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Fusion gene ID: 14113 |
FusionGeneSummary for FXN_SMC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FXN_SMC5 | Fusion gene ID: 14113 | Hgene | Tgene | Gene symbol | FXN | SMC5 | Gene ID | 2395 | 23137 |
| Gene name | frataxin | structural maintenance of chromosomes 5 | |
| Synonyms | CyaY|FA|FARR|FRDA|X25 | SMC5L1 | |
| Cytomap | 9q21.11 | 9q21.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | frataxin, mitochondrialFriedreich ataxia protein | structural maintenance of chromosomes protein 5SMC protein 5SMC-5SMC5 structural maintenance of chromosomes 5-like 1hSMC5 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q16595 | Q8IY18 | |
| Ensembl transtripts involved in fusion gene | ENST00000396364, ENST00000377270, ENST00000396366, ENST00000498653, | ENST00000361138, ENST00000471372, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 4=64 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FXN [Title/Abstract] AND SMC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FXN | GO:0010722 | regulation of ferrochelatase activity | 15123683 |
| Hgene | FXN | GO:0016540 | protein autoprocessing | 12785837 |
| Hgene | FXN | GO:0018283 | iron incorporation into metallo-sulfur cluster | 12785837 |
| Hgene | FXN | GO:0051349 | positive regulation of lyase activity | 20053667 |
| Hgene | FXN | GO:0070301 | cellular response to hydrogen peroxide | 15641778 |
| Tgene | SMC5 | GO:0006974 | cellular response to DNA damage stimulus | 11408570|25931565 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A124-01A | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396364 | ENST00000361138 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| 5CDS-intron | ENST00000396364 | ENST00000471372 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| In-frame | ENST00000377270 | ENST00000361138 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| 5CDS-intron | ENST00000377270 | ENST00000471372 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| Frame-shift | ENST00000396366 | ENST00000361138 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| 5CDS-intron | ENST00000396366 | ENST00000471372 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| In-frame | ENST00000498653 | ENST00000361138 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
| 5CDS-intron | ENST00000498653 | ENST00000471372 | FXN | chr9 | 71679951 | + | SMC5 | chr9 | 72879220 | + |
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FusionProtFeatures for FXN_SMC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FXN | SMC5 |
| Promotes the biosynthesis of heme and assembly andrepair of iron-sulfur clusters by delivering Fe(2+) to proteinsinvolved in these pathways. May play a role in the protectionagainst iron-catalyzed oxidative stress through its ability tocatalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric formbut not the monomeric form has in vitro ferroxidase activity. Maybe able to store large amounts of iron in the form of aferrihydrite mineral by oligomerization; however, thephysiological relevance is unsure as reports are conflicting andthe function has only been shown using heterologous overexpressionsystems. Modulates the RNA-binding activity of ACO1.{ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15247478,ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244,ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}. | Core component of the SMC5-SMC6 complex, a complexinvolved in repair of DNA double-strand breaks by homologousrecombination. The complex may promote sister chromatid homologousrecombination by recruiting the SMC1-SMC3 cohesin complex todouble-strand breaks. The complex is required for telomeremaintenance via recombination in ALT (alternative lengthening oftelomeres) cell lines and mediates sumoylation of shelterincomplex (telosome) components which is proposed to lead toshelterin complex disassembly in ALT-associated PML bodies (APBs).Required for recruitment of telomeres to PML nuclear bodies.Required for sister chromatid cohesion during prometaphase andmitotic progression; the function seems to be independent of SMC6.SMC5-SMC6 complex may prevent transcription of episomal DNA, suchas circular viral DNA genome (PubMed:26983541).{ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526,ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SMC5 | chr9:71679951 | chr9:72879220 | ENST00000361138 | + | 0 | 25 | 207_445 | 61 | 1102 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMC5 | chr9:71679951 | chr9:72879220 | ENST00000361138 | + | 0 | 25 | 647_828 | 61 | 1102 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMC5 | chr9:71679951 | chr9:72879220 | ENST00000361138 | + | 0 | 25 | 888_927 | 61 | 1102 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SMC5 | chr9:71679951 | chr9:72879220 | ENST00000361138 | + | 0 | 25 | 991_1026 | 61 | 1102 | Compositional bias | Note=Ala/Asp-rich (DA-box) |
