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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14061

FusionGeneSummary for FUBP3_HERPUD1

check button Fusion gene summary
Fusion gene informationFusion gene name: FUBP3_HERPUD1
Fusion gene ID: 14061
HgeneTgene
Gene symbol

FUBP3

HERPUD1

Gene ID

8939

9709

Gene namefar upstream element binding protein 3homocysteine inducible ER protein with ubiquitin like domain 1
SynonymsFBP3HERP|Mif1|SUP
Cytomap

9q34.11-q34.12

16q13

Type of geneprotein-codingprotein-coding
Descriptionfar upstream element-binding protein 3FUSE-binding protein 3far upstream element (FUSE) binding protein 3homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinMMS-induciblehomocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 proteinhomocysteine-inducible, endoplasmic reticulum
Modification date2018051920180519
UniProtAcc

Q96I24

Q15011

Ensembl transtripts involved in fusion geneENST00000467100, ENST00000319725, 
ENST00000439977, ENST00000300302, 
ENST00000344114, ENST00000570273, 
ENST00000379792, 
Fusion gene scores* DoF score2 X 3 X 1=64 X 4 X 2=32
# samples 34
** MAII scorelog2(3/6*10)=2.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUBP3 [Title/Abstract] AND HERPUD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUBP3

GO:0006351

transcription, DNA-templated

8940189

HgeneFUBP3

GO:0010628

positive regulation of gene expression

19087307

HgeneFUBP3

GO:0045893

positive regulation of transcription, DNA-templated

8940189

HgeneFUBP3

GO:0045944

positive regulation of transcription by RNA polymerase II

8940189

TgeneHERPUD1

GO:0032469

endoplasmic reticulum calcium ion homeostasis

15102845|22045699

TgeneHERPUD1

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

15102845

TgeneHERPUD1

GO:1903071

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

22045699


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA920088FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000467100ENST00000439977FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
3UTR-5UTRENST00000467100ENST00000300302FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
3UTR-5UTRENST00000467100ENST00000344114FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
3UTR-3UTRENST00000467100ENST00000570273FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
3UTR-5UTRENST00000467100ENST00000379792FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
5UTR-5UTRENST00000319725ENST00000439977FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
5UTR-5UTRENST00000319725ENST00000300302FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
5UTR-5UTRENST00000319725ENST00000344114FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
5UTR-3UTRENST00000319725ENST00000570273FUBP3chr9

133455028

+HERPUD1chr16

56966147

+
5UTR-5UTRENST00000319725ENST00000379792FUBP3chr9

133455028

+HERPUD1chr16

56966147

+

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FusionProtFeatures for FUBP3_HERPUD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUBP3

Q96I24

HERPUD1

Q15011

May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation (ERAD)involved in ubiquitin-dependent degradation of misfoldedendoplasmic reticulum proteins. Could enhance presenilin-mediatedamyloid-beta protein 40 generation. Binds to ubiquilins and thisinteraction is required for efficient degradation of CD3D via theERAD pathway (PubMed:18307982). {ECO:0000269|PubMed:16289116,ECO:0000269|PubMed:18307982}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FUBP3_HERPUD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FUBP3_HERPUD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FUBP3_HERPUD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FUBP3_HERPUD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHERPUD1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneHERPUD1C0033578Prostatic Neoplasms1CTD_human