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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14134

FusionGeneSummary for FXYD5_TSKU

check button Fusion gene summary
Fusion gene informationFusion gene name: FXYD5_TSKU
Fusion gene ID: 14134
HgeneTgene
Gene symbol

FXYD5

TSKU

Gene ID

53827

25987

Gene nameFXYD domain containing ion transport regulator 5tsukushi, small leucine rich proteoglycan
SynonymsDYSAD|HSPC113|IWU1|KCT1|OIT2|PRO6241|RICE2IG4|LRRC54|TSK
Cytomap

19q13.12

11q13.5

Type of geneprotein-codingprotein-coding
DescriptionFXYD domain-containing ion transport regulator 5dysadherinkeratinocytes associated transmembrane protein 1tsukushinE2-induced gene 4 proteinleucine rich repeat containing 54leucine-rich repeat-containing protein 54tsukushi homologtsukushi small leucine rich proteoglycan homolog
Modification date2018052320180519
UniProtAcc

Q96DB9

Q8WUA8

Ensembl transtripts involved in fusion geneENST00000543307, ENST00000392219, 
ENST00000541435, ENST00000590686, 
ENST00000342879, ENST00000588699, 
ENST00000423817, ENST00000392218, 
ENST00000591716, ENST00000392217, 
ENST00000333090, ENST00000527881, 
Fusion gene scores* DoF score3 X 3 X 4=364 X 3 X 3=36
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FXYD5 [Title/Abstract] AND TSKU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG982440FXYD5chr19

35649295

+TSKUchr11

76509039

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000543307ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000543307ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000392219ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000392219ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000541435ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000541435ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000590686ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000590686ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000342879ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000342879ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000588699ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000588699ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000423817ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000423817ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000392218ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
5CDS-3UTRENST00000392218ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
intron-3UTRENST00000591716ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
intron-3UTRENST00000591716ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-
intron-3UTRENST00000392217ENST00000333090FXYD5chr19

35649295

+TSKUchr11

76509039

-
intron-3UTRENST00000392217ENST00000527881FXYD5chr19

35649295

+TSKUchr11

76509039

-

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FusionProtFeatures for FXYD5_TSKU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FXYD5

Q96DB9

TSKU

Q8WUA8

Involved in down-regulation of E-cadherin which resultsin reduced cell adhesion. Promotes metastasis.{ECO:0000269|PubMed:11756660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FXYD5_TSKU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FXYD5_TSKU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FXYD5_TSKU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FXYD5_TSKU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFXYD5C0023893Liver Cirrhosis, Experimental1CTD_human