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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14100

FusionGeneSummary for FUT2_RASIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FUT2_RASIP1
Fusion gene ID: 14100
HgeneTgene
Gene symbol

FUT2

RASIP1

Gene ID

2524

54922

Gene namefucosyltransferase 2Ras interacting protein 1
SynonymsB12QTL1|SE|SEC2|Se2|sejRAIN
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptiongalactoside 2-alpha-L-fucosyltransferase 2GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2alpha (1,2) fucosyltransferasealpha(1,2)FT 2alpha(1,2)FT2fucosyltransferase 2 (secretor status included)galactoside 2-L-fucosyltransferasesecretras-interacting protein 1
Modification date2018052320180519
UniProtAcc

Q10981

Q5U651

Ensembl transtripts involved in fusion geneENST00000391876, ENST00000425340, 
ENST00000522283, 
ENST00000222145, 
ENST00000594232, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/27*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUT2 [Title/Abstract] AND RASIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N6-A4VE-01AFUT2chr19

49199336

+RASIP1chr19

49228217

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000391876ENST00000222145FUT2chr19

49199336

+RASIP1chr19

49228217

-
5UTR-intronENST00000391876ENST00000594232FUT2chr19

49199336

+RASIP1chr19

49228217

-
5UTR-3CDSENST00000425340ENST00000222145FUT2chr19

49199336

+RASIP1chr19

49228217

-
5UTR-intronENST00000425340ENST00000594232FUT2chr19

49199336

+RASIP1chr19

49228217

-
3UTR-3CDSENST00000522283ENST00000222145FUT2chr19

49199336

+RASIP1chr19

49228217

-
3UTR-intronENST00000522283ENST00000594232FUT2chr19

49199336

+RASIP1chr19

49228217

-

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FusionProtFeatures for FUT2_RASIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUT2

Q10981

RASIP1

Q5U651

Mediates the transfer of fucose to the terminalgalactose on glycan chains of cell surface glycoproteins andglycolipids (PubMed:7876235). The resulting epitope plays a rolein cell-cell interaction including host-microbe interaction(PubMed:12692541, PubMed:8018146). Mediates interaction withintestinal microbiota influencing its composition(PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates asoluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) calledthe H antigen which is an essential substrate for the final stepin the soluble ABO blood group antigen synthesis pathway(PubMed:7876235). {ECO:0000269|PubMed:21625510,ECO:0000269|PubMed:22068912, ECO:0000269|PubMed:24733310,ECO:0000269|PubMed:7876235, ECO:0000269|PubMed:8018146}. Required for the proper formation of vascular structuresthat develop via both vasculogenesis and angiogenesis. Acts as acritical and vascular-specific regulator of GTPase signaling, cellarchitecture, and adhesion, which is essential for endothelialcell morphogenesis and blood vessel tubulogenesis. Regulates theactivity of Rho GTPases in part by recruiting ARHGAP29 andsuppressing RhoA signaling and dampening ROCK and MYH9 activitiesin endothelial cells (By similarity). May act as effector forGolgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000250,ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUT2_RASIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUT2_RASIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FUT2ZDHHC17RASIP1HRAS, ARFGAP1, LDB2, PPP1R18, CDC42, HNRNPD, BUB3, BAG3, RNF41, ZWINT, FGFR1OP2, RACGAP1, SIKE1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUT2_RASIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUT2_RASIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUT2C0010346Crohn Disease1CTD_human
HgeneFUT2C0162677Caliciviridae Infections1CTD_human