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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 13885

FusionGeneSummary for FRMD3_BRD4

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD3_BRD4
Fusion gene ID: 13885
HgeneTgene
Gene symbol

FRMD3

BRD4

Gene ID

257019

23476

Gene nameFERM domain containing 3bromodomain containing 4
Synonyms4.1O|EPB41L4O|EPB41LO|P410CAP|HUNK1|HUNKI|MCAP
Cytomap

9q21.32

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 3band 4.1-like protein 4band 4.1-like protein 4Oovary type protein 4.1protein 4.1Obromodomain-containing protein 4chromosome-associated protein
Modification date2018052320180522
UniProtAcc

A2A2Y4

O60885

Ensembl transtripts involved in fusion geneENST00000376438, ENST00000304195, 
ENST00000328788, ENST00000376434, 
ENST00000465485, 		ENST00000263377, 
ENST00000371835, ENST00000360016, 
ENST00000602230, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 10 X 6=480
# samples 312
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD3 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD4

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

19103749|23086925

TgeneBRD4

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19103749

TgeneBRD4

GO:0045944

positive regulation of transcription by RNA polymerase II

23086925|23317504

TgeneBRD4

GO:0050727

regulation of inflammatory response

19103749

TgeneBRD4

GO:1901407

regulation of phosphorylation of RNA polymerase II C-terminal domain

23086925


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A14N-01AFRMD3chr9

85987828

-BRD4chr19

15365073

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000376438ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000376438ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000376438ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
5CDS-intronENST00000376438ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000304195ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000304195ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000304195ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
5CDS-intronENST00000304195ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000328788ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000328788ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000328788ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-intronENST00000328788ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000376434ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000376434ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000376434ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-intronENST00000376434ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000465485ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000465485ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000465485ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-intronENST00000465485ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-

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FusionProtFeatures for FRMD3_BRD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD3

A2A2Y4

BRD4

O60885

Chromatin reader protein that recognizes and bindsacetylated histones and plays a key role in transmission ofepigenetic memory across cell divisions and transcriptionregulation. Remains associated with acetylated chromatinthroughout the entire cell cycle and provides epigenetic memoryfor postmitotic G1 gene transcription by preserving acetylatedchromatin status and maintaining high-order chromatin structure.During interphase, plays a key role in regulating thetranscription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required toform the transcriptionally active P-TEFb complex by displacingnegative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can thenphosphorylate the C-terminal domain (CTD) of RNA polymerase II.Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD)of RNA polymerase II. According to a report, directly acts as anatypical protein kinase and mediates phosphorylation of 'Ser-2' ofthe C-terminal domain (CTD) of RNA polymerase II; these datahowever need additional evidences in vivo (PubMed:22509028). Inaddition to acetylated histones, also recognizes and bindsacetylated RELA, leading to further recruitment of the P-TEFbcomplex and subsequent activation of NF-kappa-B. Also acts as aregulator of p53/TP53-mediated transcription: followingphosphorylation by CK2, recruited to p53/TP53 specific targetpromoters. {ECO:0000269|PubMed:22509028}. Isoform B: Acts as a chromatin insulator in the DNAdamage response pathway. Inhibits DNA damage response signaling byrecruiting the condensin-2 complex to acetylated histones, leadingto chromatin structure remodeling, insulating the region from DNAdamage response by limiting spreading of histone H2AFX/H2A.xphosphorylation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-9201011_10146821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-9201028_10336821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-9201283_13006821363Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-9201301_13086821363Compositional biasNote=Poly-Ala
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-9201335_13386821363Compositional biasNote=Poly-Arg
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920692_7176821363Compositional biasNote=Ser-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920703_7146821363Compositional biasNote=Poly-Ser
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920738_7436821363Compositional biasNote=Poly-His
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920757_7616821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920764_7706821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920771_7756821363Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920776_7836821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920954_9646821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920974_9866821363Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-9121011_1014682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-9121028_1033682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-9121283_1300682795Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-9121301_1308682795Compositional biasNote=Poly-Ala
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-9121335_1338682795Compositional biasNote=Poly-Arg
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912692_717682795Compositional biasNote=Ser-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912703_714682795Compositional biasNote=Poly-Ser
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912738_743682795Compositional biasNote=Poly-His
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912757_761682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912764_770682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912771_775682795Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912776_783682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912954_964682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912974_986682795Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-9121011_1014682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-9121028_1033682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-9121283_1300682723Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-9121301_1308682723Compositional biasNote=Poly-Ala
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-9121335_1338682723Compositional biasNote=Poly-Arg
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912692_717682723Compositional biasNote=Ser-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912703_714682723Compositional biasNote=Poly-Ser
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912738_743682723Compositional biasNote=Poly-His
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912757_761682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912764_770682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912771_775682723Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912776_783682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912954_964682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912974_986682723Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-9201047_13626821363RegionNote=C-terminal (CTD) region
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-9121047_1362682795RegionNote=C-terminal (CTD) region
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-9121047_1362682723RegionNote=C-terminal (CTD) region

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD3chr9:85987828chr19:15365073ENST00000304195-31432_31298598DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000328788-1332_312-37214DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376434-11032_312-32363DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376438-31532_31298557DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000304195-314531_55198598TransmembraneHelical
HgeneFRMD3chr9:85987828chr19:15365073ENST00000328788-13531_551-37214TransmembraneHelical
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376434-110531_551-32363TransmembraneHelical
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376438-315531_55198557TransmembraneHelical
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920535_5946821363Compositional biasNote=Lys-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912535_594682795Compositional biasNote=Lys-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912535_594682723Compositional biasNote=Lys-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920368_4406821363DomainBromo 2
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920600_6826821363DomainNET
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-92075_1476821363DomainBromo 1
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912368_440682795DomainBromo 2
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912600_682682795DomainNET
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-91275_147682795DomainBromo 1
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912368_440682723DomainBromo 2
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912600_682682723DomainNET
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-91275_147682723DomainBromo 1
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920484_5036821363RegionNote=NPS region
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377-920524_5796821363RegionNote=BID region
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912484_503682795RegionNote=NPS region
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016-912524_579682795RegionNote=BID region
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912484_503682723RegionNote=NPS region
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835-912524_579682723RegionNote=BID region


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FusionGeneSequence for FRMD3_BRD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000263377_chr19_15365073_-_779aa
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPN
KSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQP
PPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQH
AVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPL
LPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPA
KPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEP
FSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPS
STAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAV

>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000371835_chr19_15365073_-_139aa
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPN

>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000360016_chr19_15365073_-_211aa
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPN
KSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPH

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000263377_chr19_15365073_-_779aa
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPN
KSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQP
PPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQH
AVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPL
LPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPA
KPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEP
FSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPS
STAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAV

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000371835_chr19_15365073_-_139aa
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPN

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000360016_chr19_15365073_-_211aa
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPN
KSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000263377_chr19_15365073_-_2337nt
ATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAG
GAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCAC
ATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAAC
AAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAG
AGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGATGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGGAG
CAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCCCCGGCTCCTGTGCCCCAGCAGCCGCCCCCGCCTCCCCAGCAGCCC
CCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCGCCTCCCCCACCCTCCATGCCGCAGCAGGCAGCCCCGGCGATGAAG
TCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAGCCCCAGCTCCCAGGCAGCGTCTTTGACCCCATCGGCCACTTCACC
CAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTGCCCCAGCCGCCTGAGCACAGCACTCCACCCCATCTCAACCAGCAC
GCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAGCCATCACGGCCCAGCAACCGAGCCGCTGCCCTGCCTCCCAAGCCC
GCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTGCTCCCACAGCCCCCCATGGCCCAACCCCCCCAAGTGCTGCTGGAG
GATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAGCTGTACCTGCAGCAGCTGCAGAAGGTGCAGCCCCCTACGCCGCTA
CTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCGCCCCCACCCCACCCCTCTGTGCAGCAGCAGCTGCAGCAGCAGCCG
CCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAGCATCAGCCCCCTCCACGGCCCGTGCACTTGCAGCCCATGCAGTTT
TCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCCCCCCATCCGCCCCCAGGCCAGCAGCCACCCCCGCCGCAGCCTGCC
AAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCACAAGTCGGACCCCTACTCAACCGGTCACCTCCGCGAAGCCCCCTCC
CCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTGACCCACCAGTCTCCACCCCAGCAAAACGTCCAGCCTAAGAAACAG
GAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTGGTGAAGGAGGAGAAGATCCACTCACCCATCATCCGCAGCGAGCCC
TTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGCATCAAGGCCCCCGTCCACCTGCCCCAGCGGCCGGAAATGAAGCCT
GTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCACCGCCACCAGGGGCCCCTGACAAGGACAAACAGAAACAGGAGCCG
AAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATGGGCTCCTGGGCCAGCCTAGTGCAGAAGCATCCGACCACCCCCTCC
TCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGCGCCGCTCGGGAGAAAGAGGAGCGTGAGAAGGCCCTGAAGGCTCAG
GCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGCATGAGGAGCCGAGAGGACGAGGATGCGCTGGAGCAGGCCCGGCGG
GCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAGCGCCAGGAGCAACAGCAGCAGCAGCAACAGCAAGCAGCTGCGGTG
GCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCCATGCTGGACCAGCAGAGGGAGTTGGCCCGGAAGCGGGAGCAGGAG

>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000371835_chr19_15365073_-_417nt
ATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAG
GAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCAC
ATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAAC
AAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAG

>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000360016_chr19_15365073_-_633nt
ATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAG
GAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCAC
ATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAAC
AAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAG
AGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCTTTCTGCACCAGTGGAGACTTCGTGTCCCCAGGGCCTTCCCCG
TATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGCTGGTTTCTGGTGGATGTGGAGCAGACTGCAGCTGGCCAGCCGCAT
CGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATTGCCTACCCCTCCCCAGAGTGTGCTCGTTGCTGTGTTGGCTGCTCC

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000263377_chr19_15365073_-_2337nt
ATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAG
GAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCAC
ATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAAC
AAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAG
AGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGATGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGGAG
CAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCCCCGGCTCCTGTGCCCCAGCAGCCGCCCCCGCCTCCCCAGCAGCCC
CCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCGCCTCCCCCACCCTCCATGCCGCAGCAGGCAGCCCCGGCGATGAAG
TCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAGCCCCAGCTCCCAGGCAGCGTCTTTGACCCCATCGGCCACTTCACC
CAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTGCCCCAGCCGCCTGAGCACAGCACTCCACCCCATCTCAACCAGCAC
GCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAGCCATCACGGCCCAGCAACCGAGCCGCTGCCCTGCCTCCCAAGCCC
GCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTGCTCCCACAGCCCCCCATGGCCCAACCCCCCCAAGTGCTGCTGGAG
GATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAGCTGTACCTGCAGCAGCTGCAGAAGGTGCAGCCCCCTACGCCGCTA
CTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCGCCCCCACCCCACCCCTCTGTGCAGCAGCAGCTGCAGCAGCAGCCG
CCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAGCATCAGCCCCCTCCACGGCCCGTGCACTTGCAGCCCATGCAGTTT
TCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCCCCCCATCCGCCCCCAGGCCAGCAGCCACCCCCGCCGCAGCCTGCC
AAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCACAAGTCGGACCCCTACTCAACCGGTCACCTCCGCGAAGCCCCCTCC
CCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTGACCCACCAGTCTCCACCCCAGCAAAACGTCCAGCCTAAGAAACAG
GAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTGGTGAAGGAGGAGAAGATCCACTCACCCATCATCCGCAGCGAGCCC
TTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGCATCAAGGCCCCCGTCCACCTGCCCCAGCGGCCGGAAATGAAGCCT
GTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCACCGCCACCAGGGGCCCCTGACAAGGACAAACAGAAACAGGAGCCG
AAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATGGGCTCCTGGGCCAGCCTAGTGCAGAAGCATCCGACCACCCCCTCC
TCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGCGCCGCTCGGGAGAAAGAGGAGCGTGAGAAGGCCCTGAAGGCTCAG
GCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGCATGAGGAGCCGAGAGGACGAGGATGCGCTGGAGCAGGCCCGGCGG
GCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAGCGCCAGGAGCAACAGCAGCAGCAGCAACAGCAAGCAGCTGCGGTG
GCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCCATGCTGGACCAGCAGAGGGAGTTGGCCCGGAAGCGGGAGCAGGAG

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000371835_chr19_15365073_-_417nt
ATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAG
GAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCAC
ATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAAC
AAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAG

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000360016_chr19_15365073_-_633nt
ATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAG
GAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCAC
ATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAAC
AAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAG
AGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCTTTCTGCACCAGTGGAGACTTCGTGTCCCCAGGGCCTTCCCCG
TATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGCTGGTTTCTGGTGGATGTGGAGCAGACTGCAGCTGGCCAGCCGCAT
CGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATTGCCTACCCCTCCCCAGAGTGTGCTCGTTGCTGTGTTGGCTGCTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000263377_chr19_15365073_-_4193nt
CGCGAGCCCGCCGGGGGTCTCAGGCTCTGGGCGTCCTCGGCGAGCGAGCCCGGGCAGAGGGAGGCGCACGAGCGCGCGCGACAGAAGGAG
GCGGGGAAAGGAGGGGGCGAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAG
GCGCCCGACGCTGCCGATGTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCAC
CGCGCCGGCCCTGAGCCTCCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATG
AAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCC
TGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATT
CGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATT
GCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACA
GAGATGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGGAGCAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCC
CCGGCTCCTGTGCCCCAGCAGCCGCCCCCGCCTCCCCAGCAGCCCCCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCG
CCTCCCCCACCCTCCATGCCGCAGCAGGCAGCCCCGGCGATGAAGTCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAG
CCCCAGCTCCCAGGCAGCGTCTTTGACCCCATCGGCCACTTCACCCAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTG
CCCCAGCCGCCTGAGCACAGCACTCCACCCCATCTCAACCAGCACGCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAG
CCATCACGGCCCAGCAACCGAGCCGCTGCCCTGCCTCCCAAGCCCGCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTG
CTCCCACAGCCCCCCATGGCCCAACCCCCCCAAGTGCTGCTGGAGGATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAG
CTGTACCTGCAGCAGCTGCAGAAGGTGCAGCCCCCTACGCCGCTACTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCG
CCCCCACCCCACCCCTCTGTGCAGCAGCAGCTGCAGCAGCAGCCGCCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAG
CATCAGCCCCCTCCACGGCCCGTGCACTTGCAGCCCATGCAGTTTTCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCC
CCCCATCCGCCCCCAGGCCAGCAGCCACCCCCGCCGCAGCCTGCCAAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCAC
AAGTCGGACCCCTACTCAACCGGTCACCTCCGCGAAGCCCCCTCCCCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTG
ACCCACCAGTCTCCACCCCAGCAAAACGTCCAGCCTAAGAAACAGGAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTG
GTGAAGGAGGAGAAGATCCACTCACCCATCATCCGCAGCGAGCCCTTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGC
ATCAAGGCCCCCGTCCACCTGCCCCAGCGGCCGGAAATGAAGCCTGTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCA
CCGCCACCAGGGGCCCCTGACAAGGACAAACAGAAACAGGAGCCGAAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATG
GGCTCCTGGGCCAGCCTAGTGCAGAAGCATCCGACCACCCCCTCCTCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGC
GCCGCTCGGGAGAAAGAGGAGCGTGAGAAGGCCCTGAAGGCTCAGGCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGC
ATGAGGAGCCGAGAGGACGAGGATGCGCTGGAGCAGGCCCGGCGGGCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAG
CGCCAGGAGCAACAGCAGCAGCAGCAACAGCAAGCAGCTGCGGTGGCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCC
ATGCTGGACCAGCAGAGGGAGTTGGCCCGGAAGCGGGAGCAGGAGCGAAGACGCCGGGAAGCCATGGCAGCTACCATTGACATGAATTTC
CAGAGTGATCTATTGTCAATATTTGAAGAAAATCTTTTCTGAGCGCACCTAGGTGGCTTCTGACTTTGATTTTCTGGCAAAACATTGACT
TTCCATAGTGTTAGGGGCGGTGGTGGAGGTGGGATCAGCGGCCAGGGGATGCCTCAGGGCCTGGCCCTCCTGCATGCTATGCCCGGGGCA
GGCCTGACGGGCAGCTGAGGATTGCAGAGCCTGTCTGCCTTACGGCCAGTCGGACAGACGTCCCGCCACCCACCACCCCTCACAGGACGT
CCGCTCAGCACACGCCTTGTTACGAGCAAGTGCCGGCTGGACCCAAGCCCTGCATCCCCACATGCGGGGCAGAGGCCCTTCTCTCCGCCA
AATGTCTACACAGTATACACAGGACATCGTTGCTGCCGCCGTGACTGGTTTTCTGTCCCCAAGAACGTGACGTTCGTGATGTCCTGCCCG
CCGGGAGTCTTTCCCCACACCCCAGCCATCGCCGCCCGCTCCCAGGAGGCCAGGGCAGGCCTGCGTGGGCTGGAGGCGGGCGAGGCCGGC
CCACCCCCTCGCTGGCACTGACTTTGCCTTGAACAGACCCCCCGACCCTCCCCCACAAGCCTTTAATTGAGAGCCGCTCTCTGTAAGTGT
TTGCTTGTGCAAAAGGGAATAGTGCCGTGGAGGTGTGTGTGTCCATGGCATCCGGAGCGAGGCGACTGTCCTGCGTGGGTAGCCCTCGGC
CGGGGAGTGAGGCCACCAACCAAAGTCAGTTCCTTCCCACCTGTGTTTCTGTTTCGTTTTTTTTTTTCTTTTTTTTCTATATATATTTTT
TGTTGAATTCTATTTTATTTTTAATTCTCTCTTCTCCTCCAGACACAATGGCACTGCTTATCTCCGAAATGGTGTGATCGTCTCCTCATT
GAGCAGCGGCTGCCACCGCGCTGTGGGTAGTGTGTGACCGTGGCTGTACTGTATAGTGAACATAGTTGGCATATCTTTGTTTGAAGTTTG
TTGGTGACTCCACCAAACTGGTGTGAAAAAAGAAAAAAGCTCAAAAAAATCCACAAAAAGACAAAACACACAAAAAAAATCCTGCCTATA
TTTTACTCAGTTTCAAACTTTATTAGTCTATTTTTAATTATAAAACCAGAAAGCTACAATTTCTTTTCTTTCCCCTCCACCCCCCCCCCC
CCCACCCATTTGTTGGCTTTTTTGTTTTTTAATGTCAGATCTGTTGAGTTGGTTTTTTTGGTTTTGGTTTTTGTTTTTGTTTTTGTTTTT
TACTGAGAAAGGAAGGGCCAAGGGATGAGGTGGGAACCGGGCCCTGGGGGCGCCACAGACTAAGGCAGAGACTCCCCTACCTGGCGCCCA
GCCCCAACCAGCTGGCCGCTCCTGCCCATGCTTTTTTTTTTTTTTTTTTTTAATTTTTATAATTGGAGCCCCTGGTGAGGTTACGCGTGC
CATGAGAACCCACTCTACACCACGACGCTGGTGCCTCAGTGTTGGCCAAACTCTGGAGTCACTGACTGGTTTGACTTTCATACGGTGAAT

>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000371835_chr19_15365073_-_2955nt
CGCGAGCCCGCCGGGGGTCTCAGGCTCTGGGCGTCCTCGGCGAGCGAGCCCGGGCAGAGGGAGGCGCACGAGCGCGCGCGACAGAAGGAG
GCGGGGAAAGGAGGGGGCGAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAG
GCGCCCGACGCTGCCGATGTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCAC
CGCGCCGGCCCTGAGCCTCCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATG
AAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCC
TGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATT
CGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATT
GCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACA
GGTCCTGCCTAATCATTGGACACGGACTCTTAATAAAACGGTCTTCAGTTCCAGATTCCTTCCCAGCAAGCTATAGCTTAAGTCCATTTT
CTTCCGTGAAAGGGACAGGACTCCATCAAGTTATGGAATTCCTCAGAGCCCTGGGCCTGTCCCCCGGGGTGGATTAGTCATGTCCAGCAG
CACACGCCTAGTCCCGCCTTCGGGAAGGCTGCCTGCCTGGCCAGCCGCCCAGGCCTCTCTGTGTAAAGACTGCCTGGCTGTCCTGCCCAG
CCTTCCTGGTTCTCTGGGGTCCTCTGGGTGGGTGGCATCTCCTGGAGGGTGATGACAATCCCCAACACATGCATTCATGTGGTGCTACTC
TGTGTGCAAAGCCAGACCCCAAGTATGTTTTCTCTCTTTGTCCCATCCCTCTTTTTCTGGGACTTTGGACCCTAACTACTTCCCTCCTGA
ACCTTGCAGTGACATCAGTCCAGGAGAGCTCTCGTTCAGTGTGCGGAAGAACACTCTGACCTCTAGAGCTGTCCTAGATAAGGAGTGGGA
GCTTTAGAGGCAAGGCCTCTAGACCCTGGAAGGCTCAGTGAGGCTCTTCCCACAGCATGCTTCTCACTGGTGCCCTGTAAGGCTCGAGCC
ACCGCTGACTCTGAGCCTTTTGGAGTCTTTCCTCCTTCGTCTCCATTGTTCCCGTGCATTTCCAAAAGCTTAAGTTGCCTGGTGGGCATT
TCCCCAGTTTCTTTGGCCTCCGTCTTCTCAAGTCACATAGGGAAAGTACCTCCTGGAACCAGGCTGCAGTATGCAGGACCTGCCAGGCAG
GCACTGGTGAAGGGCCTTGGGCCTATCATCCCCCCAACCCCACCTCACCCCACCCGCCTCCTCTAGTGGGGTGAGTCTGGGCTGGTGGAC
CAGAGAGGGTGTCACAGACCCTCAGGGACTGCCCCATGGACACCTCTGACTGGTGTTAACAGTGTGAACATTTTCCCCGTCTTCAGTCCC
TTAGAATGACGACAGCCCCTGGGGTTGGGGCAGGCGAGTGTGGCCACATCATCCAAGCCCTCCCAGAGACACAAATAGGCTTTTTTGCTC
TAAAAATAAATACCAGCCCTTTTTTGGTCACAAATCCAGCATCTCAGCAGAAAACTGCCTGACATGAAAAGTCCCCTGAGGAACTGCATC
TGCGTTTCAGGGGCTTTTCATTTTTTCTCCTTTTTTAAAGTGTAGATTGTGGGTGCTTCCTAGAGGCCTGCCTTCTTCTGGAACTGGAAG
TGGGCTATCACCATGGGCAAGCCCTTGGGTGCAGGCTCCCCACCTGCCTGGGAACTCTGGCAGCTCTCCTCAGCTCCTTGGGCTTGAGCA
GCTGCAACTGCCCCAGATTTGCTGTGGAAGCAGGGGCTAGCCCTGGCCTCACCAGGGCCTCCCGGGGCCCTGCATTGATGCTCAGGAGTT
CCTGGGCTGCTCTTGATCCTTTCTGGGCATCCAGCTTCCAGTTAAGCTCTGTTTGCCAAACAAACTATTCTCAGCTGCCCTTTGGCCTGC
GCCTGATGTGTTCCTGTTGCAGTCCCGCCTGCCTGAGACAGGAGCAGGCAGGAGAGCCTTCATGCCCAGATTCCCACAGGACAATTGGGG
AGCTGCTGGCATTGTCTTTCTGGGAAGATTCTGCTTTCTTGGACCAAATGGCAGCCTGATTACCAGTGTCGGGCCTGCATGCTGCCCCCG
ACACACGCACGCACGCGCACACACGTGTGCACATGGGCCATAGCCACAAGCCAGCTCTCCTCCAGGGTCCTTTCAACCTCGCTGTCCAGG
GACCCTGTCCTTCTTGCCCGTGGGGCTTCCATCTGGCAGAGAACGTTCAGGGCTTGTTGAACTTGAAAGCTCATTAGACTTAAGCTGTCA
CCTGTGCTTGGTGCCCCAGGAACAGCCAGAGAGGACAGTGCCCACTCACTTCTTGTTGGCAGCCTCCTGTGCAGGAAGTGCCAGCCGGGC
CTCGACGCACCAGCTGGCTGTGGGTCCTGAGGAGGGGCGGGAGGCGGCCGCTCAGTGCAGATGGGGACTCCTCTCCTCTGCCCTGACCTT
ACCCTCCATTACCTCCTTCACTGGAGTGGGGCTGGGGGGTGGGTGGAATCAGTGTTTTAATCGGATTTTTAAAAAACATTTTATTTCTTT

