FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14013

FusionGeneSummary for FSTL1_CPOX

check button Fusion gene summary
Fusion gene informationFusion gene name: FSTL1_CPOX
Fusion gene ID: 14013
HgeneTgene
Gene symbol

FSTL1

CPOX

Gene ID

11167

1371

Gene namefollistatin like 1coproporphyrinogen oxidase
SynonymsFRP|FSL1|MIR198|OCC-1|OCC1|tsc36CPO|CPX|HCP
Cytomap

3q13.33

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionfollistatin-related protein 1follistatin-like protein 1oxygen-dependent coproporphyrinogen-III oxidase, mitochondrialCOXcoprogen oxidasecoproporphyrinogenase
Modification date2018051920180523
UniProtAcc

Q12841

P36551

Ensembl transtripts involved in fusion geneENST00000295633, ENST00000424703, 
ENST00000485968, 
ENST00000264193, 
Fusion gene scores* DoF score8 X 7 X 2=1122 X 2 X 1=4
# samples 82
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: FSTL1 [Title/Abstract] AND CPOX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-PC-A5DM-01AFSTL1chr3

120128379

-CPOXchr3

98304503

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000295633ENST00000264193FSTL1chr3

120128379

-CPOXchr3

98304503

-
Frame-shitENST00000424703ENST00000264193FSTL1chr3

120128379

-CPOXchr3

98304503

-
intron-3CDSENST00000485968ENST00000264193FSTL1chr3

120128379

-CPOXchr3

98304503

-

Top

FusionProtFeatures for FSTL1_CPOX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FSTL1

Q12841

CPOX

P36551

May modulate the action of some growth factors on cellproliferation and differentiation. Binds heparin (By similarity).{ECO:0000250}. Involved in the heme biosynthesis. Catalyzes the aerobicoxidative decarboxylation of propionate groups of rings A and B ofcoproporphyrinogen-III to yield the vinyl groups inprotoporphyrinogen-IX.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FSTL1_CPOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FSTL1_CPOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FSTL1APPBP2, DNASE2B, SGCA, WNT10B, CRK, GPR114, IL12A, LYZL2, LRRC4C, PRG3, WNT4, ADAM33, FBXO6, FBXL14, WNT5A, WNT7A, SCGB1D2, TM2D3, PRELP, INSL6, DEFA1, ZPBP2, CHST8, SCGB2A2, DEFB121, XCL1, MTNR1A, MTNR1BCPOXELAVL1, CUL3, FH, AIFM1, UBE2G2, C10orf2, TRNT1, YARS, TCF4, MCM2, ATOH1, DUSP13, STYX, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FSTL1_CPOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FSTL1_CPOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFSTL1C0003504Aortic Valve Insufficiency1CTD_human
HgeneFSTL1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFSTL1C0036341Schizophrenia1PSYGENET
HgeneFSTL1C0043094Weight Gain1CTD_human
HgeneFSTL1C2609414Acute kidney injury1CTD_human
TgeneCPOXC0162531Hereditary Coproporphyria10CTD_human;ORPHANET;UNIPROT
TgeneCPOXC0162566Porphyria Cutanea Tarda1CTD_human