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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14202

FusionGeneSummary for GAB2_NUDC

check button Fusion gene summary
Fusion gene informationFusion gene name: GAB2_NUDC
Fusion gene ID: 14202
HgeneTgene
Gene symbol

GAB2

NUDC

Gene ID

9846

10726

Gene nameGRB2 associated binding protein 2nuclear distribution C, dynein complex regulator
Synonyms-HNUDC|MNUDC|NPD011
Cytomap

11q14.1

1p36.11

Type of geneprotein-codingprotein-coding
DescriptionGRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100nuclear migration protein nudCnuclear distribution C homolognuclear distribution gene C homolognuclear distribution protein C homolognudC nuclear distribution protein
Modification date2018052720180523
UniProtAcc

Q9UQC2

Q9Y266

Ensembl transtripts involved in fusion geneENST00000340149, ENST00000361507, 
ENST00000526030, 
ENST00000321265, 
ENST00000484772, 
Fusion gene scores* DoF score16 X 10 X 5=8004 X 5 X 5=100
# samples 166
** MAII scorelog2(16/800*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAB2 [Title/Abstract] AND NUDC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAB2

GO:0008284

positive regulation of cell proliferation

19172738


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A5SH-06AGAB2chr11

78128692

-NUDCchr1

27250580

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000340149ENST00000321265GAB2chr11

78128692

-NUDCchr1

27250580

+
intron-intronENST00000340149ENST00000484772GAB2chr11

78128692

-NUDCchr1

27250580

+
In-frameENST00000361507ENST00000321265GAB2chr11

78128692

-NUDCchr1

27250580

+
5CDS-intronENST00000361507ENST00000484772GAB2chr11

78128692

-NUDCchr1

27250580

+
5UTR-3CDSENST00000526030ENST00000321265GAB2chr11

78128692

-NUDCchr1

27250580

+
5UTR-intronENST00000526030ENST00000484772GAB2chr11

78128692

-NUDCchr1

27250580

+

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FusionProtFeatures for GAB2_NUDC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAB2

