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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1378

FusionGeneSummary for AKIRIN2_CTNNA3

check button Fusion gene summary
Fusion gene informationFusion gene name: AKIRIN2_CTNNA3
Fusion gene ID: 1378
HgeneTgene
Gene symbol

AKIRIN2

CTNNA3

Gene ID

55122

29119

Gene nameakirin 2catenin alpha 3
SynonymsC6orf166|FBI1|dJ486L4.2ARVD13|VR22
Cytomap

6q15

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionakirin-2fourteen-three-three beta interactant 1catenin alpha-3alpha-T-cateninalpha-catenin-like proteincatenin (cadherin-associated protein), alpha 3
Modification date2018051920180519
UniProtAcc

Q53H80

Q9UI47

Ensembl transtripts involved in fusion geneENST00000257787, ENST00000420494, 
ENST00000433211, ENST00000373744, 
ENST00000545309, ENST00000373735, 
Fusion gene scores* DoF score3 X 2 X 3=1810 X 8 X 6=480
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKIRIN2 [Title/Abstract] AND CTNNA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF119870AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000257787ENST00000433211AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000257787ENST00000373744AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000257787ENST00000545309AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000257787ENST00000373735AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000420494ENST00000433211AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000420494ENST00000373744AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000420494ENST00000545309AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-
intron-intronENST00000420494ENST00000373735AKIRIN2chr6

88410027

-CTNNA3chr10

68914891

-

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FusionProtFeatures for AKIRIN2_CTNNA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKIRIN2

Q53H80

CTNNA3

Q9UI47

Required for the innate immune response. Downstreameffector of the Toll-like receptor (TLR), TNF and IL-1 betasignaling pathways leading to the production of IL-6. Forms acomplex with YWHAB that acts to repress transcription of DUSP1 (Bysimilarity). {ECO:0000250}. May be involved in formation of stretch-resistant cell-cell adhesion complexes. {ECO:0000303|PubMed:11590244}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKIRIN2_CTNNA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKIRIN2_CTNNA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKIRIN2_CTNNA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKIRIN2_CTNNA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTNNA3C0004096Asthma1CTD_human
TgeneCTNNA3C0236969Substance-Related Disorders1CTD_human
TgeneCTNNA3C3810138ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 131UNIPROT