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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13935

FusionGeneSummary for FRS2_CDK4

check button Fusion gene summary
Fusion gene informationFusion gene name: FRS2_CDK4
Fusion gene ID: 13935
HgeneTgene
Gene symbol

FRS2

CDK4

Gene ID

10818

1019

Gene namefibroblast growth factor receptor substrate 2cyclin dependent kinase 4
SynonymsFRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1CMM3|PSK-J3
Cytomap

12q15

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTsuc1-associated neurotrophic factor target 1cyclin-dependent kinase 4cell division protein kinase 4
Modification date2018052220180523
UniProtAcc

Q8WU20

P11802

Ensembl transtripts involved in fusion geneENST00000299293, ENST00000549921, 
ENST00000550389, ENST00000397997, 
ENST00000257904, ENST00000312990, 
ENST00000549606, ENST00000540325, 
ENST00000551888, 
Fusion gene scores* DoF score56 X 9 X 12=60487 X 2 X 3=42
# samples 476
** MAII scorelog2(47/6048*10)=-3.68572547765607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/42*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FRS2 [Title/Abstract] AND CDK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK4

GO:0006468

protein phosphorylation

8114739

TgeneCDK4

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

19124461

TgeneCDK4

GO:0071157

negative regulation of cell cycle arrest

19124461


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-3B-A9HJ-01AFRS2chr12

69931763

+CDK4chr12

58145519

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000299293ENST00000257904FRS2chr12

69931763

+CDK4chr12

58145519

-
5UTR-5UTRENST00000299293ENST00000312990FRS2chr12

69931763

+CDK4chr12

58145519

-
5UTR-intronENST00000299293ENST00000549606FRS2chr12

69931763

+CDK4chr12

58145519

-
5UTR-5UTRENST00000299293ENST00000540325FRS2chr12

69931763

+CDK4chr12

58145519

-
5UTR-5UTRENST00000299293ENST00000551888FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000549921ENST00000257904FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000549921ENST00000312990FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-intronENST00000549921ENST00000549606FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000549921ENST00000540325FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000549921ENST00000551888FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000550389ENST00000257904FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000550389ENST00000312990FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-intronENST00000550389ENST00000549606FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000550389ENST00000540325FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000550389ENST00000551888FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000397997ENST00000257904FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000397997ENST00000312990FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-intronENST00000397997ENST00000549606FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000397997ENST00000540325FRS2chr12

69931763

+CDK4chr12

58145519

-
intron-5UTRENST00000397997ENST00000551888FRS2chr12

69931763

+CDK4chr12

58145519

-

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FusionProtFeatures for FRS2_CDK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRS2

Q8WU20

CDK4

P11802

Adapter protein that links activated FGR and NGFreceptors to downstream signaling pathways. Plays an importantrole in the activation of MAP kinases and in the phosphorylationof PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1.Modulates signaling via SHC1 by competing for a common bindingsite on NTRK1. {ECO:0000269|PubMed:12974390,ECO:0000269|PubMed:21765395}. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexesthat phosphorylate and inhibit members of the retinoblastoma (RB)protein family including RB1 and regulate the cell-cycle duringG(1)/S transition. Phosphorylation of RB1 allows dissociation ofthe transcription factor E2F from the RB/E2F complexes and thesubsequent transcription of E2F target genes which are responsiblefor the progression through the G(1) phase. Hypophosphorylates RB1in early G(1) phase. Cyclin D-CDK4 complexes are major integratorsof various mitogenenic and antimitogenic signals. Alsophosphorylates SMAD3 in a cell-cycle-dependent manner andrepresses its transcriptional activity. Component of the ternarycomplex, cyclin D/CDK4/CDKN1B, required for nuclear translocationand activity of the cyclin D-CDK4 complex.{ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403,ECO:0000269|PubMed:9003781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRS2_CDK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRS2_CDK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FRS2PTPN11, INSR, SOS1, GRB2, CBL, FGFR1, CRK, NTRK1, NTRK2, NTRK3, RET, PRKCI, FGFR2, FLOT1, SORBS1, SPRY2, LYN, BECN1, RPS6, TMEM17, GAB1, GAB2, CDH1, TRIM25CDK4CDKN2D, VTA1, CDKN2B, CCND3, CDKN2C, CDC37, CDKN2A, RPRM, ACTR3B, DBNL, SMC3, GEMIN4, UBXN1, SMC1A, LYN, SERTAD1, BAG6, SETDB1, CAPNS1, CCND1, PCNA, CCND2, CDKN1B, CNOT7, RFC1, BRCA1, CEBPA, MYOD1, BIRC5, CDKN1A, RB1, SP1, SAP25, CDT1, HSPA8, NCOA2, TSPYL2, WDR77, PRMT5, ARID4A, PPP2R1B, PPP2R1A, UHRF2, IRF8, DAZAP2, SNCA, TK1, APLP1, DDAH2, ZBTB16, QARS, HMGXB3, TRMT2A, ATP5B, PKM, LUC7L2, ANXA7, HSP90AA1, HIST1H1D, PSMD9, HIST1H1A, CDK5R1, ARRB2, MARCKS, RPL34, PSMA6, CCNE1, CCNA2, PPP1CA, CUL3, CUL4B, CUL1, COPS5, COPS6, H1F0, PSMD10, APP, UBTF, POLD1, VCP, SMAD3, SMAD2, FOXM1, CDC6, GLI1, MYC, OTX2, RBL1, RBL2, SHOX2, MZF1, SLBP, ANKRD12, SENP3, ZNF219, BCL11A, WDR33, ZNF335, ZNF101, MCM2, CDC7, UCHL1, KLHL32, CAMK1, PTMA, IL15RA, DUSP9, PGD, SKP1, CIB1, MAPRE2, CDK13, TARDBP, HSP90AB1, CDK6, TRAP1, FKBP5, RELA, HOOK1, LIMK2, RCAN3, HSP90AB4P, HSP90AB3P, HSP90AA5P, OGFR, EIF1AX, GUSB, OGFRL1, JAK3, GFER, VSIG8, NTRK1, ANKRA2, CEP135, IQGAP1, SMTN, SORBS1, NUP133, ZNFX1, ZC3H14, TMEM126A, ASPM, UBXN10, VHL, HDAC1, PRKDC, CHEK2, ERBB2, BCL2, TOP1, PTEN, YBX3, USP17L2, FNIP1, FNIP2, MTMR14, MTMR8, VTN, PTPN1, PTPN21, DNAJC9, E2F4, CDKN1C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRS2_CDK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCDK4P11802DB09073PalbociclibCyclin-dependent kinase 4small moleculeapproved|investigational

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RelatedDiseases for FRS2_CDK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDK4C0024668Mammary Neoplasms, Experimental3CTD_human
TgeneCDK4C1836892MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 33CTD_human;UNIPROT
TgeneCDK4C0023827liposarcoma2CTD_human
TgeneCDK4C0024667Animal Mammary Neoplasms2CTD_human
TgeneCDK4C0006118Brain Neoplasms1CTD_human
TgeneCDK4C0027659Neoplasms, Experimental1CTD_human
TgeneCDK4C0038356Stomach Neoplasms1CTD_human
TgeneCDK4C0677866Brain Stem Neoplasms1CTD_human
TgeneCDK4C2239176Liver carcinoma1CTD_human