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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14130

FusionGeneSummary for FXYD3_ZNF202

check button Fusion gene summary
Fusion gene informationFusion gene name: FXYD3_ZNF202
Fusion gene ID: 14130
HgeneTgene
Gene symbol

FXYD3

ZNF202

Gene ID

5349

7753

Gene nameFXYD domain containing ion transport regulator 3zinc finger protein 202
SynonymsMAT8|PLMLZKSCAN10|ZSCAN42
Cytomap

19q13.12

11q24.1

Type of geneprotein-codingprotein-coding
DescriptionFXYD domain-containing ion transport regulator 3chloride conductance inducer protein Mat-8mammary tumor 8 kDa proteinphospholemman-like proteinsodium/potassium-transporting ATPase subunit FXYD3zinc finger protein 202zinc finger protein with KRAB and SCAN domains 10
Modification date2018052320180519
UniProtAcc

Q14802

O95125

Ensembl transtripts involved in fusion geneENST00000454903, ENST00000406242, 
ENST00000604404, ENST00000435734, 
ENST00000603181, ENST00000604255, 
ENST00000346446, ENST00000344013, 
ENST00000603449, ENST00000406988, 
ENST00000605550, ENST00000604804, 
ENST00000605552, ENST00000535103, 
ENST00000603524, ENST00000604621, 
ENST00000605677, 		ENST00000336139, 
ENST00000530393, ENST00000529691, 
ENST00000525391, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: FXYD3 [Title/Abstract] AND ZNF202 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF202

GO:0000122

negative regulation of transcription by RNA polymerase II

10748193


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI274165FXYD3chr19

35614487

-ZNF202chr11

123596885

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000454903ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000454903ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000454903ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-intronENST00000454903ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000406242ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000406242ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000406242ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-intronENST00000406242ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604404ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604404ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604404ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000604404ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000435734ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000435734ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000435734ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000435734ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000603181ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000603181ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000603181ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000603181ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604255ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604255ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604255ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000604255ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000346446ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000346446ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000346446ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000346446ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000344013ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000344013ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000344013ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000344013ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000603449ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000603449ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000603449ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-intronENST00000603449ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000406988ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000406988ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000406988ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000406988ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605550ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605550ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605550ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-intronENST00000605550ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604804ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604804ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604804ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000604804ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605552ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605552ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605552ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-intronENST00000605552ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000535103ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000535103ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000535103ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000535103ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000603524ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000603524ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000603524ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000603524ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604621ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604621ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-3CDSENST00000604621ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
3UTR-intronENST00000604621ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605677ENST00000336139FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605677ENST00000530393FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-3CDSENST00000605677ENST00000529691FXYD3chr19

35614487

-ZNF202chr11

123596885

+
intron-intronENST00000605677ENST00000525391FXYD3chr19

35614487

-ZNF202chr11

123596885

+

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FusionProtFeatures for FXYD3_ZNF202


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FXYD3

Q14802

ZNF202

O95125

Associates with and regulates the activity of thesodium/potassium-transporting ATPase (NKA) which transports Na(+)out of the cell and K(+) into the cell (PubMed:17077088). Reducesglutathionylation of the NKA beta-1 subunit ATP1B1, thus reversingglutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534).Induces a hyperpolarization-activated chloride current whenexpressed in Xenopus oocytes (PubMed:7836447).{ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534,ECO:0000269|PubMed:7836447}. Isoform 1: Decreases the apparent K+ and Na+ affinity ofthe sodium/potassium-transporting ATPase over a large range ofmembrane potentials. {ECO:0000269|PubMed:17077088}. Isoform 2: Decreases the apparent K+ affinity of thesodium/potassium-transporting ATPase only at slightly negative andpositive membrane potentials and increases the apparent Na+affinity over a large range of membrane potentials.{ECO:0000269|PubMed:17077088}. Transcriptional repressor that binds to elements foundpredominantly in genes that participate in lipid metabolism. Amongits targets are structural components of lipoprotein particles(apolipoproteins AIV, CIII, and E), enzymes involved in lipidprocessing (lipoprotein lipase, lecithin cholesteryl estertransferase), transporters involved in lipid homeostasis (ABCA1,ABCG1), and several genes involved in processes related to energymetabolism and vascular disease.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FXYD3_ZNF202


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FXYD3_ZNF202


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FXYD3_ZNF202


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FXYD3_ZNF202


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFXYD3C0030297Pancreatic Neoplasm1CTD_human