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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14197

FusionGeneSummary for GAB2_FGF7

check button Fusion gene summary
Fusion gene informationFusion gene name: GAB2_FGF7
Fusion gene ID: 14197
HgeneTgene
Gene symbol

GAB2

FGF7

Gene ID

9846

2252

Gene nameGRB2 associated binding protein 2fibroblast growth factor 7
Synonyms-HBGF-7|KGF
Cytomap

11q14.1

15q21.2

Type of geneprotein-codingprotein-coding
DescriptionGRB2-associated-binding protein 2Grb2-associated binder 2growth factor receptor bound protein 2-associated protein 2pp100fibroblast growth factor 7FGF-7heparin-binding growth factor 7keratinocyte growth factor
Modification date2018052720180519
UniProtAcc

Q9UQC2

P21781

Ensembl transtripts involved in fusion geneENST00000340149, ENST00000361507, 
ENST00000526030, 		ENST00000267843, 
ENST00000560270, ENST00000560704, 
Fusion gene scores* DoF score16 X 10 X 5=8005 X 2 X 4=40
# samples 166
** MAII scorelog2(16/800*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GAB2 [Title/Abstract] AND FGF7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAB2

GO:0008284

positive regulation of cell proliferation

19172738

TgeneFGF7

GO:0010463

mesenchymal cell proliferation

11023837

TgeneFGF7

GO:0010838

positive regulation of keratinocyte proliferation

17449030

TgeneFGF7

GO:0031532

actin cytoskeleton reorganization

17449030

TgeneFGF7

GO:0034394

protein localization to cell surface

17449030

TgeneFGF7

GO:0050679

positive regulation of epithelial cell proliferation

11493558|15690149

TgeneFGF7

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17449030

TgeneFGF7

GO:0050918

positive chemotaxis

17449030

TgeneFGF7

GO:0051549

positive regulation of keratinocyte migration

17449030

TgeneFGF7

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

9740653

TgeneFGF7

GO:0061033

secretion by lung epithelial cell involved in lung growth

10541313


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A19T-06AGAB2chr11

77961203

-FGF7chr15

49775348

+
TCGARVSKCMTCGA-ER-A19T-01AGAB2chr11

77961203

-FGF7chr15

49716229

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340149ENST00000267843GAB2chr11

77961203

-FGF7chr15

49775348

+
5CDS-intronENST00000340149ENST00000560270GAB2chr11

77961203

-FGF7chr15

49775348

+
5CDS-3UTRENST00000340149ENST00000560704GAB2chr11

77961203

-FGF7chr15

49775348

+
Frame-shiftENST00000361507ENST00000267843GAB2chr11

77961203

-FGF7chr15

49775348

+
5CDS-intronENST00000361507ENST00000560270GAB2chr11

77961203

-FGF7chr15

49775348

+
5CDS-3UTRENST00000361507ENST00000560704GAB2chr11

77961203

-FGF7chr15

49775348

+
intron-3CDSENST00000526030ENST00000267843GAB2chr11

77961203

-FGF7chr15

49775348

+
intron-intronENST00000526030ENST00000560270GAB2chr11

77961203

-FGF7chr15

49775348

+
intron-3UTRENST00000526030ENST00000560704GAB2chr11

77961203

-FGF7chr15

49775348

+
5CDS-5UTRENST00000340149ENST00000267843GAB2chr11

77961203

-FGF7chr15

49716229

+
5CDS-5UTRENST00000340149ENST00000560270GAB2chr11

77961203

-FGF7chr15

49716229

+
5CDS-intronENST00000340149ENST00000560704GAB2chr11

77961203

-FGF7chr15

49716229

+
5CDS-5UTRENST00000361507ENST00000267843GAB2chr11

77961203

-FGF7chr15

49716229

+
5CDS-5UTRENST00000361507ENST00000560270GAB2chr11

77961203

-FGF7chr15

49716229

+
5CDS-intronENST00000361507ENST00000560704GAB2chr11

77961203

-FGF7chr15

49716229

+
intron-5UTRENST00000526030ENST00000267843GAB2chr11

77961203

-FGF7chr15

49716229

+
intron-5UTRENST00000526030ENST00000560270GAB2chr11

77961203

-FGF7chr15

49716229

+
intron-intronENST00000526030ENST00000560704GAB2chr11

77961203

-FGF7chr15

49716229

+

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FusionProtFeatures for GAB2_FGF7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAB2

Q9UQC2

FGF7

P21781

Adapter protein which acts downstream of severalmembrane receptors including cytokine, antigen, hormone, cellmatrix and growth factor receptors to regulate multiple signalingpathways. Regulates osteoclast differentiation mediating theTNFRSF11A/RANK signaling. In allergic response, it plays a role inmast cells activation and degranulation through PI-3-kinaseregulation. Also involved in the regulation of cell proliferationand hematopoiesis. {ECO:0000269|PubMed:15750601,ECO:0000269|PubMed:19172738}. Plays an important role in the regulation of embryonicdevelopment, cell proliferation and cell differentiation. Requiredfor normal branching morphogenesis. Growth factor active onkeratinocytes. Possible major paracrine effector of normalepithelial cell proliferation. {ECO:0000269|PubMed:16597617,ECO:0000269|PubMed:8663044}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GAB2_FGF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GAB2_FGF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GAB2BCR, GRB2, ETV6, ARHGAP32, LYN, PLCG2, PTPN11, SHC1, ZAP70, CD247, LAT, PTPN6, PIK3R1, AKT1, GRAP, SRC, NCK1, PLCG1, CRKL, MET, GRAP2, LRRK1, PIK3R2, CRK, PIK3CB, MAPK1, MAPK3, MARK2, GAB1, GAB2, YWHAE, NTRK1, XPO1, FRS2, TGM4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, CDC25B, CDK16, FAM110B, USP21, ANKRD34A, FAM53C, CGN, FAM110A, DENND4C, HDAC4, MAPKAP1, TBC1D25, NF1, NADK, CBY1, RAB3IPFGF7HSPG2, FGFR2, DESI1, UBQLN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GAB2_FGF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GAB2_FGF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAB2C0025202melanoma1CTD_human
HgeneGAB2C0027626Neoplasm Invasiveness1CTD_human
HgeneGAB2C0027627Neoplasm Metastasis1CTD_human
TgeneFGF7C0000786Spontaneous abortion1CTD_human
TgeneFGF7C0008924Cleft Lip1CTD_human
TgeneFGF7C0008925Cleft Palate1CTD_human
TgeneFGF7C0017566Gingival Hyperplasia1CTD_human
TgeneFGF7C0023890Liver Cirrhosis1CTD_human
TgeneFGF7C0034069Pulmonary Fibrosis1CTD_human
TgeneFGF7C0035126Reperfusion Injury1CTD_human
TgeneFGF7C0273115Lung Injury1CTD_human
TgeneFGF7C2937421Prostatic Hyperplasia1CTD_human