| Tgene | >SMC5 | chr9:71679951 | chr9:72879220 | ENST00000361138 | + | 0 | 25 | 80_87 | 61 | 1102 | Nucleotide binding | ATP |
| Tgene | >SMC5 | chr9:71679951 | chr9:72879220 | ENST00000361138 | + | 0 | 25 | 446_646 | 61 | 1102 | Region | Note=Flexible hinge |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FXN_SMC5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FXN_ENST00000396364_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_1201aa MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGLNQIWNVKKQSVYLMNLRKSGTLGHPGSL DETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRTYDICEVSPGPHLNMIVGA NGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSRGMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQ VGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLD LIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKH IEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDH IVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNK KLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVV KTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKI SSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH FIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQ EYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSST QLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFV >In-frame_FXN_ENST00000377270_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_1201aa MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGLNQIWNVKKQSVYLMNLRKSGTLGHPGSL DETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRTYDICEVSPGPHLNMIVGA NGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSRGMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQ VGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLD LIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKH IEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDH IVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNK KLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVV KTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKI SSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH FIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQ EYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSST QLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFV >In-frame_FXN_ENST00000498653_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_1126aa MNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSRTYDI CEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSRGMVEIELFRASGNLVITREIDVAKNQSFWFINKKST TQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERY KQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQ KCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRR ERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFES QEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQE TRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKE LLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLES DYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEER SRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDY DKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FXN_ENST00000396364_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_3603nt ATGTGGACTCTCGGGCGCCGCGCAGTAGCCGGCCTCCTGGCGTCACCCAGCCCAGCCCAGGCCCAGACCCTCACCCGGGTCCCGCGGCCG GCAGAGTTGGCCCCACTCTGCGGCCGCCGTGGCCTGCGCACCGACATCGATGCGACCTGCACGCCCCGCCGCGCAAGTTCGAACCAACGT GGCCTCAACCAGATTTGGAATGTCAAAAAGCAGAGTGTCTATTTGATGAATTTGAGGAAATCTGGAACTTTGGGCCACCCAGGCTCTCTA GATGAGACCACCTATGAAAGACTAGCAGAGGAAACGCTGGACTCTTTAGCAGAGTTTTTTGAAGACCTTGCAGACAAGCCATACACGTTT GAGGACTATGATGTCTCCTTTGGGAGTGGTGTCTTAACTGTCAAACTGGGTGGAGATCTAGGAACCTATGTGATCAACAAGCAGACGCCA AACAAGCAAATCTGGCTATCTTCTCCATCCAGAACATATGATATTTGTGAAGTATCTCCTGGACCCCACTTGAATATGATCGTTGGAGCC AATGGAACAGGGAAGTCGAGCATTGTGTGTGCCATTTGCCTTGGTTTAGCTGGAAAACCTGCTTTCATGGGACGAGCAGATAAGGTTGGG TTTTTTGTGAAGAGAGGATGTTCTAGAGGCATGGTTGAAATTGAATTGTTCAGGGCTTCTGGAAATCTTGTAATCACCCGTGAGATTGAT GTGGCAAAAAATCAGTCCTTTTGGTTCATCAACAAAAAATCTACAACCCAGAAAATAGTGGAAGAGAAAGTTGCAGCCTTAAATATTCAA GTGGGGAATCTTTGCCAGTTTCTCCCTCAGGACAAAGTTGGAGAATTTGCTAAACTCAGCAAAATTGAACTCCTCGAAGCCACTGAAAAG TCAATTGGTCCCCCAGAAATGCACAAATATCACTGTGAACTCAAAAACTTAAGGGAGAAAGAAAAACAGCTCGAGACCTCATGCAAAGAG AAAACTGAGTATCTACAGAAAATGGTTCAGAGGAATGAAAGATATAAACAAGATGTGGAGAGGTTCTATGAACGGAAGCGACATTTAGAT TTAATTGAGATGCTTGAAGCAAAAAGGCCATGGGTGGAATATGAAAATGTTCGTCAGGAATATGAAGAAGTAAAACTAGTTCGTGACCGA GTGAAGGAAGAGGTCAGAAAACTTAAAGAAGGGCAGATTCCTGTAACATGTCGAATTGAAGAAATGGAAAACGAGCGTCACAATTTGGAG GCTCGAATCAAAGAAAAGGCAACAGATATTAAGGAGGCATCTCAAAAATGCAAACAGAAGCAAGATGTTATAGAAAGGAAAGATAAACAT ATTGAGGAACTTCAGCAGGCTTTAATAGTAAAGCAAAATGAAGAGCTTGACCGACAGAGGAGAATAGGTAATACCCGCAAAATGATAGAG GATTTGCAAAATGAACTAAAGACCACGGAAAACTGCGAGAATCTTCAGCCCCAGATTGATGCCATTACAAATGATCTGAGACGGATTCAG GATGAAAAGGCATTATGTGAAGGCGAAATAATTGATAAGCGAAGAGAGAGGGAAACTCTAGAGAAGGAGAAAAAGAGTGTGGACGATCAT ATTGTACGTTTTGACAATCTTATGAATCAGAAGGAAGATAAGCTAAGACAGAGATTCCGTGACACGTATGATGCTGTTTTATGGCTAAGA AATAACAGAGACAAATTTAAACAAAGAGTCTGTGAGCCCATAATGCTCACGATCAATATGAAAGATAATAAAAATGCCAAATATATTGAA AATCATATTCCATCAAATGACTTAAGAGCCTTTGTATTTGAAAGTCAAGAAGATATGGAGGTTTTCCTCAAAGAGGTTCGTGACAATAAA AAATTAAGAGTAAATGCTGTTATTGCTCCCAAGAGTTCATATGCAGACAAAGCACCTTCAAGATCTTTGAATGAACTTAAACAATACGGA TTTTTCTCTTATTTGAGAGAATTATTTGATGCACCTGATCCTGTAATGAGTTACCTTTGCTGTCAGTATCATATTCATGAAGTTCCTGTA GGAACTGAAAAGACCAGAGAAAGAATTGAACGGGTAATACAAGAAACCCGATTAAAACAGATTTATACAGCAGAAGAAAAGTATGTGGTG AAAACTTCTTTTTATTCAAACAAAGTTATTTCTAGTAACACATCTCTAAAAGTAGCGCAGTTTCTCACTGTCACTGTGGACCTAGAGCAG AGAAGACACTTAGAAGAACAGCTAAAGGAAATTCATAGAAAATTGCAAGCAGTGGATTCAGGGTTGATTGCCTTACGTGAAACAAGCAAA CATCTGGAGCACAAAGACAATGAACTTAGACAAAAGAAGAAGGAGCTTCTTGAGAGAAAAACCAAGAAAAGACAACTGGAACAAAAAATC AGTTCCAAACTAGGAAGTTTAAAGCTGATGGAACAGGATACTTGCAATCTTGAAGAGGAAGAGCGAAAAGCAAGTACCAAAATCAAAGAA ATAAATGTTCAAAAAGCGAAACTTGTTACCGAATTAACAAACCTAATAAAGATTTGTACTTCTTTGCATATACAAAAAGTAGATTTAATT CTCCAAAATACTACAGTGATCTCTGAGAAGAACAAATTAGAATCAGATTATATGGCCGCATCTTCACAACTCCGTCTTACAGAGCAACAT TTCATTGAATTGGATGAAAATAGACAGAGATTATTGCAGAAATGCAAGGAACTTATGAAAAGAGCTAGGCAAGTATGTAACCTGGGTGCA GAGCAGACTCTTCCTCAAGAATACCAGACACAAGTACCCACCATTCCAAATGGACACAACTCCTCACTCCCCATGGTTTTCCAAGACCTT CCAAACACATTGGATGAAATTGATGCTTTATTAACTGAAGAAAGATCAAGAGCTTCCTGCTTCACGGGACTGAATCCTACAATTGTTCAG GAATATACAAAAAGAGAAGAAGAAATAGAACAGTTAACTGAGGAACTAAAGGGAAAGAAAGTTGAACTAGATCAATACAGGGAAAACATT TCACAGGTAAAAGAAAGGTGGCTTAATCCTTTAAAAGAGCTGGTAGAAAAAATTAATGAAAAATTCAGCAATTTTTTTAGTTCCATGCAG TGTGCTGGTGAAGTTGATCTCCATACAGAAAATGAGGAAGATTATGATAAATATGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACT CAACTGCATGAATTAACTCCTCATCATCAAAGTGGAGGTGAAAGAAGTGTTTCTACCATGTTATACTTGATGGCACTTCAGGAGCTAAAT AGATGTCCATTCAGAGTAGTTGATGAAATCAATCAGGGAATGGACCCAATCAATGAACGGAGAGTGTTTGAAATGGTTGTAAATACTGCC TGTAAAGAAAATACATCTCAATACTTTTTCATAACACCAAAGCTCCTGCAAAATCTTCCTTATTCTGAAAAGATGACAGTTTTGTTTGTC TACAATGGCCCTCATATGCTGGAACCAAACACATGGAATTTAAAGGCTTTCCAAAGGCGGCGGCGCCGTATTACATTCACTCAACCTTCT >In-frame_FXN_ENST00000377270_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_3603nt ATGTGGACTCTCGGGCGCCGCGCAGTAGCCGGCCTCCTGGCGTCACCCAGCCCAGCCCAGGCCCAGACCCTCACCCGGGTCCCGCGGCCG GCAGAGTTGGCCCCACTCTGCGGCCGCCGTGGCCTGCGCACCGACATCGATGCGACCTGCACGCCCCGCCGCGCAAGTTCGAACCAACGT GGCCTCAACCAGATTTGGAATGTCAAAAAGCAGAGTGTCTATTTGATGAATTTGAGGAAATCTGGAACTTTGGGCCACCCAGGCTCTCTA GATGAGACCACCTATGAAAGACTAGCAGAGGAAACGCTGGACTCTTTAGCAGAGTTTTTTGAAGACCTTGCAGACAAGCCATACACGTTT GAGGACTATGATGTCTCCTTTGGGAGTGGTGTCTTAACTGTCAAACTGGGTGGAGATCTAGGAACCTATGTGATCAACAAGCAGACGCCA AACAAGCAAATCTGGCTATCTTCTCCATCCAGAACATATGATATTTGTGAAGTATCTCCTGGACCCCACTTGAATATGATCGTTGGAGCC AATGGAACAGGGAAGTCGAGCATTGTGTGTGCCATTTGCCTTGGTTTAGCTGGAAAACCTGCTTTCATGGGACGAGCAGATAAGGTTGGG TTTTTTGTGAAGAGAGGATGTTCTAGAGGCATGGTTGAAATTGAATTGTTCAGGGCTTCTGGAAATCTTGTAATCACCCGTGAGATTGAT GTGGCAAAAAATCAGTCCTTTTGGTTCATCAACAAAAAATCTACAACCCAGAAAATAGTGGAAGAGAAAGTTGCAGCCTTAAATATTCAA GTGGGGAATCTTTGCCAGTTTCTCCCTCAGGACAAAGTTGGAGAATTTGCTAAACTCAGCAAAATTGAACTCCTCGAAGCCACTGAAAAG TCAATTGGTCCCCCAGAAATGCACAAATATCACTGTGAACTCAAAAACTTAAGGGAGAAAGAAAAACAGCTCGAGACCTCATGCAAAGAG AAAACTGAGTATCTACAGAAAATGGTTCAGAGGAATGAAAGATATAAACAAGATGTGGAGAGGTTCTATGAACGGAAGCGACATTTAGAT TTAATTGAGATGCTTGAAGCAAAAAGGCCATGGGTGGAATATGAAAATGTTCGTCAGGAATATGAAGAAGTAAAACTAGTTCGTGACCGA GTGAAGGAAGAGGTCAGAAAACTTAAAGAAGGGCAGATTCCTGTAACATGTCGAATTGAAGAAATGGAAAACGAGCGTCACAATTTGGAG GCTCGAATCAAAGAAAAGGCAACAGATATTAAGGAGGCATCTCAAAAATGCAAACAGAAGCAAGATGTTATAGAAAGGAAAGATAAACAT ATTGAGGAACTTCAGCAGGCTTTAATAGTAAAGCAAAATGAAGAGCTTGACCGACAGAGGAGAATAGGTAATACCCGCAAAATGATAGAG GATTTGCAAAATGAACTAAAGACCACGGAAAACTGCGAGAATCTTCAGCCCCAGATTGATGCCATTACAAATGATCTGAGACGGATTCAG GATGAAAAGGCATTATGTGAAGGCGAAATAATTGATAAGCGAAGAGAGAGGGAAACTCTAGAGAAGGAGAAAAAGAGTGTGGACGATCAT ATTGTACGTTTTGACAATCTTATGAATCAGAAGGAAGATAAGCTAAGACAGAGATTCCGTGACACGTATGATGCTGTTTTATGGCTAAGA AATAACAGAGACAAATTTAAACAAAGAGTCTGTGAGCCCATAATGCTCACGATCAATATGAAAGATAATAAAAATGCCAAATATATTGAA AATCATATTCCATCAAATGACTTAAGAGCCTTTGTATTTGAAAGTCAAGAAGATATGGAGGTTTTCCTCAAAGAGGTTCGTGACAATAAA AAATTAAGAGTAAATGCTGTTATTGCTCCCAAGAGTTCATATGCAGACAAAGCACCTTCAAGATCTTTGAATGAACTTAAACAATACGGA TTTTTCTCTTATTTGAGAGAATTATTTGATGCACCTGATCCTGTAATGAGTTACCTTTGCTGTCAGTATCATATTCATGAAGTTCCTGTA GGAACTGAAAAGACCAGAGAAAGAATTGAACGGGTAATACAAGAAACCCGATTAAAACAGATTTATACAGCAGAAGAAAAGTATGTGGTG AAAACTTCTTTTTATTCAAACAAAGTTATTTCTAGTAACACATCTCTAAAAGTAGCGCAGTTTCTCACTGTCACTGTGGACCTAGAGCAG AGAAGACACTTAGAAGAACAGCTAAAGGAAATTCATAGAAAATTGCAAGCAGTGGATTCAGGGTTGATTGCCTTACGTGAAACAAGCAAA CATCTGGAGCACAAAGACAATGAACTTAGACAAAAGAAGAAGGAGCTTCTTGAGAGAAAAACCAAGAAAAGACAACTGGAACAAAAAATC AGTTCCAAACTAGGAAGTTTAAAGCTGATGGAACAGGATACTTGCAATCTTGAAGAGGAAGAGCGAAAAGCAAGTACCAAAATCAAAGAA ATAAATGTTCAAAAAGCGAAACTTGTTACCGAATTAACAAACCTAATAAAGATTTGTACTTCTTTGCATATACAAAAAGTAGATTTAATT CTCCAAAATACTACAGTGATCTCTGAGAAGAACAAATTAGAATCAGATTATATGGCCGCATCTTCACAACTCCGTCTTACAGAGCAACAT TTCATTGAATTGGATGAAAATAGACAGAGATTATTGCAGAAATGCAAGGAACTTATGAAAAGAGCTAGGCAAGTATGTAACCTGGGTGCA GAGCAGACTCTTCCTCAAGAATACCAGACACAAGTACCCACCATTCCAAATGGACACAACTCCTCACTCCCCATGGTTTTCCAAGACCTT