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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14073

FusionGeneSummary for FURIN_TNFSF12-TNFSF13

check button Fusion gene summary
Fusion gene informationFusion gene name: FURIN_TNFSF12-TNFSF13
Fusion gene ID: 14073
HgeneTgene
Gene symbol

FURIN

TNFSF12-TNFSF13

Gene ID

5045

407977

Gene namefurin, paired basic amino acid cleaving enzymeTNFSF12-TNFSF13 readthrough
SynonymsFUR|PACE|PCSK3|SPC1TWE-PRIL
Cytomap

15q26.1

17p13.1

Type of geneprotein-codingprotein-coding
DescriptionfurinFES upstream regionFURIN/ADAMTS1 fusiondibasic processing enzymefurin, membrane associated receptor proteinpaired basic amino acid residue-cleaving enzymeproprotein convertase subtilisin/kexin type 3TNFSF12-TNFSF13 proteintumor necrosis factor (ligand) superfamily, member 12-member 13
Modification date2018052220180329
UniProtAcc

P09958

Ensembl transtripts involved in fusion geneENST00000268171, ENST00000293826, 
Fusion gene scores* DoF score5 X 6 X 1=302 X 2 X 2=8
# samples 92
** MAII scorelog2(9/30*10)=1.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: FURIN [Title/Abstract] AND TNFSF12-TNFSF13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFURIN

GO:0006465

signal peptide processing

16912035

HgeneFURIN

GO:0016485

protein processing

9242664|10526337|10567353|14744861|15606899|17938254

HgeneFURIN

GO:0016486

peptide hormone processing

9242664

HgeneFURIN

GO:0032804

negative regulation of low-density lipoprotein particle receptor catabolic process

16912035

HgeneFURIN

GO:0032902

nerve growth factor production

8615794

HgeneFURIN

GO:0032904

negative regulation of nerve growth factor production

10567353

HgeneFURIN

GO:0032940

secretion by cell

8615794

HgeneFURIN

GO:0043043

peptide biosynthetic process

8262946

HgeneFURIN

GO:0052548

regulation of endopeptidase activity

14744861


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG924324FURINchr15

91426504

-TNFSF12-TNFSF13chr17

7462460

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000268171ENST00000293826FURINchr15

91426504

-TNFSF12-TNFSF13chr17

7462460

+

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FusionProtFeatures for FURIN_TNFSF12-TNFSF13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FURIN

P09958

TNFSF12-TNFSF13

Furin is likely to represent the ubiquitous endoproteaseactivity within constitutive secretory pathways and capable ofcleavage at the RX(K/R)R consensus motif.{ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222,ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:2251280,ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265,ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548,ECO:0000269|PubMed:9130696}. (Microbial infection) Probably cleaves and activatesanthrax and diphtheria toxins. (Microbial infection) Required for H7N1 and H5N1influenza virus infection probably by cleaving hemagglutinin.{ECO:0000269|PubMed:25974265}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FURIN_TNFSF12-TNFSF13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FURIN_TNFSF12-TNFSF13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FURIN_TNFSF12-TNFSF13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFURINP09958DB04951PirfenidoneFurinsmall moleculeapproved|investigational

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RelatedDiseases for FURIN_TNFSF12-TNFSF13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFURINC0024667Animal Mammary Neoplasms2CTD_human
HgeneFURINC0024668Mammary Neoplasms, Experimental2CTD_human