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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 13877

FusionGeneSummary for FREM2_MTRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: FREM2_MTRF1
Fusion gene ID: 13877
HgeneTgene
Gene symbol

FREM2

MTRF1

Gene ID

341640

9617

Gene nameFRAS1 related extracellular matrix protein 2mitochondrial translation release factor 1
SynonymsFRASRS2MRF1|MTTRF1|RF1
Cytomap

13q13.3

13q14.11

Type of geneprotein-codingprotein-coding
DescriptionFRAS1-related extracellular matrix protein 2ECM3 homologpeptide chain release factor 1, mitochondrialMRF-1mitochondrial translational release factor 1mitochontrial peptide chain release factor 1mtRF-1
Modification date2018051920180523
UniProtAcc

Q5SZK8

O75570

Ensembl transtripts involved in fusion geneENST00000280481, ENST00000482551, 
ENST00000379480, ENST00000379477, 
ENST00000430347, ENST00000239852, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: FREM2 [Title/Abstract] AND MTRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-27-1831-01AFREM2chr13

39438743

+MTRF1chr13

41808143

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000280481ENST00000379480FREM2chr13

39438743

+MTRF1chr13

41808143

-
In-frameENST00000280481ENST00000379477FREM2chr13

39438743

+MTRF1chr13

41808143

-
In-frameENST00000280481ENST00000430347FREM2chr13

39438743

+MTRF1chr13

41808143

-
5CDS-intronENST00000280481ENST00000239852FREM2chr13

39438743

+MTRF1chr13

41808143

-
intron-3CDSENST00000482551ENST00000379480FREM2chr13

39438743

+MTRF1chr13

41808143

-
intron-3CDSENST00000482551ENST00000379477FREM2chr13

39438743

+MTRF1chr13

41808143

-
intron-3CDSENST00000482551ENST00000430347FREM2chr13

39438743

+MTRF1chr13

41808143

-
intron-intronENST00000482551ENST00000239852FREM2chr13

39438743

+MTRF1chr13

41808143

-

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FusionProtFeatures for FREM2_MTRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FREM2

Q5SZK8

MTRF1

O75570

Extracellular matrix protein required for maintenance ofthe integrity of the skin epithelium and for maintenance of renalepithelia. May be required for epidermal adhesion.{ECO:0000269|PubMed:15838507}. Mitochondrial peptide chain release factor that directsthe termination of translation in response to the peptide chainnon-cognate termination stop codons AGG and AGA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241759_185826613170DomainNote=Calx-beta 1
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241871_198226613170DomainNote=Calx-beta 2
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241997_210326613170DomainNote=Calx-beta 3
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16242118_222026613170DomainNote=Calx-beta 4
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16242238_234226613170DomainNote=Calx-beta 5
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241066_116826613170RepeatCSPG 7
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241189_128226613170RepeatCSPG 8
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241303_139926613170RepeatCSPG 9
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241420_151226613170RepeatCSPG 10
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241532_162126613170RepeatCSPG 11
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16241655_175226613170RepeatCSPG 12
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+1624319_41326613170RepeatCSPG 1
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+1624438_53726613170RepeatCSPG 2
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+1624560_67526613170RepeatCSPG 3
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+1624700_80726613170RepeatCSPG 4
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+1624828_91926613170RepeatCSPG 5
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+1624945_103726613170RepeatCSPG 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16243135_316926613170Topological domainCytoplasmic
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+162447_311326613170Topological domainExtracellular
HgeneFREM2chr13:39438743chr13:41808143ENST00000280481+16243114_313426613170TransmembraneHelical


Top

FusionGeneSequence for FREM2_MTRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000379480_chr13_41808143_-_2817aa
MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLD
PLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLE
VVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTA
ASRSPNRDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLT
SPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILY
EGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG
GRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWR
KEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTP
LRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRA
GNVAPGTFTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRV
SYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPL
YGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEG
DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDG
INFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIES
SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHG
LLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLT
TDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVD
NKKPVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTV
TDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLL
NLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGET
SFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSK
YSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVL
LSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF
APGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS
SVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTV
IKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH
LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTL
TRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAE
PFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETY
PYQYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPT
GLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQ

>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000379477_chr13_41808143_-_2817aa
MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLD
PLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLE
VVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTA
ASRSPNRDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLT
SPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILY
EGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG
GRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWR
KEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTP
LRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRA
GNVAPGTFTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRV
SYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPL
YGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEG
DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDG
INFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIES
SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHG
LLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLT
TDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVD
NKKPVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTV
TDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLL
NLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGET
SFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSK
YSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVL
LSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF
APGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS
SVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTV
IKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH
LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTL
TRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAE
PFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETY
PYQYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPT
GLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQ

>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000430347_chr13_41808143_-_2827aa
MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLD
PLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLE
VVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTA
ASRSPNRDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLT
SPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILY
EGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG
GRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWR
KEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTP
LRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRA
GNVAPGTFTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRV
SYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPL
YGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEG
DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDG
INFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIES
SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHG
LLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLT
TDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVD
NKKPVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTV
TDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLL
NLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGET
SFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSK
YSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVL
LSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF
APGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS
SVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTV
IKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH
LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTL
TRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAE
PFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETY
PYQYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPT
GLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKAQSHSTGGSRD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000379480_chr13_41808143_-_8451nt
ATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACCAGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTG
CTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCCGCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTC
GCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGACTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGAT
CCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCGGTACTAGACAACGACGCACTGGCCCAGCGACCGGGC
CGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTACTCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGC
GTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTGGTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAG
GTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAATGCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAG
CCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCTCGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCT
GGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCTTTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCC
GCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCACGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGC
GAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCCAAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTG
GACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCTGAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACT
TCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTGCCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTC
CTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTTGAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCA
GCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCTCCGGTGGTCACCCGGAATACCGGTCTTATTCTCTAT
GAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTGGTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGG
CTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCCAGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCT
GAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTGAGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGA
GGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGACCAGCCACCTGTTCTCAATGCCAACACGGGGCTGACA
CTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGACATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTG
GAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCCCATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGG
AAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATAACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCC
CATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCATGACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTG
ATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCCCTTCGTATGGTGGTACAGGAATCCCAGCTCACACCA
CTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTACGTTACACAGTGACTCAGTCCCCCACAGACACAGAC
GAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCAGTCGTGGTGACCCATTTTACCCAAGCCCAGATCAAC
CATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGAGTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCT
GGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAGCCACCTGAGATCCTCAACACCGGCTTCACTATTCAG
GAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGACACTGATGTTGCCCATATCTCTTTCACTCTCACTCAG
GCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGTCTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTT
TCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTCAGTGACAGACATCATGTGGTGCCCATCACTCTCAGA
GTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGCACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGG
GCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGACTTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTG
TATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGACATCTTGGAGGGCTCTGTTGTATATACCCACACCAGT
GGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGATATGTCTCAAGAATGGAGAATTGGTGGCAATACTATC
CAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAAATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGT
GATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTGAATGATGACATCTTGTGCACTATAGTTATTCAGCCT
ACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGAGCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGAT
CTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCTGTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGC
ATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGATGAACAGCCAGAGATGTTTATGAGAGAATTTATGGTG
ATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCTGATGTTCCCCTGGATGATTTAACTTTCACTATTACC
CAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTGGTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGT
TCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTGATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAG
ACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATCAATAATGGACTAGAAATAGAAATTGGGGATACCAAG
ATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCTTTGGTTTATATTATTCGTTATGGGCCAGGACATGGC
TTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATGAATTTTACCCAGGATGAAGTAGACAGAAACTTAATT
CAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTGACTGATGGAATAAATCCCCTCATAGATCGTTACTTT
TATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGAGTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACA
ACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTTACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAA
TGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCTGGAAACAAAATCTACTACATCCACACAGCTGATGAT
GAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTCTTTCGGACATTCCGTATCTCCATTAGCGATGTGGAC
AATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAACAAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGAC
AGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCATGGCCATCTCCTATTCAACAATACCAGACCTGTCATG
GTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGCACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTG
ACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACAAGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCT
GTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGCACTCTAGCCACTGGCCACTTGGGGTTCATGATCACA
AGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTTATCGTGACAGAGGCCCCTCAACATGGATATCTTCTC
AACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGATGACATGAAAATATGCTATGTCTTAAGAGAAGGGGCT
AATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAGTTAACGTACCAGAATTTTCGTCTGAATTGGGCATGG
ATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGATGTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACT
TCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTCAAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCA
GGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAGCAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCC
GTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCAGGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAA
TACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGAGATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACC
CAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGATTACATATCCAGGCCTGAGGACCACACCAGTGTTGTC
CGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGACTCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTT
CTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTTACAATCGTTCCTGACAAAGATGATGAACCCATCTTT
TACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTGCAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCT
TCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGAACAGACTATGTGGGCATCAGCCGTAATTTAGATTTT
GCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGACAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTG
GTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTGTCCATAAATGACTCTGTCTCCGATTTGCCTAAGATG
CAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACAATGATCCATAGGACTGGGGATGTCCAGTACAGATCT
TCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAAGAACGCCCAAACACTGATACCTCCATCATCACATTC
CTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTCTATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGC
ACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACTCTCATAAGGATCCGAGATGATGCTGATAAGACTGTT
ATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAGTCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGA
GACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACCTCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATT
GAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGACGGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCAC
CTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTGTACATAGAAGAAATGAGCAGCATGGCAGATGTCACT
TTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAAGCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCT
GTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGCTCTATCTGTGCAAGTGAGAACATCAATGACACTTTG
ACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGCCCTATGAGAGAAGTGGACTTCGACACCTTTTTTACG
TCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTACAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGAT
GAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTTTGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAG
CCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAACCTTATCAAGCTCACTGTCACAATGCCACACATAGAT
GGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTCAGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGC
TCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGATGCTACCAAAAATCCAGAAATAATTGGAGAGACATAT
CCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGGAACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTT
AGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACAGATGGACAGGTGGATGTGAAATTGGACCCCAAGGAT
TTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAAACTGATAGTGCCGTCAGACTTGTCCACATCCCCACA
GGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATAGCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAG
ATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGAACAAGAGCCCAGTCAGAGCGAATTCGGACATATAAT
TTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATTAAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAG

>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000379477_chr13_41808143_-_8451nt
ATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACCAGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTG
CTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCCGCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTC
GCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGACTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGAT
CCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCGGTACTAGACAACGACGCACTGGCCCAGCGACCGGGC
CGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTACTCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGC
GTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTGGTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAG
GTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAATGCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAG
CCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCTCGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCT
GGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCTTTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCC
GCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCACGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGC
GAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCCAAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTG
GACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCTGAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACT
TCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTGCCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTC
CTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTTGAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCA
GCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCTCCGGTGGTCACCCGGAATACCGGTCTTATTCTCTAT
GAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTGGTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGG
CTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCCAGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCT
GAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTGAGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGA
GGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGACCAGCCACCTGTTCTCAATGCCAACACGGGGCTGACA
CTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGACATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTG
GAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCCCATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGG
AAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATAACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCC
CATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCATGACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTG
ATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCCCTTCGTATGGTGGTACAGGAATCCCAGCTCACACCA
CTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTACGTTACACAGTGACTCAGTCCCCCACAGACACAGAC
GAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCAGTCGTGGTGACCCATTTTACCCAAGCCCAGATCAAC
CATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGAGTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCT
GGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAGCCACCTGAGATCCTCAACACCGGCTTCACTATTCAG
GAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGACACTGATGTTGCCCATATCTCTTTCACTCTCACTCAG
GCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGTCTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTT
TCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTCAGTGACAGACATCATGTGGTGCCCATCACTCTCAGA
GTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGCACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGG
GCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGACTTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTG
TATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGACATCTTGGAGGGCTCTGTTGTATATACCCACACCAGT
GGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGATATGTCTCAAGAATGGAGAATTGGTGGCAATACTATC
CAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAAATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGT
GATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTGAATGATGACATCTTGTGCACTATAGTTATTCAGCCT
ACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGAGCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGAT
CTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCTGTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGC
ATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGATGAACAGCCAGAGATGTTTATGAGAGAATTTATGGTG
ATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCTGATGTTCCCCTGGATGATTTAACTTTCACTATTACC
CAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTGGTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGT
TCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTGATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAG
ACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATCAATAATGGACTAGAAATAGAAATTGGGGATACCAAG
ATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCTTTGGTTTATATTATTCGTTATGGGCCAGGACATGGC
TTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATGAATTTTACCCAGGATGAAGTAGACAGAAACTTAATT
CAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTGACTGATGGAATAAATCCCCTCATAGATCGTTACTTT
TATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGAGTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACA
ACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTTACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAA
TGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCTGGAAACAAAATCTACTACATCCACACAGCTGATGAT
GAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTCTTTCGGACATTCCGTATCTCCATTAGCGATGTGGAC
AATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAACAAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGAC
AGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCATGGCCATCTCCTATTCAACAATACCAGACCTGTCATG
GTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGCACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTG
ACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACAAGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCT
GTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGCACTCTAGCCACTGGCCACTTGGGGTTCATGATCACA
AGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTTATCGTGACAGAGGCCCCTCAACATGGATATCTTCTC
AACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGATGACATGAAAATATGCTATGTCTTAAGAGAAGGGGCT
AATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAGTTAACGTACCAGAATTTTCGTCTGAATTGGGCATGG
ATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGATGTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACT
TCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTCAAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCA
GGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAGCAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCC
GTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCAGGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAA
TACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGAGATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACC
CAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGATTACATATCCAGGCCTGAGGACCACACCAGTGTTGTC
CGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGACTCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTT
CTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTTACAATCGTTCCTGACAAAGATGATGAACCCATCTTT
TACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTGCAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCT
TCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGAACAGACTATGTGGGCATCAGCCGTAATTTAGATTTT
GCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGACAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTG
GTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTGTCCATAAATGACTCTGTCTCCGATTTGCCTAAGATG
CAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACAATGATCCATAGGACTGGGGATGTCCAGTACAGATCT
TCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAAGAACGCCCAAACACTGATACCTCCATCATCACATTC
CTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTCTATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGC
ACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACTCTCATAAGGATCCGAGATGATGCTGATAAGACTGTT
ATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAGTCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGA
GACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACCTCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATT
GAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGACGGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCAC
CTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTGTACATAGAAGAAATGAGCAGCATGGCAGATGTCACT
TTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAAGCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCT
GTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGCTCTATCTGTGCAAGTGAGAACATCAATGACACTTTG
ACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGCCCTATGAGAGAAGTGGACTTCGACACCTTTTTTACG
TCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTACAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGAT
GAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTTTGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAG
CCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAACCTTATCAAGCTCACTGTCACAATGCCACACATAGAT
GGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTCAGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGC
TCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGATGCTACCAAAAATCCAGAAATAATTGGAGAGACATAT
CCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGGAACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTT
AGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACAGATGGACAGGTGGATGTGAAATTGGACCCCAAGGAT
TTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAAACTGATAGTGCCGTCAGACTTGTCCACATCCCCACA
GGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATAGCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAG
ATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGAACAAGAGCCCAGTCAGAGCGAATTCGGACATATAAT
TTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATTAAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAG

>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000430347_chr13_41808143_-_8481nt
ATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACCAGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTG
CTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCCGCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTC
GCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGACTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGAT
CCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCGGTACTAGACAACGACGCACTGGCCCAGCGACCGGGC
CGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTACTCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGC
GTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTGGTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAG
GTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAATGCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAG
CCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCTCGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCT
GGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCTTTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCC
GCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCACGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGC
GAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCCAAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTG
GACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCTGAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACT
TCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTGCCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTC
CTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTTGAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCA
GCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCTCCGGTGGTCACCCGGAATACCGGTCTTATTCTCTAT
GAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTGGTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGG
CTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCCAGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCT
GAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTGAGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGA
GGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGACCAGCCACCTGTTCTCAATGCCAACACGGGGCTGACA
CTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGACATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTG
GAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCCCATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGG
AAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATAACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCC
CATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCATGACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTG
ATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCCCTTCGTATGGTGGTACAGGAATCCCAGCTCACACCA
CTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTACGTTACACAGTGACTCAGTCCCCCACAGACACAGAC
GAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCAGTCGTGGTGACCCATTTTACCCAAGCCCAGATCAAC
CATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGAGTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCT
GGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAGCCACCTGAGATCCTCAACACCGGCTTCACTATTCAG
GAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGACACTGATGTTGCCCATATCTCTTTCACTCTCACTCAG
GCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGTCTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTT
TCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTCAGTGACAGACATCATGTGGTGCCCATCACTCTCAGA
GTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGCACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGG
GCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGACTTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTG
TATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGACATCTTGGAGGGCTCTGTTGTATATACCCACACCAGT
GGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGATATGTCTCAAGAATGGAGAATTGGTGGCAATACTATC
CAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAAATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGT
GATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTGAATGATGACATCTTGTGCACTATAGTTATTCAGCCT
ACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGAGCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGAT
CTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCTGTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGC
ATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGATGAACAGCCAGAGATGTTTATGAGAGAATTTATGGTG
ATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCTGATGTTCCCCTGGATGATTTAACTTTCACTATTACC
CAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTGGTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGT
TCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTGATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAG
ACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATCAATAATGGACTAGAAATAGAAATTGGGGATACCAAG
ATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCTTTGGTTTATATTATTCGTTATGGGCCAGGACATGGC
TTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATGAATTTTACCCAGGATGAAGTAGACAGAAACTTAATT
CAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTGACTGATGGAATAAATCCCCTCATAGATCGTTACTTT
TATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGAGTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACA
ACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTTACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAA
TGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCTGGAAACAAAATCTACTACATCCACACAGCTGATGAT
GAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTCTTTCGGACATTCCGTATCTCCATTAGCGATGTGGAC
AATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAACAAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGAC
AGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCATGGCCATCTCCTATTCAACAATACCAGACCTGTCATG
GTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGCACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTG
ACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACAAGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCT
GTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGCACTCTAGCCACTGGCCACTTGGGGTTCATGATCACA
AGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTTATCGTGACAGAGGCCCCTCAACATGGATATCTTCTC
AACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGATGACATGAAAATATGCTATGTCTTAAGAGAAGGGGCT
AATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAGTTAACGTACCAGAATTTTCGTCTGAATTGGGCATGG
ATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGATGTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACT
TCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTCAAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCA
GGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAGCAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCC
GTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCAGGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAA
TACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGAGATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACC
CAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGATTACATATCCAGGCCTGAGGACCACACCAGTGTTGTC
CGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGACTCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTT
CTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTTACAATCGTTCCTGACAAAGATGATGAACCCATCTTT
TACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTGCAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCT
TCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGAACAGACTATGTGGGCATCAGCCGTAATTTAGATTTT
GCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGACAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTG
GTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTGTCCATAAATGACTCTGTCTCCGATTTGCCTAAGATG
CAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACAATGATCCATAGGACTGGGGATGTCCAGTACAGATCT
TCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAAGAACGCCCAAACACTGATACCTCCATCATCACATTC
CTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTCTATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGC
ACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACTCTCATAAGGATCCGAGATGATGCTGATAAGACTGTT
ATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAGTCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGA
GACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACCTCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATT
GAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGACGGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCAC
CTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTGTACATAGAAGAAATGAGCAGCATGGCAGATGTCACT
TTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAAGCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCT
GTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGCTCTATCTGTGCAAGTGAGAACATCAATGACACTTTG
ACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGCCCTATGAGAGAAGTGGACTTCGACACCTTTTTTACG
TCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTACAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGAT
GAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTTTGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAG
CCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAACCTTATCAAGCTCACTGTCACAATGCCACACATAGAT
GGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTCAGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGC
TCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGATGCTACCAAAAATCCAGAAATAATTGGAGAGACATAT
CCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGGAACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTT
AGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACAGATGGACAGGTGGATGTGAAATTGGACCCCAAGGAT
TTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAAACTGATAGTGCCGTCAGACTTGTCCACATCCCCACA
GGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATAGCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAG
ATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGAACAAGAGCCCAGTCAGAGCGAATTCGGACATATAAT
TTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATTAAGGCTCAGTCTCATTCCACGGGTGGTAGTCGTGAC
CCTGCACATTCCACATTCCTATCCTTGGATTCTGTGAGATCACCTGGTATTCTCATTATGACTTCTTCTGTTAGGAATTTTTATGTGGTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000379480_chr13_41808143_-_9413nt
GGACGGCCTGGGAAGGCTTCGGCTCCTCGGCTGCGGCTCCAGCCCGGACGGCGCCGCGCAACTTTGCCATCCTTCTGGCCCAGCCCCGGC
TACAGGAGGACCCCGCGGGCAACGCGCGGAGTTCCTGGCACTTCCCGGCGGTGTCTCTTGTTGTCTGCCCGGGGACCGACTTCGCATGCT
CTCAGGCTGACCTGTCCAAGCCCGAACACCGGGACCATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACC
AGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTGCTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCC
GCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTCGCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGA
CTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGATCCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCG
GTACTAGACAACGACGCACTGGCCCAGCGACCGGGCCGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTAC
TCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGCGTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTG
GTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAGGTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAAT
GCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAGCCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCT
CGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCTGGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCT
TTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCCGCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCA
CGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGCGAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCC
AAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTGGACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCT
GAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACTTCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTG
CCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTCCTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTT
GAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCAGCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCT
CCGGTGGTCACCCGGAATACCGGTCTTATTCTCTATGAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTG
GTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGGCTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCC
AGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCTGAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTG
AGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGAGGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGAC
CAGCCACCTGTTCTCAATGCCAACACGGGGCTGACACTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGAC
ATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTGGAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCC
CATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGGAAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATA
ACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCCCATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCAT
GACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTGATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCC
CTTCGTATGGTGGTACAGGAATCCCAGCTCACACCACTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTA
CGTTACACAGTGACTCAGTCCCCCACAGACACAGACGAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCA
GTCGTGGTGACCCATTTTACCCAAGCCCAGATCAACCATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGA
GTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCTGGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAG
CCACCTGAGATCCTCAACACCGGCTTCACTATTCAGGAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGAC
ACTGATGTTGCCCATATCTCTTTCACTCTCACTCAGGCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGT
CTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTTTCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTC
AGTGACAGACATCATGTGGTGCCCATCACTCTCAGAGTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGC
ACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGGGCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGAC
TTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTGTATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGAC
ATCTTGGAGGGCTCTGTTGTATATACCCACACCAGTGGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGAT
ATGTCTCAAGAATGGAGAATTGGTGGCAATACTATCCAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAA
ATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGTGATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTG
AATGATGACATCTTGTGCACTATAGTTATTCAGCCTACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGA
GCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGATCTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCT
GTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGCATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGAT
GAACAGCCAGAGATGTTTATGAGAGAATTTATGGTGATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCT
GATGTTCCCCTGGATGATTTAACTTTCACTATTACCCAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTG
GTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGTTCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTG
ATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAGACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATC
AATAATGGACTAGAAATAGAAATTGGGGATACCAAGATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCT
TTGGTTTATATTATTCGTTATGGGCCAGGACATGGCTTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATG
AATTTTACCCAGGATGAAGTAGACAGAAACTTAATTCAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTG
ACTGATGGAATAAATCCCCTCATAGATCGTTACTTTTATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGA
GTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACAACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTT
ACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAATGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCT
GGAAACAAAATCTACTACATCCACACAGCTGATGATGAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTC
TTTCGGACATTCCGTATCTCCATTAGCGATGTGGACAATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAAC
AAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGACAGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCAT
GGCCATCTCCTATTCAACAATACCAGACCTGTCATGGTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGC
ACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTGACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACA
AGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCTGTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGC
ACTCTAGCCACTGGCCACTTGGGGTTCATGATCACAAGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTT
ATCGTGACAGAGGCCCCTCAACATGGATATCTTCTCAACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGAT
GACATGAAAATATGCTATGTCTTAAGAGAAGGGGCTAATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAG
TTAACGTACCAGAATTTTCGTCTGAATTGGGCATGGATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGAT
GTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACTTCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTC
AAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCAGGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAG
CAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCCGTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCA
GGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAATACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGA
GATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACCCAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGAT
TACATATCCAGGCCTGAGGACCACACCAGTGTTGTCCGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGAC
TCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTTCTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTT
ACAATCGTTCCTGACAAAGATGATGAACCCATCTTTTACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTG
CAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCTTCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGA
ACAGACTATGTGGGCATCAGCCGTAATTTAGATTTTGCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGA
CAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTGGTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTG
TCCATAAATGACTCTGTCTCCGATTTGCCTAAGATGCAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACA
ATGATCCATAGGACTGGGGATGTCCAGTACAGATCTTCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAA
GAACGCCCAAACACTGATACCTCCATCATCACATTCCTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTC
TATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGCACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACT
CTCATAAGGATCCGAGATGATGCTGATAAGACTGTTATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAG
TCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGAGACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACC
TCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATTGAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGAC
GGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCACCTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTG
TACATAGAAGAAATGAGCAGCATGGCAGATGTCACTTTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAA
GCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCTGTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGC
TCTATCTGTGCAAGTGAGAACATCAATGACACTTTGACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGC
CCTATGAGAGAAGTGGACTTCGACACCTTTTTTACGTCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTA
CAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGATGAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTT
TGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAGCCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAAC
CTTATCAAGCTCACTGTCACAATGCCACACATAGATGGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTC
AGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGCTCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGAT
GCTACCAAAAATCCAGAAATAATTGGAGAGACATATCCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGG
AACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTTAGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACA
GATGGACAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAA
ACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATA
GCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGA
ACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATT
AAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAGCTAATTCAGAGACTGCTTCAATCAGCAGATGAAGAAGCCATTGCTGAACTTTTG
GATGAACACCTTAAATCAGCAAAATAAATACTAACTTATTATTATTTATGATTATATAAATGAAATGGACCTATATCAAGAGGCAGACTG
AAGCTTGGAAATCATTATGAATATTTGTAAATTACAGCTTTAAGAACACATTACACATAAATATATGTTTTGTAATTAATCGAAGTCACA
TTTCCTGACCTAAGAATTTATTTTAGGTTTCCTGTAAAGTACAATCCAACTCATCAAGTAGAAAATAAGCATGCATCATTGAAAAGAGAA
AGTATTGAGAATTGATTGTGTCATTTAGGACAAGTCACTTGTTCTCTTTATATGCCTTTTTTCCCCAGCCATCTATGAATTAATTTAAAT
ATATTTTTAATCTACTACTTCAGGAAAATATGGTAAAATTTAGTAAAATATGAATTTTAGACTTCCTTATAAACCTTTTATTTAAATACA
AAGTACCTTGGCCTATAGTGGATGCTTATGCCTGTAATCCCAGTGCTTTGAAGGGCCAAAGGGGGAAGATCTCTTGAGGTAAGAATTTGA
GACCAGCCTGGGCAAAATAGACCCCATGTCTACAAAAAAACTCAAAACATAAAGAAAAACCATAATACTGTTAATCATGTTAAAGTTAAG
ACTTAGACTGCAACTTTTAAATAAAAATTATGAAGAATATGAGTCATTCAATAACAATGAGCATCTGGGTACAGACAGTAAAGCCCTTTG

