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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13901

FusionGeneSummary for FRMD4B_TRAK1

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD4B_TRAK1
Fusion gene ID: 13901
HgeneTgene
Gene symbol

FRMD4B

TRAK1

Gene ID

23150

22906

Gene nameFERM domain containing 4Btrafficking kinesin protein 1
Synonyms6030440G05Rik|GRSP1MILT1|OIP106
Cytomap

3p14.1

3p22.1

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 4BGRP1-binding protein GRSP1trafficking kinesin-binding protein 1106 kDa O-GlcNAc transferase-interacting proteinO-linked N-acetylglucosamine transferase interacting protein 106OGT(O-Glc-NAc transferase)-interacting protein 106 KDamilton homolog 1trafficking protein, kinesin bi
Modification date2018051920180523
UniProtAcc

Q9Y2L6

Q9UPV9

Ensembl transtripts involved in fusion geneENST00000398540, ENST00000542259, 
ENST00000497757, ENST00000478263, 
ENST00000487159, ENST00000327628, 
ENST00000449246, ENST00000341421, 
ENST00000396175, 
Fusion gene scores* DoF score8 X 6 X 6=2884 X 4 X 3=48
# samples 84
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD4B [Title/Abstract] AND TRAK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRAK1

GO:0008333

endosome to lysosome transport

18675823


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHCATCGA-DJ-A4UR-01AFRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000398540ENST00000487159FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000398540ENST00000327628FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000398540ENST00000449246FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000398540ENST00000341421FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000398540ENST00000396175FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-3UTRENST00000542259ENST00000487159FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000542259ENST00000327628FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000542259ENST00000449246FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000542259ENST00000341421FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000542259ENST00000396175FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-3UTRENST00000497757ENST00000487159FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000497757ENST00000327628FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000497757ENST00000449246FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000497757ENST00000341421FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000497757ENST00000396175FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-3UTRENST00000478263ENST00000487159FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000478263ENST00000327628FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000478263ENST00000449246FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000478263ENST00000341421FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+
intron-intronENST00000478263ENST00000396175FRMD4Bchr3

69591357

-TRAK1chr3

42128596

+

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FusionProtFeatures for FRMD4B_TRAK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD4B

Q9Y2L6

TRAK1

Q9UPV9

Member of GRP1 signaling complexes that are acutelyrecruited to plasma membrane ruffles in response to insulinreceptor signaling. May function as a scaffolding protein thatregulates epithelial cell polarity by connecting ARF6 activationwith the PAR3 complex. Plays a redundant role with FRMD4A inepithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. Involved in the regulation of endosome-to-lysosometrafficking, including endocytic trafficking of EGF-EGFR complexesand GABA-A receptors. {ECO:0000269|PubMed:18675823}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRMD4B_TRAK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRMD4B_TRAK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FRMD4BXPO1TRAK1OGT, TRAK2, CDC5L, TRAF3IP1, HGS, CDK6, SKIL, XPO1, HDAC1, KIF5B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRMD4B_TRAK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRMD4B_TRAK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRAK1C0036341Schizophrenia1CTD_human