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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 13776

FusionGeneSummary for FOXK2_AMBRA1

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXK2_AMBRA1
Fusion gene ID: 13776
HgeneTgene
Gene symbol

FOXK2

AMBRA1

Gene ID

3607

55626

Gene nameforkhead box K2autophagy and beclin 1 regulator 1
SynonymsILF|ILF-1|ILF1DCAF3|WDR94
Cytomap

17q25.3

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein K2FOXK1cellular transcription factor ILF-1interleukin enhancer-binding factor 1activating molecule in BECN1-regulated autophagy protein 1DDB1 and CUL4 associated factor 3WD repeat domain 94activating molecule in beclin-1-regulated autophagyautophagy/beclin-1 regulator 1
Modification date2018052320180523
UniProtAcc

Q01167

Q9C0C7

Ensembl transtripts involved in fusion geneENST00000335255, ENST00000529652, 
ENST00000298834, ENST00000426438, 
ENST00000314845, ENST00000533727, 
ENST00000534300, ENST00000458649, 
ENST00000528950, ENST00000529963, 
Fusion gene scores* DoF score25 X 11 X 12=330010 X 9 X 8=720
# samples 2314
** MAII scorelog2(23/3300*10)=-3.8427602581888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXK2 [Title/Abstract] AND AMBRA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXK2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065434

TgeneAMBRA1

GO:0000423

mitophagy

21753002

TgeneAMBRA1

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

21753002

TgeneAMBRA1

GO:0098780

response to mitochondrial depolarisation

21753002


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-VS-A9V0-01AFOXK2chr17

80478183

+AMBRA1chr11

46419493

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000335255ENST00000298834FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
In-frameENST00000335255ENST00000426438FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
In-frameENST00000335255ENST00000314845FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
Frame-shiftENST00000335255ENST00000533727FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
Frame-shiftENST00000335255ENST00000534300FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
Frame-shiftENST00000335255ENST00000458649FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
Frame-shiftENST00000335255ENST00000528950FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
5CDS-intronENST00000335255ENST00000529963FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000298834FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000426438FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000314845FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000533727FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000534300FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000458649FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-3CDSENST00000529652ENST00000528950FOXK2chr17

80478183

+AMBRA1chr11

46419493

-
intron-intronENST00000529652ENST00000529963FOXK2chr17

80478183

+AMBRA1chr11

46419493

-

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FusionProtFeatures for FOXK2_AMBRA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXK2

Q01167

AMBRA1

Q9C0C7

Transcriptional regulator that recognizes the coresequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) inthe IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus(PubMed:25805136). Also binds to HIV-1 long terminal repeat. Maybe involved in both positive and negative regulation of importantviral and cellular promoter elements (PubMed:1909027).{ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027,ECO:0000269|PubMed:25805136}. Regulates autophagy and development of the nervoussystem. Involved in autophagy in controlling protein turnoverduring neuronal development, and in regulating normal cellsurvival and proliferation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXK2chr17:80478183chr11:46419493ENST00000335255+1910_93139661Compositional biasNote=Gly-rich
HgeneFOXK2chr17:80478183chr11:46419493ENST00000335255+1954_128139661DomainFHA

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXK2chr17:80478183chr11:46419493ENST00000335255+19258_353139661DNA bindingFork-head
HgeneFOXK2chr17:80478183chr11:46419493ENST00000335255+19300_318139661RegionNote=DNA-binding%3B major groove
HgeneFOXK2chr17:80478183chr11:46419493ENST00000335255+19328_332139661RegionNote=DNA-binding%3B minor groove
HgeneFOXK2chr17:80478183chr11:46419493ENST00000335255+19348_353139661RegionNote=DNA-binding%3B minor groove
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000298834-1517268_27710741239Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000298834-1517592_63910741239Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000314845-1719268_27710441209Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000314845-1719592_63910441209Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000426438-1517268_27711051270Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000426438-1517592_63911051270Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000458649-1618268_27711341299Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000458649-1618592_63911341299Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000528950-1517268_27711051270Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000528950-1517592_63911051270Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000533727-1618268_27710151180Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000533727-1618592_63910151180Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000534300-1517268_27710741239Compositional biasNote=Poly-Pro
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000534300-1517592_63910741239Compositional biasNote=Ser-rich
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000298834-1517135_17510741239RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000298834-151751_9010741239RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000298834-151793_13310741239RepeatNote=WD 2
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000314845-1719135_17510441209RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000314845-171951_9010441209RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000314845-171993_13310441209RepeatNote=WD 2
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000426438-1517135_17511051270RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000426438-151751_9011051270RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000426438-151793_13311051270RepeatNote=WD 2
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000458649-1618135_17511341299RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000458649-161851_9011341299RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000458649-161893_13311341299RepeatNote=WD 2
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000528950-1517135_17511051270RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000528950-151751_9011051270RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000528950-151793_13311051270RepeatNote=WD 2
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000533727-1618135_17510151180RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000533727-161851_9010151180RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000533727-161893_13310151180RepeatNote=WD 2
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000534300-1517135_17510741239RepeatNote=WD 3
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000534300-151751_9010741239RepeatNote=WD 1
TgeneAMBRA1chr17:80478183chr11:46419493ENST00000534300-151793_13310741239RepeatNote=WD 2


