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Fusion gene ID: 14163 |
FusionGeneSummary for FZD4_LAMTOR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FZD4_LAMTOR1 | Fusion gene ID: 14163 | Hgene | Tgene | Gene symbol | FZD4 | LAMTOR1 | Gene ID | 8322 | 55004 |
| Gene name | frizzled class receptor 4 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | |
| Synonyms | CD344|EVR1|FEVR|FZD4S|Fz-4|Fz4|FzE4|GPCR|hFz4 | C11orf59|PDRO|Ragulator1|p18|p27RF-Rho | |
| Cytomap | 11q14.2 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | frizzled-4WNT receptor frizzled-4frizzled 4, seven transmembrane spanning receptorfrizzled family receptor 4frizzled homolog 4 | ragulator complex protein LAMTOR1RhoA activator C11orf59late endosomal/lysosomal adaptor and MAPK and MTOR activator 1lipid raft adaptor protein p18p27Kip1-releasing factor from RhoAp27kip1 releasing factor from RhoAprotein associated with DRMs and | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9ULV1 | Q6IAA8 | |
| Ensembl transtripts involved in fusion gene | ENST00000531380, | ENST00000545249, ENST00000535107, ENST00000278671, ENST00000538404, ENST00000539797, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FZD4 [Title/Abstract] AND LAMTOR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FZD4 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway | 12172548 |
| Hgene | FZD4 | GO:0016055 | Wnt signaling pathway | 14688793|17955262 |
| Hgene | FZD4 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
| Hgene | FZD4 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 14688793 |
| Hgene | FZD4 | GO:0060070 | canonical Wnt signaling pathway | 15035989|20802536|28733458 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0W3-01A | FZD4 | chr11 | 86665843 | - | LAMTOR1 | chr11 | 71810302 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000531380 | ENST00000545249 | FZD4 | chr11 | 86665843 | - | LAMTOR1 | chr11 | 71810302 | - |
| In-frame | ENST00000531380 | ENST00000535107 | FZD4 | chr11 | 86665843 | - | LAMTOR1 | chr11 | 71810302 | - |
| In-frame | ENST00000531380 | ENST00000278671 | FZD4 | chr11 | 86665843 | - | LAMTOR1 | chr11 | 71810302 | - |
| In-frame | ENST00000531380 | ENST00000538404 | FZD4 | chr11 | 86665843 | - | LAMTOR1 | chr11 | 71810302 | - |
| 5CDS-5UTR | ENST00000531380 | ENST00000539797 | FZD4 | chr11 | 86665843 | - | LAMTOR1 | chr11 | 71810302 | - |
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FusionProtFeatures for FZD4_LAMTOR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FZD4 | LAMTOR1 |
| Receptor for Wnt proteins. Most of frizzled receptorsare coupled to the beta-catenin (CTNNB1) canonical signalingpathway, which leads to the activation of disheveled proteins,inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin(CTNNB1) and activation of Wnt target genes. Plays a critical rolein retinal vascularization by acting as a receptor for Wntproteins and norrin (NDP). In retina, it can be both activated byWnt protein-binding, but also by a Wnt-independent signaling viabinding of norrin (NDP), promoting in both cases beta-catenin(CTNNB1) accumulation and stimulation of LEF/TCF-mediatedtranscriptional programs. A second signaling pathway involving PKCand calcium fluxes has been seen for some family members, but itis not yet clear if it represents a distinct pathway or if it canbe integrated in the canonical pathway, as PKC seems to berequired for Wnt-mediated inactivation of GSK-3 kinase. Bothpathways seem to involve interactions with