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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14077

FusionGeneSummary for FUS_CREB3L2

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS_CREB3L2
Fusion gene ID: 14077
HgeneTgene
Gene symbol

FUS

CREB3L2

Gene ID

2521

64764

Gene nameFUS RNA binding proteincAMP responsive element binding protein 3 like 2
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSBBF2H7
Cytomap

16p11.2

7q33

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinFUS/ERG chimeric proteinFUS/ERG fusion proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in lipcyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2
Modification date2018052720180523
UniProtAcc

P35637

Q70SY1

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000330387, ENST00000456390, 
ENST00000452463, ENST00000458726, 
ENST00000468127, 
Fusion gene scores* DoF score21 X 23 X 7=33813 X 5 X 1=15
# samples 275
** MAII scorelog2(27/3381*10)=-3.64641870384255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUS [Title/Abstract] AND CREB3L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREB3L2

GO:0045893

positive regulation of transcription, DNA-templated

17178827


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ549094FUSchr16

31196384

+CREB3L2chr7

137593099

-
ChiTaRS3.1AJ549093FUSchr16

31199478

-CREB3L2chr7

137593090

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000254108ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shitENST00000254108ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shitENST00000380244ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shitENST00000380244ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shitENST00000568685ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shitENST00000568685ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-intronENST00000474990ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-intronENST00000474990ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-intronENST00000474990ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-3CDSENST00000254108ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000254108ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000254108ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000254108ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000254108ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000380244ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000380244ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000380244ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000380244ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000380244ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000568685ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000568685ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000568685ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000568685ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000568685ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000474990ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000474990ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000474990ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-

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FusionProtFeatures for FUS_CREB3L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

CREB3L2

Q70SY1

Binds both single-stranded and double-stranded DNA andpromotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-strandedDNA. May play a role in maintenance of genomic integrity. Transcription factor involved in unfolded proteinresponse (UPR). In the absence of endoplasmic reticulum (ER)stress, inserted into ER membranes, with N-terminal DNA-bindingand transcription activation domains oriented toward the cytosolicface of the membrane. In response to ER stress, transported to theGolgi, where it is cleaved in a site-specific manner by residentproteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminalcytosolic domain is translocated to the nucleus to effecttranscription of specific target genes. Plays a critical role inchondrogenesis by activating the transcription of SEC23A, whichpromotes the transport and secretion of cartilage matrix proteins,and possibly that of ER biogenesis-related genes (By similarity).In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcriptionof target genes via direct binding to the CRE site(PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52,ECO:0000269|PubMed:17178827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUS_CREB3L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUS_CREB3L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUS_CREB3L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUS_CREB3L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)6UNIPROT
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41UNIPROT