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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14212

FusionGeneSummary for GABARAP_GPS2

check button Fusion gene summary
Fusion gene informationFusion gene name: GABARAP_GPS2
Fusion gene ID: 14212
HgeneTgene
Gene symbol

GABARAP

GPS2

Gene ID

11337

2874

Gene nameGABA type A receptor-associated proteinG protein pathway suppressor 2
SynonymsATG8A|GABARAP-a|MM46AMF-1
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptiongamma-aminobutyric acid receptor-associated proteinGABA(A) receptor-associated proteinG protein pathway suppressor 2GPS-2
Modification date2018052320180522
UniProtAcc

O95166

Q13227

Ensembl transtripts involved in fusion geneENST00000302386, ENST00000577035, 
ENST00000571129, ENST00000571253, 
ENST00000573928, 
ENST00000391950, 
ENST00000389167, ENST00000380728, 
Fusion gene scores* DoF score4 X 4 X 4=641 X 1 X 1=1
# samples 41
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: GABARAP [Title/Abstract] AND GPS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGABARAP

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

15977068

TgeneGPS2

GO:0000122

negative regulation of transcription by RNA polymerase II

11931768|19858209

TgeneGPS2

GO:0010875

positive regulation of cholesterol efflux

19481530

TgeneGPS2

GO:0045944

positive regulation of transcription by RNA polymerase II

19481530

TgeneGPS2

GO:0046329

negative regulation of JNK cascade

11931768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CV-5979-01AGABARAPchr17

7144743

-GPS2chr17

7217978

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000302386ENST00000391950GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000302386ENST00000389167GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000302386ENST00000380728GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000577035ENST00000391950GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000577035ENST00000389167GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000577035ENST00000380728GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000571129ENST00000391950GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000571129ENST00000389167GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000571129ENST00000380728GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000571253ENST00000391950GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000571253ENST00000389167GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000571253ENST00000380728GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000573928ENST00000391950GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000573928ENST00000389167GABARAPchr17

7144743

-GPS2chr17

7217978

-
intron-intronENST00000573928ENST00000380728GABARAPchr17

7144743

-GPS2chr17

7217978

-

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FusionProtFeatures for GABARAP_GPS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GABARAP

O95166

GPS2

Q13227

Ubiquitin-like modifier that plays a role inintracellular transport of GABA(A) receptors and its interactionwith the cytoskeleton. Involved in apoptosis. Involved inautophagy. Whereas LC3s are involved in elongation of thephagophore membrane, the GABARAP/GATE-16 subfamily is essentialfor a later stage in autophagosome maturation.{ECO:0000269|PubMed:15977068}. Key regulator of inflammation, lipid metabolism andmitochondrion homeostasis that acts by inhibiting the activity ofthe ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting'Lys-63'-linked ubiquitination (By similarity). In the nucleus,can both acts as a corepressor and coactivator of transcription,depending on the context (PubMed:24943844). Acts as atranscription coactivator in adipocytes by promoting therecruitment of PPARG to promoters: acts by inhibiting the activityof the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading tostabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9)demethylation (By similarity). Promotes cholesterol efflux byacting as a transcription coactivator (PubMed:19481530). Acts as aregulator of B-cell development by inhibiting UBE2N/Ubc13, therebyrestricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity).Acts as a key mediator of mitochondrial stress response: inresponse to mitochondrial depolarization, relocates from themitochondria to the nucleus following desumoylation andspecifically promotes expression of nuclear-encoded mitochondrialgenes (PubMed:29499132). Promotes transcription of nuclear-encodedmitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132).Can also act as a corepressor as part of the N-Cor repressorcomplex by repressing active PPARG (PubMed:19858209,PubMed:24943844). Plays an anti-inflammatory role in macrophagesand is required for insulin sensitivity by acting as a corepressor(By similarity). Plays an anti-inflammatory role during thehepatic acute phase response by interacting with sumoylated NR1H2and NR5A2 proteins, thereby preventing N-Cor corepressor complexdissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as anegative regulator of inflammation by inhibiting theproinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13activity (By similarity). In the cytoplasm of adipocytes,restricts the activation of insulin signaling via inhibition ofUBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Ableto suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081).{ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:19481530,ECO:0000269|PubMed:19858209, ECO:0000269|PubMed:20159957,ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:27460081,ECO:0000269|PubMed:29499132, ECO:0000269|PubMed:8943324}. (Microbial infection) Required for efficient replicationof hepatitis C virus (HCV) by promoting the interaction betweenVAPA and HCV virus protein NS5A. {ECO:0000269|PubMed:24223774}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GABARAP_GPS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GABARAP_GPS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GABARAPGABRG2, ULK1, HDAC5, TUBB3, ATG4B, TFRC, GABARAP, ATG12, ATG3, ATG7, FNBP1, TBC1D15, PI4K2A, NCOA7, DYX1C1, NEDD4, STBD1, SQSTM1, IPO5, NBR1, ANKFY1, GBAS, GABARAPL2, TECPR2, FKBP4, KEAP1, GABARAPL1, MAP1LC3B, MAP1LC3C, DVL2, TBC1D25, ATG13, RB1CC1, ULK2, KATNB1, BNIP3L, MLH1, MAPK15, SRPK2, SRPK1, ATG101, TAX1BP1, MUL1, AMBRA1, OPTN, TSPAN3, RWDD2A, TP53INP1, WDFY3, KBTBD6, KBTBD7, CUL3, MEFV, TRIM21, CALCOCO2, FLCN, FNIP1, NIPSNAP1, CCPG1, FNIP2, MTMR14, TGDS, FOXN4, LMNB1GPS2ATF4, C19orf57, MAP3K7CL, DBNL, CCNA1, NCOR1, HDAC3, HDAC5, TBL1X, EP300, GOLGA2, SPDL1, CHD3, SETDB1, PBK, TP53, SIN3A, CNOT2, THRA, THRB, NCOR2, NR0B2, HDAC1, NR5A2, HNF4A, NR1H4, MSH4, MSH5, TBL1XR1, KRT31, RALBP1, RBPMS, TFIP11, SESTD1, PPFIA1, PPFIA3, MAPK3, ARMC8, MKLN1, MAEA, DCTN4, RMND5A, RANBP10, ANKRD11, CYTH3, GID4, ACTR10, DAPK3, TRIM68, GID8, FOXK2, FOXK1, CREB1, DCTN6, DCTN3, YPEL5, PRMT6, NINL, XPO1, NANOG, MAPK8, TBL1Y, ACTR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GABARAP_GPS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GABARAP_GPS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGABARAPC0036341Schizophrenia1PSYGENET