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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14139

FusionGeneSummary for FYB_FYB

check button Fusion gene summary
Fusion gene informationFusion gene name: FYB_FYB
Fusion gene ID: 14139
HgeneTgene
Gene symbol

FYB

FYB

Gene ID

Gene name
Synonyms
Cytomap

Type of gene
Description
Modification date
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000351578, ENST00000515010, 
ENST00000505428, ENST00000512982, 
ENST00000540520, ENST00000503065, 
ENST00000351578, ENST00000515010, 
ENST00000505428, ENST00000512982, 
ENST00000540520, ENST00000503065, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 5=245
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FYB [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE840894FYBchr5

39105929

-FYBchr5

39105975

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000351578ENST00000351578FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000351578ENST00000515010FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000351578ENST00000505428FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000351578ENST00000512982FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000351578ENST00000540520FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000351578ENST00000503065FYBchr5

39105929

-FYBchr5

39105975

+
intron-3UTRENST00000515010ENST00000351578FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000515010ENST00000515010FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000515010ENST00000505428FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000515010ENST00000512982FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000515010ENST00000540520FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000515010ENST00000503065FYBchr5

39105929

-FYBchr5

39105975

+
intron-3UTRENST00000505428ENST00000351578FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000505428ENST00000515010FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000505428ENST00000505428FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000505428ENST00000512982FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000505428ENST00000540520FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000505428ENST00000503065FYBchr5

39105929

-FYBchr5

39105975

+
intron-3UTRENST00000512982ENST00000351578FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000512982ENST00000515010FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000512982ENST00000505428FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000512982ENST00000512982FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000512982ENST00000540520FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000512982ENST00000503065FYBchr5

39105929

-FYBchr5

39105975

+
intron-3UTRENST00000540520ENST00000351578FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000540520ENST00000515010FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000540520ENST00000505428FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000540520ENST00000512982FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000540520ENST00000540520FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000540520ENST00000503065FYBchr5

39105929

-FYBchr5

39105975

+
intron-3UTRENST00000503065ENST00000351578FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000503065ENST00000515010FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000503065ENST00000505428FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000503065ENST00000512982FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000503065ENST00000540520FYBchr5

39105929

-FYBchr5

39105975

+
intron-intronENST00000503065ENST00000503065FYBchr5

39105929

-FYBchr5

39105975

+

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FusionProtFeatures for FYB_FYB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FYB

FYB

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FYB_FYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FYB_FYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FYB_FYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FYB_FYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource