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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14273

FusionGeneSummary for GALK2_C15orf43

check button Fusion gene summary
Fusion gene informationFusion gene name: GALK2_C15orf43
Fusion gene ID: 14273
HgeneTgene
Gene symbol

GALK2

C15orf43

Gene ID

2585

145645

Gene namegalactokinase 2telomere repeat binding bouquet formation protein 2
SynonymsGK2C15orf43
Cytomap

15q21.1-q21.2

15q21.1

Type of geneprotein-codingprotein-coding
DescriptionN-acetylgalactosamine kinasegalNAc kinasetelomere repeats-binding bouquet formation protein 2
Modification date2018052320180519
UniProtAcc

Q01415

Ensembl transtripts involved in fusion geneENST00000327171, ENST00000560031, 
ENST00000396509, ENST00000543495, 
ENST00000544523, ENST00000559454, 
ENST00000561014, 
ENST00000340827, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 2 X 3=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GALK2 [Title/Abstract] AND C15orf43 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CQ-6228-01AGALK2chr15

49584734

+C15orf43chr15

45270687

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000327171ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+
Frame-shiftENST00000560031ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+
Frame-shiftENST00000396509ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+
Frame-shiftENST00000543495ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+
Frame-shiftENST00000544523ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+
Frame-shiftENST00000559454ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+
3UTR-3CDSENST00000561014ENST00000340827GALK2chr15

49584734

+C15orf43chr15

45270687

+

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FusionProtFeatures for GALK2_C15orf43


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GALK2

Q01415

C15orf43

Acts on GalNAc. Also acts as a galactokinase whengalactose is present at high concentrations. May be involved in asalvage pathway for the reutilization of free GalNAc derived fromthe degradation of complex carbohydrates.{ECO:0000269|PubMed:16006554}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GALK2_C15orf43


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GALK2_C15orf43


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GALK2ASPDH, GALE, GALM, PGM1, LTA4H, MEMO1, MVD, POTEF, CCDC18, PABPC3, GNB4, GNB2, PLS1, CD59, AHNAKC15orf43APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GALK2_C15orf43


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GALK2_C15orf43


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource