thatcatalyzes the initiation of protein O-linked glycosylation and isinvolved in left/right asymmetry by mediating O-glycosylation ofNOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1,modulating the balance between motile and immotile (sensory) ciliaat the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue onthe protein receptor. Displays the same enzyme activity towardMUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation oferythropoietin (EPO). {ECO:0000269|PubMed:11925450,ECO:0000269|PubMed:24226769}. Metalloprotease that acts as a negative regulator of theWnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage,Wnt proteins become oxidized and form large disulfide-bondoligomers, leading to their inactivation. Able to cleave WNT3A,WNT5, but not WNT11. Required for head formation.{ECO:0000269|PubMed:22726442}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GALNT11_TRABD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GALNT11_TRABD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GALNT11KLK11, HLA-DPA1, SPACA1, NRG1, SDF4, DHRS9, SUCLG2, VSIG4, FNDC4, TOR1AIP2, P2RX2, TMPRSS11B, PDCD1, ARMC6TRABD2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GALNT11_TRABD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GALNT11_TRABD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource