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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13886

FusionGeneSummary for FRMD3_MYH11

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD3_MYH11
Fusion gene ID: 13886
HgeneTgene
Gene symbol

FRMD3

MYH11

Gene ID

257019

4629

Gene nameFERM domain containing 3myosin heavy chain 11
Synonyms4.1O|EPB41L4O|EPB41LO|P410AAT4|FAA4|SMHC|SMMHC
Cytomap

9q21.32

16p13.11

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 3band 4.1-like protein 4band 4.1-like protein 4Oovary type protein 4.1protein 4.1Omyosin-11myosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle
Modification date2018052320180519
UniProtAcc

A2A2Y4

P35749

Ensembl transtripts involved in fusion geneENST00000376438, ENST00000304195, 
ENST00000328788, ENST00000376434, 
ENST00000465485, 
ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000300036, ENST00000573908, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 15 X 6=990
# samples 321
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(21/990*10)=-2.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD3 [Title/Abstract] AND MYH11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW835471FRMD3chr9

86094301

+MYH11chr16

15835419

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000376438ENST00000396324FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376438ENST00000452625FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376438ENST00000576790FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376438ENST00000300036FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-intronENST00000376438ENST00000573908FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000304195ENST00000396324FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000304195ENST00000452625FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000304195ENST00000576790FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000304195ENST00000300036FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-intronENST00000304195ENST00000573908FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000328788ENST00000396324FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000328788ENST00000452625FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000328788ENST00000576790FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000328788ENST00000300036FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-intronENST00000328788ENST00000573908FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376434ENST00000396324FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376434ENST00000452625FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376434ENST00000576790FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000376434ENST00000300036FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-intronENST00000376434ENST00000573908FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000465485ENST00000396324FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000465485ENST00000452625FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000465485ENST00000576790FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-3CDSENST00000465485ENST00000300036FRMD3chr9

86094301

+MYH11chr16

15835419

-
intron-intronENST00000465485ENST00000573908FRMD3chr9

86094301

+MYH11chr16

15835419

-

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FusionProtFeatures for FRMD3_MYH11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD3

A2A2Y4

MYH11

P35749

Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRMD3_MYH11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRMD3_MYH11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRMD3_MYH11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRMD3_MYH11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRMD3C0263454Chloracne1CTD_human
TgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneMYH11C0023479Acute myelomonocytic leukemia1CTD_human;ORPHANET
TgeneMYH11C1851504Aortic aneurysm, familial thoracic 41CTD_human;UNIPROT