>In-frame_FRMD3_ENST00000376438_chr9_85987828_-_BRD4_ENST00000360016_chr19_15365073_-_1513nt
CGCGAGCCCGCCGGGGGTCTCAGGCTCTGGGCGTCCTCGGCGAGCGAGCCCGGGCAGAGGGAGGCGCACGAGCGCGCGCGACAGAAGGAG
GCGGGGAAAGGAGGGGGCGAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAG
GCGCCCGACGCTGCCGATGTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCAC
CGCGCCGGCCCTGAGCCTCCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATG
AAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCC
TGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATT
CGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATT
GCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACA
GCTTTCTGCACCAGTGGAGACTTCGTGTCCCCAGGGCCTTCCCCGTATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGC
TGGTTTCTGGTGGATGTGGAGCAGACTGCAGCTGGCCAGCCGCATCGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATT
GCCTACCCCTCCCCAGAGTGTGCTCGTTGCTGTGTTGGCTGCTCCTGAATCTGCCCTAACTCCACACGCACCTGGACTTGCGTGTCCCTC
CTGCAGTTCTAACTAACAGTCCCTTCTTTTCAAGCCCCGTGGGTCTGCACGTTGGACCCTGGGTTCCCCATTAGAGCCCACCTTCTGAGC
AGCAGCCTCAGTGGGAGGTGGAGGCAGGTAGTGATGCTGGGTGCCAGGTGGGAGTGGAGAGGGGACTGCTCTCCTCCAAGTGTGCACTTT
CCTCATTATTCTCAGGGGCGCAGATGCTCAGGCTGGCGCAGGGGAGAGGCTAGGGAGGGAGCCATGGTGCCCAGAAGGCCTGGCGACCAG
CCCCTGCTGAGAGATGGAGCTAACATCCTGTGTTTACGGCCAACGGGGTTGCCGCTAGGCTGGTGCAGCTGTCAGTGAGCTGGCGTGCTG
CAGACCACCTGAGAGCTGGCCCTAGGGTCTCAGGCAGACTGGGGAGTGGGGATCCACAGTGGGAAACCTGTGTTTTGGCAGTAGACTCCT