CCAAACACATTGGATGAAATTGATGCTTTATTAACTGAAGAAAGATCAAGAGCTTCCTGCTTCACGGGACTGAATCCTACAATTGTTCAG GAATATACAAAAAGAGAAGAAGAAATAGAACAGTTAACTGAGGAACTAAAGGGAAAGAAAGTTGAACTAGATCAATACAGGGAAAACATT TCACAGGTAAAAGAAAGGTGGCTTAATCCTTTAAAAGAGCTGGTAGAAAAAATTAATGAAAAATTCAGCAATTTTTTTAGTTCCATGCAG TGTGCTGGTGAAGTTGATCTCCATACAGAAAATGAGGAAGATTATGATAAATATGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACT CAACTGCATGAATTAACTCCTCATCATCAAAGTGGAGGTGAAAGAAGTGTTTCTACCATGTTATACTTGATGGCACTTCAGGAGCTAAAT AGATGTCCATTCAGAGTAGTTGATGAAATCAATCAGGGAATGGACCCAATCAATGAACGGAGAGTGTTTGAAATGGTTGTAAATACTGCC TGTAAAGAAAATACATCTCAATACTTTTTCATAACACCAAAGCTCCTGCAAAATCTTCCTTATTCTGAAAAGATGACAGTTTTGTTTGTC TACAATGGCCCTCATATGCTGGAACCAAACACATGGAATTTAAAGGCTTTCCAAAGGCGGCGGCGCCGTATTACATTCACTCAACCTTCT >In-frame_FXN_ENST00000498653_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_3378nt ATGAATTTGAGGAAATCTGGAACTTTGGGCCACCCAGGCTCTCTAGATGAGACCACCTATGAAAGACTAGCAGAGGAAACGCTGGACTCT TTAGCAGAGTTTTTTGAAGACCTTGCAGACAAGCCATACACGTTTGAGGACTATGATGTCTCCTTTGGGAGTGGTGTCTTAACTGTCAAA CTGGGTGGAGATCTAGGAACCTATGTGATCAACAAGCAGACGCCAAACAAGCAAATCTGGCTATCTTCTCCATCCAGAACATATGATATT TGTGAAGTATCTCCTGGACCCCACTTGAATATGATCGTTGGAGCCAATGGAACAGGGAAGTCGAGCATTGTGTGTGCCATTTGCCTTGGT TTAGCTGGAAAACCTGCTTTCATGGGACGAGCAGATAAGGTTGGGTTTTTTGTGAAGAGAGGATGTTCTAGAGGCATGGTTGAAATTGAA TTGTTCAGGGCTTCTGGAAATCTTGTAATCACCCGTGAGATTGATGTGGCAAAAAATCAGTCCTTTTGGTTCATCAACAAAAAATCTACA ACCCAGAAAATAGTGGAAGAGAAAGTTGCAGCCTTAAATATTCAAGTGGGGAATCTTTGCCAGTTTCTCCCTCAGGACAAAGTTGGAGAA TTTGCTAAACTCAGCAAAATTGAACTCCTCGAAGCCACTGAAAAGTCAATTGGTCCCCCAGAAATGCACAAATATCACTGTGAACTCAAA AACTTAAGGGAGAAAGAAAAACAGCTCGAGACCTCATGCAAAGAGAAAACTGAGTATCTACAGAAAATGGTTCAGAGGAATGAAAGATAT AAACAAGATGTGGAGAGGTTCTATGAACGGAAGCGACATTTAGATTTAATTGAGATGCTTGAAGCAAAAAGGCCATGGGTGGAATATGAA AATGTTCGTCAGGAATATGAAGAAGTAAAACTAGTTCGTGACCGAGTGAAGGAAGAGGTCAGAAAACTTAAAGAAGGGCAGATTCCTGTA ACATGTCGAATTGAAGAAATGGAAAACGAGCGTCACAATTTGGAGGCTCGAATCAAAGAAAAGGCAACAGATATTAAGGAGGCATCTCAA AAATGCAAACAGAAGCAAGATGTTATAGAAAGGAAAGATAAACATATTGAGGAACTTCAGCAGGCTTTAATAGTAAAGCAAAATGAAGAG CTTGACCGACAGAGGAGAATAGGTAATACCCGCAAAATGATAGAGGATTTGCAAAATGAACTAAAGACCACGGAAAACTGCGAGAATCTT CAGCCCCAGATTGATGCCATTACAAATGATCTGAGACGGATTCAGGATGAAAAGGCATTATGTGAAGGCGAAATAATTGATAAGCGAAGA GAGAGGGAAACTCTAGAGAAGGAGAAAAAGAGTGTGGACGATCATATTGTACGTTTTGACAATCTTATGAATCAGAAGGAAGATAAGCTA AGACAGAGATTCCGTGACACGTATGATGCTGTTTTATGGCTAAGAAATAACAGAGACAAATTTAAACAAAGAGTCTGTGAGCCCATAATG CTCACGATCAATATGAAAGATAATAAAAATGCCAAATATATTGAAAATCATATTCCATCAAATGACTTAAGAGCCTTTGTATTTGAAAGT CAAGAAGATATGGAGGTTTTCCTCAAAGAGGTTCGTGACAATAAAAAATTAAGAGTAAATGCTGTTATTGCTCCCAAGAGTTCATATGCA GACAAAGCACCTTCAAGATCTTTGAATGAACTTAAACAATACGGATTTTTCTCTTATTTGAGAGAATTATTTGATGCACCTGATCCTGTA ATGAGTTACCTTTGCTGTCAGTATCATATTCATGAAGTTCCTGTAGGAACTGAAAAGACCAGAGAAAGAATTGAACGGGTAATACAAGAA ACCCGATTAAAACAGATTTATACAGCAGAAGAAAAGTATGTGGTGAAAACTTCTTTTTATTCAAACAAAGTTATTTCTAGTAACACATCT CTAAAAGTAGCGCAGTTTCTCACTGTCACTGTGGACCTAGAGCAGAGAAGACACTTAGAAGAACAGCTAAAGGAAATTCATAGAAAATTG CAAGCAGTGGATTCAGGGTTGATTGCCTTACGTGAAACAAGCAAACATCTGGAGCACAAAGACAATGAACTTAGACAAAAGAAGAAGGAG CTTCTTGAGAGAAAAACCAAGAAAAGACAACTGGAACAAAAAATCAGTTCCAAACTAGGAAGTTTAAAGCTGATGGAACAGGATACTTGC AATCTTGAAGAGGAAGAGCGAAAAGCAAGTACCAAAATCAAAGAAATAAATGTTCAAAAAGCGAAACTTGTTACCGAATTAACAAACCTA ATAAAGATTTGTACTTCTTTGCATATACAAAAAGTAGATTTAATTCTCCAAAATACTACAGTGATCTCTGAGAAGAACAAATTAGAATCA GATTATATGGCCGCATCTTCACAACTCCGTCTTACAGAGCAACATTTCATTGAATTGGATGAAAATAGACAGAGATTATTGCAGAAATGC AAGGAACTTATGAAAAGAGCTAGGCAAGTATGTAACCTGGGTGCAGAGCAGACTCTTCCTCAAGAATACCAGACACAAGTACCCACCATT CCAAATGGACACAACTCCTCACTCCCCATGGTTTTCCAAGACCTTCCAAACACATTGGATGAAATTGATGCTTTATTAACTGAAGAAAGA TCAAGAGCTTCCTGCTTCACGGGACTGAATCCTACAATTGTTCAGGAATATACAAAAAGAGAAGAAGAAATAGAACAGTTAACTGAGGAA CTAAAGGGAAAGAAAGTTGAACTAGATCAATACAGGGAAAACATTTCACAGGTAAAAGAAAGGTGGCTTAATCCTTTAAAAGAGCTGGTA GAAAAAATTAATGAAAAATTCAGCAATTTTTTTAGTTCCATGCAGTGTGCTGGTGAAGTTGATCTCCATACAGAAAATGAGGAAGATTAT GATAAATATGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACTCAACTGCATGAATTAACTCCTCATCATCAAAGTGGAGGTGAAAGA AGTGTTTCTACCATGTTATACTTGATGGCACTTCAGGAGCTAAATAGATGTCCATTCAGAGTAGTTGATGAAATCAATCAGGGAATGGAC CCAATCAATGAACGGAGAGTGTTTGAAATGGTTGTAAATACTGCCTGTAAAGAAAATACATCTCAATACTTTTTCATAACACCAAAGCTC CTGCAAAATCTTCCTTATTCTGAAAAGATGACAGTTTTGTTTGTCTACAATGGCCCTCATATGCTGGAACCAAACACATGGAATTTAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FXN_ENST00000396364_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_6380nt AGTCTCCCTTGGGTCAGGGGTCCTGGTTGCACTCCGTGCTTTGCACAAAGCAGGCTCTCCATTTTTGTTAAATGCACGAATAGTGCTAAG CTGGGAAGTTCTTCCTGAGGTCTAACCTCTAGCTGCTCCCCCACAGAAGAGTGCCTGCGGCCAGTGGCCACCAGGGGTCGCCGCAGCACC CAGCGCTGGAGGGCGGAGCGGGCGGCAGACCCGGAGCAGCATGTGGACTCTCGGGCGCCGCGCAGTAGCCGGCCTCCTGGCGTCACCCAG CCCAGCCCAGGCCCAGACCCTCACCCGGGTCCCGCGGCCGGCAGAGTTGGCCCCACTCTGCGGCCGCCGTGGCCTGCGCACCGACATCGA TGCGACCTGCACGCCCCGCCGCGCAAGTTCGAACCAACGTGGCCTCAACCAGATTTGGAATGTCAAAAAGCAGAGTGTCTATTTGATGAA TTTGAGGAAATCTGGAACTTTGGGCCACCCAGGCTCTCTAGATGAGACCACCTATGAAAGACTAGCAGAGGAAACGCTGGACTCTTTAGC AGAGTTTTTTGAAGACCTTGCAGACAAGCCATACACGTTTGAGGACTATGATGTCTCCTTTGGGAGTGGTGTCTTAACTGTCAAACTGGG