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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14147

FusionGeneSummary for FYN_CEACAM5

check button Fusion gene summary
Fusion gene informationFusion gene name: FYN_CEACAM5
Fusion gene ID: 14147
HgeneTgene
Gene symbol

FYN

CEACAM5

Gene ID

2534

1048

Gene nameFYN proto-oncogene, Src family tyrosine kinasecarcinoembryonic antigen related cell adhesion molecule 5
SynonymsSLK|SYN|p59-FYNCD66e|CEA
Cytomap

6q21

19q13.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)carcinoembryonic antigen-related cell adhesion molecule 5meconium antigen 100
Modification date2018052320180523
UniProtAcc

P06241

P06731

Ensembl transtripts involved in fusion geneENST00000368682, ENST00000354650, 
ENST00000229471, ENST00000368667, 
ENST00000368678, ENST00000229470, 
ENST00000356013, ENST00000538466, 
ENST00000476769, 
ENST00000398599, 
ENST00000221992, ENST00000405816, 
Fusion gene scores* DoF score7 X 6 X 4=1684 X 3 X 3=36
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FYN [Title/Abstract] AND CEACAM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293

TgeneCEACAM5

GO:0010832

negative regulation of myotube differentiation

8408226|10931872

TgeneCEACAM5

GO:0034109

homotypic cell-cell adhesion

10864933

TgeneCEACAM5

GO:0043066

negative regulation of apoptotic process

11448920

TgeneCEACAM5

GO:2000811

negative regulation of anoikis

10910050


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW844098FYNchr6

112073071

-CEACAM5chr19

42224927

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368682ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368682ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368682ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000354650ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000354650ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000354650ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000229471ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000229471ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000229471ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368667ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368667ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368667ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368678ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368678ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000368678ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000229470ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000229470ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000229470ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000356013ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000356013ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000356013ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000538466ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000538466ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000538466ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000476769ENST00000398599FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000476769ENST00000221992FYNchr6

112073071

-CEACAM5chr19

42224927

-
intron-3CDSENST00000476769ENST00000405816FYNchr6

112073071

-CEACAM5chr19

42224927

-

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FusionProtFeatures for FYN_CEACAM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FYN

P06241

CEACAM5

P06731

Non-receptor tyrosine-protein kinase that plays a rolein many biological processes including regulation of cell growthand survival, cell adhesion, integrin-mediated signaling,cytoskeletal remodeling, cell motility, immune response and axonguidance. Inactive FYN is phosphorylated on its C-terminal tailwithin the catalytic domain. Following activation by PKA, theprotein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1phosphorylation, activation and targeting to focal adhesions.Involved in the regulation of cell adhesion and motility throughphosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylatingseveral proteins including the actin regulator WAS and themicrotubule-associated proteins MAP2 and MAPT. Promotes cellsurvival by phosphorylating AGAP2/PIKE-A and preventing itsapoptotic cleavage. Participates in signal transduction pathwaysthat regulate the integrity of the glomerular slit diaphragm (anessential part of the glomerular filter of the kidney) byphosphorylating several slit diaphragm components including NPHS1,KIRREL1 and TRPC6. Plays a role in neural processes byphosphorylating DPYSL2, a multifunctional adapter protein withinthe central nervous system, ARHGAP32, a regulator for Rho familyGTPases implicated in various neural functions, and SNCA, a smallpre-synaptic protein. Participates in the downstream signalingpathways that lead to T-cell differentiation and proliferationfollowing T-cell receptor (TCR) stimulation. PhosphorylatesPTK2B/PYK2 in response to T-cell receptor activation. Alsoparticipates in negative feedback regulation of TCR signalingthrough phosphorylation of PAG1, thereby promoting interactionbetween PAG1 and CSK and recruitment of CSK to lipid rafts. CSKmaintains LCK and FYN in an inactive form. Promotes CD28-inducedphosphorylation of VAV1. {ECO:0000269|PubMed:11005864,ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198,ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117,ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091,ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660,ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753,ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597,ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227,ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835,ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038,ECO:0000269|PubMed:7822789}. Cell surface glycoprotein that plays a role in celladhesion, intracellular signaling and tumor progression(PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediateshomophilic and heterophilic cell adhesion with othercarcinoembryonic antigen-related cell adhesion molecules, such asCEACAM6 (PubMed:2803308). Plays a role as an oncogene by promotingtumor progression; induces resistance to anoikis of colorectalcarcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933,ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}. (Microbial infection) Receptor for E.coli Dr adhesins.Binding of E.coli Dr adhesins leads to dissociation of thehomodimer. {ECO:0000269|PubMed:18086185}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FYN_CEACAM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FYN_CEACAM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FYN_CEACAM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFYNP06241DB01254DasatinibTyrosine-protein kinase Fynsmall moleculeapproved|investigational

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RelatedDiseases for FYN_CEACAM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFYNC0005586Bipolar Disorder2PSYGENET
HgeneFYNC0036341Schizophrenia2PSYGENET
HgeneFYNC0001969Alcoholic Intoxication1PSYGENET
HgeneFYNC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneFYNC0007370Catalepsy1CTD_human
HgeneFYNC0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneFYNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFYNC0038356Stomach Neoplasms1CTD_human
HgeneFYNC0079774Peripheral T-Cell Lymphoma1CTD_human
HgeneFYNC0085762Alcohol abuse1PSYGENET
TgeneCEACAM5C0000786Spontaneous abortion1CTD_human