G-proteins. May beinvolved in transduction and intercellular transmission ofpolarity information during tissue morphogenesis and/or indifferentiated tissues. | As part of the Ragulator complex it is involved in aminoacid sensing and activation of mTORC1, a signaling complexpromoting cell growth in response to growth factors, energylevels, and amino acids. Activated by amino acids through amechanism involving the lysosomal V-ATPase, the Ragulatorfunctions as a guanine nucleotide exchange factor activating thesmall GTPases Rag. Activated Ragulator and Rag GTPases function asa scaffold recruiting mTORC1 to lysosomes where it is in turnactivated. LAMTOR1 is directly responsible for anchoring theRagulator complex to membranes. Also required for lateendosomes/lysosomes biogenesis it may regulate both the recyclingof receptors through endosomes and the MAPK signaling pathwaythrough recruitment of some of its components to late endosomes.May be involved in cholesterol homeostasis regulating LDL uptakeand cholesterol release from late endosomes/lysosomes. May alsoplay a role in RHOA activation. {ECO:0000269|PubMed:19654316,ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018,ECO:0000269|PubMed:22980980}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 40_161 | 95 | 538 | Domain | FZ |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 535_537 | 95 | 538 | Motif | Note=PDZ-binding |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 244_254 | 95 | 538 | Topological domain | Cytoplasmic |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 276_302 | 95 | 538 | Topological domain | Extracellular |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 324_344 | 95 | 538 | Topological domain | Cytoplasmic |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 366_389 | 95 | 538 | Topological domain | Extracellular |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 37_222 | 95 | 538 | Topological domain | Extracellular |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 411_436 | 95 | 538 | Topological domain | Cytoplasmic |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 458_477 | 95 | 538 | Topological domain | Extracellular |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 499_537 | 95 | 538 | Topological domain | Cytoplasmic |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 223_243 | 95 | 538 | Transmembrane | Helical%3B Name%3D1 |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 255_275 | 95 | 538 | Transmembrane | Helical%3B Name%3D2 |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 303_323 | 95 | 538 | Transmembrane | Helical%3B Name%3D3 |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 345_365 | 95 | 538 | Transmembrane | Helical%3B Name%3D4 |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 390_410 | 95 | 538 | Transmembrane | Helical%3B Name%3D5 |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 437_457 | 95 | 538 | Transmembrane | Helical%3B Name%3D6 |
| Hgene | >FZD4 | chr11:86665843 | chr11:71810302 | ENST00000531380 | - | 1 | 2 | 478_498 | 95 | 538 | Transmembrane | Helical%3B Name%3D7 |
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FusionGeneSequence for FZD4_LAMTOR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000545249_chr11_71810302_-_224aa MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGC SSQLQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSL >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000535107_chr11_71810302_-_181aa MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGC SSQLQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYRHTGHHTEKEL >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000278671_chr11_71810302_-_243aa MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGC SSQLQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSL >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000538404_chr11_71810302_-_242aa MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGC SSQLQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000545249_chr11_71810302_-_672nt ATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGTCTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTC CTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATCCGCATCTCCATGTGCCAGAACCTCGGCTACAACGTG ACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAGCTGACAACTTTCACACCGCTCATCCAGTACGGCTGC TCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAAC TACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGTGTCT GCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTG ACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTG >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000535107_chr11_71810302_-_543nt ATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGTCTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTC CTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATCCGCATCTCCATGTGCCAGAACCTCGGCTACAACGTG ACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAGCTGACAACTTTCACACCGCTCATCCAGTACGGCTGC TCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAAC TACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGTGTCT GCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGACATACAGGGCATCACACTGAAAAGGAGCTG >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000278671_chr11_71810302_-_729nt ATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGTCTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTC CTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATCCGCATCTCCATGTGCCAGAACCTCGGCTACAACGTG ACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAGCTGACAACTTTCACACCGCTCATCCAGTACGGCTGC TCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAAC TACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGTGTCT GCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTG ACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTG CAGCAGGTCTCCAGGATAGCTGCTTATGCCTACAGTGCACTTTCTCAGATCCGTGTGGACGCAAAAGAGGAGCTGGTTGTACAGTTTGGG >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000538404_chr11_71810302_-_726nt ATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGTCTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTC CTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATCCGCATCTCCATGTGCCAGAACCTCGGCTACAACGTG ACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAGCTGACAACTTTCACACCGCTCATCCAGTACGGCTGC TCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAAC TACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGTGTCT GCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTG ACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTG CAGCAGGTGAGACACCCCTCACCTGCCCCTGCCCACCCTTCTCACACTGCCCAGGGTATGGCAGAGGGTTCACCCACTCTGCCTCAGAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000545249_chr11_71810302_-_1492nt GCTGCGCAGCGCTGGCTGCTGGCTGGCCTCGCGGAGACGCCGAACGGACGCGGCCGGCGCCGGCTTGTGGGCTCGCCGCCTGCAGCCATG ACCCTCGCAGCCTGTCCCTCGGCCTCGGCCCGGGACGTCTAAAATCCCACACAGTCGCGCGCAGCTGCTGGAGAGCCGGCCGCTGCCCCC TCGTCGCCGCATCACACTCCCGTCCCGGGAGCTGGGAGCAGCGCGGGCAGCCGGCGCCCCCGTGCAAACTGGGGGTGTCTGCCAGAGCAG CCCCAGCCGCTGCCGCTGCTACCCCCGATGCTGGCCATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGT CTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTCCTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATC CGCATCTCCATGTGCCAGAACCTCGGCTACAACGTGACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAG CTGACAACTTTCACACCGCTCATCCAGTACGGCTGCTCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGC CCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATC CTTGCCAAGACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAG TACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAA GTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGGTTCAGCTGTTTCAGTCCACACCTTGTTCACAGTAAGATATTCAATTC AATTCAGCAAACATTTGTTGAGTGCTTGCTGCTCTGTGCCTGACCAGAAGAAATGAAGCCAAGATACAAATAATAGAACCCTGTCATGAG CACAGAAAGACCTGCTGAGTTTCTATTGATTGTGGTAAACCAGCCTGCATCCAGTTCCAAGTAACAGCTGCCCACTTAGTGAATACTCTC TCATGTTTCAACACTCAGTTCTAGTGTAGCCTCTTCTATAAAGCCTTTCTTTTCCAGATAAAATTGGTTAATGTGTCCTGTGTTAGGCTG ATTGTTTTGATGATCCCTATTCATGGTCTCCCCTGTATCCATCTCTTTTTGCCTATAACATTGTAGTCCCATCTCACTCTGATGCTGGGA CCAGACATGTGACTTGTTTTAGCCAATGAGATGTCGATAAACATGAAGCAAACAGAAGCTTTAAAGGAGGCCTGCCCTCTTGCTCTTTGC >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000535107_chr11_71810302_-_1155nt GCTGCGCAGCGCTGGCTGCTGGCTGGCCTCGCGGAGACGCCGAACGGACGCGGCCGGCGCCGGCTTGTGGGCTCGCCGCCTGCAGCCATG ACCCTCGCAGCCTGTCCCTCGGCCTCGGCCCGGGACGTCTAAAATCCCACACAGTCGCGCGCAGCTGCTGGAGAGCCGGCCGCTGCCCCC TCGTCGCCGCATCACACTCCCGTCCCGGGAGCTGGGAGCAGCGCGGGCAGCCGGCGCCCCCGTGCAAACTGGGGGTGTCTGCCAGAGCAG CCCCAGCCGCTGCCGCTGCTACCCCCGATGCTGGCCATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGT CTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTCCTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATC CGCATCTCCATGTGCCAGAACCTCGGCTACAACGTGACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAG CTGACAACTTTCACACCGCTCATCCAGTACGGCTGCTCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGC CCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATC CTTGCCAAGACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAG TACAGACATACAGGGCATCACACTGAAAAGGAGCTGTGATCTGAGGGTCAGGAGTGTGGGCCTGGGTACCAGCACTGCCACTGACTTGCC TCTCTCAGCCTTAGTTGCCCCTTCACTGAAGACCTTTCCAGCTTTGGTGATCTACGATTCTATCACAGCAAGCAACAGGAAGACAGAGCA TCATGCTAGGCACATAAGAAGCTTTTAAAATACTGGTTAAATTGAGATCACCACACCAGGGGAATAGTGTCCAAGTCATGCTCCAGCTCC >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000278671_chr11_71810302_-_1565nt GCTGCGCAGCGCTGGCTGCTGGCTGGCCTCGCGGAGACGCCGAACGGACGCGGCCGGCGCCGGCTTGTGGGCTCGCCGCCTGCAGCCATG ACCCTCGCAGCCTGTCCCTCGGCCTCGGCCCGGGACGTCTAAAATCCCACACAGTCGCGCGCAGCTGCTGGAGAGCCGGCCGCTGCCCCC TCGTCGCCGCATCACACTCCCGTCCCGGGAGCTGGGAGCAGCGCGGGCAGCCGGCGCCCCCGTGCAAACTGGGGGTGTCTGCCAGAGCAG CCCCAGCCGCTGCCGCTGCTACCCCCGATGCTGGCCATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGT CTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTCCTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATC CGCATCTCCATGTGCCAGAACCTCGGCTACAACGTGACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAG CTGACAACTTTCACACCGCTCATCCAGTACGGCTGCTCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGC CCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATC CTTGCCAAGACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAG TACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAA GTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGGTCTCCAGGATAGCTGCTTATGCCTACAGTGCACTTTCTCAGATCCGT GTGGACGCAAAAGAGGAGCTGGTTGTACAGTTTGGGATCCCATGAAGAGAGGGGTCCTTGGACAGCTCTTCTCCTCTCTTCATCCCATCT CTACCCCACCCCCTTGGCCCCCAGCCTCACTGCGGCTTATACAGTACCCTAACCTGCTACTAATCACAGAGAAAAATGTGAAGAAGGAGG