TGGAGATCTAGGAACCTATGTGATCAACAAGCAGACGCCAAACAAGCAAATCTGGCTATCTTCTCCATCCAGAACATATGATATTTGTGA AGTATCTCCTGGACCCCACTTGAATATGATCGTTGGAGCCAATGGAACAGGGAAGTCGAGCATTGTGTGTGCCATTTGCCTTGGTTTAGC TGGAAAACCTGCTTTCATGGGACGAGCAGATAAGGTTGGGTTTTTTGTGAAGAGAGGATGTTCTAGAGGCATGGTTGAAATTGAATTGTT CAGGGCTTCTGGAAATCTTGTAATCACCCGTGAGATTGATGTGGCAAAAAATCAGTCCTTTTGGTTCATCAACAAAAAATCTACAACCCA GAAAATAGTGGAAGAGAAAGTTGCAGCCTTAAATATTCAAGTGGGGAATCTTTGCCAGTTTCTCCCTCAGGACAAAGTTGGAGAATTTGC TAAACTCAGCAAAATTGAACTCCTCGAAGCCACTGAAAAGTCAATTGGTCCCCCAGAAATGCACAAATATCACTGTGAACTCAAAAACTT AAGGGAGAAAGAAAAACAGCTCGAGACCTCATGCAAAGAGAAAACTGAGTATCTACAGAAAATGGTTCAGAGGAATGAAAGATATAAACA AGATGTGGAGAGGTTCTATGAACGGAAGCGACATTTAGATTTAATTGAGATGCTTGAAGCAAAAAGGCCATGGGTGGAATATGAAAATGT TCGTCAGGAATATGAAGAAGTAAAACTAGTTCGTGACCGAGTGAAGGAAGAGGTCAGAAAACTTAAAGAAGGGCAGATTCCTGTAACATG TCGAATTGAAGAAATGGAAAACGAGCGTCACAATTTGGAGGCTCGAATCAAAGAAAAGGCAACAGATATTAAGGAGGCATCTCAAAAATG CAAACAGAAGCAAGATGTTATAGAAAGGAAAGATAAACATATTGAGGAACTTCAGCAGGCTTTAATAGTAAAGCAAAATGAAGAGCTTGA CCGACAGAGGAGAATAGGTAATACCCGCAAAATGATAGAGGATTTGCAAAATGAACTAAAGACCACGGAAAACTGCGAGAATCTTCAGCC CCAGATTGATGCCATTACAAATGATCTGAGACGGATTCAGGATGAAAAGGCATTATGTGAAGGCGAAATAATTGATAAGCGAAGAGAGAG GGAAACTCTAGAGAAGGAGAAAAAGAGTGTGGACGATCATATTGTACGTTTTGACAATCTTATGAATCAGAAGGAAGATAAGCTAAGACA GAGATTCCGTGACACGTATGATGCTGTTTTATGGCTAAGAAATAACAGAGACAAATTTAAACAAAGAGTCTGTGAGCCCATAATGCTCAC GATCAATATGAAAGATAATAAAAATGCCAAATATATTGAAAATCATATTCCATCAAATGACTTAAGAGCCTTTGTATTTGAAAGTCAAGA AGATATGGAGGTTTTCCTCAAAGAGGTTCGTGACAATAAAAAATTAAGAGTAAATGCTGTTATTGCTCCCAAGAGTTCATATGCAGACAA AGCACCTTCAAGATCTTTGAATGAACTTAAACAATACGGATTTTTCTCTTATTTGAGAGAATTATTTGATGCACCTGATCCTGTAATGAG TTACCTTTGCTGTCAGTATCATATTCATGAAGTTCCTGTAGGAACTGAAAAGACCAGAGAAAGAATTGAACGGGTAATACAAGAAACCCG ATTAAAACAGATTTATACAGCAGAAGAAAAGTATGTGGTGAAAACTTCTTTTTATTCAAACAAAGTTATTTCTAGTAACACATCTCTAAA AGTAGCGCAGTTTCTCACTGTCACTGTGGACCTAGAGCAGAGAAGACACTTAGAAGAACAGCTAAAGGAAATTCATAGAAAATTGCAAGC AGTGGATTCAGGGTTGATTGCCTTACGTGAAACAAGCAAACATCTGGAGCACAAAGACAATGAACTTAGACAAAAGAAGAAGGAGCTTCT TGAGAGAAAAACCAAGAAAAGACAACTGGAACAAAAAATCAGTTCCAAACTAGGAAGTTTAAAGCTGATGGAACAGGATACTTGCAATCT TGAAGAGGAAGAGCGAAAAGCAAGTACCAAAATCAAAGAAATAAATGTTCAAAAAGCGAAACTTGTTACCGAATTAACAAACCTAATAAA GATTTGTACTTCTTTGCATATACAAAAAGTAGATTTAATTCTCCAAAATACTACAGTGATCTCTGAGAAGAACAAATTAGAATCAGATTA TATGGCCGCATCTTCACAACTCCGTCTTACAGAGCAACATTTCATTGAATTGGATGAAAATAGACAGAGATTATTGCAGAAATGCAAGGA ACTTATGAAAAGAGCTAGGCAAGTATGTAACCTGGGTGCAGAGCAGACTCTTCCTCAAGAATACCAGACACAAGTACCCACCATTCCAAA TGGACACAACTCCTCACTCCCCATGGTTTTCCAAGACCTTCCAAACACATTGGATGAAATTGATGCTTTATTAACTGAAGAAAGATCAAG AGCTTCCTGCTTCACGGGACTGAATCCTACAATTGTTCAGGAATATACAAAAAGAGAAGAAGAAATAGAACAGTTAACTGAGGAACTAAA GGGAAAGAAAGTTGAACTAGATCAATACAGGGAAAACATTTCACAGGTAAAAGAAAGGTGGCTTAATCCTTTAAAAGAGCTGGTAGAAAA AATTAATGAAAAATTCAGCAATTTTTTTAGTTCCATGCAGTGTGCTGGTGAAGTTGATCTCCATACAGAAAATGAGGAAGATTATGATAA ATATGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACTCAACTGCATGAATTAACTCCTCATCATCAAAGTGGAGGTGAAAGAAGTGT TTCTACCATGTTATACTTGATGGCACTTCAGGAGCTAAATAGATGTCCATTCAGAGTAGTTGATGAAATCAATCAGGGAATGGACCCAAT CAATGAACGGAGAGTGTTTGAAATGGTTGTAAATACTGCCTGTAAAGAAAATACATCTCAATACTTTTTCATAACACCAAAGCTCCTGCA AAATCTTCCTTATTCTGAAAAGATGACAGTTTTGTTTGTCTACAATGGCCCTCATATGCTGGAACCAAACACATGGAATTTAAAGGCTTT CCAAAGGCGGCGGCGCCGTATTACATTCACTCAACCTTCTTAATAAAAGTAAAGAGAGGGAACTTGGGAATTTTTTTTGTTAAATTCTGT TTATAAGTATGGCTCAACTGAATAAAAGGAGATTCACTAAAACGAAAAGCAGTTATTTTTGGAAACCTGCTTTTAAATACAAATAGGTTG ATAATGGAAACTATAATGACCTTTCCAAAATAGCAGCTGGTAGTAAAAGTTAAGTCTTCTTCAGTCTTGGTTGAACTTGAGTTCTTGGCA CTCTGACCATGAGTCATTCAGTTCTCATGTTAAAATGTACTTAATATTACAAATCAAAGGTACAGTGGAAGAAGGGTTAATCACAAGAAG TTACTTATATGGTAGCCCTGAGCTTTAATTGCAGAGTAACTTTAATTACTTTTAGAGCCTAAAGATGACTCTAGAGCCTAAGTCCTAGTT TCTCCCAATGTTATATTTAATTTTAAAAAATTGATATGAAAATGTCTAATGTATAGTAATAATTTATGACAGATCTAGTCATTTCTTCCT ATTAAAAAAGATTACCTTATCTCCAGTAGGAAATGGAATTTTATGGGCCTTTAAAAGAAAGTTTTATGAAACTTGATGCTATAATTTTAT TGGTATTTCAAGGGGAAAAAAGCACTGGGGTTCAAAAATGGTAGCAGAACTGCTTTGAAATGCTGCAAGGTGGCCACTAGATGATGCAAA ATACAACCAAAAGATTGACTGAGAATAAAATTAGGTGACAAGGGTTTTTAAAGAATAACCTTTTAAAGTGTGGGGGCAGGGGTTGCTTTT TTTTATTTTATTTAAAGTCAATTATATTTTACATCTTACATTTCTAAAAGCATTTTATAATTATTTTTAGTAAGATTTTTCTTAAAATTT CATATACTGGTTTCTACAATTTATATTTGAAATTTCTCAGTGTTATGTAAAGAGTGATGGAAAAGCATTGATTTCTTTAAAACCGTAATG TTTTTAGAACTTAAGCCTATAGGGCCTTTCTTACAATGTTGATGTACCCATTATCTTAGAAAATCTAGTTTAAACTGTTTTCTTTCACCG CAAAAGAATTAAATGGGAAAATCATTTGTTTATCTCTAAGTTATACTAATTAGTAGAACCAAACAAATTATCTTCTTTTAAAAAATAAAT CTTATAGGAAAATAGACAGTCCAAAGTCATGTCTTTGAACAGTGGATTGGATCTGTGCCAGTAATGACAAAATTATTTTTTTGACTTGCT TGCCTGAATAAATTGAAGAATTGCTTTCAGTTTGGGTTTTGTATATTCTTAAGTAGCCATTGAAATTTATATTCTTAACTAGGTCAAAAA ATAATGAGCCATAAGTTTATGTCCTCTCACTTAGACATTTTCTCTTTAAAAAGGTATTTTCTTCTTTATAAACATTTTAAAAGAGCCTTC CCTTCTTAAACTAACTCCAGTGCATGAAGTGTGAAAATATTTTAAAATGACATTTTTACTAATATGAGCAAGTCATGTAAACATTGAAGA ACTTGGTAACATATTAGTAAATGGATATTACCAAATGTTTTCATCGTTAATTACTTTGCGTTCCACCAAAATATCTTTACTAAAATGTGC TTGGTGTAGTTTGTTTATTGTCTAAATTAGTACCAGTCATCTTATTTCTGCAAAATGAGTATCAATGTGAAAAAGACACGTGAAGATTAA GCATGTTTGAAAATAAAATGGTCAATTACATTTCAATTTACATAGGCCAACAACTGTTCCATACTTTGTTTGTAAACATTTAATTTCTCT ACTGGACAAAATTAATATTTGGCTTTACATTGAATTTTGAGCTGTGAAGAATAAATTATGTATCATTTTAGCATATTAAACAGTAGTAAG TCTAGCACATAGTCTCAGCCACTTAAAACAAAAGTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGAGATGGAGTCTCACTCTGTTGCCC AGGCTGGAGTGCAGTGGCGTGATCTCGGCTTACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAACT GGGACAACAGGCGCGTCCCACCACACCCAGCTAATTTTTTATACTTTTAGTAGAGATGGGGTTTCAGCATATTGGCCAGGCTGGTCTCGA ACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCCCTGCACCCGGCCAAAAGTTGATTTTT AATTACATAAAAATCGTAAAAACTTCTAGTAAAAACTTGATTTGGTGAATACAGTTATATTTAAAAACCTTAAGGTGACAAGCATTTTCT ATGCCTAAATCTTCATTGGTTTGCCTGGAAAGAGTCTCTGTTAAAAGATTTTCCATATTCAAAGTAAAAGGAAAGATTTCTTGCTTTCTA ATTGTCTTTTGGACACATGCCTATTTTCTTTGAGGTATAAACCTTTAGATGTGAAAAATGTAATTTCATTCTGCTATTGTGTGTGCTTGT >In-frame_FXN_ENST00000377270_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_6684nt TTTACAGGGCTTAACTCATTTTATCCTTACCACAATCCTATGAAGTAGGAACTTTTATAAAACGCATTTTATAAACAAGGCACAGAGAGG TTAATTAACTTGCCCTCTGGTCACACAGCTAGGAAGTGGGCAGAGTACAGATTTACACAAGGCATCCGTCTCCTGGCCCCACATACCCAA CTGCTGTAAACCCATACCGGCGGCCAAGCAGCCTCAATTTGTGCATGCACCCACTTCCCAGCAAGACAGCAGCTCCCAAGTTCCTCCTGT TTAGAATTTTAGAAGCGGCGGGCCACCAGGCTGCAGTCTCCCTTGGGTCAGGGGTCCTGGTTGCACTCCGTGCTTTGCACAAAGCAGGCT CTCCATTTTTGTTAAATGCACGAATAGTGCTAAGCTGGGAAGTTCTTCCTGAGGTCTAACCTCTAGCTGCTCCCCCACAGAAGAGTGCCT GCGGCCAGTGGCCACCAGGGGTCGCCGCAGCACCCAGCGCTGGAGGGCGGAGCGGGCGGCAGACCCGGAGCAGCATGTGGACTCTCGGGC GCCGCGCAGTAGCCGGCCTCCTGGCGTCACCCAGCCCAGCCCAGGCCCAGACCCTCACCCGGGTCCCGCGGCCGGCAGAGTTGGCCCCAC TCTGCGGCCGCCGTGGCCTGCGCACCGACATCGATGCGACCTGCACGCCCCGCCGCGCAAGTTCGAACCAACGTGGCCTCAACCAGATTT GGAATGTCAAAAAGCAGAGTGTCTATTTGATGAATTTGAGGAAATCTGGAACTTTGGGCCACCCAGGCTCTCTAGATGAGACCACCTATG AAAGACTAGCAGAGGAAACGCTGGACTCTTTAGCAGAGTTTTTTGAAGACCTTGCAGACAAGCCATACACGTTTGAGGACTATGATGTCT CCTTTGGGAGTGGTGTCTTAACTGTCAAACTGGGTGGAGATCTAGGAACCTATGTGATCAACAAGCAGACGCCAAACAAGCAAATCTGGC TATCTTCTCCATCCAGAACATATGATATTTGTGAAGTATCTCCTGGACCCCACTTGAATATGATCGTTGGAGCCAATGGAACAGGGAAGT CGAGCATTGTGTGTGCCATTTGCCTTGGTTTAGCTGGAAAACCTGCTTTCATGGGACGAGCAGATAAGGTTGGGTTTTTTGTGAAGAGAG GATGTTCTAGAGGCATGGTTGAAATTGAATTGTTCAGGGCTTCTGGAAATCTTGTAATCACCCGTGAGATTGATGTGGCAAAAAATCAGT CCTTTTGGTTCATCAACAAAAAATCTACAACCCAGAAAATAGTGGAAGAGAAAGTTGCAGCCTTAAATATTCAAGTGGGGAATCTTTGCC AGTTTCTCCCTCAGGACAAAGTTGGAGAATTTGCTAAACTCAGCAAAATTGAACTCCTCGAAGCCACTGAAAAGTCAATTGGTCCCCCAG AAATGCACAAATATCACTGTGAACTCAAAAACTTAAGGGAGAAAGAAAAACAGCTCGAGACCTCATGCAAAGAGAAAACTGAGTATCTAC AGAAAATGGTTCAGAGGAATGAAAGATATAAACAAGATGTGGAGAGGTTCTATGAACGGAAGCGACATTTAGATTTAATTGAGATGCTTG AAGCAAAAAGGCCATGGGTGGAATATGAAAATGTTCGTCAGGAATATGAAGAAGTAAAACTAGTTCGTGACCGAGTGAAGGAAGAGGTCA GAAAACTTAAAGAAGGGCAGATTCCTGTAACATGTCGAATTGAAGAAATGGAAAACGAGCGTCACAATTTGGAGGCTCGAATCAAAGAAA AGGCAACAGATATTAAGGAGGCATCTCAAAAATGCAAACAGAAGCAAGATGTTATAGAAAGGAAAGATAAACATATTGAGGAACTTCAGC AGGCTTTAATAGTAAAGCAAAATGAAGAGCTTGACCGACAGAGGAGAATAGGTAATACCCGCAAAATGATAGAGGATTTGCAAAATGAAC TAAAGACCACGGAAAACTGCGAGAATCTTCAGCCCCAGATTGATGCCATTACAAATGATCTGAGACGGATTCAGGATGAAAAGGCATTAT GTGAAGGCGAAATAATTGATAAGCGAAGAGAGAGGGAAACTCTAGAGAAGGAGAAAAAGAGTGTGGACGATCATATTGTACGTTTTGACA ATCTTATGAATCAGAAGGAAGATAAGCTAAGACAGAGATTCCGTGACACGTATGATGCTGTTTTATGGCTAAGAAATAACAGAGACAAAT TTAAACAAAGAGTCTGTGAGCCCATAATGCTCACGATCAATATGAAAGATAATAAAAATGCCAAATATATTGAAAATCATATTCCATCAA ATGACTTAAGAGCCTTTGTATTTGAAAGTCAAGAAGATATGGAGGTTTTCCTCAAAGAGGTTCGTGACAATAAAAAATTAAGAGTAAATG CTGTTATTGCTCCCAAGAGTTCATATGCAGACAAAGCACCTTCAAGATCTTTGAATGAACTTAAACAATACGGATTTTTCTCTTATTTGA GAGAATTATTTGATGCACCTGATCCTGTAATGAGTTACCTTTGCTGTCAGTATCATATTCATGAAGTTCCTGTAGGAACTGAAAAGACCA GAGAAAGAATTGAACGGGTAATACAAGAAACCCGATTAAAACAGATTTATACAGCAGAAGAAAAGTATGTGGTGAAAACTTCTTTTTATT CAAACAAAGTTATTTCTAGTAACACATCTCTAAAAGTAGCGCAGTTTCTCACTGTCACTGTGGACCTAGAGCAGAGAAGACACTTAGAAG AACAGCTAAAGGAAATTCATAGAAAATTGCAAGCAGTGGATTCAGGGTTGATTGCCTTACGTGAAACAAGCAAACATCTGGAGCACAAAG ACAATGAACTTAGACAAAAGAAGAAGGAGCTTCTTGAGAGAAAAACCAAGAAAAGACAACTGGAACAAAAAATCAGTTCCAAACTAGGAA GTTTAAAGCTGATGGAACAGGATACTTGCAATCTTGAAGAGGAAGAGCGAAAAGCAAGTACCAAAATCAAAGAAATAAATGTTCAAAAAG CGAAACTTGTTACCGAATTAACAAACCTAATAAAGATTTGTACTTCTTTGCATATACAAAAAGTAGATTTAATTCTCCAAAATACTACAG TGATCTCTGAGAAGAACAAATTAGAATCAGATTATATGGCCGCATCTTCACAACTCCGTCTTACAGAGCAACATTTCATTGAATTGGATG AAAATAGACAGAGATTATTGCAGAAATGCAAGGAACTTATGAAAAGAGCTAGGCAAGTATGTAACCTGGGTGCAGAGCAGACTCTTCCTC AAGAATACCAGACACAAGTACCCACCATTCCAAATGGACACAACTCCTCACTCCCCATGGTTTTCCAAGACCTTCCAAACACATTGGATG AAATTGATGCTTTATTAACTGAAGAAAGATCAAGAGCTTCCTGCTTCACGGGACTGAATCCTACAATTGTTCAGGAATATACAAAAAGAG AAGAAGAAATAGAACAGTTAACTGAGGAACTAAAGGGAAAGAAAGTTGAACTAGATCAATACAGGGAAAACATTTCACAGGTAAAAGAAA GGTGGCTTAATCCTTTAAAAGAGCTGGTAGAAAAAATTAATGAAAAATTCAGCAATTTTTTTAGTTCCATGCAGTGTGCTGGTGAAGTTG ATCTCCATACAGAAAATGAGGAAGATTATGATAAATATGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACTCAACTGCATGAATTAA CTCCTCATCATCAAAGTGGAGGTGAAAGAAGTGTTTCTACCATGTTATACTTGATGGCACTTCAGGAGCTAAATAGATGTCCATTCAGAG