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FusionGeneSequence for FOXK2_AMBRA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000298834_chr11_46419493_-_304aa
MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGG
HGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVXGFRVWCQWRRCAQQDPEADGGGRHDSRGAAGAEHHHGLH
GRLRQQHHRQPPHSPQLSDGHXTWCRPHLLTPALHLSGTAPRGRATGRARPKPPDSFLGPAWYPWAGANPANPALFLPCPHSCFPSQRXG

>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000426438_chr11_46419493_-_304aa
MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGG
HGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVXGFRVWCQWRRCAQQDPEADGGGRHDSRGAAGAEHHHGLH
GRLRQQHHRQPPHSPQLSDGHXTWCRPHLLTPALHLSGTAPRGRATGRARPKPPDSFLGPAWYPWAGANPANPALFLPCPHSCFPSQRXG

>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000314845_chr11_46419493_-_304aa
MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGG
HGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVXGFRVWCQWRRCAQQDPEADGGGRHDSRGAAGAEHHHGLH
GRLRQQHHRQPPHSPQLSDGHXTWCRPHLLTPALHLSGTAPRGRATGRARPKPPDSFLGPAWYPWAGANPANPALFLPCPHSCFPSQRXG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000298834_chr11_46419493_-_913nt
ATGGCGGCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCC
CCGCCGGGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCG
TCGCAGGGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGC
CATGGCGGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGG
GTATTCGTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGAGGGTTCAGAGTATGGTGCCAGTGGAGA
AGATGCGCTCAGCAGGATCCAGAGGCTGATGGCGGAGGGCGGCATGACAGCCGTGGTGCAGCGGGAGCAGAGCACCACCATGGCCTCCAT
GGGCGGCTTCGGCAACAACATCATCGTCAGCCACCGCATTCACCGCAGCTCTCAGACGGGCACTGAACCTGGTGCCGCCCACACCTCCTC
ACCCCAGCCCTCCACCTCTCGGGGACTGCTCCCAGAGGCCGGGCAACTGGCAGAGCGAGGCCTAAGCCCCCGGACAGCTTCCTGGGACCA
GCCTGGTACCCCTGGGCGGGAGCCAACCCAGCCAACCCTGCCCTCTTCCTCCCCTGTCCCCATTCCTGTTTCCCTTCCCAGCGCTGAGGG
ACCAACCCTCCACTGCGAGTTGACCAATAACAACCACCTTCTGGATGGTGGCAGCAGCAGGGGGGACGCTGCAGGCCCTAGGGGAGAACC

>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000426438_chr11_46419493_-_913nt
ATGGCGGCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCC
CCGCCGGGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCG
TCGCAGGGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGC
CATGGCGGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGG
GTATTCGTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGAGGGTTCAGAGTATGGTGCCAGTGGAGA
AGATGCGCTCAGCAGGATCCAGAGGCTGATGGCGGAGGGCGGCATGACAGCCGTGGTGCAGCGGGAGCAGAGCACCACCATGGCCTCCAT
GGGCGGCTTCGGCAACAACATCATCGTCAGCCACCGCATTCACCGCAGCTCTCAGACGGGCACTGAACCTGGTGCCGCCCACACCTCCTC
ACCCCAGCCCTCCACCTCTCGGGGACTGCTCCCAGAGGCCGGGCAACTGGCAGAGCGAGGCCTAAGCCCCCGGACAGCTTCCTGGGACCA
GCCTGGTACCCCTGGGCGGGAGCCAACCCAGCCAACCCTGCCCTCTTCCTCCCCTGTCCCCATTCCTGTTTCCCTTCCCAGCGCTGAGGG
ACCAACCCTCCACTGCGAGTTGACCAATAACAACCACCTTCTGGATGGTGGCAGCAGCAGGGGGGACGCTGCAGGCCCTAGGGGAGAACC