Q9UQC2

NUDC

Q9Y266

Adapter protein which acts downstream of severalmembrane receptors including cytokine, antigen, hormone, cellmatrix and growth factor receptors to regulate multiple signalingpathways. Regulates osteoclast differentiation mediating theTNFRSF11A/RANK signaling. In allergic response, it plays a role inmast cells activation and degranulation through PI-3-kinaseregulation. Also involved in the regulation of cell proliferationand hematopoiesis. {ECO:0000269|PubMed:15750601,ECO:0000269|PubMed:19172738}. Plays a role in neurogenesis and neuronal migration (Bysimilarity). Necessary for correct formation of mitotic spindlesand chromosome separation during mitosis. Necessary forcytokinesis and cell proliferation. {ECO:0000250,ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GAB2_NUDC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GAB2_ENST00000361507_chr11_78128692_-_NUDC_ENST00000321265_chr1_27250580_+_330aa
MSGGGDVVCTGWLRKSPPEKKLRRTLVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFSHHNQLAQKTRREKRARQEAERREKAERAARLA
KEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLKPNLGNGADLPNYRWTQTLSELD
LAVPFCVNFRLKGKDMVVDIQRRHLRVGLKGQPAIIDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GAB2_ENST00000361507_chr11_78128692_-_NUDC_ENST00000321265_chr1_27250580_+_990nt
ATGAGCGGCGGCGGCGACGTGGTGTGCACCGGCTGGCTGAGGAAATCGCCTCCCGAGAAGAAGTTGAGGCGCTATCTTGTGAACACCTTC
TTCAGCTTCCTTCGACGCAAAACAGACTTTTTCATTGGAGGAGAAGAAGGGATGGCAGAGAAGCTTATCACACAGACTTTCAGCCACCAC
AATCAGCTGGCACAGAAGACCCGGCGGGAGAAGAGAGCCCGGCAGGAGGCCGAGCGGCGGGAGAAGGCGGAGCGGGCGGCCAGACTGGCC
AAGGAAGCCAAGTCAGAGACCTCAGGGCCCCAGATCAAGGAGCTAACTGATGAAGAGGCAGAGAGGCTGCAGCTAGAGATTGACCAGAAA
AAGGATGCAGAGAATCATGAGGCCCAGCTCAAGAACGGCAGCCTTGACTCCCCAGGGAAGCAGGATACTGAGGAAGATGAGGAGGAAGAT
GAGAAGGACAAAGGAAAACTGAAGCCCAACCTAGGCAACGGGGCAGACCTGCCCAATTACCGCTGGACCCAGACCCTGTCGGAGCTGGAC
CTGGCGGTCCCTTTCTGTGTGAACTTCCGGCTGAAAGGGAAGGACATGGTGGTGGACATCCAGCGGCGGCACCTCCGGGTGGGGCTCAAG
GGGCAGCCAGCGATCATTGATGGGGAGCTCTACAATGAAGTGAAGGTGGAGGAGAGCTCGTGGCTCATTGAGGACGGCAAGGTGGTGACT
GTGCATCTGGAGAAGATCAATAAGATGGAGTGGTGGAGCCGCTTGGTGTCCAGTGACCCTGAGATCAACACCAAGAAGATTAACCCTGAG
AATTCCAAGCTGTCAGACCTGGACAGTGAGACTCGCAGCATGGTGGAAAAGATGATGTATGACCAGCGACAGAAGTCCATGGGGCTGCCA
ACTTCAGACGAACAGAAGAAACAGGAGATTCTGAAGAAGTTCATGGATCAACATCCGGAGATGGATTTTTCCAAGGCTAAATTCAACTAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GAB2_ENST00000361507_chr11_78128692_-_NUDC_ENST00000321265_chr1_27250580_+_1757nt
GAGCTGCGCACCGCCGGCCGCTGCCCCAGCTGCCCGAGCCCGCGCCCTCGTCCGCGCGACCCGGCGGGGGGCTCCAGGCCGGCAGCATGA
GCGGCGGCGGCGACGTGGTGTGCACCGGCTGGCTGAGGAAATCGCCTCCCGAGAAGAAGTTGAGGCGCTATCTTGTGAACACCTTCTTCA
GCTTCCTTCGACGCAAAACAGACTTTTTCATTGGAGGAGAAGAAGGGATGGCAGAGAAGCTTATCACACAGACTTTCAGCCACCACAATC
AGCTGGCACAGAAGACCCGGCGGGAGAAGAGAGCCCGGCAGGAGGCCGAGCGGCGGGAGAAGGCGGAGCGGGCGGCCAGACTGGCCAAGG
AAGCCAAGTCAGAGACCTCAGGGCCCCAGATCAAGGAGCTAACTGATGAAGAGGCAGAGAGGCTGCAGCTAGAGATTGACCAGAAAAAGG
ATGCAGAGAATCATGAGGCCCAGCTCAAGAACGGCAGCCTTGACTCCCCAGGGAAGCAGGATACTGAGGAAGATGAGGAGGAAGATGAGA
AGGACAAAGGAAAACTGAAGCCCAACCTAGGCAACGGGGCAGACCTGCCCAATTACCGCTGGACCCAGACCCTGTCGGAGCTGGACCTGG
CGGTCCCTTTCTGTGTGAACTTCCGGCTGAAAGGGAAGGACATGGTGGTGGACATCCAGCGGCGGCACCTCCGGGTGGGGCTCAAGGGGC
AGCCAGCGATCATTGATGGGGAGCTCTACAATGAAGTGAAGGTGGAGGAGAGCTCGTGGCTCATTGAGGACGGCAAGGTGGTGACTGTGC
ATCTGGAGAAGATCAATAAGATGGAGTGGTGGAGCCGCTTGGTGTCCAGTGACCCTGAGATCAACACCAAGAAGATTAACCCTGAGAATT
CCAAGCTGTCAGACCTGGACAGTGAGACTCGCAGCATGGTGGAAAAGATGATGTATGACCAGCGACAGAAGTCCATGGGGCTGCCAACTT
CAGACGAACAGAAGAAACAGGAGATTCTGAAGAAGTTCATGGATCAACATCCGGAGATGGATTTTTCCAAGGCTAAATTCAACTAGCCCC
TGTTTTTTCCTCCCTGAACTCTTGGGGCTGAGCTGCAACCACCCAACTTTCTTTCCCACTCTTCTCTGGGACTTGTGGGCCTCAGGGCTT
GGGGCAGGCATGGGACTGGCCCAGGCACACAGGTCCCGGGGCATCAGGAGAAAGGCTGGGTCTTGGGACCTTGTCCTCCCCAGTTGGCCT
ACTGTTACACATTAAAACGATTTGCCCAGCTCCTTCTGTGTCCTCTCTTGCCTCTGGCCTTTCTCTGGGGCACAGGCCTCTTACGGCTGC
TGCTGGGAACTGGGAGTTTGGCTTCTAGCCCAGATTCTGCCATGTGACCTAGGGCACATCCTTGCCCCTCTCTGGGCCTCAGTTTCTCAT
TACTTAAAGATTAAAACAAGGCTTGGCCGGGTGTGATGGTTCATGTCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGAGCAGATCACCT
GATGTCAGGAGTTTGAGACCAGCTTGGCCAACATGGAGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGCACA
CCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGTGGCGGAGGTTGCAGTGAGCCGAGATTGCACTACTT


