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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14046

FusionGeneSummary for FTO_KIAA0430

check button Fusion gene summary
Fusion gene informationFusion gene name: FTO_KIAA0430
Fusion gene ID: 14046
HgeneTgene
Gene symbol

FTO

KIAA0430

Gene ID

79068

Gene nameFTO, alpha-ketoglutarate dependent dioxygenase
SynonymsALKBH9|BMIQ14|GDFD
Cytomap

16q12.2

Type of geneprotein-coding
Descriptionalpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9fat mass and obesity associatedfat mass and obesity-associated protein
Modification date20180527
UniProtAcc

Q9C0B1

Ensembl transtripts involved in fusion geneENST00000471389, ENST00000394647, 
ENST00000431610, ENST00000460382, 
ENST00000463855, ENST00000472835, 
ENST00000396368, ENST00000540441, 
ENST00000344181, ENST00000551742, 
ENST00000602337, ENST00000548025, 
ENST00000547936, 
Fusion gene scores* DoF score5 X 2 X 5=504 X 4 X 3=48
# samples 54
** MAII scorelog2(5/50*10)=0log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FTO [Title/Abstract] AND KIAA0430 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFTO

GO:0006307

DNA dealkylation involved in DNA repair

18775698|20376003

HgeneFTO

GO:0035552

oxidative single-stranded DNA demethylation

18775698|20376003

HgeneFTO

GO:0035553

oxidative single-stranded RNA demethylation

18775698|22002720

HgeneFTO

GO:0042245

RNA repair

18775698

HgeneFTO

GO:0070989

oxidative demethylation

18775698

HgeneFTO

GO:0080111

DNA demethylation

18775698


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW812420FTOchr16

54003345

-KIAA0430chr16

15713204

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000471389ENST00000396368FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000471389ENST00000540441FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000471389ENST00000344181FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000471389ENST00000551742FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000471389ENST00000602337FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000471389ENST00000548025FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000471389ENST00000547936FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000396368FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000540441FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000344181FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000551742FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000602337FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000548025FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000394647ENST00000547936FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000396368FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000540441FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000344181FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000551742FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000602337FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000548025FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000431610ENST00000547936FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000396368FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000540441FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000344181FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000551742FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000602337FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000548025FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000460382ENST00000547936FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000396368FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000540441FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000344181FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000551742FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000602337FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000548025FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000463855ENST00000547936FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000396368FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000540441FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000344181FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000551742FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000602337FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000548025FTOchr16

54003345

-KIAA0430chr16

15713204

+
intron-intronENST00000472835ENST00000547936FTOchr16

54003345

-KIAA0430chr16

15713204

+

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FusionProtFeatures for FTO_KIAA0430


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FTO

Q9C0B1

KIAA0430

Dioxygenase that repairs alkylated DNA and RNA byoxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylaseactivity towards single-stranded DNA containing 1-methyladenine or3-methylcytosine (PubMed:18775698, PubMed:20376003). Specificallydemethylates N(6)-methyladenosine (m6A) RNA, the most prevalentinternal modification of messenger RNA (mRNA) in higher eukaryotes(PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-strandedDNA. Requires molecular oxygen, alpha-ketoglutarate and iron.Contributes to the regulation of the global metabolic rate, energyexpenditure and energy homeostasis. Contributes to the regulationof body size and body fat accumulation (PubMed:18775698,PubMed:20376003). In particular, it is involved in the regulationof thermogenesis and the control of adipocyte differentiation intobrown or white fat cells (PubMed:26287746).{ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003,ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:26287746,ECO:0000269|PubMed:26458103}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FTO_KIAA0430


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FTO_KIAA0430


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FTO_KIAA0430


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFTOQ9C0B1DB11638ArtenimolAlpha-ketoglutarate-dependent dioxygenase FTOsmall moleculeapproved|investigational

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RelatedDiseases for FTO_KIAA0430


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFTOC0028754Obesity6CTD_human
HgeneFTOC0001973Alcoholic Intoxication, Chronic3PSYGENET
HgeneFTOC0011581Depressive disorder3PSYGENET
HgeneFTOC2752001Growth Retardation, Developmental Delay, Coarse Facies, And Early Death3CTD_human;ORPHANET;UNIPROT
HgeneFTOC0005910Body Weight2CTD_human
HgeneFTOC0011570Mental Depression2PSYGENET
HgeneFTOC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneFTOC0025202melanoma1CTD_human
HgeneFTOC0043094Weight Gain1CTD_human
HgeneFTOC0525045Mood Disorders1PSYGENET
HgeneFTOC1458155Mammary Neoplasms1CTD_human
HgeneFTOC2362324Pediatric Obesity1CTD_human