>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000314845_chr11_46419493_-_913nt
ATGGCGGCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCC
CCGCCGGGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCG
TCGCAGGGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGC
CATGGCGGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGG
GTATTCGTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGAGGGTTCAGAGTATGGTGCCAGTGGAGA
AGATGCGCTCAGCAGGATCCAGAGGCTGATGGCGGAGGGCGGCATGACAGCCGTGGTGCAGCGGGAGCAGAGCACCACCATGGCCTCCAT
GGGCGGCTTCGGCAACAACATCATCGTCAGCCACCGCATTCACCGCAGCTCTCAGACGGGCACTGAACCTGGTGCCGCCCACACCTCCTC
ACCCCAGCCCTCCACCTCTCGGGGACTGCTCCCAGAGGCCGGGCAACTGGCAGAGCGAGGCCTAAGCCCCCGGACAGCTTCCTGGGACCA
GCCTGGTACCCCTGGGCGGGAGCCAACCCAGCCAACCCTGCCCTCTTCCTCCCCTGTCCCCATTCCTGTTTCCCTTCCCAGCGCTGAGGG
ACCAACCCTCCACTGCGAGTTGACCAATAACAACCACCTTCTGGATGGTGGCAGCAGCAGGGGGGACGCTGCAGGCCCTAGGGGAGAACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000298834_chr11_46419493_-_2123nt
CGGCCGCGCGTGCTCCCGCCCCTCGCCGCCGCTCGCTCGCTCGCCGGCCGGCGGCCTCCGCTCGGCCCCCTCCCTCAGCTCCGGTGCGCG
GCGGCCGACGACCCGCGCGGCCTGGGCCTCGGCCCGCGCCACCGGCGCCCGCGCGGAGCGGCCCGGGGGCCCTCACGCAGGCCCATGGCG
GCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCCCCGCCG
GGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCGTCGCAG
GGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGCCATGGC
GGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGGGTATTC
GTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGAGGGTTCAGAGTATGGTGCCAGTGGAGAAGATGC
GCTCAGCAGGATCCAGAGGCTGATGGCGGAGGGCGGCATGACAGCCGTGGTGCAGCGGGAGCAGAGCACCACCATGGCCTCCATGGGCGG
CTTCGGCAACAACATCATCGTCAGCCACCGCATTCACCGCAGCTCTCAGACGGGCACTGAACCTGGTGCCGCCCACACCTCCTCACCCCA
GCCCTCCACCTCTCGGGGACTGCTCCCAGAGGCCGGGCAACTGGCAGAGCGAGGCCTAAGCCCCCGGACAGCTTCCTGGGACCAGCCTGG
TACCCCTGGGCGGGAGCCAACCCAGCCAACCCTGCCCTCTTCCTCCCCTGTCCCCATTCCTGTTTCCCTTCCCAGCGCTGAGGGACCAAC
CCTCCACTGCGAGTTGACCAATAACAACCACCTTCTGGATGGTGGCAGCAGCAGGGGGGACGCTGCAGGCCCTAGGGGAGAACCACGGAA
CAGGTAGAGACAAACGTTGCACTGGTGCCTCCCCTCGAACCGCCAAGCAGAAACCGGACCTCACAGCTGACTGGGAACTGGACATGTGGA
AGAGCTGCTGGCTGCATCAGGGAACAGGAGGAGGAAGAGGGTCAGGGTGGAGAGGAAGATCAGTCAGTGGGCACAAGACAGTCAAATGGG
CAAGGCCTGCCTCGGGGAACTAGAACCTTCCAGGATCTGGAGCCCGGGAGAGCCACACTGTGGGCTTAATGTGAATAGAGGAACAAGTGG
GTATCTCTGCCAGGCACCCCACTTTCTCCTAGTAACATGGGCTCAGGGGACTCAGCCCTGGACAGAGAGCCTCCAGAGAGTGAACAGTCT
TCCAGATCTGGGCCAATCATCCTGGACAGAGGCCCGCGAGGCAGCTTTGCCCTGTCCACCTGTTGGGTGGGCAGAGCCACCAGGAACCCA
GACACCACCTCCAACTCTGAGCCTTCCAGAGCTTCAGCCTCTCTTCGTCGTCTTACCCCACTGAAACCAACAGGGATCGGGCCAGGCTCC
CAGATTCTTGAGGACAGGGACTTCGGCATTTACTAATGGGGGACTACTGTGGGGTAAGGGGGCGCCTGCTTGCCTGATACAGGATGGGGT
CAAGGGACAGTGGGCAGGTCCTCACTCAGGAGTGGGGGGTGTAGGCTGGCCAGCCCCCAGGGCTTGTCCACCAGTCTTCTCCCCGCAAGG
CCCTCAGAGCAGCGCCTGTGGGTGTCAGTATTACCTGAGCCTAGGCCAAAGCTAGCCCAAGGCTGGGGAAGGGGAGGAGACTCCAGGTCA
GAATGTGAGGTCTCAGTCTGTGATTTAAGGTGTTGCATGTGGACTCTTAACTGTACGTGTAGTTTCTAGTGGAGAAATCAAGGCTCTGAT
CATTTTGTTTTTAGTATGAAAATGTGATTTCCTTTCTGTTTGTAACTCATCATAGAAACATTGTGGTGGGAGGAGAGGGGATAGTCTACA

