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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14045

FusionGeneSummary for FTL_TUBA1B

check button Fusion gene summary
Fusion gene informationFusion gene name: FTL_TUBA1B
Fusion gene ID: 14045
HgeneTgene
Gene symbol

FTL

TUBA1B

Gene ID

2512

10376

Gene nameferritin light chaintubulin alpha 1b
SynonymsLFTD|NBIA3K-ALPHA-1
Cytomap

19q13.33

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionferritin light chainferritin L subunitferritin L-chainferritin light polypeptide-like 3ferritin, light polypeptidetubulin alpha-1B chainalpha tubulinalpha-tubulin ubiquitoustubulin K-alpha-1tubulin alpha-ubiquitous chaintubulin, alpha, ubiquitous
Modification date2018052320180523
UniProtAcc

P02792

P68363

Ensembl transtripts involved in fusion geneENST00000331825, ENST00000336023, 
Fusion gene scores* DoF score13 X 16 X 4=8328 X 7 X 3=168
# samples 179
** MAII scorelog2(17/832*10)=-2.29104878200339
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FTL [Title/Abstract] AND TUBA1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1H93515FTLchr19

49468779

+TUBA1Bchr12

49522573

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000331825ENST00000336023FTLchr19

49468779

+TUBA1Bchr12

49522573

-

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FusionProtFeatures for FTL_TUBA1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FTL

P02792

TUBA1B

P68363

Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FTL_TUBA1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FTL_ENST00000331825_chr19_49468779_+_TUBA1B_ENST00000336023_chr12_49522573_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FTL_ENST00000331825_chr19_49468779_+_TUBA1B_ENST00000336023_chr12_49522573_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_FTL_ENST00000331825_chr19_49468779_+_TUBA1B_ENST00000336023_chr12_49522573_-_0nt


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FusionGenePPI for FTL_TUBA1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FTL_TUBA1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FTL_TUBA1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFTLC0011581Depressive disorder1CTD_human
HgeneFTLC0012715Iron Metabolism Disorders1CTD_human
HgeneFTLC0022548Keloid1CTD_human
HgeneFTLC0027626Neoplasm Invasiveness1CTD_human
HgeneFTLC0027627Neoplasm Metastasis1CTD_human
HgeneFTLC0028754Obesity1CTD_human
HgeneFTLC0029408Degenerative polyarthritis1CTD_human
HgeneFTLC0033975Psychotic Disorders1PSYGENET
HgeneFTLC0349204Nonorganic psychosis1PSYGENET
HgeneFTLC0751870Heredodegenerative Disorders, Nervous System1CTD_human
HgeneFTLC1833213Hyperferritinemia, hereditary, with congenital cataracts1CTD_human;ORPHANET;UNIPROT
HgeneFTLC1853578Neuroferritinopathy1CTD_human;ORPHANET;UNIPROT
TgeneTUBA1BC0029456Osteoporosis1CTD_human