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FusionGenePPI for GAB2_NUDC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GAB2BCR, GRB2, ETV6, ARHGAP32, LYN, PLCG2, PTPN11, SHC1, ZAP70, CD247, LAT, PTPN6, PIK3R1, AKT1, GRAP, SRC, NCK1, PLCG1, CRKL, MET, GRAP2, LRRK1, PIK3R2, CRK, PIK3CB, MAPK1, MAPK3, MARK2, GAB1, GAB2, YWHAE, NTRK1, XPO1, FRS2, TGM4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, CDC25B, CDK16, FAM110B, USP21, ANKRD34A, FAM53C, CGN, FAM110A, DENND4C, HDAC4, MAPKAP1, TBC1D25, NF1, NADK, CBY1, RAB3IPNUDCDGKE, PLK1, PAFAH1B1, BTRC, FBXW11, WIPI2, HDAC5, HDGF, TINF2, ACD, POT1, HSP90AA1, IGBP1, TRMT1, NUBP2, CSTB, PPME1, TP53BP1, ITGA4, PPP6R2, ETF1, H3F3A, KARS, CORO1B, CORO1C, FAM129B, PUF60, TARS, UGP2, VPS26A, VPS29, VPS35, ZYX, PAPOLA, TLN1, FKBP5, DNAJA2, DNAJB1, MAEL, DNAJA1, RPS17, HUWE1, ENO1, MOV10, NXF1, CUL7, LLGL2, RPS6KB2, ADAM9, CAST, CCDC6, GAPDH, MAD1L1, MDH2, TIMM9, SOD1, NTRK1, NUP85, OFD1, MKS1, NPHP4, EVC2, NEK8, POC1A, POC1B, RPGR, SNW1, CDC5L, OTUB1, DCDC5, EML4, NFATC2, CDH1, PHLPP1, DNAJB4, GTF2H1, IFT80, WDR35, IFT172, WDR60, DLD, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GAB2_NUDC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GAB2_NUDC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAB2C0025202melanoma1CTD_human
HgeneGAB2C0027626Neoplasm Invasiveness1CTD_human
HgeneGAB2C0027627Neoplasm Metastasis1CTD_human