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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14288

FusionGeneSummary for GALNT11_EZH2

check button Fusion gene summary
Fusion gene informationFusion gene name: GALNT11_EZH2
Fusion gene ID: 14288
HgeneTgene
Gene symbol

GALNT11

EZH2

Gene ID

63917

2146

Gene namepolypeptide N-acetylgalactosaminyltransferase 11enhancer of zeste 2 polycomb repressive complex 2 subunit
SynonymsGALNAC-T11|GALNACT11ENX-1|ENX1|EZH2b|KMT6|KMT6A|WVS|WVS2
Cytomap

7q36.1|7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionpolypeptide N-acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)polypeptide GalNAc transferase 11pp-GaNTase 11phistone-lysine N-methyltransferase EZH2enhancer of zeste homolog 2lysine N-methyltransferase 6
Modification date2018052320180527
UniProtAcc

Q8NCW6

Q15910

Ensembl transtripts involved in fusion geneENST00000482812, ENST00000430044, 
ENST00000452146, ENST00000434507, 
ENST00000415421, ENST00000320311, 
ENST00000422997, 		ENST00000478654, 
ENST00000460911, ENST00000350995, 
ENST00000320356, ENST00000541220, 
ENST00000476773, ENST00000483967, 
ENST00000536783, 
Fusion gene scores* DoF score11 X 5 X 8=4403 X 3 X 3=27
# samples 123
** MAII scorelog2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GALNT11 [Title/Abstract] AND EZH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGALNT11

GO:0018243

protein O-linked glycosylation via threonine

24226769

TgeneEZH2

GO:0000122

negative regulation of transcription by RNA polymerase II

20154697

TgeneEZH2

GO:0010718

positive regulation of epithelial to mesenchymal transition

20154697

TgeneEZH2

GO:0043406

positive regulation of MAP kinase activity

20154697

TgeneEZH2

GO:0043547

positive regulation of GTPase activity

20154697

TgeneEZH2

GO:0045814

negative regulation of gene expression, epigenetic

20154697

TgeneEZH2

GO:0070734

histone H3-K27 methylation

24474760

TgeneEZH2

GO:0071902

positive regulation of protein serine/threonine kinase activity

20154697


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-2659-01AGALNT11chr7

151722969

+EZH2chr7

148529842

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482812ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-3CDSENST00000482812ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-intronENST00000482812ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-intronENST00000482812ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-intronENST00000482812ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-intronENST00000482812ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-intronENST00000482812ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
3UTR-5UTRENST00000482812ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-3CDSENST00000430044ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-3CDSENST00000430044ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-intronENST00000430044ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-intronENST00000430044ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-intronENST00000430044ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-intronENST00000430044ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-intronENST00000430044ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
5UTR-5UTRENST00000430044ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-
Frame-shiftENST00000452146ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
Frame-shiftENST00000452146ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
5CDS-intronENST00000452146ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
5CDS-intronENST00000452146ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
5CDS-intronENST00000452146ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
5CDS-intronENST00000452146ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
5CDS-intronENST00000452146ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
5CDS-5UTRENST00000452146ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000434507ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000434507ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000434507ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000434507ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000434507ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000434507ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000434507ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-5UTRENST00000434507ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000415421ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000415421ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000415421ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000415421ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000415421ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000415421ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000415421ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-5UTRENST00000415421ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000320311ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000320311ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000320311ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000320311ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000320311ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000320311ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000320311ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-5UTRENST00000320311ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000422997ENST00000478654GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-3CDSENST00000422997ENST00000460911GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000422997ENST00000350995GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000422997ENST00000320356GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000422997ENST00000541220GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000422997ENST00000476773GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-intronENST00000422997ENST00000483967GALNT11chr7

151722969

+EZH2chr7

148529842

-
intron-5UTRENST00000422997ENST00000536783GALNT11chr7

151722969

+EZH2chr7

148529842

-

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FusionProtFeatures for GALNT11_EZH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALNT11