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000263377_chr19_15365073_-_4085nt
GAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAGGCGCCCGACGCTGCCGAT
GTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCACCGCGCCGGCCCTGAGCCT
CCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGG
AGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAA
ACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAG
AAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATG
AAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGATGGCTCCGAAGTCA
AAAAAGAAGGGGCACCCCGGGAGGGAGCAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCCCCGGCTCCTGTGCCCCAG
CAGCCGCCCCCGCCTCCCCAGCAGCCCCCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCGCCTCCCCCACCCTCCATG
CCGCAGCAGGCAGCCCCGGCGATGAAGTCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAGCCCCAGCTCCCAGGCAGC
GTCTTTGACCCCATCGGCCACTTCACCCAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTGCCCCAGCCGCCTGAGCAC
AGCACTCCACCCCATCTCAACCAGCACGCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAGCCATCACGGCCCAGCAAC
CGAGCCGCTGCCCTGCCTCCCAAGCCCGCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTGCTCCCACAGCCCCCCATG
GCCCAACCCCCCCAAGTGCTGCTGGAGGATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAGCTGTACCTGCAGCAGCTG
CAGAAGGTGCAGCCCCCTACGCCGCTACTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCGCCCCCACCCCACCCCTCT
GTGCAGCAGCAGCTGCAGCAGCAGCCGCCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAGCATCAGCCCCCTCCACGG
CCCGTGCACTTGCAGCCCATGCAGTTTTCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCCCCCCATCCGCCCCCAGGC
CAGCAGCCACCCCCGCCGCAGCCTGCCAAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCACAAGTCGGACCCCTACTCA
ACCGGTCACCTCCGCGAAGCCCCCTCCCCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTGACCCACCAGTCTCCACCC
CAGCAAAACGTCCAGCCTAAGAAACAGGAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTGGTGAAGGAGGAGAAGATC
CACTCACCCATCATCCGCAGCGAGCCCTTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGCATCAAGGCCCCCGTCCAC
CTGCCCCAGCGGCCGGAAATGAAGCCTGTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCACCGCCACCAGGGGCCCCT
GACAAGGACAAACAGAAACAGGAGCCGAAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATGGGCTCCTGGGCCAGCCTA
GTGCAGAAGCATCCGACCACCCCCTCCTCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGCGCCGCTCGGGAGAAAGAG
GAGCGTGAGAAGGCCCTGAAGGCTCAGGCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGCATGAGGAGCCGAGAGGAC
GAGGATGCGCTGGAGCAGGCCCGGCGGGCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAGCGCCAGGAGCAACAGCAG
CAGCAGCAACAGCAAGCAGCTGCGGTGGCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCCATGCTGGACCAGCAGAGG
GAGTTGGCCCGGAAGCGGGAGCAGGAGCGAAGACGCCGGGAAGCCATGGCAGCTACCATTGACATGAATTTCCAGAGTGATCTATTGTCA
ATATTTGAAGAAAATCTTTTCTGAGCGCACCTAGGTGGCTTCTGACTTTGATTTTCTGGCAAAACATTGACTTTCCATAGTGTTAGGGGC
GGTGGTGGAGGTGGGATCAGCGGCCAGGGGATGCCTCAGGGCCTGGCCCTCCTGCATGCTATGCCCGGGGCAGGCCTGACGGGCAGCTGA
GGATTGCAGAGCCTGTCTGCCTTACGGCCAGTCGGACAGACGTCCCGCCACCCACCACCCCTCACAGGACGTCCGCTCAGCACACGCCTT
GTTACGAGCAAGTGCCGGCTGGACCCAAGCCCTGCATCCCCACATGCGGGGCAGAGGCCCTTCTCTCCGCCAAATGTCTACACAGTATAC
ACAGGACATCGTTGCTGCCGCCGTGACTGGTTTTCTGTCCCCAAGAACGTGACGTTCGTGATGTCCTGCCCGCCGGGAGTCTTTCCCCAC
ACCCCAGCCATCGCCGCCCGCTCCCAGGAGGCCAGGGCAGGCCTGCGTGGGCTGGAGGCGGGCGAGGCCGGCCCACCCCCTCGCTGGCAC
TGACTTTGCCTTGAACAGACCCCCCGACCCTCCCCCACAAGCCTTTAATTGAGAGCCGCTCTCTGTAAGTGTTTGCTTGTGCAAAAGGGA
ATAGTGCCGTGGAGGTGTGTGTGTCCATGGCATCCGGAGCGAGGCGACTGTCCTGCGTGGGTAGCCCTCGGCCGGGGAGTGAGGCCACCA
ACCAAAGTCAGTTCCTTCCCACCTGTGTTTCTGTTTCGTTTTTTTTTTTCTTTTTTTTCTATATATATTTTTTGTTGAATTCTATTTTAT
TTTTAATTCTCTCTTCTCCTCCAGACACAATGGCACTGCTTATCTCCGAAATGGTGTGATCGTCTCCTCATTGAGCAGCGGCTGCCACCG
CGCTGTGGGTAGTGTGTGACCGTGGCTGTACTGTATAGTGAACATAGTTGGCATATCTTTGTTTGAAGTTTGTTGGTGACTCCACCAAAC
TGGTGTGAAAAAAGAAAAAAGCTCAAAAAAATCCACAAAAAGACAAAACACACAAAAAAAATCCTGCCTATATTTTACTCAGTTTCAAAC
TTTATTAGTCTATTTTTAATTATAAAACCAGAAAGCTACAATTTCTTTTCTTTCCCCTCCACCCCCCCCCCCCCCACCCATTTGTTGGCT
TTTTTGTTTTTTAATGTCAGATCTGTTGAGTTGGTTTTTTTGGTTTTGGTTTTTGTTTTTGTTTTTGTTTTTTACTGAGAAAGGAAGGGC
CAAGGGATGAGGTGGGAACCGGGCCCTGGGGGCGCCACAGACTAAGGCAGAGACTCCCCTACCTGGCGCCCAGCCCCAACCAGCTGGCCG
CTCCTGCCCATGCTTTTTTTTTTTTTTTTTTTTAATTTTTATAATTGGAGCCCCTGGTGAGGTTACGCGTGCCATGAGAACCCACTCTAC
ACCACGACGCTGGTGCCTCAGTGTTGGCCAAACTCTGGAGTCACTGACTGGTTTGACTTTCATACGGTGAATATGCATTTGGTCTGTACT