>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000379477_chr13_41808143_-_8807nt
GGACGGCCTGGGAAGGCTTCGGCTCCTCGGCTGCGGCTCCAGCCCGGACGGCGCCGCGCAACTTTGCCATCCTTCTGGCCCAGCCCCGGC
TACAGGAGGACCCCGCGGGCAACGCGCGGAGTTCCTGGCACTTCCCGGCGGTGTCTCTTGTTGTCTGCCCGGGGACCGACTTCGCATGCT
CTCAGGCTGACCTGTCCAAGCCCGAACACCGGGACCATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACC
AGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTGCTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCC
GCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTCGCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGA
CTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGATCCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCG
GTACTAGACAACGACGCACTGGCCCAGCGACCGGGCCGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTAC
TCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGCGTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTG
GTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAGGTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAAT
GCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAGCCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCT
CGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCTGGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCT
TTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCCGCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCA
CGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGCGAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCC
AAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTGGACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCT
GAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACTTCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTG
CCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTCCTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTT
GAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCAGCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCT
CCGGTGGTCACCCGGAATACCGGTCTTATTCTCTATGAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTG
GTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGGCTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCC
AGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCTGAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTG
AGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGAGGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGAC
CAGCCACCTGTTCTCAATGCCAACACGGGGCTGACACTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGAC
ATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTGGAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCC
CATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGGAAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATA
ACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCCCATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCAT
GACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTGATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCC
CTTCGTATGGTGGTACAGGAATCCCAGCTCACACCACTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTA
CGTTACACAGTGACTCAGTCCCCCACAGACACAGACGAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCA
GTCGTGGTGACCCATTTTACCCAAGCCCAGATCAACCATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGA
GTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCTGGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAG
CCACCTGAGATCCTCAACACCGGCTTCACTATTCAGGAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGAC
ACTGATGTTGCCCATATCTCTTTCACTCTCACTCAGGCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGT
CTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTTTCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTC
AGTGACAGACATCATGTGGTGCCCATCACTCTCAGAGTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGC
ACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGGGCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGAC
TTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTGTATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGAC
ATCTTGGAGGGCTCTGTTGTATATACCCACACCAGTGGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGAT
ATGTCTCAAGAATGGAGAATTGGTGGCAATACTATCCAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAA
ATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGTGATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTG
AATGATGACATCTTGTGCACTATAGTTATTCAGCCTACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGA
GCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGATCTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCT
GTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGCATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGAT
GAACAGCCAGAGATGTTTATGAGAGAATTTATGGTGATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCT
GATGTTCCCCTGGATGATTTAACTTTCACTATTACCCAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTG
GTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGTTCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTG
ATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAGACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATC
AATAATGGACTAGAAATAGAAATTGGGGATACCAAGATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCT
TTGGTTTATATTATTCGTTATGGGCCAGGACATGGCTTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATG
AATTTTACCCAGGATGAAGTAGACAGAAACTTAATTCAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTG
ACTGATGGAATAAATCCCCTCATAGATCGTTACTTTTATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGA
GTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACAACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTT
ACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAATGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCT
GGAAACAAAATCTACTACATCCACACAGCTGATGATGAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTC
TTTCGGACATTCCGTATCTCCATTAGCGATGTGGACAATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAAC
AAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGACAGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCAT
GGCCATCTCCTATTCAACAATACCAGACCTGTCATGGTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGC
ACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTGACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACA
AGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCTGTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGC
ACTCTAGCCACTGGCCACTTGGGGTTCATGATCACAAGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTT
ATCGTGACAGAGGCCCCTCAACATGGATATCTTCTCAACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGAT
GACATGAAAATATGCTATGTCTTAAGAGAAGGGGCTAATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAG
TTAACGTACCAGAATTTTCGTCTGAATTGGGCATGGATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGAT
GTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACTTCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTC
AAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCAGGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAG
CAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCCGTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCA
GGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAATACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGA
GATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACCCAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGAT
TACATATCCAGGCCTGAGGACCACACCAGTGTTGTCCGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGAC
TCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTTCTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTT
ACAATCGTTCCTGACAAAGATGATGAACCCATCTTTTACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTG
CAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCTTCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGA
ACAGACTATGTGGGCATCAGCCGTAATTTAGATTTTGCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGA
CAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTGGTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTG
TCCATAAATGACTCTGTCTCCGATTTGCCTAAGATGCAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACA
ATGATCCATAGGACTGGGGATGTCCAGTACAGATCTTCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAA
GAACGCCCAAACACTGATACCTCCATCATCACATTCCTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTC
TATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGCACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACT
CTCATAAGGATCCGAGATGATGCTGATAAGACTGTTATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAG
TCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGAGACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACC
TCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATTGAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGAC
GGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCACCTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTG
TACATAGAAGAAATGAGCAGCATGGCAGATGTCACTTTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAA
GCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCTGTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGC
TCTATCTGTGCAAGTGAGAACATCAATGACACTTTGACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGC
CCTATGAGAGAAGTGGACTTCGACACCTTTTTTACGTCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTA
CAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGATGAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTT
TGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAGCCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAAC
CTTATCAAGCTCACTGTCACAATGCCACACATAGATGGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTC
AGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGCTCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGAT
GCTACCAAAAATCCAGAAATAATTGGAGAGACATATCCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGG
AACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTTAGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACA
GATGGACAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAA
ACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATA
GCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGA
ACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATT
AAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAGCTAATTCAGAGACTGCTTCAATCAGCAGATGAAGAAGCCATTGCTGAACTTTTG
GATGAACACCTTAAATCAGCAAAATAAATACTAACTTATTATTATTTATGATTATATAAATGAAATGGACCTATATCAAGAGGCAGACTG

>In-frame_FREM2_ENST00000280481_chr13_39438743_+_MTRF1_ENST00000430347_chr13_41808143_-_8811nt
GGACGGCCTGGGAAGGCTTCGGCTCCTCGGCTGCGGCTCCAGCCCGGACGGCGCCGCGCAACTTTGCCATCCTTCTGGCCCAGCCCCGGC
TACAGGAGGACCCCGCGGGCAACGCGCGGAGTTCCTGGCACTTCCCGGCGGTGTCTCTTGTTGTCTGCCCGGGGACCGACTTCGCATGCT
CTCAGGCTGACCTGTCCAAGCCCGAACACCGGGACCATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACC
AGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTGCTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCC
GCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTCGCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGA
CTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGATCCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCG
GTACTAGACAACGACGCACTGGCCCAGCGACCGGGCCGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTAC
TCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGCGTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTG
GTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAGGTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAAT
GCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAGCCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCT
CGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCTGGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCT
TTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCCGCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCA
CGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGCGAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCC
AAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTGGACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCT
GAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACTTCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTG
CCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTCCTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTT
GAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCAGCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCT
CCGGTGGTCACCCGGAATACCGGTCTTATTCTCTATGAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTG
GTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGGCTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCC
AGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCTGAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTG
AGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGAGGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGAC
CAGCCACCTGTTCTCAATGCCAACACGGGGCTGACACTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGAC
ATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTGGAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCC
CATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGGAAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATA
ACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCCCATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCAT
GACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTGATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCC
CTTCGTATGGTGGTACAGGAATCCCAGCTCACACCACTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTA
CGTTACACAGTGACTCAGTCCCCCACAGACACAGACGAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCA
GTCGTGGTGACCCATTTTACCCAAGCCCAGATCAACCATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGA
GTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCTGGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAG
CCACCTGAGATCCTCAACACCGGCTTCACTATTCAGGAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGAC
ACTGATGTTGCCCATATCTCTTTCACTCTCACTCAGGCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGT
CTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTTTCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTC
AGTGACAGACATCATGTGGTGCCCATCACTCTCAGAGTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGC
ACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGGGCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGAC
TTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTGTATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGAC
ATCTTGGAGGGCTCTGTTGTATATACCCACACCAGTGGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGAT
ATGTCTCAAGAATGGAGAATTGGTGGCAATACTATCCAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAA
ATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGTGATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTG
AATGATGACATCTTGTGCACTATAGTTATTCAGCCTACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGA
GCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGATCTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCT
GTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGCATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGAT
GAACAGCCAGAGATGTTTATGAGAGAATTTATGGTGATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCT
GATGTTCCCCTGGATGATTTAACTTTCACTATTACCCAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTG
GTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGTTCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTG
ATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAGACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATC
AATAATGGACTAGAAATAGAAATTGGGGATACCAAGATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCT
TTGGTTTATATTATTCGTTATGGGCCAGGACATGGCTTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATG
AATTTTACCCAGGATGAAGTAGACAGAAACTTAATTCAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTG
ACTGATGGAATAAATCCCCTCATAGATCGTTACTTTTATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGA
GTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACAACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTT
ACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAATGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCT
GGAAACAAAATCTACTACATCCACACAGCTGATGATGAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTC
TTTCGGACATTCCGTATCTCCATTAGCGATGTGGACAATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAAC
AAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGACAGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCAT
GGCCATCTCCTATTCAACAATACCAGACCTGTCATGGTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGC
ACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTGACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACA
AGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCTGTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGC
ACTCTAGCCACTGGCCACTTGGGGTTCATGATCACAAGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTT
ATCGTGACAGAGGCCCCTCAACATGGATATCTTCTCAACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGAT
GACATGAAAATATGCTATGTCTTAAGAGAAGGGGCTAATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAG
TTAACGTACCAGAATTTTCGTCTGAATTGGGCATGGATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGAT
GTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACTTCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTC
AAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCAGGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAG
CAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCCGTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCA
GGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAATACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGA
GATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACCCAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGAT
TACATATCCAGGCCTGAGGACCACACCAGTGTTGTCCGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGAC
TCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTTCTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTT
ACAATCGTTCCTGACAAAGATGATGAACCCATCTTTTACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTG
CAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCTTCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGA
ACAGACTATGTGGGCATCAGCCGTAATTTAGATTTTGCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGA
CAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTGGTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTG
TCCATAAATGACTCTGTCTCCGATTTGCCTAAGATGCAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACA
ATGATCCATAGGACTGGGGATGTCCAGTACAGATCTTCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAA
GAACGCCCAAACACTGATACCTCCATCATCACATTCCTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTC
TATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGCACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACT
CTCATAAGGATCCGAGATGATGCTGATAAGACTGTTATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAG
TCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGAGACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACC
TCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATTGAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGAC
GGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCACCTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTG
TACATAGAAGAAATGAGCAGCATGGCAGATGTCACTTTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAA
GCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCTGTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGC
TCTATCTGTGCAAGTGAGAACATCAATGACACTTTGACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGC
CCTATGAGAGAAGTGGACTTCGACACCTTTTTTACGTCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTA
CAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGATGAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTT
TGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAGCCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAAC
CTTATCAAGCTCACTGTCACAATGCCACACATAGATGGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTC
AGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGCTCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGAT
GCTACCAAAAATCCAGAAATAATTGGAGAGACATATCCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGG
AACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTTAGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACA
GATGGACAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAA
ACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATA
GCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGA
ACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATT
AAGGCTCAGTCTCATTCCACGGGTGGTAGTCGTGACCCTGCACATTCCACATTCCTATCCTTGGATTCTGTGAGATCACCTGGTATTCTC
ATTATGACTTCTTCTGTTAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAGCTAATTCAGAGACTGCTTCAATCAGCAGATGAAGAAG


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FusionGenePPI for FREM2_MTRF1


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ChiPPI page

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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FREM2RYK, CTSG, TAZ, NXPH2, KLK5, DTWD2, DNASE2B, CALR3, DDX39A, CHST8, TNF, LIPH, DKKL1, SCGB1D1, RPL28, FCGR1A, PCDHGB1, ST8SIA4, DEFA5, ZBBX, PSG8, XAGE1B, FAM19A4, PDGFB, ARNTL2MTRF1PARK7, MOV10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FREM2_MTRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FREM2_MTRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFREM2C0265233Cryptophthalmos syndrome2CTD_human;ORPHANET;UNIPROT