Q8NCW6

EZH2

Q15910

Polypeptide N-acetylgalactosaminyltransferase thatcatalyzes the initiation of protein O-linked glycosylation and isinvolved in left/right asymmetry by mediating O-glycosylation ofNOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1,modulating the balance between motile and immotile (sensory) ciliaat the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue onthe protein receptor. Displays the same enzyme activity towardMUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation oferythropoietin (EPO). {ECO:0000269|PubMed:11925450,ECO:0000269|PubMed:24226769}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GALNT11_EZH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GALNT11_EZH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GALNT11KLK11, HLA-DPA1, SPACA1, NRG1, SDF4, DHRS9, SUCLG2, VSIG4, FNDC4, TOR1AIP2, P2RX2, TMPRSS11B, PDCD1, ARMC6EZH2VAV1, EED, CCDC85B, ATRX, HDAC1, HDAC2, PHF1, ATP1A1, NINL, PSMB6, WDR61, RPN2, WSB2, GTF3C1, KLHDC2, PIN4, POLA2, SUZ12, ZMYND11, E2F6, SNAI1, JARID2, MTF2, RBBP4, KDM2B, EZH1, EZH2, CTNNB1, EWSR1, HIST1H3A, HIST1H1A, DNMT1, DNMT3A, DNMT3B, AKT1, KDM5A, SETD8, SIRT1, EPC1, MYOD1, YY1, RBL2, PHB2, PPP1R8, WT1, USP7, CDK1, CDK2, RUNX3, PPARG, POU5F1, PHF19, HOTAIR, HIST3H3, MAPK8IP2, C7orf25, GADD45G, TAF1D, MAPKAPK3, RASA1, ATP1B1, RPS6KA5, TNFSF11, MAP3K7, TK1, DNAJB11, SMN1, PFDN1, ZAK, GATA4, PJA1, CDYL, RELA, RELB, EHMT1, SMYD3, EPC2, CDKN2B-AS1, UHRF1, HIC1, HDAC3, RORA, PML, RARA, SS18, SSX2, TLE1, CDK6, ASXL1, ESR1, MED1, SUV39H1, KDM1A, PRMT5, CUL1, BTRC, JAK2, BRCA1, FBXW11, CEP63, LOXL2, VCP, NPLOC4, CPSF6, KIF5B, RAP1GAP, TDRD1, ACTG1, NUDT21, PLEC, UFD1L, THRAP3, CIT, WWP2, AEBP2, DHX9, ILF3, UBB, DDX5, SON, SNRPA, HIST4H4, UPF1, LIMA1, TAF15, FBXL18, PABPC4, U2AF1, SNRNP70, CALML3, POTEE, SNRPD3, YBX1, SNRPN, TUBB4B, ANXA4, LARP1, NCL, ARG1, SRSF1, C10orf12, TUBA1B, LUC7L2, TRIM28, AR, IMMT, FUS, SRSF3, WWP1, RBM14, SNRPD2, U2AF2, ATP5B, ELAVL1, FLG, HIST1H2AE, HIST1H2AB, DDX3X, FABP5, TRA2A, SAFB2, FAM120A, RALY, SRSF7, SNRPD1, SF3B1, HSPB1, SNRNP200, ZC3HAV1, COPB1, ILF2, KLC2, LRRC40, SRSF9, SERPINB12, CPSF1, GNB2L1, HSPA1A, HSPA1B, RBBP7, FIP1L1, PDCD6IP, SNRPF, SF3B2, ZNF638, ADAR, DBN1, PKM, SRSF10, EFTUD2, ACTN1, PHGDH, DSC3, ATP2A2, ASPSCR1, ATP5C1, EPRS, CHCHD3, IGLL5, KLC4, NUMA1, RBM39, SF3B3, TPI1, CNBP, DAZAP1, ERH, KLHL12, SLC25A10, SYNE1, DHX36, FBL, SDCBP, AKAP8, CPSF7, LGALS7, MYLPF, PHF5A, DHX30, PDS5A, ANKFY1, CPSF2, DYNLT3, TRIM25, HNRNPAB, KHDRBS1, KLC1, LRPPRC, MAGOH, NOP2, FAM208A, H2AFY, YBX3, KAT7, HYOU1, P4HB, CSNK2B, DEC1, CRY2, CHD4, NCOA1, RIN3, CDKN2C, GEMIN7, FAT1, MKI67, SEPT2, SNRPB2, SSR1, API5, NOP14, RBX1, HUWE1, EHMT2, OIP5, MKRN2, RPL36, ITSN2, MRPL2, CCDC93, FNBP1L, DNAAF5, CEP192, CDCA7L, WDR76, REEP4, DNAJC21, CENPV, C17orf96, TRIM37, PRDM14, DDB2, KAT2B, PCGF1, MDM2, ZBTB16, HNF4A, DANCR, LATS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GALNT11_EZH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GALNT11_EZH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEZH2C0033578Prostatic Neoplasms3CTD_human
TgeneEZH2C0001815Primary Myelofibrosis1CTD_human
TgeneEZH2C0010278Craniosynostosis1CTD_human
TgeneEZH2C0014170Endometrial Neoplasms1CTD_human
TgeneEZH2C0024301Lymphoma, Follicular1CTD_human
TgeneEZH2C0029463Osteosarcoma1CTD_human
TgeneEZH2C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneEZH2C0265210Weaver syndrome1ORPHANET;UNIPROT
TgeneEZH2C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneEZH2C0749794Upper Extremity Deformities, Congenital1CTD_human
TgeneEZH2C1301355Myelodysplastic-Myeloproliferative Diseases1CTD_human
TgeneEZH2C1458155Mammary Neoplasms1CTD_human
TgeneEZH2C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
TgeneEZH2C3463824MYELODYSPLASTIC SYNDROME1CTD_human