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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13834

FusionGeneSummary for FOXP1_FHIT

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXP1_FHIT
Fusion gene ID: 13834
HgeneTgene
Gene symbol

FOXP1

FHIT

Gene ID

27086

2272

Gene nameforkhead box P1fragile histidine triad
Synonyms12CC4|HSPC215|MFH|QRF1|hFKH1BAP3Aase|FRA3B
Cytomap

3p13

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkheadbis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase
Modification date2018052220180519
UniProtAcc

Q9H334

P49789

Ensembl transtripts involved in fusion geneENST00000318789, ENST00000475937, 
ENST00000493089, ENST00000484350, 
ENST00000318779, ENST00000491238, 
ENST00000498215, ENST00000468577, 
ENST00000472382, 
ENST00000476844, 
ENST00000492590, ENST00000466788, 
ENST00000468189, ENST00000341848, 
Fusion gene scores* DoF score21 X 13 X 11=300317 X 7 X 10=1190
# samples 2620
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/1190*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXP1 [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

HgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

HgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

HgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

HgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

HgeneFOXP1

GO:0036035

osteoclast development

18799727

HgeneFOXP1

GO:0042116

macrophage activation

18799727

HgeneFOXP1

GO:0042117

monocyte activation

18799727

HgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

HgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

HgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

HgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

HgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

HgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

HgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

HgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727

TgeneFHIT

GO:0006163

purine nucleotide metabolic process

9323207


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHYMTCGA-ZB-A969-01AFOXP1chr3

71348971

-FHITchr3

59908140

-
TCGALDTHYMTCGA-ZB-A969-01AFOXP1chr3

71348971

-FHITchr3

59738047

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000318789ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000318789ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000318789ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000318789ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000318789ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000475937ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000475937ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000475937ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000475937ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000475937ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000493089ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000493089ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000493089ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000493089ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000493089ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000484350ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000484350ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000484350ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000484350ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000484350ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000318779ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000318779ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000318779ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000318779ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-5UTRENST00000318779ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000491238ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000491238ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000491238ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000491238ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000491238ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000498215ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000498215ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000498215ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000498215ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000498215ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000468577ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000468577ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000468577ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000468577ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000468577ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000472382ENST00000476844FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-3CDSENST00000472382ENST00000492590FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000472382ENST00000466788FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000472382ENST00000468189FOXP1chr3

71348971

-FHITchr3

59908140

-
intron-5UTRENST00000472382ENST00000341848FOXP1chr3

71348971

-FHITchr3

59908140

-
5UTR-3CDSENST00000318789ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000318789ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000318789ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000318789ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000318789ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000475937ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000475937ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000475937ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000475937ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000475937ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000493089ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000493089ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000493089ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000493089ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000493089ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000484350ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000484350ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000484350ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000484350ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000484350ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000318779ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-3CDSENST00000318779ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000318779ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000318779ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
5UTR-5UTRENST00000318779ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000491238ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000491238ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000491238ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000491238ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000491238ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000498215ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000498215ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000498215ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000498215ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000498215ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000468577ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000468577ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000468577ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000468577ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000468577ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000472382ENST00000476844FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-3CDSENST00000472382ENST00000492590FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000472382ENST00000466788FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000472382ENST00000468189FOXP1chr3

71348971

-FHITchr3

59738047

-
intron-5UTRENST00000472382ENST00000341848FOXP1chr3

71348971

-FHITchr3

59738047

-

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FusionProtFeatures for FOXP1_FHIT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXP1

Q9H334

FHIT

P49789

Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A)to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activitywith ATP. Modulates transcriptional activation by CTNNB1 andthereby contributes to regulate the expression of genes essentialfor cell proliferation and survival, such as CCND1 and BIRC5.Plays a role in the induction of apoptosis via SRC and AKT1signaling pathways. Inhibits MDM2-mediated proteasomal degradationof p53/TP53 and thereby plays a role in p53/TP53-mediatedapoptosis. Induction of apoptosis depends on the ability of FHITto bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or relatedcompounds, but does not require its catalytic activity, it may inpart come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calciumuptake. Functions as tumor suppressor.{ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915,ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326,ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:8794732,ECO:0000269|PubMed:9323207}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FOXP1_FHIT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOXP1_FHIT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FOXP1CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70FHITFHIT, UBE2I, CTNNB1, LEF1, TRIM23, RAB40B, MDM2, REL, TP53, ARHGAP19, MTMR6, RABL2A, CHEK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOXP1_FHIT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFHITP49789DB04173FructoseBis(5'-adenosyl)-triphosphatasesmall moleculeapproved|experimental

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RelatedDiseases for FOXP1_FHIT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
HgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
HgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
HgeneFOXP1C0042900Vitiligo1CTD_human
HgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
HgeneFOXP1C3495559Juvenile arthritis1CTD_human
HgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT
TgeneFHITC0024121Lung Neoplasms2CTD_human
TgeneFHITC0025500Mesothelioma2CTD_human
TgeneFHITC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneFHITC0023903Liver neoplasms1CTD_human
TgeneFHITC0033578Prostatic Neoplasms1CTD_human
TgeneFHITC0036341Schizophrenia1PSYGENET
TgeneFHITC0038356Stomach Neoplasms1CTD_human
TgeneFHITC0042076Urologic Neoplasms1CTD_human
TgeneFHITC0236733Amphetamine-Related Disorders1CTD_human
TgeneFHITC0236969Substance-Related Disorders1CTD_human