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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14000

FusionGeneSummary for FSCN1_CLIC2

check button Fusion gene summary
Fusion gene informationFusion gene name: FSCN1_CLIC2
Fusion gene ID: 14000
HgeneTgene
Gene symbol

FSCN1

CLIC2

Gene ID

6624

1193

Gene namefascin actin-bundling protein 1chloride intracellular channel 2
SynonymsFAN1|HSN|SNL|p55CLIC2b|MRXS32|XAP121
Cytomap

7p22.1

Xq28

Type of geneprotein-codingprotein-coding
Descriptionfascin55 kDa actin-bundling proteinfascin homolog 1, actin-bundling proteinsinged-like (fascin homolog, sea urchin)chloride intracellular channel protein 2
Modification date2018052320180523
UniProtAcc

Q16658

O15247

Ensembl transtripts involved in fusion geneENST00000340250, ENST00000382361, 
ENST00000369449, ENST00000465553, 
Fusion gene scores* DoF score5 X 4 X 4=802 X 2 X 2=8
# samples 62
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FSCN1 [Title/Abstract] AND CLIC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFSCN1

GO:0007043

cell-cell junction assembly

9571235

HgeneFSCN1

GO:0010592

positive regulation of lamellipodium assembly

9571235

HgeneFSCN1

GO:0030035

microspike assembly

9571235

HgeneFSCN1

GO:0030036

actin cytoskeleton organization

9571235

HgeneFSCN1

GO:0032534

regulation of microvillus assembly

9571235

HgeneFSCN1

GO:0032956

regulation of actin cytoskeleton organization

20137952

HgeneFSCN1

GO:0035089

establishment of apical/basal cell polarity

9571235

HgeneFSCN1

GO:0048870

cell motility

9571235

HgeneFSCN1

GO:0051017

actin filament bundle assembly

20393565

HgeneFSCN1

GO:0051491

positive regulation of filopodium assembly

9571235

HgeneFSCN1

GO:0071803

positive regulation of podosome assembly

20137952

HgeneFSCN1

GO:0090091

positive regulation of extracellular matrix disassembly

20137952

TgeneCLIC2

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

15147738|15916532

TgeneCLIC2

GO:0051099

positive regulation of binding

15916532

TgeneCLIC2

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

15147738|15916532


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-JV-A75J-01AFSCN1chr7

5633399

+CLIC2chrX

154528458

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340250ENST00000369449FSCN1chr7

5633399

+CLIC2chrX

154528458

-
5CDS-5UTRENST00000340250ENST00000465553FSCN1chr7

5633399

+CLIC2chrX

154528458

-
Frame-shiftENST00000382361ENST00000369449FSCN1chr7

5633399

+CLIC2chrX

154528458

-
5CDS-5UTRENST00000382361ENST00000465553FSCN1chr7

5633399

+CLIC2chrX

154528458

-

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FusionProtFeatures for FSCN1_CLIC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FSCN1

Q16658

CLIC2

O15247

Organizes filamentous actin into bundles with a minimumof 4.1:1 actin/fascin ratio. Plays a role in the organization ofactin filament bundles and the formation of microspikes, membraneruffles, and stress fibers. Important for the formation of adiverse set of cell protrusions, such as filopodia, and for cellmotility and migration. {ECO:0000269|PubMed:20137952,ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:9362073,ECO:0000269|PubMed:9571235}. Can insert into membranes and form chloride ionchannels. Channel activity depends on the pH. Membrane insertionseems to be redox-regulated and may occur only under oxydizingconditions. Modulates the activity of RYR2 and inhibits calciuminflux. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532,ECO:0000269|PubMed:17945253}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FSCN1_CLIC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FSCN1_CLIC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FSCN1GNAS, VHL, PRKCA, NGFR, RAB1A, DNAJB9, ACTA1, MAPK8IP2, SIRT7, CDK2, ACTA2, AIFM1, SEPT11, ZYX, CNN2, FN1, VCAM1, ATF2, IQCB1, MAPK7, YWHAQ, ASS1, COTL1, CRYZ, AK2, IMPA2, FUBP1, MIF, PCBP1, PRDX1, PRDX2, TKT, NTRK1, DBN1, FLNA, ANLN, MCM2, SMURF1, CDH1, DLST, TRIM25, G3BP1, TESCLIC2TRAPPC2, NEDD4, NEDD4L, FN1, CLIC4, CLIC5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FSCN1_CLIC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FSCN1_CLIC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLIC2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCLIC2C3550913MENTAL RETARDATION, X-LINKED, SYNDROMIC 321ORPHANET;UNIPROT