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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14190

FusionGeneSummary for G6PD_STAT6

check button Fusion gene summary
Fusion gene informationFusion gene name: G6PD_STAT6
Fusion gene ID: 14190
HgeneTgene
Gene symbol

G6PD

STAT6

Gene ID

2539

6778

Gene nameglucose-6-phosphate dehydrogenasesignal transducer and activator of transcription 6
SynonymsG6PD1D12S1644|IL-4-STAT|STAT6B|STAT6C
Cytomap

Xq28

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionglucose-6-phosphate 1-dehydrogenasesignal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT
Modification date2018052720180519
UniProtAcc

P11413

P42226

Ensembl transtripts involved in fusion geneENST00000393562, ENST00000369620, 
ENST00000393564, ENST00000497281, 
ENST00000300134, ENST00000538913, 
ENST00000543873, ENST00000556155, 
ENST00000537215, ENST00000454075, 
Fusion gene scores* DoF score4 X 6 X 3=7237 X 8 X 15=4440
# samples 643
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(43/4440*10)=-3.36815111164801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: G6PD [Title/Abstract] AND STAT6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneG6PD

GO:0006098

pentose-phosphate shunt

2297768

HgeneG6PD

GO:0006739

NADP metabolic process

15858258

HgeneG6PD

GO:0019322

pentose biosynthetic process

5643703

HgeneG6PD

GO:0051156

glucose 6-phosphate metabolic process

15858258

TgeneSTAT6

GO:0045944

positive regulation of transcription by RNA polymerase II

8810328


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-D1-A3JP-01AG6PDchrX

153759606

-STAT6chr12

57496773

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000393562ENST00000300134G6PDchrX

153759606

-STAT6chr12

57496773

-
5CDS-intronENST00000393562ENST00000538913G6PDchrX

153759606

-STAT6chr12

57496773

-
5CDS-intronENST00000393562ENST00000543873G6PDchrX

153759606

-STAT6chr12

57496773

-
5CDS-intronENST00000393562ENST00000556155G6PDchrX

153759606

-STAT6chr12

57496773

-
5CDS-intronENST00000393562ENST00000537215G6PDchrX

153759606

-STAT6chr12

57496773

-
5CDS-intronENST00000393562ENST00000454075G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000369620ENST00000300134G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000369620ENST00000538913G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000369620ENST00000543873G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000369620ENST00000556155G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000369620ENST00000537215G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000369620ENST00000454075G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000393564ENST00000300134G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000393564ENST00000538913G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000393564ENST00000543873G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000393564ENST00000556155G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000393564ENST00000537215G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000393564ENST00000454075G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000497281ENST00000300134G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000497281ENST00000538913G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000497281ENST00000543873G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000497281ENST00000556155G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000497281ENST00000537215G6PDchrX

153759606

-STAT6chr12

57496773

-
intron-intronENST00000497281ENST00000454075G6PDchrX

153759606

-STAT6chr12

57496773

-

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FusionProtFeatures for G6PD_STAT6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
G6PD

P11413

STAT6

P42226

Catalyzes the rate-limiting step of the oxidativepentose-phosphate pathway, which represents a route for thedissimilation of carbohydrates besides glycolysis. The mainfunction of this enzyme is to provide reducing power (NADPH) andpentose phosphates for fatty acid and nucleic acid synthesis.{ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394}. Carries out a dual function: signal transduction andactivation of transcription. Involved in IL4/interleukin-4- andIL3/interleukin-3-mediated signaling.{ECO:0000269|PubMed:17210636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for G6PD_STAT6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for G6PD_STAT6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
G6PDG6PD, HSPB1, HARS, CCT4, FN1, BAG3, ALDH7A1, CAPN1, EIF4H, EIF5, ERP44, CKB, CNDP2, GNS, LDHB, PAK2, SLC9A3R1, TGM2, UBE2V1, GBP2, GLA, ISOC1, MAT2B, PGD, PPP1R2, SFN, UBFD1, VCL, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ, ZFYVE19, ZNF622, CA10, PPAT, ARFIP1, C6orf211, CDA, DUT, FDPS, BLMH, NDRG1, RAD23B, SEPHS1, TSTA3, HSPA9, IDH2, MYO6, PDXK, PGAM1, RPE, TANGO2, UFM1, UNC13D, XPO1, NTRK1, CTR9, MCM2, CDC73, SBF2, MED18, COMMD1, PLA2G10STAT6NCOA1, CREBBP, IRF4, EP300, NFKB1, SND1, ANXA2, TP53, STAT3, TRIM24, DAZAP2, CEBPZ, WWP1, RLIM, ANKZF1, ZNF407, ZBTB2, ZNF92, PARP14, NCOA3, NCOA2, JUN, SFPQ, IGHE, FCER2, CEBPE, SSSCA1, SRXN1, PPM1G, RAD23B, SEC24A, NUBP2, AHCYL1, DSTN, IGBP1, SH3BGRL, PSAT1, STAT2, IFNAR1, IL4R, IFNG, JAK1, PTPN2, VKORC1, LITAF, JAK3, TRIM28, RCN3, EEF1A1, API5, EHD1, PDE12, PGGT1B, USP8, PPARG, KDM3A, AACS, GART, TSTA3, KIF22, POLK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for G6PD_STAT6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneG6PDP11413DB11638ArtenimolGlucose-6-phosphate 1-dehydrogenasesmall moleculeapproved|investigational

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RelatedDiseases for G6PD_STAT6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneG6PDC2720289ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY17ORPHANET;UNIPROT
HgeneG6PDC0005586Bipolar Disorder5PSYGENET
HgeneG6PDC0002878Anemia, Hemolytic3CTD_human
HgeneG6PDC2609414Acute kidney injury3CTD_human
HgeneG6PDC2939465Deficiency of glucose-6-phosphate dehydrogenase3CTD_human
HgeneG6PDC0002882Anemia, Hemolytic, Congenital Nonspherocytic2CTD_human
HgeneG6PDC0015702Favism2CTD_human
HgeneG6PDC0019054Hemolysis (disorder)2CTD_human
HgeneG6PDC0011616Contact Dermatitis1CTD_human
HgeneG6PDC0018203Chronic granulomatous disease1CTD_human
HgeneG6PDC0031306Phagocyte Bactericidal Dysfunction1CTD_human
TgeneSTAT6C1266119Solitary fibrous tumor2CTD_human
TgeneSTAT6C0011615Dermatitis, Atopic1CTD_human
TgeneSTAT6C0013604Edema1CTD_human
TgeneSTAT6C0018671Head and Neck Neoplasms1CTD_human