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Fusion gene ID: 14057 |
FusionGeneSummary for FUBP1_GPM6A |
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Fusion gene information | Fusion gene name: FUBP1_GPM6A | Fusion gene ID: 14057 | Hgene | Tgene | Gene symbol | FUBP1 | GPM6A | Gene ID | 8880 | 2823 |
Gene name | far upstream element binding protein 1 | glycoprotein M6A | |
Synonyms | FBP|FUBP|hDH V | GPM6|M6A | |
Cytomap | 1p31.1 | 4q34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | far upstream element-binding protein 1DNA helicase VFUSE binding protein 1far upstream element (FUSE) binding protein 1 | neuronal membrane glycoprotein M6-a | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96AE4 | P51674 | |
Ensembl transtripts involved in fusion gene | ENST00000489495, ENST00000370768, ENST00000370767, ENST00000436586, | ENST00000280187, ENST00000393658, ENST00000506894, ENST00000515090, ENST00000506219, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 4 X 2=32 |
# samples | 4 | 4 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FUBP1 [Title/Abstract] AND GPM6A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FUBP1 | GO:0010628 | positive regulation of gene expression | 19087307 |
Tgene | GPM6A | GO:0001764 | neuron migration | 19298174 |
Tgene | GPM6A | GO:0048863 | stem cell differentiation | 19298174 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA113820 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000489495 | ENST00000280187 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
intron-5UTR | ENST00000489495 | ENST00000393658 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
intron-intron | ENST00000489495 | ENST00000506894 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
intron-intron | ENST00000489495 | ENST00000515090 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
intron-intron | ENST00000489495 | ENST00000506219 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-5UTR | ENST00000370768 | ENST00000280187 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-5UTR | ENST00000370768 | ENST00000393658 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000370768 | ENST00000506894 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000370768 | ENST00000515090 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000370768 | ENST00000506219 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-5UTR | ENST00000370767 | ENST00000280187 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-5UTR | ENST00000370767 | ENST00000393658 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000370767 | ENST00000506894 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000370767 | ENST00000515090 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000370767 | ENST00000506219 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-5UTR | ENST00000436586 | ENST00000280187 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-5UTR | ENST00000436586 | ENST00000393658 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000436586 | ENST00000506894 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000436586 | ENST00000515090 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
5CDS-intron | ENST00000436586 | ENST00000506219 | FUBP1 | chr1 | 78433849 | - | GPM6A | chr4 | 176733402 | - |
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FusionProtFeatures for FUBP1_GPM6A |
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Hgene | Tgene |
FUBP1 | GPM6A |
Regulates MYC expression by binding to a single-strandedfar-upstream element (FUSE) upstream of the MYC promoter. May actboth as activator and repressor of transcription.{ECO:0000269|PubMed:8125259}. | Involved in neuronal differentiation, includingdifferentiation and migration of neuronal stem cells. Plays a rolein neuronal plasticity and is involved in neurite and filopodiaoutgrowth, filopodia motility and probably synapse formation.GPM6A-induced filopodia formation involves mitogen-activatedprotein kinase (MAPK) and Src signaling pathways. May be involvedin neuronal NGF-dependent Ca(2+) influx. May be involved inregulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization andrecycling of mu-type opioid receptor.{ECO:0000269|PubMed:19298174}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FUBP1_GPM6A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FUBP1_GPM6A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FUBP1 | SNCG, CELF1, CRMP1, CHD3, VIM, TLE1, SMN1, CCNH, GTF2H1, SRRM1, ELAVL1, CUL3, CDK2, COPS5, MYOC, USP22, MRPL32, MRPL41, PKM, MRPL38, MRPL2, MRPL46, DHX36, ITGA5, CRK, RPS15, SRSF3, PCBP1, CERS2, MRPL42, PGM1, PDCD6, FN1, VCAM1, ATF2, ITGA4, CD81, AIMP2, ACO1, CNN2, DDX19A, AARSD1, ACTR2, ACTR3, ARPC2, ARPC4, BAG1, NIF3L1, NSUN2, RPA1, RPRD1B, SH3GL1, GRPEL1, HIST1H2BO, LGALS1, PLD3, PPP5C, MDM2, CUL7, OBSL1, EED, ESR1, MAEL, ANXA11, ANXA2, CCDC58, CHORDC1, DUT, ARF4, ATP1B1, CAPG, CRIP1, FSCN1, GNB2L1, KYNU, LAP3, PIR, SMARCA2, SPR, TOMM40, FUBP3, NDUFS4, NME1, PCBP2, PPIC, PRDX2, PRDX5, RAB1A, SIN3A, SMARCC1, SMARCC2, NTRK1, PARK2, RAB32, CEP170P1, MCM2, SNW1, U2AF2, SMURF2, PDHA1, SOD1, TRIM25, YAP1 | GPM6A | PAM16, ZDHHC17, CCDC126, MGAT5, RMDN3, SLC35B2, AGPAT3, FITM2, ERMP1, HAX1, IKBIP, RFT1, UQCR10, YIPF3, FAM189B, SCAMP2, PXMP2, GP1BB, VKORC1L1, ZDHHC18, ARMC1, NUFIP1, DNAAF2, TSPAN17, EDA, GPR114, TSPAN3, HTR3A, VNN2, P2RY1, FKRP, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FUBP1_GPM6A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FUBP1_GPM6A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GPM6A | C0036341 | Schizophrenia | 1 | PSYGENET |