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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14141

FusionGeneSummary for FYCO1_FKBP15

check button Fusion gene summary
Fusion gene informationFusion gene name: FYCO1_FKBP15
Fusion gene ID: 14141
HgeneTgene
Gene symbol

FYCO1

FKBP15

Gene ID

79443

23307

Gene nameFYVE and coiled-coil domain containing 1FK506 binding protein 15
SynonymsCATC2|CTRCT18|RUFY3|ZFYVE7FKBP133|KIAA0674|PPP1R76
Cytomap

3p21.31

9q32

Type of geneprotein-codingprotein-coding
DescriptionFYVE and coiled-coil domain-containing protein 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7FK506-binding protein 15133 kDa FK506-binding protein133 kDa FKBPFK506 binding protein 15, 133kDaFK506-binding protein 133kDaFKBP-133FKBP-15WAFLWASP and FKBP-like proteinprotein phosphatase 1, regulatory subunit 76
Modification date2018052320180523
UniProtAcc

Q9BQS8

Q5T1M5

Ensembl transtripts involved in fusion geneENST00000296137, ENST00000535325, 
ENST00000438446, 
ENST00000238256, 
ENST00000493847, 
Fusion gene scores* DoF score6 X 6 X 3=1088 X 8 X 2=128
# samples 69
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/128*10)=-0.508146903670325
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FYCO1 [Title/Abstract] AND FKBP15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFKBP15

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI023624FYCO1chr3

46023102

-FKBP15chr9

115945097

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000296137ENST00000238256FYCO1chr3

46023102

-FKBP15chr9

115945097

-
intron-intronENST00000296137ENST00000493847FYCO1chr3

46023102

-FKBP15chr9

115945097

-
intron-3CDSENST00000535325ENST00000238256FYCO1chr3

46023102

-FKBP15chr9

115945097

-
intron-intronENST00000535325ENST00000493847FYCO1chr3

46023102

-FKBP15chr9

115945097

-
intron-3CDSENST00000438446ENST00000238256FYCO1chr3

46023102

-FKBP15chr9

115945097

-
intron-intronENST00000438446ENST00000493847FYCO1chr3

46023102

-FKBP15chr9

115945097

-

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FusionProtFeatures for FYCO1_FKBP15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FYCO1

Q9BQS8

FKBP15

Q5T1M5

May mediate microtubule plus end-directed vesicletransport. {ECO:0000269|PubMed:20100911}. May be involved in the cytoskeletal organization ofneuronal growth cones. Seems to be inactive as a PPIase (Bysimilarity). Involved in the transport of early endosomes at thelevel of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FYCO1_FKBP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FYCO1_FKBP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FYCO1_FKBP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FYCO1_FKBP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFYCO1C1864908Cataract, autosomal recessive congenital 21UNIPROT
TgeneFKBP15C0236733Amphetamine-Related Disorders1CTD_human
TgeneFKBP15C0236969Substance-Related Disorders1CTD_human