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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13831

FusionGeneSummary for FOXP1_C5orf51

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXP1_C5orf51
Fusion gene ID: 13831
HgeneTgene
Gene symbol

FOXP1

C5orf51

Gene ID

27086

285636

Gene nameforkhead box P1chromosome 5 open reading frame 51
Synonyms12CC4|HSPC215|MFH|QRF1|hFKH1B-
Cytomap

3p13

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkheadUPF0600 protein C5orf51
Modification date2018052220180519
UniProtAcc

Q9H334

A6NDU8

Ensembl transtripts involved in fusion geneENST00000318789, ENST00000475937, 
ENST00000493089, ENST00000484350, 
ENST00000318779, ENST00000491238, 
ENST00000498215, ENST00000468577, 
ENST00000472382, 
ENST00000505931, 
ENST00000381647, 
Fusion gene scores* DoF score21 X 13 X 11=30032 X 2 X 2=8
# samples 262
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FOXP1 [Title/Abstract] AND C5orf51 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

HgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

HgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

HgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

HgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

HgeneFOXP1

GO:0036035

osteoclast development

18799727

HgeneFOXP1

GO:0042116

macrophage activation

18799727

HgeneFOXP1

GO:0042117

monocyte activation

18799727

HgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

HgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

HgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

HgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

HgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

HgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

HgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

HgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A1FE-01AFOXP1chr3

71348971

-C5orf51chr5

41907838

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000318789ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000318789ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000475937ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000475937ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000493089ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000493089ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000484350ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000484350ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000318779ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
5UTR-3UTRENST00000318779ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000491238ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000491238ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000498215ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000498215ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000468577ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000468577ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000472382ENST00000505931FOXP1chr3

71348971

-C5orf51chr5

41907838

+
intron-3UTRENST00000472382ENST00000381647FOXP1chr3

71348971

-C5orf51chr5

41907838

+

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FusionProtFeatures for FOXP1_C5orf51


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXP1

Q9H334

C5orf51

A6NDU8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FOXP1_C5orf51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOXP1_C5orf51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FOXP1CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70C5orf51ELAVL1, HAT1, CENPJ, FBXW7, LRFN4, FAM19A3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOXP1_C5orf51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FOXP1_C5orf51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
HgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
HgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
HgeneFOXP1C0042900Vitiligo1CTD_human
HgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
HgeneFOXP1C3495559Juvenile arthritis1CTD_human
HgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT