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Fusion gene ID: 14165 |
FusionGeneSummary for FZD6_DPYS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FZD6_DPYS | Fusion gene ID: 14165 | Hgene | Tgene | Gene symbol | FZD6 | DPYS | Gene ID | 8323 | 1807 |
| Gene name | frizzled class receptor 6 | dihydropyrimidinase | |
| Synonyms | FZ-6|FZ6|HFZ6|NDNC10 | DHP|DHPase | |
| Cytomap | 8q22.3 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | frizzled-6frizzled 6, seven transmembrane spanning receptorfrizzled family receptor 6frizzled homolog 6seven transmembrane helix receptor | dihydropyrimidinasedihydropyrimidine amidohydrolasehydantoinase | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O60353 | Q14117 | |
| Ensembl transtripts involved in fusion gene | ENST00000522566, ENST00000358755, ENST00000523739, ENST00000540287, | ENST00000521601, ENST00000351513, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FZD6 [Title/Abstract] AND DPYS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FZD6 | GO:0035567 | non-canonical Wnt signaling pathway | 14747478 |
| Hgene | FZD6 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 14747478 |
| Tgene | DPYS | GO:0006208 | pyrimidine nucleobase catabolic process | 9718352 |
| Tgene | DPYS | GO:0006212 | uracil catabolic process | 10410956 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-LC-A66R-01A | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000522566 | ENST00000521601 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000522566 | ENST00000351513 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000358755 | ENST00000521601 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000358755 | ENST00000351513 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000523739 | ENST00000521601 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000523739 | ENST00000351513 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000540287 | ENST00000521601 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
| 5CDS-intron | ENST00000540287 | ENST00000351513 | FZD6 | chr8 | 104312512 | + | DPYS | chr8 | 105405219 | - |
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FusionProtFeatures for FZD6_DPYS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FZD6 | DPYS |
| Receptor for Wnt proteins. Most of frizzled receptorsare coupled to the beta-catenin canonical signaling pathway, whichleads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation ofWnt target genes. A second signaling pathway involving PKC andcalcium fluxes has been seen for some family members, but it isnot yet clear if it represents a distinct pathway or if it can beintegrated in the canonical pathway, as PKC seems to be requiredfor Wnt-mediated inactivation of GSK-3 kinase. Both pathways seemto involve interactions with G-proteins. May be involved intransduction and intercellular transmission of polarityinformation during tissue morphogenesis and/or in differentiatedtissues. Together with FZD3, is involved in the neural tubeclosure and plays a role in the regulation of the establishment ofplanar cell polarity (PCP), particularly in the orientation ofasymmetric bundles of stereocilia on the apical faces of a subsetof auditory and vestibular sensory cells located in the inner ear(By similarity). {ECO:0000250|UniProtKB:Q61089}. | Catalyzes the second step of the reductive pyrimidinedegradation, the reversible hydrolytic ring opening ofdihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine toN-carbamyl-amino isobutyrate. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FZD6_DPYS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FZD6_DPYS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FZD6 | SFRP1, ELAVL1, KLRAP1, SYNE4, GABRE, TMEM17, TMEM216, TMEM132A, ZNRF4, VNN2, TMPRSS12, GPR114 | DPYS | ADM, TMEM41B, DPYSL3, DPYSL2, DPYSL5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FZD6_DPYS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FZD6_DPYS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FZD6 | C3279974 | NAIL DISORDER, NONSYNDROMIC CONGENITAL, 10 | 1 | ORPHANET;UNIPROT |
| Tgene | DPYS | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | DPYS | C0342803 | Dihydropyrimidinase deficiency | 1 | CTD_human;ORPHANET;UNIPROT |
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