FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14275

FusionGeneSummary for GALK2_MAPK6

check button Fusion gene summary
Fusion gene informationFusion gene name: GALK2_MAPK6
Fusion gene ID: 14275
HgeneTgene
Gene symbol

GALK2

MAPK6

Gene ID

2585

5597

Gene namegalactokinase 2mitogen-activated protein kinase 6
SynonymsGK2ERK3|HsT17250|PRKM6|p97MAPK
Cytomap

15q21.1-q21.2

15q21.2

Type of geneprotein-codingprotein-coding
DescriptionN-acetylgalactosamine kinasegalNAc kinasemitogen-activated protein kinase 6ERK-3MAP kinase 6MAP kinase isoform p97MAPK 6extracellular signal-regulated kinase 3extracellular signal-regulated kinase, p97p97-MAPKprotein kinase, mitogen-activated 5protein kinase, mitogen-activated 6
Modification date2018052320180523
UniProtAcc

Q01415

Q16659

Ensembl transtripts involved in fusion geneENST00000327171, ENST00000560031, 
ENST00000396509, ENST00000543495, 
ENST00000544523, ENST00000559454, 
ENST00000561014, 
ENST00000261845, 
ENST00000558841, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: GALK2 [Title/Abstract] AND MAPK6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-OL-A5RW-01AGALK2chr15

49462572

+MAPK6chr15

52350830

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000327171ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-intronENST00000327171ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+
Frame-shiftENST00000560031ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
5CDS-intronENST00000560031ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-3CDSENST00000396509ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-intronENST00000396509ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-3CDSENST00000543495ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-intronENST00000543495ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+
5UTR-3CDSENST00000544523ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
5UTR-intronENST00000544523ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-3CDSENST00000559454ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-intronENST00000559454ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-3CDSENST00000561014ENST00000261845GALK2chr15

49462572

+MAPK6chr15

52350830

+
intron-intronENST00000561014ENST00000558841GALK2chr15

49462572

+MAPK6chr15

52350830

+

Top

FusionProtFeatures for GALK2_MAPK6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALK2

Q01415

MAPK6

Q16659

Acts on GalNAc. Also acts as a galactokinase whengalactose is present at high concentrations. May be involved in asalvage pathway for the reutilization of free GalNAc derived fromthe degradation of complex carbohydrates.{ECO:0000269|PubMed:16006554}. Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of thecomplex formed with MAPKAPK5 is still unclear, but the complexfollows a complex set of phosphorylation events: upon interactionwith atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189and then mediates phosphorylation and activation of MAPKAPK5,which in turn phosphorylates ERK3/MAPK6. May promote entry in thecell cycle (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GALK2_MAPK6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GALK2_MAPK6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GALK2ASPDH, GALE, GALM, PGM1, LTA4H, MEMO1, MVD, POTEF, CCDC18, PABPC3, GNB4, GNB2, PLS1, CD59, AHNAKMAPK6ANK3, DST, CSE1L, HSP90AB1, HSPD1, HSP90B1, CCT3, MAPKAPK5, CNTRL, ZNF600, PHACTR3, HACL1, NAT9, PDCD6IP, EIF3C, ACTG1, STX7, RAB2A, BBS10, ZNF133, ATP5J, SNAPC4, MOK, RPL10, THAP4, SPRR2D, MZB1, ITSN1, ELOF1, PLK1, DBN1, FBXL16, UBA52, ATG9A, RGS19, TDP2, MBOAT7, NRXN2, ARPC3, MDK, C21orf59, COPS6, CYTH2, APBA2, RAP1GAP, MASP1, MTG2, ANAPC5, ACTR1B, GORASP1, FXYD3, NDUFS6, PPP1R7, CA12, HNRNPA0, KLC1, SLC41A3, METTL17, ZNF671, MYOZ3, PHGDH, PSIP1, HAUS2, CALR, EMD, AMPH, PIH1D1, SERPINA4, TTK, OSTF1, MAP3K12, BARX1, PPBP, SMS, MYBL2, HIP1, WWC1, SRSF5, RANBP9, ITGB3BP, PDLIM1, PVRL2, RAB31, APOA1, DPPA4, PRKAB1, RRP7A, HDAC11, WDR34, GLRX3, DDR1, URB1, PHC2, ZNF775, SHC1, PPP2R1A, CDH13, BAG6, CFL1, NELFB, KNSTRN, GATA1, RARA, TUBA1A, ZNF579, METTL2A, EDF1, DKC1, INS, SOCS3, DDOST, DNAJC28, DSCR3, MIPEP, RBL1, WFS1, ARHGDIA, SEPT5, MCM3, TPI1, PRKAR1A, CNTN1, NOL4, DGKZ, PRPF38A, CASP6, DCTN2, WDR26, FOXO3, ZNF205, LPXN, SNW1, MGAT1, EIF1, EEF1A2, HNRNPD, NUDT5, MAP3K7, SMAD6, SEPT3, SPTAN1, PLSCR1, FAM49B, PSAT1, MON1A, UBE2L3, EIF4A1, CA1, GNB2L1, ZNF331, PTPMT1, SPG7, HNRNPH3, APOA1BP, PLEKHM1, CERS1, IDH3B, GPX1, ELAVL1, UBE3A, NEURL4, CCND3, MBIP, KDSR, JUNB, SLC20A1, GALNT7, EGLN3, EIF2S3, A2M, MAPK6, HERC2, PSMA7, AURKA, USP20, ZNF7, SERPINA1, FGB, HP, HBB, FGG, FGA, HBA2, C3, ORM1, IGHG2, ALB, TF, ZNF28, AHSG, ZNF92, ZNF813, SERPINB4, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GALK2_MAPK6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GALK2_MAPK6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAPK6C0020507Hyperplasia1CTD_human