TAGTTGATGAAATCAATCAGGGAATGGACCCAATCAATGAACGGAGAGTGTTTGAAATGGTTGTAAATACTGCCTGTAAAGAAAATACAT CTCAATACTTTTTCATAACACCAAAGCTCCTGCAAAATCTTCCTTATTCTGAAAAGATGACAGTTTTGTTTGTCTACAATGGCCCTCATA TGCTGGAACCAAACACATGGAATTTAAAGGCTTTCCAAAGGCGGCGGCGCCGTATTACATTCACTCAACCTTCTTAATAAAAGTAAAGAG AGGGAACTTGGGAATTTTTTTTGTTAAATTCTGTTTATAAGTATGGCTCAACTGAATAAAAGGAGATTCACTAAAACGAAAAGCAGTTAT TTTTGGAAACCTGCTTTTAAATACAAATAGGTTGATAATGGAAACTATAATGACCTTTCCAAAATAGCAGCTGGTAGTAAAAGTTAAGTC TTCTTCAGTCTTGGTTGAACTTGAGTTCTTGGCACTCTGACCATGAGTCATTCAGTTCTCATGTTAAAATGTACTTAATATTACAAATCA AAGGTACAGTGGAAGAAGGGTTAATCACAAGAAGTTACTTATATGGTAGCCCTGAGCTTTAATTGCAGAGTAACTTTAATTACTTTTAGA GCCTAAAGATGACTCTAGAGCCTAAGTCCTAGTTTCTCCCAATGTTATATTTAATTTTAAAAAATTGATATGAAAATGTCTAATGTATAG TAATAATTTATGACAGATCTAGTCATTTCTTCCTATTAAAAAAGATTACCTTATCTCCAGTAGGAAATGGAATTTTATGGGCCTTTAAAA GAAAGTTTTATGAAACTTGATGCTATAATTTTATTGGTATTTCAAGGGGAAAAAAGCACTGGGGTTCAAAAATGGTAGCAGAACTGCTTT GAAATGCTGCAAGGTGGCCACTAGATGATGCAAAATACAACCAAAAGATTGACTGAGAATAAAATTAGGTGACAAGGGTTTTTAAAGAAT AACCTTTTAAAGTGTGGGGGCAGGGGTTGCTTTTTTTTATTTTATTTAAAGTCAATTATATTTTACATCTTACATTTCTAAAAGCATTTT ATAATTATTTTTAGTAAGATTTTTCTTAAAATTTCATATACTGGTTTCTACAATTTATATTTGAAATTTCTCAGTGTTATGTAAAGAGTG ATGGAAAAGCATTGATTTCTTTAAAACCGTAATGTTTTTAGAACTTAAGCCTATAGGGCCTTTCTTACAATGTTGATGTACCCATTATCT TAGAAAATCTAGTTTAAACTGTTTTCTTTCACCGCAAAAGAATTAAATGGGAAAATCATTTGTTTATCTCTAAGTTATACTAATTAGTAG AACCAAACAAATTATCTTCTTTTAAAAAATAAATCTTATAGGAAAATAGACAGTCCAAAGTCATGTCTTTGAACAGTGGATTGGATCTGT GCCAGTAATGACAAAATTATTTTTTTGACTTGCTTGCCTGAATAAATTGAAGAATTGCTTTCAGTTTGGGTTTTGTATATTCTTAAGTAG CCATTGAAATTTATATTCTTAACTAGGTCAAAAAATAATGAGCCATAAGTTTATGTCCTCTCACTTAGACATTTTCTCTTTAAAAAGGTA TTTTCTTCTTTATAAACATTTTAAAAGAGCCTTCCCTTCTTAAACTAACTCCAGTGCATGAAGTGTGAAAATATTTTAAAATGACATTTT TACTAATATGAGCAAGTCATGTAAACATTGAAGAACTTGGTAACATATTAGTAAATGGATATTACCAAATGTTTTCATCGTTAATTACTT TGCGTTCCACCAAAATATCTTTACTAAAATGTGCTTGGTGTAGTTTGTTTATTGTCTAAATTAGTACCAGTCATCTTATTTCTGCAAAAT GAGTATCAATGTGAAAAAGACACGTGAAGATTAAGCATGTTTGAAAATAAAATGGTCAATTACATTTCAATTTACATAGGCCAACAACTG TTCCATACTTTGTTTGTAAACATTTAATTTCTCTACTGGACAAAATTAATATTTGGCTTTACATTGAATTTTGAGCTGTGAAGAATAAAT TATGTATCATTTTAGCATATTAAACAGTAGTAAGTCTAGCACATAGTCTCAGCCACTTAAAACAAAAGTTTTTTTGTTTGTTTGTTTGTT TGTTTTTTTGAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTTACTGCAACCTCCGCCTCCCGGGTTC AAGCGATTCTCCTGCCTCAGCCTCCCAAGTAACTGGGACAACAGGCGCGTCCCACCACACCCAGCTAATTTTTTATACTTTTAGTAGAGA TGGGGTTTCAGCATATTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGC GTGAGCCCCTGCACCCGGCCAAAAGTTGATTTTTAATTACATAAAAATCGTAAAAACTTCTAGTAAAAACTTGATTTGGTGAATACAGTT ATATTTAAAAACCTTAAGGTGACAAGCATTTTCTATGCCTAAATCTTCATTGGTTTGCCTGGAAAGAGTCTCTGTTAAAAGATTTTCCAT ATTCAAAGTAAAAGGAAAGATTTCTTGCTTTCTAATTGTCTTTTGGACACATGCCTATTTTCTTTGAGGTATAAACCTTTAGATGTGAAA AATGTAATTTCATTCTGCTATTGTGTGTGCTTGTGTGTGTGTAATTGAAAAAACTGGGAAATCCTGCTTTGTTGGTAATAAATCAATATT >In-frame_FXN_ENST00000498653_chr9_71679951_+_SMC5_ENST00000361138_chr9_72879220_+_6040nt AAGGAAAAGGGGACATTTTGTCCTGCGGTGCGACTGCGGGTCAAGAGTTCGAACCAACGTGGCCTCAACCAGATTTGGAATGTCAAAAAG CAGAGTGTCTATTTGATGAATTTGAGGAAATCTGGAACTTTGGGCCACCCAGGCTCTCTAGATGAGACCACCTATGAAAGACTAGCAGAG GAAACGCTGGACTCTTTAGCAGAGTTTTTTGAAGACCTTGCAGACAAGCCATACACGTTTGAGGACTATGATGTCTCCTTTGGGAGTGGT GTCTTAACTGTCAAACTGGGTGGAGATCTAGGAACCTATGTGATCAACAAGCAGACGCCAAACAAGCAAATCTGGCTATCTTCTCCATCC AGAACATATGATATTTGTGAAGTATCTCCTGGACCCCACTTGAATATGATCGTTGGAGCCAATGGAACAGGGAAGTCGAGCATTGTGTGT GCCATTTGCCTTGGTTTAGCTGGAAAACCTGCTTTCATGGGACGAGCAGATAAGGTTGGGTTTTTTGTGAAGAGAGGATGTTCTAGAGGC ATGGTTGAAATTGAATTGTTCAGGGCTTCTGGAAATCTTGTAATCACCCGTGAGATTGATGTGGCAAAAAATCAGTCCTTTTGGTTCATC AACAAAAAATCTACAACCCAGAAAATAGTGGAAGAGAAAGTTGCAGCCTTAAATATTCAAGTGGGGAATCTTTGCCAGTTTCTCCCTCAG GACAAAGTTGGAGAATTTGCTAAACTCAGCAAAATTGAACTCCTCGAAGCCACTGAAAAGTCAATTGGTCCCCCAGAAATGCACAAATAT CACTGTGAACTCAAAAACTTAAGGGAGAAAGAAAAACAGCTCGAGACCTCATGCAAAGAGAAAACTGAGTATCTACAGAAAATGGTTCAG AGGAATGAAAGATATAAACAAGATGTGGAGAGGTTCTATGAACGGAAGCGACATTTAGATTTAATTGAGATGCTTGAAGCAAAAAGGCCA TGGGTGGAATATGAAAATGTTCGTCAGGAATATGAAGAAGTAAAACTAGTTCGTGACCGAGTGAAGGAAGAGGTCAGAAAACTTAAAGAA GGGCAGATTCCTGTAACATGTCGAATTGAAGAAATGGAAAACGAGCGTCACAATTTGGAGGCTCGAATCAAAGAAAAGGCAACAGATATT AAGGAGGCATCTCAAAAATGCAAACAGAAGCAAGATGTTATAGAAAGGAAAGATAAACATATTGAGGAACTTCAGCAGGCTTTAATAGTA AAGCAAAATGAAGAGCTTGACCGACAGAGGAGAATAGGTAATACCCGCAAAATGATAGAGGATTTGCAAAATGAACTAAAGACCACGGAA AACTGCGAGAATCTTCAGCCCCAGATTGATGCCATTACAAATGATCTGAGACGGATTCAGGATGAAAAGGCATTATGTGAAGGCGAAATA ATTGATAAGCGAAGAGAGAGGGAAACTCTAGAGAAGGAGAAAAAGAGTGTGGACGATCATATTGTACGTTTTGACAATCTTATGAATCAG AAGGAAGATAAGCTAAGACAGAGATTCCGTGACACGTATGATGCTGTTTTATGGCTAAGAAATAACAGAGACAAATTTAAACAAAGAGTC TGTGAGCCCATAATGCTCACGATCAATATGAAAGATAATAAAAATGCCAAATATATTGAAAATCATATTCCATCAAATGACTTAAGAGCC TTTGTATTTGAAAGTCAAGAAGATATGGAGGTTTTCCTCAAAGAGGTTCGTGACAATAAAAAATTAAGAGTAAATGCTGTTATTGCTCCC AAGAGTTCATATGCAGACAAAGCACCTTCAAGATCTTTGAATGAACTTAAACAATACGGATTTTTCTCTTATTTGAGAGAATTATTTGAT GCACCTGATCCTGTAATGAGTTACCTTTGCTGTCAGTATCATATTCATGAAGTTCCTGTAGGAACTGAAAAGACCAGAGAAAGAATTGAA CGGGTAATACAAGAAACCCGATTAAAACAGATTTATACAGCAGAAGAAAAGTATGTGGTGAAAACTTCTTTTTATTCAAACAAAGTTATT