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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14176

FusionGeneSummary for G2E3_UBR3

check button Fusion gene summary
Fusion gene informationFusion gene name: G2E3_UBR3
Fusion gene ID: 14176
HgeneTgene
Gene symbol

G2E3

UBR3

Gene ID

55632

130507

Gene nameG2/M-phase specific E3 ubiquitin protein ligaseubiquitin protein ligase E3 component n-recognin 3 (putative)
SynonymsKIAA1333|PHF7BZNF650
Cytomap

14q12

2q31.1

Type of geneprotein-codingprotein-coding
DescriptionG2/M phase-specific E3 ubiquitin-protein ligaseG2/M phase-specific HECT-type E3 ubiquitin transferaseG2/M-phase specific E3 ubiquitin ligasePHD finger protein 7BE3 ubiquitin-protein ligase UBR3N-recognin-3RING-type E3 ubiquitin transferase UBR3ubiquitin-protein ligase E3-alpha-3ubiquitin-protein ligase E3-alpha-IIIzinc finger protein 650
Modification date2018051920180523
UniProtAcc

Q7L622

Q6ZT12

Ensembl transtripts involved in fusion geneENST00000206595, ENST00000544007, 
ENST00000438909, ENST00000553504, 
ENST00000272793, ENST00000418381, 
ENST00000392631, ENST00000465630, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 2=32
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: G2E3 [Title/Abstract] AND UBR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV751440G2E3chr14

31086454

-UBR3chr2

170775185

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000206595ENST00000272793G2E3chr14

31086454

-UBR3chr2

170775185

+
3UTR-intronENST00000206595ENST00000418381G2E3chr14

31086454

-UBR3chr2

170775185

+
3UTR-intronENST00000206595ENST00000392631G2E3chr14

31086454

-UBR3chr2

170775185

+
3UTR-intronENST00000206595ENST00000465630G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000544007ENST00000272793G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000544007ENST00000418381G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000544007ENST00000392631G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000544007ENST00000465630G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000438909ENST00000272793G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000438909ENST00000418381G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000438909ENST00000392631G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000438909ENST00000465630G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000553504ENST00000272793G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000553504ENST00000418381G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000553504ENST00000392631G2E3chr14

31086454

-UBR3chr2

170775185

+
intron-intronENST00000553504ENST00000465630G2E3chr14

31086454

-UBR3chr2

170775185

+

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FusionProtFeatures for G2E3_UBR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
G2E3

Q7L622

UBR3

Q6ZT12

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.Essential in early embryonic development to prevent apoptoticdeath. {ECO:0000269|PubMed:18511420}. E3 ubiquitin-protein ligase which is a component of theN-end rule pathway (By similarity). Does not bind to proteinsbearing specific N-terminal residues that are destabilizingaccording to the N-end rule, leading to their ubiquitination andsubsequent degradation (By similarity). May play a role in Shhsignaling by mediating the ubiquitination of Kif7 (By similarity).May be important for MYH9 function in certain tissues, possibly byregulating the ubiquitination of MYH9 and consequently affectingits interaction with MYO7A (PubMed:27331610).{ECO:0000250|UniProtKB:Q5U430, ECO:0000269|PubMed:27331610}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for G2E3_UBR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for G2E3_UBR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for G2E3_UBR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for G2E3_UBR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource