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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13838

FusionGeneSummary for FOXP1_HRH1

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXP1_HRH1
Fusion gene ID: 13838
HgeneTgene
Gene symbol

FOXP1

HRH1

Gene ID

27086

9704

Gene nameforkhead box P1DExH-box helicase 34
Synonyms12CC4|HSPC215|MFH|QRF1|hFKH1BDDX34|HRH1
Cytomap

3p13

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkheadprobable ATP-dependent RNA helicase DHX34DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34DEAH (Asp-Glu-Ala-His) box polypeptide 34DEAH box protein 34DEAH-box helicase 34probable ATP-dependent helicase DHX34
Modification date2018052220180523
UniProtAcc

Q9H334

P35367

Ensembl transtripts involved in fusion geneENST00000318789, ENST00000475937, 
ENST00000493089, ENST00000484350, 
ENST00000318779, ENST00000491238, 
ENST00000498215, ENST00000468577, 
ENST00000472382, 
ENST00000438284, 
ENST00000431010, ENST00000397056, 
Fusion gene scores* DoF score21 X 13 X 11=30035 X 5 X 2=50
# samples 265
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: FOXP1 [Title/Abstract] AND HRH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

HgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

HgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

HgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

HgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

HgeneFOXP1

GO:0036035

osteoclast development

18799727

HgeneFOXP1

GO:0042116

macrophage activation

18799727

HgeneFOXP1

GO:0042117

monocyte activation

18799727

HgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

HgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

HgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

HgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

HgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

HgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

HgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

HgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YL-A8SA-01AFOXP1chr3

71247353

-HRH1chr3

11300689

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000318789ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000318789ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000318789ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000475937ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000475937ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000475937ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000493089ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000493089ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000493089ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000484350ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000484350ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000484350ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000318779ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000318779ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000318779ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
intron-5UTRENST00000491238ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
intron-5UTRENST00000491238ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
intron-5UTRENST00000491238ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000498215ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000498215ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000498215ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000468577ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000468577ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
5CDS-5UTRENST00000468577ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+
intron-5UTRENST00000472382ENST00000438284FOXP1chr3

71247353

-HRH1chr3

11300689

+
intron-5UTRENST00000472382ENST00000431010FOXP1chr3

71247353

-HRH1chr3

11300689

+
intron-5UTRENST00000472382ENST00000397056FOXP1chr3

71247353

-HRH1chr3

11300689

+

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FusionProtFeatures for FOXP1_HRH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXP1

Q9H334

HRH1

P35367

In peripheral tissues, the H1 subclass of histaminereceptors mediates the contraction of smooth muscles, increase incapillary permeability due to contraction of terminal venules, andcatecholamine release from adrenal medulla, as well as mediatingneurotransmission in the central nervous system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FOXP1_HRH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOXP1_HRH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FOXP1CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70HRH1IL6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOXP1_HRH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHRH1P35367DB00215CitalopramHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00245BenzatropineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00246ZiprasidoneHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00321AmitriptylineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00341CetirizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00354BuclizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00363ClozapineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00370MirtazapineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00405DexbrompheniramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00408LoxapineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00427TriprolidineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00434CyproheptadineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00458ImipramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00540NortriptylineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00543AmoxapineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00557HydroxyzineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00719AzatadineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00726TrimipramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00737MeclizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00748CarbinoxamineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00768OlopatadineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00777PropiomazineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00835BrompheniramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00902MethdilazineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00920KetotifenHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00972AzelastineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00985DimenhydrinateHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01071MequitazineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01084EmedastineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01114ChlorphenamineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01173OrphenadrineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01176CyclizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01224QuetiapineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01237BromodiphenhydramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01267PaliperidoneHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01619PhenindamineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB01620PheniramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB04841FlunarizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB04946IloperidoneHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB06216AsenapineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB06282LevocetirizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB06766AlcaftadineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB08799AntazolineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB08800ChloropyramineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB08802IsothipendylHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB08936ChlorcyclizineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB09016ButriptylineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB09167DosulepinHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB09488AcrivastineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB11614RupatadineHistamine H1 receptorsmall moleculeapproved
TgeneHRH1P35367DB00283ClemastineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00334OlanzapineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00455LoratadineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00555LamotrigineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00568CinnarizineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00656TrazodoneHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00734RisperidoneHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00751EpinastineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00934MaprotilineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00950FexofenadineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00967DesloratadineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01069PromethazineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01075DiphenhydramineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01106LevocabastineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01142DoxepinHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01146DiphenylpyralineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01151DesipramineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01175EscitalopramHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01238AripiprazoleHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01403MethotrimeprazineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB01624ZuclopenthixolHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB05381HistamineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB06016CariprazineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB06148MianserinHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB06698BetahistineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB08801DimetindeneHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB11591BilastineHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB13025TiaprideHistamine H1 receptorsmall moleculeapproved|investigational
TgeneHRH1P35367DB00477ChlorpromazineHistamine H1 receptorsmall moleculeapproved|investigational|vet_approved
TgeneHRH1P35367DB01239ChlorprothixeneHistamine H1 receptorsmall moleculeapproved|investigational|withdrawn
TgeneHRH1P35367DB00366DoxylamineHistamine H1 receptorsmall moleculeapproved|vet_approved
TgeneHRH1P35367DB00420PromazineHistamine H1 receptorsmall moleculeapproved|vet_approved
TgeneHRH1P35367DB00792TripelennamineHistamine H1 receptorsmall moleculeapproved|vet_approved
TgeneHRH1P35367DB00797TolazolineHistamine H1 receptorsmall moleculeapproved|vet_approved
TgeneHRH1P35367DB01246AlimemazineHistamine H1 receptorsmall moleculeapproved|vet_approved
TgeneHRH1P35367DB06691MepyramineHistamine H1 receptorsmall moleculeapproved|vet_approved
TgeneHRH1P35367DB00342TerfenadineHistamine H1 receptorsmall moleculeapproved|withdrawn
TgeneHRH1P35367DB00637AstemizoleHistamine H1 receptorsmall moleculeapproved|withdrawn
TgeneHRH1P35367DB04837ClofedanolHistamine H1 receptorsmall moleculeapproved|withdrawn

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RelatedDiseases for FOXP1_HRH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
HgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
HgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
HgeneFOXP1C0042900Vitiligo1CTD_human
HgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
HgeneFOXP1C3495559Juvenile arthritis1CTD_human
HgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT
TgeneHRH1C0030193Pain2CTD_human
TgeneHRH1C0004153Atherosclerosis1CTD_human
TgeneHRH1C0020649Hypotension1CTD_human
TgeneHRH1C0033774Pruritus1CTD_human
TgeneHRH1C0035228Respiratory Hypersensitivity1CTD_human
TgeneHRH1C0035455Rhinitis1CTD_human
TgeneHRH1C0036341Schizophrenia1CTD_human
TgeneHRH1C0038587Substance Withdrawal Syndrome1CTD_human
TgeneHRH1C2607914Allergic rhinitis (disorder)1CTD_human