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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 140

FusionGeneSummary for ABCC1_DLGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC1_DLGAP1
Fusion gene ID: 140
HgeneTgene
Gene symbol

ABCC1

DLGAP1

Gene ID

4363

9229

Gene nameATP binding cassette subfamily C member 1DLG associated protein 1
SynonymsABC29|ABCC|GS-X|MRP|MRP1DAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1
Cytomap

16p13.11

18p11.31

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 1ATP-binding cassette transporter variant ABCC1delta-ex13ATP-binding cassette transporter variant ABCC1delta-ex13&14ATP-binding cassette transporter variant ABCC1delta-ex25ATP-binding cassette transporter variandisks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated protein
Modification date2018052320180519
UniProtAcc

P33527

O14490

Ensembl transtripts involved in fusion geneENST00000399410, ENST00000349029, 
ENST00000351154, ENST00000399408, 
ENST00000345148, ENST00000346370, 
ENST00000576557, 		ENST00000315677, 
ENST00000581527, ENST00000400147, 
ENST00000400149, ENST00000400155, 
ENST00000400150, ENST00000584874, 
ENST00000534970, ENST00000539435, 
ENST00000581699, ENST00000400145, 
ENST00000515196, ENST00000478161, 
Fusion gene scores* DoF score6 X 6 X 4=14414 X 11 X 7=1078
# samples 615
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1078*10)=-2.84532277225662
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC1 [Title/Abstract] AND DLGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-7723-01AABCC1chr16

16043656

+DLGAP1chr18

3582246

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000399410ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399410ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399410ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399410ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000349029ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000349029ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000349029ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000349029ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000351154ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000351154ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000351154ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000351154ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399408ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399408ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000399408ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000399408ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000345148ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000345148ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000345148ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000345148ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000346370ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000346370ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
Frame-shiftENST00000346370ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
5CDS-intronENST00000346370ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-3CDSENST00000576557ENST00000315677ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-3CDSENST00000576557ENST00000581527ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-3CDSENST00000576557ENST00000400147ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000400149ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000400155ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000400150ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000584874ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000534970ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000539435ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000581699ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000400145ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000515196ABCC1chr16

16043656

+DLGAP1chr18

3582246

-
intron-intronENST00000576557ENST00000478161ABCC1chr16

16043656

+DLGAP1chr18

3582246

-

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FusionProtFeatures for ABCC1_DLGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC1

P33527

DLGAP1

O14490


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABCC1_DLGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABCC1_DLGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABCC1TMEM173, UNC93B1, EIF3C, NDUFAF3, PUF60, MRPL17, NDUFB9, RPS7, VDAC3, TMX2, TMCO1, MCU, PGRMC2, RAVER1, STX4, FLOT1, ATP6V1F, DBT, FKBP8, STT3B, PDHX, SURF1, PDCD6IP, ATP6V1H, SAFB, TMOD2, AZGP1, NPM1, TRAF3, ABCC1, CAV1, CANX, CLGN, FASN, IDH3A, NFS1, PAICS, TMEM33, VCP, ECHS1, HNRNPL, PSMC5, PSMD2, PTGES3, SEC63, VDAC1, VDAC2, NTRK1, TMEM17, ATP5A1, EEF1A1, CSNK2A1, CTDSPL, LGALS8, TRIM25DLGAP1SHANK1, DYNLL2, DYNLL1, MYO5A, DLG2, SHANK2, DLG4, DLG1, DLG3, GRIN2A, CTNNB1, APC, SHANK3, SORBS2, GRB2, ITSN1, ITSN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ABCC1_DLGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneABCC1P33527DB01138SulfinpyrazoneMultidrug resistance-associated protein 1small moleculeapproved
HgeneABCC1P33527DB06176RomidepsinMultidrug resistance-associated protein 1small moleculeapproved|investigational

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RelatedDiseases for ABCC1_DLGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC1C0009404Colorectal Neoplasms1CTD_human
HgeneABCC1C0018799Heart Diseases1CTD_human
HgeneABCC1C0020538Hypertensive disease1CTD_human
HgeneABCC1C0031117Peripheral Neuropathy1CTD_human
HgeneABCC1C0041755Adverse reaction to drug1CTD_human
HgeneABCC1C1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneABCC1C1458155Mammary Neoplasms1CTD_human
HgeneABCC1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneDLGAP1C0036341Schizophrenia3PSYGENET