>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000426438_chr11_46419493_-_2123nt
CGGCCGCGCGTGCTCCCGCCCCTCGCCGCCGCTCGCTCGCTCGCCGGCCGGCGGCCTCCGCTCGGCCCCCTCCCTCAGCTCCGGTGCGCG
GCGGCCGACGACCCGCGCGGCCTGGGCCTCGGCCCGCGCCACCGGCGCCCGCGCGGAGCGGCCCGGGGGCCCTCACGCAGGCCCATGGCG
GCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCCCCGCCG
GGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCGTCGCAG
GGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGCCATGGC
GGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGGGTATTC
GTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGAGGGTTCAGAGTATGGTGCCAGTGGAGAAGATGC
GCTCAGCAGGATCCAGAGGCTGATGGCGGAGGGCGGCATGACAGCCGTGGTGCAGCGGGAGCAGAGCACCACCATGGCCTCCATGGGCGG
CTTCGGCAACAACATCATCGTCAGCCACCGCATTCACCGCAGCTCTCAGACGGGCACTGAACCTGGTGCCGCCCACACCTCCTCACCCCA
GCCCTCCACCTCTCGGGGACTGCTCCCAGAGGCCGGGCAACTGGCAGAGCGAGGCCTAAGCCCCCGGACAGCTTCCTGGGACCAGCCTGG
TACCCCTGGGCGGGAGCCAACCCAGCCAACCCTGCCCTCTTCCTCCCCTGTCCCCATTCCTGTTTCCCTTCCCAGCGCTGAGGGACCAAC
CCTCCACTGCGAGTTGACCAATAACAACCACCTTCTGGATGGTGGCAGCAGCAGGGGGGACGCTGCAGGCCCTAGGGGAGAACCACGGAA
CAGGTAGAGACAAACGTTGCACTGGTGCCTCCCCTCGAACCGCCAAGCAGAAACCGGACCTCACAGCTGACTGGGAACTGGACATGTGGA
AGAGCTGCTGGCTGCATCAGGGAACAGGAGGAGGAAGAGGGTCAGGGTGGAGAGGAAGATCAGTCAGTGGGCACAAGACAGTCAAATGGG
CAAGGCCTGCCTCGGGGAACTAGAACCTTCCAGGATCTGGAGCCCGGGAGAGCCACACTGTGGGCTTAATGTGAATAGAGGAACAAGTGG
GTATCTCTGCCAGGCACCCCACTTTCTCCTAGTAACATGGGCTCAGGGGACTCAGCCCTGGACAGAGAGCCTCCAGAGAGTGAACAGTCT
TCCAGATCTGGGCCAATCATCCTGGACAGAGGCCCGCGAGGCAGCTTTGCCCTGTCCACCTGTTGGGTGGGCAGAGCCACCAGGAACCCA
GACACCACCTCCAACTCTGAGCCTTCCAGAGCTTCAGCCTCTCTTCGTCGTCTTACCCCACTGAAACCAACAGGGATCGGGCCAGGCTCC
CAGATTCTTGAGGACAGGGACTTCGGCATTTACTAATGGGGGACTACTGTGGGGTAAGGGGGCGCCTGCTTGCCTGATACAGGATGGGGT
CAAGGGACAGTGGGCAGGTCCTCACTCAGGAGTGGGGGGTGTAGGCTGGCCAGCCCCCAGGGCTTGTCCACCAGTCTTCTCCCCGCAAGG
CCCTCAGAGCAGCGCCTGTGGGTGTCAGTATTACCTGAGCCTAGGCCAAAGCTAGCCCAAGGCTGGGGAAGGGGAGGAGACTCCAGGTCA
GAATGTGAGGTCTCAGTCTGTGATTTAAGGTGTTGCATGTGGACTCTTAACTGTACGTGTAGTTTCTAGTGGAGAAATCAAGGCTCTGAT
CATTTTGTTTTTAGTATGAAAATGTGATTTCCTTTCTGTTTGTAACTCATCATAGAAACATTGTGGTGGGAGGAGAGGGGATAGTCTACA

>In-frame_FOXK2_ENST00000335255_chr17_80478183_+_AMBRA1_ENST00000314845_chr11_46419493_-_2123nt
CGGCCGCGCGTGCTCCCGCCCCTCGCCGCCGCTCGCTCGCTCGCCGGCCGGCGGCCTCCGCTCGGCCCCCTCCCTCAGCTCCGGTGCGCG
GCGGCCGACGACCCGCGCGGCCTGGGCCTCGGCCCGCGCCACCGGCGCCCGCGCGGAGCGGCCCGGGGGCCCTCACGCAGGCCCATGGCG
GCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCCCCGCCG
GGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCGTCGCAG
GGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGCCATGGC
GGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGGGTATTC
GTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGAGGGTTCAGAGTATGGTGCCAGTGGAGAAGATGC
GCTCAGCAGGATCCAGAGGCTGATGGCGGAGGGCGGCATGACAGCCGTGGTGCAGCGGGAGCAGAGCACCACCATGGCCTCCATGGGCGG
CTTCGGCAACAACATCATCGTCAGCCACCGCATTCACCGCAGCTCTCAGACGGGCACTGAACCTGGTGCCGCCCACACCTCCTCACCCCA
GCCCTCCACCTCTCGGGGACTGCTCCCAGAGGCCGGGCAACTGGCAGAGCGAGGCCTAAGCCCCCGGACAGCTTCCTGGGACCAGCCTGG
TACCCCTGGGCGGGAGCCAACCCAGCCAACCCTGCCCTCTTCCTCCCCTGTCCCCATTCCTGTTTCCCTTCCCAGCGCTGAGGGACCAAC
CCTCCACTGCGAGTTGACCAATAACAACCACCTTCTGGATGGTGGCAGCAGCAGGGGGGACGCTGCAGGCCCTAGGGGAGAACCACGGAA
CAGGTAGAGACAAACGTTGCACTGGTGCCTCCCCTCGAACCGCCAAGCAGAAACCGGACCTCACAGCTGACTGGGAACTGGACATGTGGA
AGAGCTGCTGGCTGCATCAGGGAACAGGAGGAGGAAGAGGGTCAGGGTGGAGAGGAAGATCAGTCAGTGGGCACAAGACAGTCAAATGGG
CAAGGCCTGCCTCGGGGAACTAGAACCTTCCAGGATCTGGAGCCCGGGAGAGCCACACTGTGGGCTTAATGTGAATAGAGGAACAAGTGG
GTATCTCTGCCAGGCACCCCACTTTCTCCTAGTAACATGGGCTCAGGGGACTCAGCCCTGGACAGAGAGCCTCCAGAGAGTGAACAGTCT
TCCAGATCTGGGCCAATCATCCTGGACAGAGGCCCGCGAGGCAGCTTTGCCCTGTCCACCTGTTGGGTGGGCAGAGCCACCAGGAACCCA
GACACCACCTCCAACTCTGAGCCTTCCAGAGCTTCAGCCTCTCTTCGTCGTCTTACCCCACTGAAACCAACAGGGATCGGGCCAGGCTCC
CAGATTCTTGAGGACAGGGACTTCGGCATTTACTAATGGGGGACTACTGTGGGGTAAGGGGGCGCCTGCTTGCCTGATACAGGATGGGGT
CAAGGGACAGTGGGCAGGTCCTCACTCAGGAGTGGGGGGTGTAGGCTGGCCAGCCCCCAGGGCTTGTCCACCAGTCTTCTCCCCGCAAGG
CCCTCAGAGCAGCGCCTGTGGGTGTCAGTATTACCTGAGCCTAGGCCAAAGCTAGCCCAAGGCTGGGGAAGGGGAGGAGACTCCAGGTCA
GAATGTGAGGTCTCAGTCTGTGATTTAAGGTGTTGCATGTGGACTCTTAACTGTACGTGTAGTTTCTAGTGGAGAAATCAAGGCTCTGAT
CATTTTGTTTTTAGTATGAAAATGTGATTTCCTTTCTGTTTGTAACTCATCATAGAAACATTGTGGTGGGAGGAGAGGGGATAGTCTACA