AGAAGAGGAAGGCTAGAAGCCTGAGCAAGTGAGGGTAGAACCTTTTGGGACTGGCCTTTGAAGCTCTGGCCAGGGATGGGGTGGGGGCCA AAAGGACAGAGCCTGGTATGTCTTCATAGTCATTGAGAATGTGGAGATACCAGTTTGGGTGGGGGGTGATCACCAGGGGACCTAGGGAGA TCCCCTTCCCACCCTCTCTGTTGGCCTCAGAGTCACTCCTGCCCCCTCTCCCTGACTTGGTGCTCACATGCACCTCACTAGGGTTTGTGA CCAGGGTCTGGATGAGCTTGAATTTGAATGAATTGAGTTTGTATTTCTAGAACCCTGGGTTTTTACATGTTTGGTCTTTTTTTGTTTTGG >In-frame_FZD4_ENST00000531380_chr11_86665843_-_LAMTOR1_ENST00000538404_chr11_71810302_-_1883nt GCTGCGCAGCGCTGGCTGCTGGCTGGCCTCGCGGAGACGCCGAACGGACGCGGCCGGCGCCGGCTTGTGGGCTCGCCGCCTGCAGCCATG ACCCTCGCAGCCTGTCCCTCGGCCTCGGCCCGGGACGTCTAAAATCCCACACAGTCGCGCGCAGCTGCTGGAGAGCCGGCCGCTGCCCCC TCGTCGCCGCATCACACTCCCGTCCCGGGAGCTGGGAGCAGCGCGGGCAGCCGGCGCCCCCGTGCAAACTGGGGGTGTCTGCCAGAGCAG CCCCAGCCGCTGCCGCTGCTACCCCCGATGCTGGCCATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGT CTCAGTCTGGGGTTGCTCCTGCAGTTGCTGCTGCTCCTGGGGCCGGCGCGGGGCTTCGGGGACGAGGAAGAGCGGCGCTGCGACCCCATC CGCATCTCCATGTGCCAGAACCTCGGCTACAACGTGACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAG CTGACAACTTTCACACCGCTCATCCAGTACGGCTGCTCCAGCCAGCTGCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGC CCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATC CTTGCCAAGACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAG TACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAA GTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGGTGAGACACCCCTCACCTGCCCCTGCCCACCCTTCTCACACTGCCCAG GGTATGGCAGAGGGTTCACCCACTCTGCCTCAGAGGAGGTAGGGAAGGTGGAGTTAGGGAGCCTGGTAGCCTTGTAGGCCCCAGCTCCCT CCCACCTCGTTCTCTTAACTTTTTATGTCTTTCCTATCTCCTTCCTGCAACCTTTATTGTTTCACTCCCCTTTGTTCTTTTCCTTCTGTC TCTCCCATCCCTGTCTTTCTCTTTGCCTTCCTGTTCCCCTTCATTCCCTCCTTCTCCATCACCATCTAATCTCCCCTCCCCATTTTTCCT GATTGCCCTCCTCACCTGTCTCTGTTCCTCTCCTCCCCGGCCCCTCTCTGTCTCAGGTCTCCAGGATAGCTGCTTATGCCTACAGTGCAC TTTCTCAGATCCGTGTGGACGCAAAAGAGGAGCTGGTTGTACAGTTTGGGATCCCATGAAGAGAGGGGTCCTTGGACAGCTCTTCTCCTC TCTTCATCCCATCTCTACCCCACCCCCTTGGCCCCCAGCCTCACTGCGGCTTATACAGTACCCTAACCTGCTACTAATCACAGAGAAAAA TGTGAAGAAGGAGGAGAAGAGGAAGGCTAGAAGCCTGAGCAAGTGAGGGTAGAACCTTTTGGGACTGGCCTTTGAAGCTCTGGCCAGGGA TGGGGTGGGGGCCAAAAGGACAGAGCCTGGTATGTCTTCATAGTCATTGAGAATGTGGAGATACCAGTTTGGGTGGGGGGTGATCACCAG GGGACCTAGGGAGATCCCCTTCCCACCCTCTCTGTTGGCCTCAGAGTCACTCCTGCCCCCTCTCCCTGACTTGGTGCTCACATGCACCTC |
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FusionGenePPI for FZD4_LAMTOR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FZD4 | DLG4, BAG6, ZNRF3, NDP, PDZRN3, RAB5A | LAMTOR1 | ABCF3, CCDC90B, EEF1A1, RRAGA, MME, ELAVL1, ATP6V1B1, LAMTOR2, LAMTOR3, GNAS, SLC25A46, RRAGC, RRAGD, BAG3, LAMTOR5, LAMTOR4, RRAGB, C17orf59, LIMK1, XRCC5, ATP6AP2, TMEM132A, ZNRF2, DUSP22, TBC1D7, SLC38A9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | LAMTOR1 | chr11:86665843 | chr11:71810302 | ENST00000278671 | - | 0 | 5 | 121_161 | 14 | 162 | LAMTOR2 and LAMTOR3 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FZD4_LAMTOR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FZD4_LAMTOR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FZD4 | C1851402 | Exudative vitreoretinopathy 1 | 9 | CTD_human;ORPHANET;UNIPROT |
| Hgene | FZD4 | C0003706 | Arachnodactyly | 1 | CTD_human |
| Hgene | FZD4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | FZD4 | C0008925 | Cleft Palate | 1 | CTD_human |
| Hgene | FZD4 | C0035309 | Retinal Diseases | 1 | CTD_human |
| Hgene | FZD4 | C0039075 | Syndactyly | 1 | CTD_human |
| Hgene | FZD4 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Hgene | FZD4 | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
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