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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13809

FusionGeneSummary for FOXN3_FOXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXN3_FOXN3
Fusion gene ID: 13809
HgeneTgene
Gene symbol

FOXN3

FOXN3

Gene ID

1112

1112

Gene nameforkhead box N3forkhead box N3
SynonymsC14orf116|CHES1|PRO1635C14orf116|CHES1|PRO1635
Cytomap

14q31.3-q32.11

14q31.3-q32.11

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein N3checkpoint suppressor 1forkhead box protein N3checkpoint suppressor 1
Modification date2018051920180519
UniProtAcc

O00409

O00409

Ensembl transtripts involved in fusion geneENST00000345097, ENST00000261302, 
ENST00000557258, ENST00000555353, 
ENST00000555658, 		ENST00000345097, 
ENST00000261302, ENST00000557258, 
ENST00000555353, ENST00000555658, 
Fusion gene scores* DoF score7 X 7 X 4=1968 X 7 X 6=336
# samples 78
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXN3 [Title/Abstract] AND FOXN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXN3

GO:0045892

negative regulation of transcription, DNA-templated

16102918

TgeneFOXN3

GO:0045892

negative regulation of transcription, DNA-templated

16102918


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF367909FOXN3chr14

90047930

-FOXN3chr14

90047857

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000345097ENST00000345097FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000345097ENST00000261302FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000345097ENST00000557258FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000345097ENST00000555353FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000345097ENST00000555658FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000261302ENST00000345097FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000261302ENST00000261302FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000261302ENST00000557258FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000261302ENST00000555353FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000261302ENST00000555658FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000557258ENST00000345097FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000557258ENST00000261302FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000557258ENST00000557258FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000557258ENST00000555353FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000557258ENST00000555658FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555353ENST00000345097FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555353ENST00000261302FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555353ENST00000557258FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555353ENST00000555353FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555353ENST00000555658FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555658ENST00000345097FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555658ENST00000261302FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555658ENST00000557258FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555658ENST00000555353FOXN3chr14

90047930

-FOXN3chr14

90047857

+
intron-intronENST00000555658ENST00000555658FOXN3chr14

90047930

-FOXN3chr14

90047857

+

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FusionProtFeatures for FOXN3_FOXN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXN3

O00409

FOXN3

O00409

Acts as a transcriptional repressor. May be involved inDNA damage-inducible cell cycle arrests (checkpoints).{ECO:0000269|PubMed:16102918}. Acts as a transcriptional repressor. May be involved inDNA damage-inducible cell cycle arrests (checkpoints).{ECO:0000269|PubMed:16102918}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FOXN3_FOXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOXN3_FOXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOXN3_FOXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FOXN3_FOXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource