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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14259

FusionGeneSummary for GADD45A_FRA10AC1

check button Fusion gene summary
Fusion gene informationFusion gene name: GADD45A_FRA10AC1
Fusion gene ID: 14259
HgeneTgene
Gene symbol

GADD45A

FRA10AC1

Gene ID

1647

118924

Gene namegrowth arrest and DNA damage inducible alphaFRA10A associated CGG repeat 1
SynonymsDDIT1|GADD45C10orf4|F26C11.1-like|FRA10A
Cytomap

1p31.3

10q23.33

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest and DNA damage-inducible protein GADD45 alphaDDIT-1DNA damage-inducible transcript 1 proteinDNA damage-inducible transcript-1growth arrest and DNA-damage-inducible 45 alphaprotein FRA10AC1fragile site 10q23.3fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1rare folic acid-type fragile site, FRA(10)(q23.3), candidate gene 1
Modification date2018052320180519
UniProtAcc

P24522

Q70Z53

Ensembl transtripts involved in fusion geneENST00000370986, ENST00000370985, 
ENST00000460575, 
ENST00000359204, 
ENST00000460752, ENST00000536233, 
ENST00000371430, ENST00000394100, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: GADD45A [Title/Abstract] AND FRA10AC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGADD45A

GO:0000185

activation of MAPKKK activity

9827804

HgeneGADD45A

GO:0043065

positive regulation of apoptotic process

9827804

HgeneGADD45A

GO:0046330

positive regulation of JNK cascade

9827804

HgeneGADD45A

GO:0071850

mitotic cell cycle arrest

10097101

HgeneGADD45A

GO:1900745

positive regulation of p38MAPK cascade

9827804


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM718128GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000370986ENST00000359204GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
3UTR-intronENST00000370986ENST00000460752GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
3UTR-intronENST00000370986ENST00000536233GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
3UTR-intronENST00000370986ENST00000371430GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
3UTR-intronENST00000370986ENST00000394100GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-3CDSENST00000370985ENST00000359204GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000370985ENST00000460752GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000370985ENST00000536233GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000370985ENST00000371430GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000370985ENST00000394100GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-3CDSENST00000460575ENST00000359204GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000460575ENST00000460752GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000460575ENST00000536233GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000460575ENST00000371430GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-
intron-intronENST00000460575ENST00000394100GADD45Achr1

68153708

+FRA10AC1chr10

95441337

-

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FusionProtFeatures for GADD45A_FRA10AC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GADD45A

P24522

FRA10AC1

Q70Z53

In T-cells, functions as a regulator of p38 MAPKs byinhibiting p88 phosphorylation and activity (By similarity). Mightaffect PCNA interaction with some CDK (cell division proteinkinase) complexes; stimulates DNA excision repair in vitro andinhibits entry of cells into S phase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GADD45A_FRA10AC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GADD45A_FRA10AC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GADD45A_FRA10AC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GADD45A_FRA10AC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGADD45AC0019693HIV Infections1CTD_human
HgeneGADD45AC0030297Pancreatic Neoplasm1CTD_human
HgeneGADD45AC0033578Prostatic Neoplasms1CTD_human
HgeneGADD45AC0038356Stomach Neoplasms1CTD_human
HgeneGADD45AC0263454Chloracne1CTD_human
HgeneGADD45AC0919267ovarian neoplasm1CTD_human
HgeneGADD45AC3495559Juvenile arthritis1CTD_human
HgeneGADD45AC4277682Chemical and Drug Induced Liver Injury1CTD_human