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Fusion gene ID: 14212 |
FusionGeneSummary for GABARAP_GPS2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GABARAP_GPS2 | Fusion gene ID: 14212 | Hgene | Tgene | Gene symbol | GABARAP | GPS2 | Gene ID | 11337 | 2874 |
Gene name | GABA type A receptor-associated protein | G protein pathway suppressor 2 | |
Synonyms | ATG8A|GABARAP-a|MM46 | AMF-1 | |
Cytomap | 17p13.1 | 17p13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | gamma-aminobutyric acid receptor-associated proteinGABA(A) receptor-associated protein | G protein pathway suppressor 2GPS-2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O95166 | Q13227 | |
Ensembl transtripts involved in fusion gene | ENST00000302386, ENST00000577035, ENST00000571129, ENST00000571253, ENST00000573928, | ENST00000391950, ENST00000389167, ENST00000380728, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GABARAP [Title/Abstract] AND GPS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GABARAP | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 15977068 |
Tgene | GPS2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11931768|19858209 |
Tgene | GPS2 | GO:0010875 | positive regulation of cholesterol efflux | 19481530 |
Tgene | GPS2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19481530 |
Tgene | GPS2 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-CV-5979-01A | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000302386 | ENST00000391950 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000302386 | ENST00000389167 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000302386 | ENST00000380728 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000577035 | ENST00000391950 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000577035 | ENST00000389167 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000577035 | ENST00000380728 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000571129 | ENST00000391950 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000571129 | ENST00000389167 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000571129 | ENST00000380728 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000571253 | ENST00000391950 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000571253 | ENST00000389167 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000571253 | ENST00000380728 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000573928 | ENST00000391950 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000573928 | ENST00000389167 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
intron-intron | ENST00000573928 | ENST00000380728 | GABARAP | chr17 | 7144743 | - | GPS2 | chr17 | 7217978 | - |
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FusionProtFeatures for GABARAP_GPS2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GABARAP | GPS2 |
Ubiquitin-like modifier that plays a role inintracellular transport of GABA(A) receptors and its interactionwith the cytoskeleton. Involved in apoptosis. Involved inautophagy. Whereas LC3s are involved in elongation of thephagophore membrane, the GABARAP/GATE-16 subfamily is essentialfor a later stage in autophagosome maturation.{ECO:0000269|PubMed:15977068}. | Key regulator of inflammation, lipid metabolism andmitochondrion homeostasis that acts by inhibiting the activity ofthe ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting'Lys-63'-linked ubiquitination (By similarity). In the nucleus,can both acts as a corepressor and coactivator of transcription,depending on the context (PubMed:24943844). Acts as atranscription coactivator in adipocytes by promoting therecruitment of PPARG to promoters: acts by inhibiting the activityof the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading tostabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9)demethylation (By similarity). Promotes cholesterol efflux byacting as a transcription coactivator (PubMed:19481530). Acts as aregulator of B-cell development by inhibiting UBE2N/Ubc13, therebyrestricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity).Acts as a key mediator of mitochondrial stress response: inresponse to mitochondrial depolarization, relocates from themitochondria to the nucleus following desumoylation andspecifically promotes expression of nuclear-encoded mitochondrialgenes (PubMed:29499132). Promotes transcription of nuclear-encodedmitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132).Can also act as a corepressor as part of the N-Cor repressorcomplex by repressing active PPARG (PubMed:19858209,PubMed:24943844). Plays an anti-inflammatory role in macrophagesand is required for insulin sensitivity by acting as a corepressor(By similarity). Plays an anti-inflammatory role during thehepatic acute phase response by interacting with sumoylated NR1H2and NR5A2 proteins, thereby preventing N-Cor corepressor complexdissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as anegative regulator of inflammation by inhibiting theproinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13activity (By similarity). In the cytoplasm of adipocytes,restricts the activation of insulin signaling via inhibition ofUBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Ableto suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081).{ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:19481530,ECO:0000269|PubMed:19858209, ECO:0000269|PubMed:20159957,ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:27460081,ECO:0000269|PubMed:29499132, ECO:0000269|PubMed:8943324}. (Microbial infection) Required for efficient replicationof hepatitis C virus (HCV) by promoting the interaction betweenVAPA and HCV virus protein NS5A. {ECO:0000269|PubMed:24223774}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GABARAP_GPS2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GABARAP_GPS2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GABARAP | GABRG2, ULK1, HDAC5, TUBB3, ATG4B, TFRC, GABARAP, ATG12, ATG3, ATG7, FNBP1, TBC1D15, PI4K2A, NCOA7, DYX1C1, NEDD4, STBD1, SQSTM1, IPO5, NBR1, ANKFY1, GBAS, GABARAPL2, TECPR2, FKBP4, KEAP1, GABARAPL1, MAP1LC3B, MAP1LC3C, DVL2, TBC1D25, ATG13, RB1CC1, ULK2, KATNB1, BNIP3L, MLH1, MAPK15, SRPK2, SRPK1, ATG101, TAX1BP1, MUL1, AMBRA1, OPTN, TSPAN3, RWDD2A, TP53INP1, WDFY3, KBTBD6, KBTBD7, CUL3, MEFV, TRIM21, CALCOCO2, FLCN, FNIP1, NIPSNAP1, CCPG1, FNIP2, MTMR14, TGDS, FOXN4, LMNB1 | GPS2 | ATF4, C19orf57, MAP3K7CL, DBNL, CCNA1, NCOR1, HDAC3, HDAC5, TBL1X, EP300, GOLGA2, SPDL1, CHD3, SETDB1, PBK, TP53, SIN3A, CNOT2, THRA, THRB, NCOR2, NR0B2, HDAC1, NR5A2, HNF4A, NR1H4, MSH4, MSH5, TBL1XR1, KRT31, RALBP1, RBPMS, TFIP11, SESTD1, PPFIA1, PPFIA3, MAPK3, ARMC8, MKLN1, MAEA, DCTN4, RMND5A, RANBP10, ANKRD11, CYTH3, GID4, ACTR10, DAPK3, TRIM68, GID8, FOXK2, FOXK1, CREB1, DCTN6, DCTN3, YPEL5, PRMT6, NINL, XPO1, NANOG, MAPK8, TBL1Y, ACTR1B |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GABARAP_GPS2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GABARAP_GPS2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GABARAP | C0036341 | Schizophrenia | 1 | PSYGENET |