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000371835_chr19_15365073_-_2847nt
GAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAGGCGCCCGACGCTGCCGAT
GTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCACCGCGCCGGCCCTGAGCCT
CCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGG
AGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAA
ACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAG
AAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATG
AAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGGTCCTGCCTAATCATTG
GACACGGACTCTTAATAAAACGGTCTTCAGTTCCAGATTCCTTCCCAGCAAGCTATAGCTTAAGTCCATTTTCTTCCGTGAAAGGGACAG
GACTCCATCAAGTTATGGAATTCCTCAGAGCCCTGGGCCTGTCCCCCGGGGTGGATTAGTCATGTCCAGCAGCACACGCCTAGTCCCGCC
TTCGGGAAGGCTGCCTGCCTGGCCAGCCGCCCAGGCCTCTCTGTGTAAAGACTGCCTGGCTGTCCTGCCCAGCCTTCCTGGTTCTCTGGG
GTCCTCTGGGTGGGTGGCATCTCCTGGAGGGTGATGACAATCCCCAACACATGCATTCATGTGGTGCTACTCTGTGTGCAAAGCCAGACC
CCAAGTATGTTTTCTCTCTTTGTCCCATCCCTCTTTTTCTGGGACTTTGGACCCTAACTACTTCCCTCCTGAACCTTGCAGTGACATCAG
TCCAGGAGAGCTCTCGTTCAGTGTGCGGAAGAACACTCTGACCTCTAGAGCTGTCCTAGATAAGGAGTGGGAGCTTTAGAGGCAAGGCCT
CTAGACCCTGGAAGGCTCAGTGAGGCTCTTCCCACAGCATGCTTCTCACTGGTGCCCTGTAAGGCTCGAGCCACCGCTGACTCTGAGCCT
TTTGGAGTCTTTCCTCCTTCGTCTCCATTGTTCCCGTGCATTTCCAAAAGCTTAAGTTGCCTGGTGGGCATTTCCCCAGTTTCTTTGGCC
TCCGTCTTCTCAAGTCACATAGGGAAAGTACCTCCTGGAACCAGGCTGCAGTATGCAGGACCTGCCAGGCAGGCACTGGTGAAGGGCCTT
GGGCCTATCATCCCCCCAACCCCACCTCACCCCACCCGCCTCCTCTAGTGGGGTGAGTCTGGGCTGGTGGACCAGAGAGGGTGTCACAGA
CCCTCAGGGACTGCCCCATGGACACCTCTGACTGGTGTTAACAGTGTGAACATTTTCCCCGTCTTCAGTCCCTTAGAATGACGACAGCCC
CTGGGGTTGGGGCAGGCGAGTGTGGCCACATCATCCAAGCCCTCCCAGAGACACAAATAGGCTTTTTTGCTCTAAAAATAAATACCAGCC
CTTTTTTGGTCACAAATCCAGCATCTCAGCAGAAAACTGCCTGACATGAAAAGTCCCCTGAGGAACTGCATCTGCGTTTCAGGGGCTTTT
CATTTTTTCTCCTTTTTTAAAGTGTAGATTGTGGGTGCTTCCTAGAGGCCTGCCTTCTTCTGGAACTGGAAGTGGGCTATCACCATGGGC
AAGCCCTTGGGTGCAGGCTCCCCACCTGCCTGGGAACTCTGGCAGCTCTCCTCAGCTCCTTGGGCTTGAGCAGCTGCAACTGCCCCAGAT
TTGCTGTGGAAGCAGGGGCTAGCCCTGGCCTCACCAGGGCCTCCCGGGGCCCTGCATTGATGCTCAGGAGTTCCTGGGCTGCTCTTGATC
CTTTCTGGGCATCCAGCTTCCAGTTAAGCTCTGTTTGCCAAACAAACTATTCTCAGCTGCCCTTTGGCCTGCGCCTGATGTGTTCCTGTT
GCAGTCCCGCCTGCCTGAGACAGGAGCAGGCAGGAGAGCCTTCATGCCCAGATTCCCACAGGACAATTGGGGAGCTGCTGGCATTGTCTT
TCTGGGAAGATTCTGCTTTCTTGGACCAAATGGCAGCCTGATTACCAGTGTCGGGCCTGCATGCTGCCCCCGACACACGCACGCACGCGC
ACACACGTGTGCACATGGGCCATAGCCACAAGCCAGCTCTCCTCCAGGGTCCTTTCAACCTCGCTGTCCAGGGACCCTGTCCTTCTTGCC
CGTGGGGCTTCCATCTGGCAGAGAACGTTCAGGGCTTGTTGAACTTGAAAGCTCATTAGACTTAAGCTGTCACCTGTGCTTGGTGCCCCA
GGAACAGCCAGAGAGGACAGTGCCCACTCACTTCTTGTTGGCAGCCTCCTGTGCAGGAAGTGCCAGCCGGGCCTCGACGCACCAGCTGGC
TGTGGGTCCTGAGGAGGGGCGGGAGGCGGCCGCTCAGTGCAGATGGGGACTCCTCTCCTCTGCCCTGACCTTACCCTCCATTACCTCCTT
CACTGGAGTGGGGCTGGGGGGTGGGTGGAATCAGTGTTTTAATCGGATTTTTAAAAAACATTTTATTTCTTTGTACAATTACCATCCTAT

