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Fusion gene ID: 13798 |
FusionGeneSummary for FOXK2_TNFSF13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOXK2_TNFSF13 | Fusion gene ID: 13798 | Hgene | Tgene | Gene symbol | FOXK2 | TNFSF13 | Gene ID | 3607 | 8741 |
| Gene name | forkhead box K2 | TNF superfamily member 13 | |
| Synonyms | ILF|ILF-1|ILF1 | APRIL|CD256|TALL-2|TALL2|TNLG7B|TRDL-1|UNQ383/PRO715|ZTNF2 | |
| Cytomap | 17q25.3 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | forkhead box protein K2FOXK1cellular transcription factor ILF-1interleukin enhancer-binding factor 1 | tumor necrosis factor ligand superfamily member 13TNF- and APOL-related leukocyte expressed ligand 2a proliferation-inducing ligandtumor necrosis factor (ligand) superfamily, member 13tumor necrosis factor ligand 7Btumor necrosis factor superfamily m | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q01167 | O75888 | |
| Ensembl transtripts involved in fusion gene | ENST00000335255, ENST00000529652, | ENST00000483039, ENST00000396542, ENST00000349228, ENST00000338784, ENST00000380535, ENST00000396545, | |
| Fusion gene scores | * DoF score | 25 X 11 X 12=3300 | 1 X 1 X 1=1 |
| # samples | 23 | 1 | |
| ** MAII score | log2(23/3300*10)=-3.8427602581888 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FOXK2 [Title/Abstract] AND TNFSF13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FOXK2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065434 |
| Tgene | TNFSF13 | GO:0048298 | positive regulation of isotype switching to IgA isotypes | 14988498 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ACC | TCGA-OR-A5LO-01A | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000335255 | ENST00000483039 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| 5CDS-5UTR | ENST00000335255 | ENST00000396542 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| 5CDS-intron | ENST00000335255 | ENST00000349228 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| 5CDS-intron | ENST00000335255 | ENST00000338784 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| 5CDS-intron | ENST00000335255 | ENST00000380535 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| 5CDS-intron | ENST00000335255 | ENST00000396545 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| intron-5UTR | ENST00000529652 | ENST00000483039 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| intron-5UTR | ENST00000529652 | ENST00000396542 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| intron-intron | ENST00000529652 | ENST00000349228 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| intron-intron | ENST00000529652 | ENST00000338784 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| intron-intron | ENST00000529652 | ENST00000380535 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
| intron-intron | ENST00000529652 | ENST00000396545 | FOXK2 | chr17 | 80478183 | + | TNFSF13 | chr17 | 7463163 | + |
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FusionProtFeatures for FOXK2_TNFSF13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXK2 | TNFSF13 |
| Transcriptional regulator that recognizes the coresequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) inthe IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus(PubMed:25805136). Also binds to HIV-1 long terminal repeat. Maybe involved in both positive and negative regulation of importantviral and cellular promoter elements (PubMed:1909027).{ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027,ECO:0000269|PubMed:25805136}. | Cytokine that binds to TNFRSF13B/TACI and toTNFRSF17/BCMA. Plays a role in the regulation of tumor cellgrowth. May be involved in monocyte/macrophage-mediatedimmunological processes. {ECO:0000269|PubMed:10973284}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FOXK2_TNFSF13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FOXK2_TNFSF13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FOXK2 | BAP1, AMOT, IRF2, CBX6, SOX2, HECW2, GPS2, RBBP7, SMU1, TEAD1, ESR1, BARD1, XPO1, SAP30, CTR9, HCFC1, MAX, TEAD2, FOXE1, FOXK1, SIN3A, ARID4B, BPTF, NCOR1, ARID4A, SMARCA5, TFAP4, MNT, SAP130, SUDS3, SMARCA1, ZBTB10, BRMS1L, KANSL1, TBL1XR1, ASXL2, BRMS1, MAP1B, TPR, CIC, C17orf49, LIG3, KMT2D, ASXL1, CHD4, HDAC2, ING2, MCRS1, PRDM10, RB1, RBBP5, TBP, KDM1B, DVL2, ING1, KDM5A, KANSL3, PHF20L1, CUX1, DMAP1, DRAP1, HIRA, HMGXB4, HOXD13, NCOR2, SATB2, SIN3B, TBL1X, TBL1Y, ADNP, C11orf30, KANSL2, DPY30, GTF3C3, H2AFY, HOXB9, NFYC, NRF1, NUP107, PSIP1, SAP30L, SF3B1, TP53BP1, SNX9, UBR4, RBM26, PUF60, ANKRD52, EIF2AK3, CHEK2, PRRC2C, UHRF1BP1, ANKRD28, SRPK2, CDK11A, KIAA0513, PER1, USP47, FLJ25613, TMF1, ABHD10, EIF5B, KANK2, RSRC2, FAM120A, NHP2, PHF23, SNRNP200, THRAP3, TP53, YTHDC1, HDAC1, NFATC1, DVL3, ZNF428, AHCYL2, TNFRSF1A, TULP3, FAM60A, PDGFRB, IKZF1, TP63, ZBTB39, CPD, TRIM25 | TNFSF13 | TNFSF13B, TNFSF13, TNFRSF13B, TNFRSF1A, TNFRSF14, FAS, TNFRSF11B, CAMK1D, KRAS, PIK3CA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FOXK2_TNFSF13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FOXK2_TNFSF13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TNFSF13 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Tgene | TNFSF13 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | TNFSF13 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| Tgene | TNFSF13 | C0036341 | Schizophrenia | 1 | PSYGENET |
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