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Fusion gene ID: 14046 |
FusionGeneSummary for FTO_KIAA0430 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FTO_KIAA0430 | Fusion gene ID: 14046 | Hgene | Tgene | Gene symbol | FTO | KIAA0430 | Gene ID | 79068 |
Gene name | FTO, alpha-ketoglutarate dependent dioxygenase | ||
Synonyms | ALKBH9|BMIQ14|GDFD | ||
Cytomap | 16q12.2 | ||
Type of gene | protein-coding | ||
Description | alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9fat mass and obesity associatedfat mass and obesity-associated protein | ||
Modification date | 20180527 | ||
UniProtAcc | Q9C0B1 | ||
Ensembl transtripts involved in fusion gene | ENST00000471389, ENST00000394647, ENST00000431610, ENST00000460382, ENST00000463855, ENST00000472835, | ENST00000396368, ENST00000540441, ENST00000344181, ENST00000551742, ENST00000602337, ENST00000548025, ENST00000547936, | |
Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 4 X 4 X 3=48 |
# samples | 5 | 4 | |
** MAII score | log2(5/50*10)=0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FTO [Title/Abstract] AND KIAA0430 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FTO | GO:0006307 | DNA dealkylation involved in DNA repair | 18775698|20376003 |
Hgene | FTO | GO:0035552 | oxidative single-stranded DNA demethylation | 18775698|20376003 |
Hgene | FTO | GO:0035553 | oxidative single-stranded RNA demethylation | 18775698|22002720 |
Hgene | FTO | GO:0042245 | RNA repair | 18775698 |
Hgene | FTO | GO:0070989 | oxidative demethylation | 18775698 |
Hgene | FTO | GO:0080111 | DNA demethylation | 18775698 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW812420 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000471389 | ENST00000396368 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000471389 | ENST00000540441 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000471389 | ENST00000344181 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000471389 | ENST00000551742 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000471389 | ENST00000602337 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000471389 | ENST00000548025 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000471389 | ENST00000547936 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000396368 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000540441 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000344181 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000551742 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000602337 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000548025 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000394647 | ENST00000547936 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000396368 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000540441 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000344181 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000551742 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000602337 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000548025 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000431610 | ENST00000547936 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000396368 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000540441 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000344181 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000551742 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000602337 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000548025 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000460382 | ENST00000547936 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000396368 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000540441 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000344181 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000551742 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000602337 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000548025 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000463855 | ENST00000547936 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000396368 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000540441 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000344181 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000551742 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000602337 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000548025 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
intron-intron | ENST00000472835 | ENST00000547936 | FTO | chr16 | 54003345 | - | KIAA0430 | chr16 | 15713204 | + |
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FusionProtFeatures for FTO_KIAA0430 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FTO | KIAA0430 |
Dioxygenase that repairs alkylated DNA and RNA byoxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylaseactivity towards single-stranded DNA containing 1-methyladenine or3-methylcytosine (PubMed:18775698, PubMed:20376003). Specificallydemethylates N(6)-methyladenosine (m6A) RNA, the most prevalentinternal modification of messenger RNA (mRNA) in higher eukaryotes(PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-strandedDNA. Requires molecular oxygen, alpha-ketoglutarate and iron.Contributes to the regulation of the global metabolic rate, energyexpenditure and energy homeostasis. Contributes to the regulationof body size and body fat accumulation (PubMed:18775698,PubMed:20376003). In particular, it is involved in the regulationof thermogenesis and the control of adipocyte differentiation intobrown or white fat cells (PubMed:26287746).{ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003,ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26287746,ECO:0000269|PubMed:26458103}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FTO_KIAA0430 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FTO_KIAA0430 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FTO_KIAA0430 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | FTO | Q9C0B1 | DB11638 | Artenimol | Alpha-ketoglutarate-dependent dioxygenase FTO | small molecule | approved|investigational |
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RelatedDiseases for FTO_KIAA0430 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FTO | C0028754 | Obesity | 6 | CTD_human |
Hgene | FTO | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Hgene | FTO | C0011581 | Depressive disorder | 3 | PSYGENET |
Hgene | FTO | C2752001 | Growth Retardation, Developmental Delay, Coarse Facies, And Early Death | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | FTO | C0005910 | Body Weight | 2 | CTD_human |
Hgene | FTO | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | FTO | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | FTO | C0025202 | melanoma | 1 | CTD_human |
Hgene | FTO | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | FTO | C0525045 | Mood Disorders | 1 | PSYGENET |
Hgene | FTO | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | FTO | C2362324 | Pediatric Obesity | 1 | CTD_human |