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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13998

FusionGeneSummary for FRZB_SDC2

check button Fusion gene summary
Fusion gene informationFusion gene name: FRZB_SDC2
Fusion gene ID: 13998
HgeneTgene
Gene symbol

FRZB

SDC2

Gene ID

2487

6383

Gene namefrizzled related proteinsyndecan 2
SynonymsFRE|FRITZ|FRP-3|FRZB-1|FRZB-PEN|FRZB1|FZRB|OS1|SFRP3|SRFP3|hFIZCD362|HSPG|HSPG1|SYND2
Cytomap

2q32.1

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionsecreted frizzled-related protein 3frezzledfrizzled homolog-relatedfrizzled-related protein 1sFRP-3syndecan-2cell surface-associated heparan sulfate proteoglycan 1fibroglycanheparan sulfate proteoglycan 1, cell surface-associatedheparan sulfate proteoglycan core proteinsyndecan proteoglycan 2
Modification date2018052320180523
UniProtAcc

Q92765

P34741

Ensembl transtripts involved in fusion geneENST00000295113, ENST00000302190, 
ENST00000520233, ENST00000518385, 
ENST00000522911, ENST00000519914, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 4 X 2=24
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FRZB [Title/Abstract] AND SDC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFRZB

GO:0008285

negative regulation of cell proliferation

20208569

HgeneFRZB

GO:0030178

negative regulation of Wnt signaling pathway

20208569

HgeneFRZB

GO:0030308

negative regulation of cell growth

20208569

HgeneFRZB

GO:0045600

positive regulation of fat cell differentiation

12055200

HgeneFRZB

GO:0090090

negative regulation of canonical Wnt signaling pathway

17471511


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI366039FRZBchr2

183699376

+SDC2chr8

97622731

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000295113ENST00000302190FRZBchr2

183699376

+SDC2chr8

97622731

-
intron-intronENST00000295113ENST00000520233FRZBchr2

183699376

+SDC2chr8

97622731

-
intron-intronENST00000295113ENST00000518385FRZBchr2

183699376

+SDC2chr8

97622731

-
intron-intronENST00000295113ENST00000522911FRZBchr2

183699376

+SDC2chr8

97622731

-
intron-intronENST00000295113ENST00000519914FRZBchr2

183699376

+SDC2chr8

97622731

-

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FusionProtFeatures for FRZB_SDC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRZB

Q92765

SDC2

P34741

Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP3/FRZB appears to be involved in limbskeletogenesis. Antagonist of Wnt8 signaling. Regulateschondrocyte maturation and long bone development. Cell surface proteoglycan that bears heparan sulfate.Regulates dendritic arbor morphogenesis (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRZB_SDC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRZB_SDC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRZB_SDC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSDC2P34741DB00020SargramostimSyndecan-2biotechapproved|investigational

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RelatedDiseases for FRZB_SDC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRZBC3887876OSTEOARTHRITIS SUSCEPTIBILITY 11UNIPROT