TCTAGTAACACATCTCTAAAAGTAGCGCAGTTTCTCACTGTCACTGTGGACCTAGAGCAGAGAAGACACTTAGAAGAACAGCTAAAGGAA ATTCATAGAAAATTGCAAGCAGTGGATTCAGGGTTGATTGCCTTACGTGAAACAAGCAAACATCTGGAGCACAAAGACAATGAACTTAGA CAAAAGAAGAAGGAGCTTCTTGAGAGAAAAACCAAGAAAAGACAACTGGAACAAAAAATCAGTTCCAAACTAGGAAGTTTAAAGCTGATG GAACAGGATACTTGCAATCTTGAAGAGGAAGAGCGAAAAGCAAGTACCAAAATCAAAGAAATAAATGTTCAAAAAGCGAAACTTGTTACC GAATTAACAAACCTAATAAAGATTTGTACTTCTTTGCATATACAAAAAGTAGATTTAATTCTCCAAAATACTACAGTGATCTCTGAGAAG AACAAATTAGAATCAGATTATATGGCCGCATCTTCACAACTCCGTCTTACAGAGCAACATTTCATTGAATTGGATGAAAATAGACAGAGA TTATTGCAGAAATGCAAGGAACTTATGAAAAGAGCTAGGCAAGTATGTAACCTGGGTGCAGAGCAGACTCTTCCTCAAGAATACCAGACA CAAGTACCCACCATTCCAAATGGACACAACTCCTCACTCCCCATGGTTTTCCAAGACCTTCCAAACACATTGGATGAAATTGATGCTTTA TTAACTGAAGAAAGATCAAGAGCTTCCTGCTTCACGGGACTGAATCCTACAATTGTTCAGGAATATACAAAAAGAGAAGAAGAAATAGAA CAGTTAACTGAGGAACTAAAGGGAAAGAAAGTTGAACTAGATCAATACAGGGAAAACATTTCACAGGTAAAAGAAAGGTGGCTTAATCCT TTAAAAGAGCTGGTAGAAAAAATTAATGAAAAATTCAGCAATTTTTTTAGTTCCATGCAGTGTGCTGGTGAAGTTGATCTCCATACAGAA AATGAGGAAGATTATGATAAATATGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACTCAACTGCATGAATTAACTCCTCATCATCAA AGTGGAGGTGAAAGAAGTGTTTCTACCATGTTATACTTGATGGCACTTCAGGAGCTAAATAGATGTCCATTCAGAGTAGTTGATGAAATC AATCAGGGAATGGACCCAATCAATGAACGGAGAGTGTTTGAAATGGTTGTAAATACTGCCTGTAAAGAAAATACATCTCAATACTTTTTC ATAACACCAAAGCTCCTGCAAAATCTTCCTTATTCTGAAAAGATGACAGTTTTGTTTGTCTACAATGGCCCTCATATGCTGGAACCAAAC ACATGGAATTTAAAGGCTTTCCAAAGGCGGCGGCGCCGTATTACATTCACTCAACCTTCTTAATAAAAGTAAAGAGAGGGAACTTGGGAA TTTTTTTTGTTAAATTCTGTTTATAAGTATGGCTCAACTGAATAAAAGGAGATTCACTAAAACGAAAAGCAGTTATTTTTGGAAACCTGC TTTTAAATACAAATAGGTTGATAATGGAAACTATAATGACCTTTCCAAAATAGCAGCTGGTAGTAAAAGTTAAGTCTTCTTCAGTCTTGG TTGAACTTGAGTTCTTGGCACTCTGACCATGAGTCATTCAGTTCTCATGTTAAAATGTACTTAATATTACAAATCAAAGGTACAGTGGAA GAAGGGTTAATCACAAGAAGTTACTTATATGGTAGCCCTGAGCTTTAATTGCAGAGTAACTTTAATTACTTTTAGAGCCTAAAGATGACT CTAGAGCCTAAGTCCTAGTTTCTCCCAATGTTATATTTAATTTTAAAAAATTGATATGAAAATGTCTAATGTATAGTAATAATTTATGAC AGATCTAGTCATTTCTTCCTATTAAAAAAGATTACCTTATCTCCAGTAGGAAATGGAATTTTATGGGCCTTTAAAAGAAAGTTTTATGAA ACTTGATGCTATAATTTTATTGGTATTTCAAGGGGAAAAAAGCACTGGGGTTCAAAAATGGTAGCAGAACTGCTTTGAAATGCTGCAAGG TGGCCACTAGATGATGCAAAATACAACCAAAAGATTGACTGAGAATAAAATTAGGTGACAAGGGTTTTTAAAGAATAACCTTTTAAAGTG TGGGGGCAGGGGTTGCTTTTTTTTATTTTATTTAAAGTCAATTATATTTTACATCTTACATTTCTAAAAGCATTTTATAATTATTTTTAG TAAGATTTTTCTTAAAATTTCATATACTGGTTTCTACAATTTATATTTGAAATTTCTCAGTGTTATGTAAAGAGTGATGGAAAAGCATTG ATTTCTTTAAAACCGTAATGTTTTTAGAACTTAAGCCTATAGGGCCTTTCTTACAATGTTGATGTACCCATTATCTTAGAAAATCTAGTT TAAACTGTTTTCTTTCACCGCAAAAGAATTAAATGGGAAAATCATTTGTTTATCTCTAAGTTATACTAATTAGTAGAACCAAACAAATTA TCTTCTTTTAAAAAATAAATCTTATAGGAAAATAGACAGTCCAAAGTCATGTCTTTGAACAGTGGATTGGATCTGTGCCAGTAATGACAA AATTATTTTTTTGACTTGCTTGCCTGAATAAATTGAAGAATTGCTTTCAGTTTGGGTTTTGTATATTCTTAAGTAGCCATTGAAATTTAT ATTCTTAACTAGGTCAAAAAATAATGAGCCATAAGTTTATGTCCTCTCACTTAGACATTTTCTCTTTAAAAAGGTATTTTCTTCTTTATA AACATTTTAAAAGAGCCTTCCCTTCTTAAACTAACTCCAGTGCATGAAGTGTGAAAATATTTTAAAATGACATTTTTACTAATATGAGCA AGTCATGTAAACATTGAAGAACTTGGTAACATATTAGTAAATGGATATTACCAAATGTTTTCATCGTTAATTACTTTGCGTTCCACCAAA ATATCTTTACTAAAATGTGCTTGGTGTAGTTTGTTTATTGTCTAAATTAGTACCAGTCATCTTATTTCTGCAAAATGAGTATCAATGTGA AAAAGACACGTGAAGATTAAGCATGTTTGAAAATAAAATGGTCAATTACATTTCAATTTACATAGGCCAACAACTGTTCCATACTTTGTT TGTAAACATTTAATTTCTCTACTGGACAAAATTAATATTTGGCTTTACATTGAATTTTGAGCTGTGAAGAATAAATTATGTATCATTTTA GCATATTAAACAGTAGTAAGTCTAGCACATAGTCTCAGCCACTTAAAACAAAAGTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGAGAT GGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTTACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTG CCTCAGCCTCCCAAGTAACTGGGACAACAGGCGCGTCCCACCACACCCAGCTAATTTTTTATACTTTTAGTAGAGATGGGGTTTCAGCAT ATTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCCCTGCAC CCGGCCAAAAGTTGATTTTTAATTACATAAAAATCGTAAAAACTTCTAGTAAAAACTTGATTTGGTGAATACAGTTATATTTAAAAACCT TAAGGTGACAAGCATTTTCTATGCCTAAATCTTCATTGGTTTGCCTGGAAAGAGTCTCTGTTAAAAGATTTTCCATATTCAAAGTAAAAG GAAAGATTTCTTGCTTTCTAATTGTCTTTTGGACACATGCCTATTTTCTTTGAGGTATAAACCTTTAGATGTGAAAAATGTAATTTCATT CTGCTATTGTGTGTGCTTGTGTGTGTGTAATTGAAAAAACTGGGAAATCCTGCTTTGTTGGTAATAAATCAATATTTTTATATTCTTTTG |
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FusionGenePPI for FXN_SMC5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FXN | PMPCB, ACTN1, PICK1, LYRM4, RNF126 | SMC5 | SMC6, TK1, SMN1, NSMCE1, NSMCE2, RABL2A, SGTA, NSMCE4A, EID3, OBFC1, ZNF597, NDNL2, RAD50, PJA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FXN_SMC5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FXN | Q16595 | DB01592 | Iron | Frataxin, mitochondrial | small molecule | approved |
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RelatedDiseases for FXN_SMC5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FXN | C0016719 | Friedreich Ataxia | 8 | CTD_human;ORPHANET |
| Hgene | FXN | C1856689 | FRIEDREICH ATAXIA 1 | 6 | CTD_human;UNIPROT |
| Tgene | SMC5 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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