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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14065

FusionGeneSummary for FUK_DNMT3B

check button Fusion gene summary
Fusion gene informationFusion gene name: FUK_DNMT3B
Fusion gene ID: 14065
HgeneTgene
Gene symbol

FUK

DNMT3B

Gene ID

197258

1789

Gene namefucokinaseDNA methyltransferase 3 beta
Synonyms1110046B12RikICF|ICF1|M.HsaIIIB
Cytomap

16q22.1

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionL-fucose kinaseDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIB
Modification date2018052320180522
UniProtAcc

Q8N0W3

Q9UBC3

Ensembl transtripts involved in fusion geneENST00000288078, ENST00000428974, 
ENST00000571514, ENST00000378912, 
ENST00000328111, ENST00000348286, 
ENST00000353855, ENST00000443239, 
ENST00000344505, ENST00000375623, 
ENST00000456297, ENST00000201963, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FUK [Title/Abstract] AND DNMT3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB451208FUKchr16

70497624

+DNMT3Bchr20

31390240

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000288078ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000288078ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000288078ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000288078ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000428974ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000428974ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000428974ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-intronENST00000571514ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-intronENST00000571514ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-intronENST00000571514ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000378912ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000378912ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000378912ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+

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FusionProtFeatures for FUK_DNMT3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUK

Q8N0W3

DNMT3B

Q9UBC3

Takes part in the salvage pathway for reutilization offucose from the degradation of oligosaccharides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUK_DNMT3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0aa

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000288078_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000428974_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000328111_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000348286_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000353855_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000443239_chr20_31390240_+_0nt

>In-frame_FUK_ENST00000378912_chr16_70497624_+_DNMT3B_ENST00000344505_chr20_31390240_+_0nt


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FusionGenePPI for FUK_DNMT3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUK_DNMT3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUK_DNMT3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDNMT3BC0398788Immunodeficiency syndrome, variable10CTD_human;UNIPROT
TgeneDNMT3BC1458155Mammary Neoplasms2CTD_human
TgeneDNMT3BC0021051Immunologic Deficiency Syndromes1CTD_human;HPO
TgeneDNMT3BC0033578Prostatic Neoplasms1CTD_human
TgeneDNMT3BC0036341Schizophrenia1PSYGENET
TgeneDNMT3BC0038356Stomach Neoplasms1CTD_human
TgeneDNMT3BC0376634Craniofacial Abnormalities1CTD_human
TgeneDNMT3BC0525045Mood Disorders1PSYGENET
TgeneDNMT3BC1510586Autism Spectrum Disorders1CTD_human
TgeneDNMT3BC1656427early onset schizophrenia1PSYGENET
TgeneDNMT3BC1834671FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B1UNIPROT