>In-frame_FRMD3_ENST00000304195_chr9_85987828_-_BRD4_ENST00000360016_chr19_15365073_-_1405nt
GAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAGGCGCCCGACGCTGCCGAT
GTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCACCGCGCCGGCCCTGAGCCT
CCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGG
AGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAA
ACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAG
AAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATG
AAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCTTTCTGCACCAGTGGA
GACTTCGTGTCCCCAGGGCCTTCCCCGTATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGCTGGTTTCTGGTGGATGTG
GAGCAGACTGCAGCTGGCCAGCCGCATCGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATTGCCTACCCCTCCCCAGAG
TGTGCTCGTTGCTGTGTTGGCTGCTCCTGAATCTGCCCTAACTCCACACGCACCTGGACTTGCGTGTCCCTCCTGCAGTTCTAACTAACA
GTCCCTTCTTTTCAAGCCCCGTGGGTCTGCACGTTGGACCCTGGGTTCCCCATTAGAGCCCACCTTCTGAGCAGCAGCCTCAGTGGGAGG
TGGAGGCAGGTAGTGATGCTGGGTGCCAGGTGGGAGTGGAGAGGGGACTGCTCTCCTCCAAGTGTGCACTTTCCTCATTATTCTCAGGGG
CGCAGATGCTCAGGCTGGCGCAGGGGAGAGGCTAGGGAGGGAGCCATGGTGCCCAGAAGGCCTGGCGACCAGCCCCTGCTGAGAGATGGA
GCTAACATCCTGTGTTTACGGCCAACGGGGTTGCCGCTAGGCTGGTGCAGCTGTCAGTGAGCTGGCGTGCTGCAGACCACCTGAGAGCTG
GCCCTAGGGTCTCAGGCAGACTGGGGAGTGGGGATCCACAGTGGGAAACCTGTGTTTTGGCAGTAGACTCCTGCATGTTCTCCCACGGGC


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FusionGenePPI for FRMD3_BRD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FRMD3ATP5D, ATP5O, OXA1L, COLEC12, LCLAT1, KLHL15, REEP4, KIAA1467, GYLTL1B, CKAP4, LMBR1BRD4RFC1, RFC2, RFC3, RFC4, RFC5, HIST4H4, SIPA1, MED12, MED14, MED24, MED17, CCNT1, CDK9, CCNT2, HEXIM1, HIST2H3C, HIST2H4A, KDM5B, EP300, AFF1, MESDC2, C8orf33, HIST1H3A, HIST1H4A, KAT8, YWHAZ, YWHAE, MED1, CHD4, JMJD6, BAIAP2, BAIAP2L1, RBM25, BRD3, BRD2, WHSC1, GLTSCR1, ATAD5, SMARCA4, ZNF592, BRD9, WHSC1L1, SIRT1, SIRT5, AK1, PGAM2, LDHC, CKM, ELAVL1, MYC, MLLT1, RPL6, PRPF40A, RN7SK, TCERG1, STAT3, GPSM1, FAM90A1, CYP1A1, AP3M1, NUMA1, DMAP1, RTF1, ZC3H18, MMGT1, SMC1A, CDC5L, CHD8, PTAR1, BRCA1, PTEN, FGFR3, KDM5C, DHFR, RB1, MAP2K1, PIP4K2A, CAMKV, CHEK2, CHEK1, WEE1, CDC7, INO80B, TRIM25, CUL1, CUL3, SPOP, AR, ERG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRMD3_BRD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRMD3_BRD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRMD3C0263454Chloracne1CTD_human
TgeneBRD4C0017636Glioblastoma2CTD_human
TgeneBRD4C0002170Alopecia1CTD_human
TgeneBRD4C0009375Colonic Neoplasms1CTD_human
TgeneBRD4C0020507Hyperplasia1CTD_human
TgeneBRD4C0020542Pulmonary Hypertension1CTD_human
TgeneBRD4C0025149Medulloblastoma1CTD_human
TgeneBRD4C0029463Osteosarcoma1CTD_human
TgeneBRD4C0033578Prostatic Neoplasms1CTD_human
TgeneBRD4C0040136Thyroid Neoplasm1CTD_human
TgeneBRD4C0085413Polycystic Kidney, Autosomal Dominant1CTD_human