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FusionGenePPI for FOXK2_AMBRA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FOXK2BAP1, AMOT, IRF2, CBX6, SOX2, HECW2, GPS2, RBBP7, SMU1, TEAD1, ESR1, BARD1, XPO1, SAP30, CTR9, HCFC1, MAX, TEAD2, FOXE1, FOXK1, SIN3A, ARID4B, BPTF, NCOR1, ARID4A, SMARCA5, TFAP4, MNT, SAP130, SUDS3, SMARCA1, ZBTB10, BRMS1L, KANSL1, TBL1XR1, ASXL2, BRMS1, MAP1B, TPR, CIC, C17orf49, LIG3, KMT2D, ASXL1, CHD4, HDAC2, ING2, MCRS1, PRDM10, RB1, RBBP5, TBP, KDM1B, DVL2, ING1, KDM5A, KANSL3, PHF20L1, CUX1, DMAP1, DRAP1, HIRA, HMGXB4, HOXD13, NCOR2, SATB2, SIN3B, TBL1X, TBL1Y, ADNP, C11orf30, KANSL2, DPY30, GTF3C3, H2AFY, HOXB9, NFYC, NRF1, NUP107, PSIP1, SAP30L, SF3B1, TP53BP1, SNX9, UBR4, RBM26, PUF60, ANKRD52, EIF2AK3, CHEK2, PRRC2C, UHRF1BP1, ANKRD28, SRPK2, CDK11A, KIAA0513, PER1, USP47, FLJ25613, TMF1, ABHD10, EIF5B, KANK2, RSRC2, FAM120A, NHP2, PHF23, SNRNP200, THRAP3, TP53, YTHDC1, HDAC1, NFATC1, DVL3, ZNF428, AHCYL2, TNFRSF1A, TULP3, FAM60A, PDGFRB, IKZF1, TP63, ZBTB39, CPD, TRIM25AMBRA1USP50, DDB1, MAP1B, ATG3, ATG4B, DDA1, BECN1, PARK2, CUL4A, COPS5, ULK1, BCL2, ATG13, TRAF6, MTOR, RPTOR, UBE2D3, ASB8, RNF2, CUL4B, DYNLL1, DYNC1I1, PIK3C3, GABARAP, LRRC29, CISH, RFPL4B, F12, HPS1, CCDC132, TRIM10, LRRC42, TBC1D22A, CAMKMT, PRAMEF5, FBXW11, HSP90AA1, HSPA5, HSPA8, STIP1, CCT3, HSPD1, CCT8, CCT4, CCT2, TUBA1A, TUBB3, BAG5, DNAJB1, ACTN1, SUGT1, STUB1, BAG2, TCEB2, WDR1, GPS1, COPS8, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB2, PSMB3, PSMB5, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD2, PSMD3, PSMD6, PSMD8, PSMD10, PSMD12, PSMD13, UBL4A, UBC, CUL7, NES, IRGM, PPP2CA, PPP2R1A, MYC, DUSP4, SOCS3, WSB2, DCAF7, DYNLL2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOXK2_AMBRA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FOXK2_AMBRA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAMBRA1C0036341Schizophrenia1PSYGENET