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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14088

FusionGeneSummary for FUS_PHLDB2

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS_PHLDB2
Fusion gene ID: 14088
HgeneTgene
Gene symbol

FUS

PHLDB2

Gene ID

2521

90102

Gene nameFUS RNA binding proteinpleckstrin homology like domain family B member 2
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSLL5b|LL5beta
Cytomap

16p11.2

3q13.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lippleckstrin homology-like domain family B member 2LL5 betaprotein LL5-beta
Modification date2018052720180522
UniProtAcc

P35637

Q86SQ0

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000393923, ENST00000412622, 
ENST00000431670, ENST00000393925, 
ENST00000481953, ENST00000495180, 
ENST00000478922, ENST00000477695, 
ENST00000470699, 
Fusion gene scores* DoF score21 X 23 X 7=33814 X 4 X 2=32
# samples 274
** MAII scorelog2(27/3381*10)=-3.64641870384255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUS [Title/Abstract] AND PHLDB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN418196FUSchr16

31195546

+PHLDB2chr3

111632288

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000254108ENST00000393923FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000254108ENST00000412622FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000254108ENST00000431670FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000254108ENST00000393925FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000254108ENST00000481953FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000254108ENST00000495180FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000254108ENST00000478922FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000254108ENST00000477695FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000254108ENST00000470699FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000380244ENST00000393923FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000380244ENST00000412622FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000380244ENST00000431670FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000380244ENST00000393925FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000380244ENST00000481953FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000380244ENST00000495180FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000380244ENST00000478922FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000380244ENST00000477695FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000380244ENST00000470699FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000568685ENST00000393923FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000568685ENST00000412622FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000568685ENST00000431670FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000568685ENST00000393925FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000568685ENST00000481953FUSchr16

31195546

+PHLDB2chr3

111632288

+
Frame-shiftENST00000568685ENST00000495180FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000568685ENST00000478922FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000568685ENST00000477695FUSchr16

31195546

+PHLDB2chr3

111632288

+
5CDS-intronENST00000568685ENST00000470699FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-3CDSENST00000474990ENST00000393923FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-3CDSENST00000474990ENST00000412622FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-3CDSENST00000474990ENST00000431670FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-3CDSENST00000474990ENST00000393925FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-3CDSENST00000474990ENST00000481953FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-3CDSENST00000474990ENST00000495180FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-intronENST00000474990ENST00000478922FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-intronENST00000474990ENST00000477695FUSchr16

31195546

+PHLDB2chr3

111632288

+
intron-intronENST00000474990ENST00000470699FUSchr16

31195546

+PHLDB2chr3

111632288

+

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FusionProtFeatures for FUS_PHLDB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

PHLDB2

Q86SQ0

Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. Seems to be involved in the assembly of the postsynapticapparatus. May play a role in acetyl-choline receptor (AChR)aggregation in the postsynaptic membrane (By similarity).{ECO:0000250, ECO:0000269|PubMed:12376540}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUS_PHLDB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUS_PHLDB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUS_PHLDB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUS_PHLDB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)6UNIPROT
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41UNIPROT